Vitamin K level in maintenance hemodialysis patients_West China Medical Journal

Authors：

 FENG Yunlin , HE Qiang , RUAN Yizhe , ZHANG Wensong , WANG Li , DENG Fei

Department of Nephrology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

FENG Yunlin, Email: fengyunlinsc@qq.com

Keywords：

Hemodialysis; Vitamin K; Matrix gla protein; Osteocalcin

DOI：

10.7507/1002-0179.201605077

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Objective To explore the vitamin K level in Chinese maintenance hemodialysis (MHD) patients. Methods MHD patients and healthy subjects from our outpatient clinic were enrolled from 1 to 30 in March 2016. Demographic data was collected. Fasting serum samples from all subjects were collected for biochemistry tests and the measurement of known vitamin K-dependent proteins, i.e. matrix Gla protein (MGP), osteocalcin (OC) and uncarboxylated osteocalcin (ucOC). We also quantified the fraction of ucOC of total OC (%ucOC). Differences of these parameters between the two groups were analyzed. Results We enrolled 70 MHD patients as a test group and 70 healthy subjects as a control group. There was no significant difference in MGP between MHD group and the control group [(4.1±2.2) vs. (4.4±1.0) pg/mL, P=0.441]. The value of %ucOC was significantly higher in the MHD group than that in the control group [(79.3±19.3)% vs. (51.9±13.0)%, P<0.001]. Conclusions Deficiency of vitamin K appears common in Chinese MHD patients. Besides pathological reasons, dietary habit may also contribute to this phenomenon.

Citation： FENG Yunlin, HE Qiang, RUAN Yizhe, ZHANG Wensong, WANG Li, DENG Fei. Vitamin K level in maintenance hemodialysis patients. West China Medical Journal, 2017, 32(8): 1225-1228. doi: 10.7507/1002-0179.201605077 Copy

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9.	Booth SL, Martini L, Peterson JW, et al. Dietary phylloquinone depletion and repletion in older women. J Nutr, 2003, 133(8): 2565-2569.
10.	黃世蓉, 游健, 李靜. 成都市青羊區居民飲食習慣調查報告. 現代預防醫學, 2002, 29(6): 857-858.
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13.	Danziger J. Vitamin K-dependent proteins, warfarin, and vascular calcification. Clin J Am Soc Nephrol, 2008, 3(5): 1504-1510.
14.	Eleftheriadis T, Antoniadi G, Liakopoulos V, et al. Plasma serotonin and markers of bone formation and bone resorption in hemodialysis patients. Iran J Kidney Dis, 2013, 7(1): 36-41.
15.	Scarpioni R, Ricardi M, Albertazzi V, et al. Dialysis-related amyloidosis: challenges and solutions. Int J Nephrol Renovasc Dis, 2016, 9(9): 319-328.

1. Vermeer C. Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J, 1990, 266(3): 625-636.
2. Furie B, Furie BC. Molecular and cellular biology of blood coagulation. N Engl J Med, 1992, 326(12): 800-806.
3. Berkner KL, Runge KW. The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J Thromb Haemost, 2004, 2(12): 2118-2132.
4. Westenfeld R, Krueger T, Schlieper G, et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis, 2012, 59(2): 186-195.
5. Pilkey RM, Morton AR, Boffa MB, et al. Subclinical vitamin K deficiency in hemodialysis patients. Am J Kidney Dis, 2007, 49(3): 432-439.
6. Kohlmeier M, Saupe J, Shearer MJ, et al. Bone health of adult hemodialysis patients is related to vitamin K status. Kidney Int, 1997, 51(4): 1218-1221.
7. Davidson KW, Sadowski JA. Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods Enzymol, 1997, 282: 408-421.
8. Binkley NC, Krueger DC, Kawahara TN, et al. A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. Am J Clin Nutr, 2002, 76(5): 1055-1060.
9. Booth SL, Martini L, Peterson JW, et al. Dietary phylloquinone depletion and repletion in older women. J Nutr, 2003, 133(8): 2565-2569.
10. 黃世蓉, 游健, 李靜. 成都市青羊區居民飲食習慣調查報告. 現代預防醫學, 2002, 29(6): 857-858.
11. 中國營養學會修訂《中國居民膳食指南》專家委員會. 《中國居民膳食指南》(2007)(節錄). 營養學報, 2008, 30(1): 2-18.
12. 李昕睿, 熊犍. 韶關市市區居民日常飲食營養狀況抽樣調查報告. 現代食品科技, 2008, 24(9): 933-936, 942, 946.
13. Danziger J. Vitamin K-dependent proteins, warfarin, and vascular calcification. Clin J Am Soc Nephrol, 2008, 3(5): 1504-1510.
14. Eleftheriadis T, Antoniadi G, Liakopoulos V, et al. Plasma serotonin and markers of bone formation and bone resorption in hemodialysis patients. Iran J Kidney Dis, 2013, 7(1): 36-41.
15. Scarpioni R, Ricardi M, Albertazzi V, et al. Dialysis-related amyloidosis: challenges and solutions. Int J Nephrol Renovasc Dis, 2016, 9(9): 319-328.

West China Medical Journal

Vitamin K level in maintenance hemodialysis patients

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