Correlation between plasma aminoterminal pro-B-type natriuretic peptide level and severity of coronary artery lesions in patients with non-ST segment elevation myocardial infarction_West China Medical Journal

Authors：

WANG Lin ¹ , HE Yue ² , WEI Wei ³ ,  WAN Zhi ³

1. Department of Cardiology, Chengdu Shangjinnanfu Hospital, Chengdu, Sichuan 611730, P. R. China;
2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Emergency Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

WAN Zhi, Email: 456wz@163.com

Keywords：

Aminoterminal pro-B-type natriuretic peptide; Non-ST elevation myocardial infaction; Gensini score

DOI：

10.7507/1002-0179.201705104

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Objective To investigate the correlation between plasma aminoterminal pro-B-type natriuretic peptide (NT-proBNP) level and severity of coronary artery lesions in patients with non-ST segment elevation myocardial infarction (NSTEMI). Methods NSTEMI patients presenting to the Emergency Department and Department of Cardiology from January 2013 to March 2017 were divided into four groups: thrombosis without stenosis, single vessel disease, double vessel diseases, and three vessel diseases. The general situation of the patients, the plasma NT-proBNP, troponin T, echocardiogram and coronary angiography results were analyzed. Results A total of 88 patients were included including 6 in thrombosis without stenosis group, 20 in single vessel disease group, 31 in double vessel diseases group, and 31 in three vessel diseases group. The NT-proBNP level, left ventricular ejection fraction, left ventricular end diastolic diameter, and coronary Gensini score in three vessel diseases group differed much from those in the other groups (P<0.05). The correlation of NT-proBNP with coronary Gensini score in all the patients was positve (t=0.663, P<0.05). Conclusion The level of plasma NT-proBNP in patients with NSTEMI is related to the severity of coronary artery disease.

Citation： WANG Lin, HE Yue, WEI Wei, WAN Zhi. Correlation between plasma aminoterminal pro-B-type natriuretic peptide level and severity of coronary artery lesions in patients with non-ST segment elevation myocardial infarction. West China Medical Journal, 2017, 32(6): 804-807. doi: 10.7507/1002-0179.201705104 Copy

1.	Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent st-segment elevation of the European Society of Cardiology (ESC). Eur Heart J, 2016, 37(3): 267-315.
2.	Alame AJ, Karatasakis A, Karacsonyi J, et al. Comparison of the American College of Cardiology/American Heart Association and the European Society of Cardiology guidelines for the management of patients with non-ST-segment elevation acute coronary syndromes. Coron Artery Dis, 2017, 28(4): 294-300.
3.	Worrall-Carter L, McEvedy S, Kuhn L, et al. Systematic review and meta-analyses investigating whether risk stratification explains lower rates of coronary angiography among women with non-ST-segment elevation acute coronary syndrome. J Cardiovasc Nurs, 2017, 32(2): 112-124.
4.	李亞, 耿濤, 劉永興, 等. NT-proBNP 和 hs-CTNI 聯合檢測在急性非 ST 段抬高型冠狀動脈綜合征危險分層及治療中的意義. 重慶醫學, 2013, 42(28): 3377-3378, 3381.
5.	張春艷, 王聰霞, 李永勤, 等. MMP-9 聯合 NT-proBNP 在非 ST 段抬高急性冠脈綜合征危險分層的研究. 西安交通大學學報: 醫學版, 2016, 37(3): 313-317.
6.	Tóth M, Vuorinen KH, Vuolteenaho O, et al. Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium. Am J Physiol, 1994, 266(4 Pt 2): H1572-H1580.
7.	Struthers AD, Davies J. B-type natriuretic peptide: a simple new test to identify coronary artery disease?. QJM, 2005, 98(10): 765-769.
8.	吳焱賢, 黃裕立, 陳玉映, 等. 血漿 NT-proBNP 與急性非 ST 段抬高型心肌梗死患者冠脈病變的相關性研究. 實用醫學雜志, 2013, 29(13): 2135-2137.
9.	陳豐運, 肖驊. NT-proBNP、hs-CRP 和超聲心動圖與急性冠狀動脈綜合征病變程度的相關性研究. 重慶醫學, 2015, 44(31): 4338-4342.
10.	Schellings DA, Adiyaman A, Dambrink JE, et al. Predictive value of NT-proBNP for 30-day mortality in patients with non-ST-elevation acute coronary syndromes: a comparison with the GRACE and TIMI risk scores. Vasc Health Risk Manag, 2016, 12: 471-476.
11.	Morrow DA, De Lemos JA, Sabatine MS, et al. Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18. J Am Coll Cardiol, 2003, 41(8): 1264-1272.
12.	Jarai R, Huber K, Bogaerts K, et al. Plasma N-terminal fragment of the prohormone B-type natriuretic peptide concentrations in relation to time to treatment and Thrombolysis in Myocardial Infarction (TIMI) flow: a substudy of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention (ASSENT IV-PCI) trial. Am Heart J, 2010, 159(1): 131-140.
13.	Castro LR, Alencar MC, Barbosa MM, et al. NT-proBNP levels in patients with Non-ST-segment elevation acute coronary syndrome. Arq Bras Cardiol, 2011, 97(6): 454-461.
14.	Riezebos RK, Ronner E, Tijssen JG, et al. NT-ProBNP serum levels reflect severity and extent of ischemia in patients admitted with non-ST-elevation acute coronary syndrome. Acute Card Care, 2006, 8(1): 51-57.
15.	Kashani H, Zeraati H, Mohammad K, et al. Analyzing gensini score as a semi-continuous outcome. J Tehran Heart Cent, 2016, 11(2): 55-61.
16.	熊信林, 唐炯, 蔡琳. 尿酸和白細胞與急性冠狀動脈綜合征嚴重程度的相關性研究. 華西醫學, 2014, 29(10): 1814-1817.
17.	黃萍, 王斌. 全球急性冠狀動脈事件注冊評分聯合血清肌鈣蛋白 Ⅰ 濃度在急性非 ST 段抬高型心肌梗死危險分層中的意義. 華西醫學, 2015, 30(12): 2201-2204.

1. Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: task force for the management of acute coronary syndromes in patients presenting without persistent st-segment elevation of the European Society of Cardiology (ESC). Eur Heart J, 2016, 37(3): 267-315.
2. Alame AJ, Karatasakis A, Karacsonyi J, et al. Comparison of the American College of Cardiology/American Heart Association and the European Society of Cardiology guidelines for the management of patients with non-ST-segment elevation acute coronary syndromes. Coron Artery Dis, 2017, 28(4): 294-300.
3. Worrall-Carter L, McEvedy S, Kuhn L, et al. Systematic review and meta-analyses investigating whether risk stratification explains lower rates of coronary angiography among women with non-ST-segment elevation acute coronary syndrome. J Cardiovasc Nurs, 2017, 32(2): 112-124.
4. 李亞, 耿濤, 劉永興, 等. NT-proBNP 和 hs-CTNI 聯合檢測在急性非 ST 段抬高型冠狀動脈綜合征危險分層及治療中的意義. 重慶醫學, 2013, 42(28): 3377-3378, 3381.
5. 張春艷, 王聰霞, 李永勤, 等. MMP-9 聯合 NT-proBNP 在非 ST 段抬高急性冠脈綜合征危險分層的研究. 西安交通大學學報: 醫學版, 2016, 37(3): 313-317.
6. Tóth M, Vuorinen KH, Vuolteenaho O, et al. Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium. Am J Physiol, 1994, 266(4 Pt 2): H1572-H1580.
7. Struthers AD, Davies J. B-type natriuretic peptide: a simple new test to identify coronary artery disease?. QJM, 2005, 98(10): 765-769.
8. 吳焱賢, 黃裕立, 陳玉映, 等. 血漿 NT-proBNP 與急性非 ST 段抬高型心肌梗死患者冠脈病變的相關性研究. 實用醫學雜志, 2013, 29(13): 2135-2137.
9. 陳豐運, 肖驊. NT-proBNP、hs-CRP 和超聲心動圖與急性冠狀動脈綜合征病變程度的相關性研究. 重慶醫學, 2015, 44(31): 4338-4342.
10. Schellings DA, Adiyaman A, Dambrink JE, et al. Predictive value of NT-proBNP for 30-day mortality in patients with non-ST-elevation acute coronary syndromes: a comparison with the GRACE and TIMI risk scores. Vasc Health Risk Manag, 2016, 12: 471-476.
11. Morrow DA, De Lemos JA, Sabatine MS, et al. Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18. J Am Coll Cardiol, 2003, 41(8): 1264-1272.
12. Jarai R, Huber K, Bogaerts K, et al. Plasma N-terminal fragment of the prohormone B-type natriuretic peptide concentrations in relation to time to treatment and Thrombolysis in Myocardial Infarction (TIMI) flow: a substudy of the Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention (ASSENT IV-PCI) trial. Am Heart J, 2010, 159(1): 131-140.
13. Castro LR, Alencar MC, Barbosa MM, et al. NT-proBNP levels in patients with Non-ST-segment elevation acute coronary syndrome. Arq Bras Cardiol, 2011, 97(6): 454-461.
14. Riezebos RK, Ronner E, Tijssen JG, et al. NT-ProBNP serum levels reflect severity and extent of ischemia in patients admitted with non-ST-elevation acute coronary syndrome. Acute Card Care, 2006, 8(1): 51-57.
15. Kashani H, Zeraati H, Mohammad K, et al. Analyzing gensini score as a semi-continuous outcome. J Tehran Heart Cent, 2016, 11(2): 55-61.
16. 熊信林, 唐炯, 蔡琳. 尿酸和白細胞與急性冠狀動脈綜合征嚴重程度的相關性研究. 華西醫學, 2014, 29(10): 1814-1817.
17. 黃萍, 王斌. 全球急性冠狀動脈事件注冊評分聯合血清肌鈣蛋白 Ⅰ 濃度在急性非 ST 段抬高型心肌梗死危險分層中的意義. 華西醫學, 2015, 30(12): 2201-2204.

West China Medical Journal

Correlation between plasma aminoterminal pro-B-type natriuretic peptide level and severity of coronary artery lesions in patients with non-ST segment elevation myocardial infarction

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