Relevance of serum homocysteine level to erythrocyte and platelet parameters in patients with unstable angina pectoris_West China Medical Journal

Authors：

 TANG Sihai

Department of Clinical Laboratory, Tongling Municipal Hospital, Tongling, Anhui 244000, P. R. China;

Corresponding?author：

TANG Sihai, Email: tangsihai123456@163.com

Keywords：

Unstable angina pectoris; Homocysteine; Erythrocyte parameters; Platelet parameters; Coefficient of variation of red blood cell volume distribution width

DOI：

10.7507/1002-0179.201602110

Video：

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Objective To explore the relevance of serum homocysteine (Hcy) level to erythrocyte and platelet parameters in patients with unstable angina pectoris (UAP). Methods Sixty patients with UAP were collected in Tongling Municipal Hospital from August 1st, 2012 to December 31st, 2015. Serum Hcy was measured by enzymatic cycling method. Erythrocyte parameters, such as red blood cell count (RBC), hemoglobin, mean corpuscular volume (MCV), coefficient of variation of red blood cell volume distribution width (RDW-CV), and platelet parameters, such as platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), platelet large cell ratio (P-LCR), were measured with blood cell counter. All patients were classified into UAP with hyperhomocystinemia (HHcy) group and UAP with normal Hcy group according to the level of Hcy. The data in two groups were analyzed and the relevance of serum Hcy level to erythrocyte and platelet parameters was evaluated. Results The differences in the levels of RBC, hemoglobin, MCV, PLT, PDW, MPV, P-LCR between the two groups were not statistically significant (P>0.05); while the levels of RDW-CV and the proportion of RDW-CV above the upper reference limit of patients in the UAP with HHcy group (13.81%±1.13%, 39.4%) were higher than those in the UAP with normal Hcy group (13.06%±0.97%, 4.8%), and the differences between the two groups were statistically significant (P<0.05). Correlation analysis showed that serum Hcy level of patients with UAP was significantly correlated with RDW-CV (r=0.380, P<0.01) and was not significantly correlated with other erythrocyte and platelet parameters (P>0.05). Conclusion The high level of Hcy affects red blood cell volume heterogeneity in patients with UAP, which may be one of the mechanisms of HHcy participating in the occurrence and development of UAP.

Citation： TANG Sihai. Relevance of serum homocysteine level to erythrocyte and platelet parameters in patients with unstable angina pectoris. West China Medical Journal, 2017, 32(11): 1749-1752. doi: 10.7507/1002-0179.201602110 Copy

1.	李梅. 急性冠脈綜合征患者血 hs-CRP、Hcy、sCD40L 與冠狀動脈狹窄程度的相關性分析. 中國實用醫刊, 2013, 40(15): 44-46.
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4.	吳東, 陳嘉林. 貧血 (一). 中華全科醫師雜志, 2012, 11(5): 332-333.
5.	Djuric D, Jakovljevic V, Rasic-Markovic A, et al. Homocysteine, folic acid and coronary artery disease: possible impact on prognosis and therapy. Indian J Chest Dis Allied Sci, 2008, 50(1): 39-48.
6.	Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest, 1986, 77(4): 1370-1376.
7.	Jarosz A, Nowicka G. C-reactive protein and homocysteine as risk factors of atherosclerosis. Przegl Lek, 2008, 65(6): 268-272.
8.	呂國齡, 霍正祿. 急性冠脈綜合征患者血清胱抑素 C、同型半胱氨酸和急性時相 C 反應蛋白水平及其影響因素研究. 實用臨床醫藥雜志, 2013, 17(11): 12-14.
9.	李美蘭, 張佩生. 血同型半胱氨酸水平對判斷冠狀動脈粥樣硬化斑塊易損性的意義. 中國社區醫師: 醫學專業, 2013, 15(1): 240.
10.	梁潔, 孫堯. 血清同型半胱氨酸和高敏 C 反應蛋白在不穩定型心絞痛危險度分層中的作用. 河北醫藥, 2009, 31(3): 273-274.
11.	羅南芬, 柳俊, 萬傳意. 血紅蛋白和急性冠脈綜合征的關系. 嶺南心血管病雜志, 2011, 17(6): 486-488.
12.	Dunkelgrun M, Hoeks SE, Welten GM, et al. Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery. Am J Cardiol, 2008, 101(8): 1196-1200.
13.	Cavusoglu E, Chopra V, Gupta A, et al. Usefulness of anemia in men as an independent predictor of two-year cardiovascular outcome in patients presenting with acute coronary syndrome. Am J Cardiol, 2006, 98(5): 580-584.
14.	王俊, 鐘勇, 江時森. 貧血與冠狀動脈病變的關系研究. 醫學研究生學報, 2008, 21(9): 944-947.
15.	Tsuboi S, Miyauchi K, Kasai T, et al. Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circ J, 2013, 77(2): 456-461.
16.	張翠蘋, 馬向紅. 紅細胞體積分布寬度與冠心病的關系研究. 中國全科醫學, 2013, 16(12): 1332-1335.

