Analysis of the retinal and choroidal thickness in myopia patients with different diopters_West China Medical Journal

Authors：

BAO Li , YANG Tao , WANG Xiaoyue ,  LIU Longqian

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LIU Longqian, Email: bq15651@hotmail.com

Keywords：

Myopia; Optical coherence tomography; Retina; Choroid; Thickness

DOI：

10.7507/1002-0179.201610140

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the retinal and choroidal thickness of myopic patients with different diopters, and analyze the change rule and its relation with the diopter. Methods From October 2015 to June 2016, a total of 161 patients (322 eyes) with myopia and 53 normal volunteers (106 eyes) were selected from Department of Ophthalmology, West China Hospital of Sichuan University. Optical coherence tomography (OCT) examination was performed in all the subjects with Macular cube 512×128 and EDI HD-OCT model in Cirrus HD-OCT 5000 of Carl Zeiss Company from Germany, measuring the retinal and choroidal thickness in macular central fovea, and 3 and 6 mm above, below, on the nose side, and on the temporal side of macular central fovea; the data were averaged. According to the different diopters, the subjects were divided into four groups, including emmetropia group with 53 patients (106 eyes), low myopia group (equivalent diopter from –0.25 to –3.00) with 64 patients (128 eyes), moderate myopia group (equivalent diopter from –3.25 to –6.00) with 47 patients (94 eyes), and high myopia group (equivalent diopter <–6.00) with 50 patients (100 eyes). All the subjects’ best corrected visual acuities were ≥0.8. The changes of retinal and choroidal thickness in myopia patients with different diopters were compared and analyzed. Results The average retinal thickness of the patients in the emmetropia group, the low myopia group, the moderate myopia group, and the high myopia group was (242.50±29.86), (238.46±23.85), (224.52±26.01), (211.91±23.07) μm, respectively; the average choroidal thickness of the patients in the emmetropia group, the low myopia group, the moderate myopia group, and the high myopia group was (220.16±66.00), (252.39±79.56), (191.09±103.03), (121.83±92.54) μm, respectively. There was no significant difference in retinal thickness between the moderate myopia group and the high myopia group (P>0.05), while the differences in retinal thickness between the remaining groups were statistically significant (P<0.05); there was no statistically significant difference between the emmetropia group and moderate myopia group (P>0.05), while the differences in choroid thickness between the remaining groups were statistically significant (P<0.05). Conclusion In general, there are decreasing trends of the retinal thickness and choroid thickness with the increase of the diopter, which may be associated with the formation process of myopia.

Citation： BAO Li, YANG Tao, WANG Xiaoyue, LIU Longqian. Analysis of the retinal and choroidal thickness in myopia patients with different diopters. West China Medical Journal, 2017, 32(10): 1520-1524. doi: 10.7507/1002-0179.201610140 Copy

1.	McCarty CA, Taylor HR. Myopia and vision 2020. Am J Ophthalmol, 2000, 129(4): 525-527.
2.	呂燕, 竇思東, 陳燕, 等. 青少年近視眼相關因素調查研究. 亞太傳統醫藥, 2013, 9(8): 79-80.
3.	葛堅. 眼科學. 北京: 高等教育出版社, 2004: 367.
4.	Samuel NE, Krishnagopal S. Foveal and macular thickness evaluation by spectral OCT SLO and its relation with axial length in various degree of myopia. J Clin Diagn Res, 2015, 9(3): NC01-NC04.
5.	Yau GS, Lee JW, Woo TT, et al. Central macular thickness in children with myopia, emmetropia, and hyperopia: an optical coherence tomography study. Biomed Res Int, 2015: 1-4.
6.	Xiang F, He M, Morgan IG. The impact of severity of parental myopia on myopia in Chinese children. Optom Vis Sci, 2012, 89(6): 884-891.
7.	李娜, 王玲. 近視眼黃斑視網膜厚度最值的研究. 眼科新進展, 2008, 28(3): 210-213.
8.	王麗霞, 王幼生, 王小川, 等. 高度近視患者黃斑部視網膜厚度光學相干斷層掃描分析. 臨床醫學工程, 2016, 23(3): 261-263.
9.	Duan XR, Liang YB, Friedman DS, et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study. Ophthalmology, 2010, 117(8): 1585-1594.
10.	Hwang YH, Kim YY. Macular thickness and volume of myopic eyes measured using spectral-domain optical coherence tomography. Clin Exp Optom, 2012, 95(5): 492-498.
11.	趙桂玲, 龐燕華, 周舟, 等. OCT 研究黃斑厚度與近視程度關系. 中國實用眼科雜志, 2014, 32(6): 735-737.
12.	張偉亮, 李雙農. EDI SD-OCT 的眼科應用. 中國中醫眼科雜志, 2015, 25(3): 223-227.
13.	紀曉倩, 吳昌凡, 方嚴. 脈絡膜厚度在近視發病機制中的研究進展. 臨床眼科雜志, 2016, 24(1): 88-90.
14.	Huang W, Wang W, Zhou M, et al. Peripapillary choroidal thickness in healthy Chinese subjects. BMC Ophthalmol, 2013, 13: 23.
15.	Ho J, Branchini L, Regatieri C, et al. Analysis of normal peripapillary choroidal thickness via spectral domain optical coherence tomography. Ophthalmology, 2011, 118(10): 2001-2007.
16.	陳莉莉, 陳子林, 李澤斌, 等. Cirrus HD OCT 檢測近視眼黃斑中心凹下脈絡膜厚度的研究. 國際眼科雜志, 2014, 14(9): 1641-1643.
17.	Gupta P, Cheung CY, Saw SM, et al. Peripapillary choroidal thickness in young Asians with high myopia. Invest Ophthalmol Vis Sci, 2015, 56(3): 1475-1481.
18.	Song WK, Lee SC, Lee ES, et al. Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study. Invest Ophthalmol Vis Sci, 2010, 51(8): 3913-3918.

