Effect of smoking on pulmonary function of male patients with chronic obstructive pulmonary disease and their correlation_West China Medical Journal

Authors：

 NIE Xiaohong , JIANG Chuan , LI Xuemei

Department of Respiratory Medicine, 416 Hospital of Nuclear Industry, Chengdu, Sichuan 610051, P. R. China;

Corresponding?author：

NIE Xiaohong, Email: xhnie1226@sina.com

Keywords：

Smoking; Chronic obstructive pulmonary disease; Pulmonary function; Correlation analysis

DOI：

10.7507/1002-0179.201602114

Video：

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Objective To explore the effect of smoking on pulmonary function parameters of male patients with chronic obstructive pulmonary disease (COPD) and to analyze the correlation between smoking and pulmonary function parameters. Methods From January 2014 to October 2015, the pulmonary function parameters of 223 male outpatients or hospitalized patients with COPD in the Department of Respiratory Medicine were retrospectively analyzed by using SPSS 17.0 software. The patients were randomly divided into smoking group (n=98), smoking cessation group (n=82) and non-smoking group (n=43). Results Various degrees of damage or abnormality of lung capacity, ventilatory function, gas exchange function and airway resistance (Raw) existed in the patients with COPD. Compared with smoking cessation group and non-smoking group, residual volume/ total lung capacity (RV/TLC) and Raw were significantly higher (P< 0.05), maximum ventilatory volume, ventilation reserve percent, forced vital capacity, the percent of first second forced expiratory volume compared its predicted value (FEV₁%pred), maximum mid-expiratory flow (MMEF), forced expiratory flow 50%, forced expiratory flow 75% and diffusing capacity of carbon monoxide were significantly lower (P<0.05) in the smoking group. There was a negative relationship between MMEF, FEV₁%pred and smoking index (r=–0.352, –0.381, P<0.05), and a positive relationship between Raw, RV/TLC and smoking index (r=0.403, 0.378, P<0.05). Conclusions Most of the male COPD patients smoke or used to smoke. Smoking leads to ventilation and gas exchange function decrease, small airway limitation aggravation, airway resistance and emphysema degree increase in COPD patients. Smoking index has a negative relationship with MMEF, FEV₁%pred and a positive relationship with Raw and RV/TLC.

Citation： NIE Xiaohong, JIANG Chuan, LI Xuemei. Effect of smoking on pulmonary function of male patients with chronic obstructive pulmonary disease and their correlation. West China Medical Journal, 2017, 32(6): 852-856. doi: 10.7507/1002-0179.201602114 Copy

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10.	陳勃江, 李為民, 袁玉茹. 吸煙對無呼吸道癥狀個體肺功能的影響. 中華肺部疾病雜志: 電子版, 2011, 4(6): 483-486.
11.	王曉如, 孔慶華, 范穎, 等. 吸煙與老年慢性阻塞性肺疾病患者肺功能受損程度相關性分析. 中國臨床醫學, 2011, 18(6): 794-796.
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13.	羅勤利. 戒煙干預對不同風險程度慢性阻塞性肺疾病患者預后的影響對比. 臨床肺科雜志, 2015, 20(6): 1076-1079.
14.	王聰穎, 張慶, 王少飛, 等. 不同風險慢性阻塞性肺疾病患者戒煙干預后臨床癥狀及肺功能變化研究. 中國全科醫學, 2014, 17(1): 50-52.

1. Vozoris NT, Stanbrook MB. Smoking prevalence, behaviours, and cessation among individuals with COPD or asthma. Respir Med, 2011, 105(3): 477-484.
2. 蘭豐鈴, 王勝鋒, 曹衛華, 等. 慢性阻塞性肺疾病危險因素流行病學研究新進展. 中華疾病控制雜志, 2014, 18(10): 998-1002.
3. 中華醫學會呼吸病學會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南 (2013 年修訂版). 中華結核和呼吸雜志, 2013, 36(4): 255-264.
4. 陳明勇, 劉小英, 吳友茹, 等. 遠程醫學干預對慢性阻塞性肺疾病穩定期患者慢性阻塞性肺疾病評估測試評分的影響. 華西醫學, 2014, 29(10): 1807-1809.
5. Miller MR. Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax, 2014, 69(12): 1145-1146.
6. Zuo L, He F, Sergakis GG, et al. Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments. Am J Physiol Lung Cell Mol Physiol, 2014, 307(3): L205-L218.
7. Sears MR. Smoking, asthma, chronic airflow obstruction and COPD. Eur Respir J, 2015, 45(3): 586-588.
8. 李曉茹, 趙子軍. 吸煙與慢性阻塞性肺疾病相關性的研究進展. 中國慢性病預防與控制, 2014, 22(1): 110-112.
9. 雒志明, 馬麗娜, 聶秀紅, 等. 吸煙對 COPD 患者肺功能的影響. 臨床肺科雜志, 2011, 16(8): 1250-1251.
10. 陳勃江, 李為民, 袁玉茹. 吸煙對無呼吸道癥狀個體肺功能的影響. 中華肺部疾病雜志: 電子版, 2011, 4(6): 483-486.
11. 王曉如, 孔慶華, 范穎, 等. 吸煙與老年慢性阻塞性肺疾病患者肺功能受損程度相關性分析. 中國臨床醫學, 2011, 18(6): 794-796.
12. Melzer AC, Feemster LC, Crothers K, et al. Respiratory and bronchitic symptoms predict intention to quit smoking among current smokers with, and at risk for, chronic obstructive pulmonary disease. Ann Am Thorac Soc, 2016, 13(9): 1490-1496.
13. 羅勤利. 戒煙干預對不同風險程度慢性阻塞性肺疾病患者預后的影響對比. 臨床肺科雜志, 2015, 20(6): 1076-1079.
14. 王聰穎, 張慶, 王少飛, 等. 不同風險慢性阻塞性肺疾病患者戒煙干預后臨床癥狀及肺功能變化研究. 中國全科醫學, 2014, 17(1): 50-52.

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