1. 李梅. 急性冠脈綜合征患者血 hs-CRP、Hcy、sCD40L 與冠狀動脈狹窄程度的相關性分析. 中國實用醫刊, 2013, 40(15): 44-46.
2. 彭章平, 朱建華. 現代缺血性心臟病學. 北京: 人民軍醫出版社, 2000: 289-297.
3. 中華醫學會心血管病學分會, 中華心血管病雜志編輯委員會. 不穩定型心絞痛診斷和治療建議. 中華心血管病雜志, 2000, 28(6): 409-412.
4. 吳東, 陳嘉林. 貧血 (一). 中華全科醫師雜志, 2012, 11(5): 332-333.
5. Djuric D, Jakovljevic V, Rasic-Markovic A, et al. Homocysteine, folic acid and coronary artery disease: possible impact on prognosis and therapy. Indian J Chest Dis Allied Sci, 2008, 50(1): 39-48.
6. Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest, 1986, 77(4): 1370-1376.
7. Jarosz A, Nowicka G. C-reactive protein and homocysteine as risk factors of atherosclerosis. Przegl Lek, 2008, 65(6): 268-272.
8. 呂國齡, 霍正祿. 急性冠脈綜合征患者血清胱抑素 C、同型半胱氨酸和急性時相 C 反應蛋白水平及其影響因素研究. 實用臨床醫藥雜志, 2013, 17(11): 12-14.
9. 李美蘭, 張佩生. 血同型半胱氨酸水平對判斷冠狀動脈粥樣硬化斑塊易損性的意義. 中國社區醫師: 醫學專業, 2013, 15(1): 240.
10. 梁潔, 孫堯. 血清同型半胱氨酸和高敏 C 反應蛋白在不穩定型心絞痛危險度分層中的作用. 河北醫藥, 2009, 31(3): 273-274.
11. 羅南芬, 柳俊, 萬傳意. 血紅蛋白和急性冠脈綜合征的關系. 嶺南心血管病雜志, 2011, 17(6): 486-488.
12. Dunkelgrun M, Hoeks SE, Welten GM, et al. Anemia as an independent predictor of perioperative and long-term cardiovascular outcome in patients scheduled for elective vascular surgery. Am J Cardiol, 2008, 101(8): 1196-1200.
13. Cavusoglu E, Chopra V, Gupta A, et al. Usefulness of anemia in men as an independent predictor of two-year cardiovascular outcome in patients presenting with acute coronary syndrome. Am J Cardiol, 2006, 98(5): 580-584.
14. 王俊, 鐘勇, 江時森. 貧血與冠狀動脈病變的關系研究. 醫學研究生學報, 2008, 21(9): 944-947.
15. Tsuboi S, Miyauchi K, Kasai T, et al. Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circ J, 2013, 77(2): 456-461.
16. 張翠蘋, 馬向紅. 紅細胞體積分布寬度與冠心病的關系研究. 中國全科醫學, 2013, 16(12): 1332-1335.

West China Medical Journal

Relevance of serum homocysteine level to erythrocyte and platelet parameters in patients with unstable angina pectoris

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