1. McCarty CA, Taylor HR. Myopia and vision 2020. Am J Ophthalmol, 2000, 129(4): 525-527.
2. 呂燕, 竇思東, 陳燕, 等. 青少年近視眼相關因素調查研究. 亞太傳統醫藥, 2013, 9(8): 79-80.
3. 葛堅. 眼科學. 北京: 高等教育出版社, 2004: 367.
4. Samuel NE, Krishnagopal S. Foveal and macular thickness evaluation by spectral OCT SLO and its relation with axial length in various degree of myopia. J Clin Diagn Res, 2015, 9(3): NC01-NC04.
5. Yau GS, Lee JW, Woo TT, et al. Central macular thickness in children with myopia, emmetropia, and hyperopia: an optical coherence tomography study. Biomed Res Int, 2015: 1-4.
6. Xiang F, He M, Morgan IG. The impact of severity of parental myopia on myopia in Chinese children. Optom Vis Sci, 2012, 89(6): 884-891.
7. 李娜, 王玲. 近視眼黃斑視網膜厚度最值的研究. 眼科新進展, 2008, 28(3): 210-213.
8. 王麗霞, 王幼生, 王小川, 等. 高度近視患者黃斑部視網膜厚度光學相干斷層掃描分析. 臨床醫學工程, 2016, 23(3): 261-263.
9. Duan XR, Liang YB, Friedman DS, et al. Normal macular thickness measurements using optical coherence tomography in healthy eyes of adult Chinese persons: the Handan Eye Study. Ophthalmology, 2010, 117(8): 1585-1594.
10. Hwang YH, Kim YY. Macular thickness and volume of myopic eyes measured using spectral-domain optical coherence tomography. Clin Exp Optom, 2012, 95(5): 492-498.
11. 趙桂玲, 龐燕華, 周舟, 等. OCT 研究黃斑厚度與近視程度關系. 中國實用眼科雜志, 2014, 32(6): 735-737.
12. 張偉亮, 李雙農. EDI SD-OCT 的眼科應用. 中國中醫眼科雜志, 2015, 25(3): 223-227.
13. 紀曉倩, 吳昌凡, 方嚴. 脈絡膜厚度在近視發病機制中的研究進展. 臨床眼科雜志, 2016, 24(1): 88-90.
14. Huang W, Wang W, Zhou M, et al. Peripapillary choroidal thickness in healthy Chinese subjects. BMC Ophthalmol, 2013, 13: 23.
15. Ho J, Branchini L, Regatieri C, et al. Analysis of normal peripapillary choroidal thickness via spectral domain optical coherence tomography. Ophthalmology, 2011, 118(10): 2001-2007.
16. 陳莉莉, 陳子林, 李澤斌, 等. Cirrus HD OCT 檢測近視眼黃斑中心凹下脈絡膜厚度的研究. 國際眼科雜志, 2014, 14(9): 1641-1643.
17. Gupta P, Cheung CY, Saw SM, et al. Peripapillary choroidal thickness in young Asians with high myopia. Invest Ophthalmol Vis Sci, 2015, 56(3): 1475-1481.
18. Song WK, Lee SC, Lee ES, et al. Macular thickness variations with sex, age, and axial length in healthy subjects: a spectral domain-optical coherence tomography study. Invest Ophthalmol Vis Sci, 2010, 51(8): 3913-3918.

West China Medical Journal

Analysis of the retinal and choroidal thickness in myopia patients with different diopters

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content