Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children_West China Medical Journal

Authors：

DU Jiyu ,  LIU Rong , LI Yan , WANG Xiaoshuang , YANG Jinyu , XIE Li

Department of Paediatrics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;

Corresponding?author：

LIU Rong, Email: 734287795@qq.com

Keywords：

Childhood asthma; Inducing factor; Serum total immunoglobulin E; Serum specific immunoglobulin E

DOI：

10.7507/1002-0179.201605043

Video：

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Objective To explore the inducing factors, the serum total immunoglobulin E (IgE) and specific IgE of bronchial asthma in Mianyang children, for better control of childhood asthma. Methods A total of 1 288 cases of asthma who were hospitalized in pediatric respiratory ward or asthma clinic from March 2013 to February 2016 were enrolled in the study. All cases complied with the diagnostic criteria for acute episode of childhood bronchial asthma revised in 2008 by the National Children’s Asthma Cooperative Group. The causes of asthma attack were asked by doctors, and the patient’s serum total IgE and specific IgE was tested. Results Respiratory tract infections were the most common cause (1 057 cases, 82.1%), which was followed by weather changes and exposure to cold air (694 cases, 53.9%), and then food (304, 23.6%). The risk of asthma induced by respiratory infections was highest in <2-year old group (358 cases, 97.5%), and lowest in 10-14-year old group (42 cases, 33.3%), with a decreasing trend with age (χ²_trend=239.865, P<0.001). Food was also an important inducing factor, and seafood was the most frequent (121 cases, 39.8%). Total serum IgE was positive in 868 cases (67.4%). The positive rate in <2-year old group (52.6%) was the lowest, and the positive rate in 10-14-year old group (89.7%) was the highest, with an increasing trend with age (χ²_trend=88.055, P<0.001). Serum specific IgE was positive in 733 cases (56.9%). The positive rate in <2-year old group (37.1%) was the lowest, and the positive rate in 10-14-year old group (92.6%) was the highest, with an increasing trend with age (χ²_trend=150.361, P<0.001). The progressive rate of dust mites in inhalation and dietary allergens was highest (668 cases, 51.8%), which was followed by house dust (431 cases, 33.4%). Conclusions The most common inducing factor for bronchial asthma in Mianyang children is respiratory tract infection, followed by the weather changes and cold air exposure, and then food. Detection of serum total IgE and specific IgE is more valuable in elderly children with bronchial asthma.

Citation： DU Jiyu, LIU Rong, LI Yan, WANG Xiaoshuang, YANG Jinyu, XIE Li. Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children. West China Medical Journal, 2017, 32(7): 1029-1032. doi: 10.7507/1002-0179.201605043 Copy

1.	全國兒童哮喘協作組. 第三次中國城市兒童哮喘流行病學調查. 中華兒科雜志, 2013, 51(10): 729-735.
2.	中華醫學會兒科分會呼吸學組, 《中華兒科雜志》編輯委員會. 兒童支氣管哮喘診斷與防治指南. 中華兒科雜志, 2008, 46(10): 745-753.
3.	全國兒科哮喘防治協作組. 全國 90 萬 0-14 歲兒童支氣管哮喘患病情況調查. 中華結核呼吸雜志, 1993, 16(增刊1): 64-68.
4.	全國兒科哮喘防治協作組. 中國城區兒童哮喘患病率調查. 中華兒科雜志, 2003, 41(20): 123-127.
5.	Papadopoulos NG, Arakawa H, Carlsen KH, et al. 兒童哮喘國際共識. 中華實用兒科臨床雜志, 2014, 29(1): 67-76.
6.	中國哮喘兒童家長知信行調查項目組. 中國大陸 29 城市哮喘患兒病情控制狀況及影響因素. 中華兒科雜志, 2013, 51(2): 90-95.
7.	Wong G, Kwon N, Hong JG, et al. Pediatric asthma control in Asia: Phase 2 of the Asthma Insights and Reality in Asia-Pacific (AIRIAP 2) survey. Allergy, 2013, 68(4): 524-530.
8.	Papadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma. Allergy, 2012, 67(8): 976-997.
9.	Singer F, Luchsinger I, Inci D, et al. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma. Allergy, 2013, 68(4): 531-538.
10.	鄭躍杰, 劉萍, 袁雄偉, 等. 總免疫球蛋白 E 和特異性免疫球蛋白 E 在兒童呼吸道變態反應性疾病中的分布. 實用兒科臨床雜志, 2006, 21(21): 1455-1456.
11.	王靜, 付亞南, 王群, 等. 總免疫球蛋白 E 和特異性免疫球蛋白 E 在兒童呼吸道變態反應性疾病中的分布. 中華實用兒科臨床雜志, 2014, 29(4): 289-294.
12.	陳宇明, 黃東明, 肖曉雄, 等. 皮膚和血清過敏原檢測對兒童支氣管哮喘的意義. 第三軍醫大學學報, 2010, 32(13): 1477-1478.
13.	趙凱, 徐紅梅, 葉侃. 蘇州地區支氣管哮喘兒童特異性過敏原檢查的意義. 中華實用兒科臨床雜志, 2007, 22(4): 279-280.
14.	杭金國, 姚澤忠, 管敏昌, 等. 臺州地區支氣管哮喘患兒過敏原特異性 IgE 檢查分析及臨床意義. 檢驗醫學, 2011, 26(9): 627.
15.	武其文, 蔡鵬程, 陳治中, 等. 武漢地區支氣管哮喘患兒過敏原特異性 IgE 分析. 臨床血液學雜志, 2009, 22(1): 65-67.
16.	吳艷, 范曉東, 惠復新, 等. 江蘇無錫地區支氣管哮喘患者過敏原特異性 IgE 分析. 實用臨床醫藥雜志, 2010, 14(15): 119-121.
17.	蔡幸生, 林麗愛, 黃育濤, 等. 兒童支氣管哮喘 112 例過敏原分析. 廣東醫學, 2016, 37(9): 1360-1361.

1. 全國兒童哮喘協作組. 第三次中國城市兒童哮喘流行病學調查. 中華兒科雜志, 2013, 51(10): 729-735.
2. 中華醫學會兒科分會呼吸學組, 《中華兒科雜志》編輯委員會. 兒童支氣管哮喘診斷與防治指南. 中華兒科雜志, 2008, 46(10): 745-753.
3. 全國兒科哮喘防治協作組. 全國 90 萬 0-14 歲兒童支氣管哮喘患病情況調查. 中華結核呼吸雜志, 1993, 16(增刊1): 64-68.
4. 全國兒科哮喘防治協作組. 中國城區兒童哮喘患病率調查. 中華兒科雜志, 2003, 41(20): 123-127.
5. Papadopoulos NG, Arakawa H, Carlsen KH, et al. 兒童哮喘國際共識. 中華實用兒科臨床雜志, 2014, 29(1): 67-76.
6. 中國哮喘兒童家長知信行調查項目組. 中國大陸 29 城市哮喘患兒病情控制狀況及影響因素. 中華兒科雜志, 2013, 51(2): 90-95.
7. Wong G, Kwon N, Hong JG, et al. Pediatric asthma control in Asia: Phase 2 of the Asthma Insights and Reality in Asia-Pacific (AIRIAP 2) survey. Allergy, 2013, 68(4): 524-530.
8. Papadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma. Allergy, 2012, 67(8): 976-997.
9. Singer F, Luchsinger I, Inci D, et al. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma. Allergy, 2013, 68(4): 531-538.
10. 鄭躍杰, 劉萍, 袁雄偉, 等. 總免疫球蛋白 E 和特異性免疫球蛋白 E 在兒童呼吸道變態反應性疾病中的分布. 實用兒科臨床雜志, 2006, 21(21): 1455-1456.
11. 王靜, 付亞南, 王群, 等. 總免疫球蛋白 E 和特異性免疫球蛋白 E 在兒童呼吸道變態反應性疾病中的分布. 中華實用兒科臨床雜志, 2014, 29(4): 289-294.
12. 陳宇明, 黃東明, 肖曉雄, 等. 皮膚和血清過敏原檢測對兒童支氣管哮喘的意義. 第三軍醫大學學報, 2010, 32(13): 1477-1478.
13. 趙凱, 徐紅梅, 葉侃. 蘇州地區支氣管哮喘兒童特異性過敏原檢查的意義. 中華實用兒科臨床雜志, 2007, 22(4): 279-280.
14. 杭金國, 姚澤忠, 管敏昌, 等. 臺州地區支氣管哮喘患兒過敏原特異性 IgE 檢查分析及臨床意義. 檢驗醫學, 2011, 26(9): 627.
15. 武其文, 蔡鵬程, 陳治中, 等. 武漢地區支氣管哮喘患兒過敏原特異性 IgE 分析. 臨床血液學雜志, 2009, 22(1): 65-67.
16. 吳艷, 范曉東, 惠復新, 等. 江蘇無錫地區支氣管哮喘患者過敏原特異性 IgE 分析. 實用臨床醫藥雜志, 2010, 14(15): 119-121.
17. 蔡幸生, 林麗愛, 黃育濤, 等. 兒童支氣管哮喘 112 例過敏原分析. 廣東醫學, 2016, 37(9): 1360-1361.

West China Medical Journal

Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children

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