Idiopathic inflammatory myopathies associated interstitial lung disease_West China Medical Journal

Authors：

HU Yidan ,  LIU Gang , XIE Qibing

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LIU Gang, Email: neoliugang@163.com

Keywords：

Idiopathic inflammatory myopathies; Myositis-specific autoantibodies; Interstitial lung diseases; Inflammatory myopathies associated interstitial lung disease

DOI：

10.7507/1002-0179.201805070

Video：

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Idiopathic inflammatory myopathies are a group of connective tissue diseases characterized by nonsuppurative inflammation of the striated muscle. At present, the diagnostic criteria for polymyositis/dermatomyositis classification proposed by Bohan and Peter in 1976 is mainly used clinically. In clinical observations, it is found that myopathy involves not only skin and muscle but also affects many systems of the body. Interstitial lung disease occupies an important part, and it is an important cause of death of patients with inflammatory myopathy. Patients with idiopathic myositis should be examined as early as possible by high-resolution CT to improve the detection rate of myositis-associated interstitial lung disease and start treatment as soon as possible. At the same time, the patients with myositis have different clinical manifestations due to specific antibodies in the serum; some specific antibodies may indicate poor prognosis and poor treatment response. Timely screening of patients with positive myositis-specific antibodies in patients with the pulmonary interstitial disease can help the patient’s diagnosis and treatment process.

Citation： HU Yidan, LIU Gang, XIE Qibing. Idiopathic inflammatory myopathies associated interstitial lung disease. West China Medical Journal, 2018, 33(12): 1544-1548. doi: 10.7507/1002-0179.201805070 Copy

1.	Marie I, Hatron PY, Dominique S, et al. Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis a series of 107 patients. Arthritis Rheum, 2011, 63(11): 3439-3447.
2.	中華醫學會呼吸病學分會間質性肺疾病學組. 特發性肺纖維化診斷和治療中國專家共識. 中華結核和呼吸雜志, 2016, 39(6): 427-432.
3.	謝苗苗, 蔡后榮. 特發性炎性肌病自身抗體與間質性肺疾病的研究進展. 中華結核和呼吸雜志, 2017, 40(11): 870-873.
4.	Fujisawa T, Suda T, Nakamura Y, et al. Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis. J Rheumatol, 2005, 32(1): 58-64.
5.	Connors GR, Christopher-Stine L, Oddis CV, et al. Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?. J Chest, 2010, 138(6): 1464-1474.
6.	Malkan A, Cappelen-Smith C, Beran R, et al. Anti-synthetase syndrome associated with anti PL-12 and anti-signal recognition particle antibodies and a necrotizing auto-immune myositis. J Clin Neurosci, 2015, 22(2): 396-398.
7.	Cojocaru M, Cojocaru IM, Chicos B. New insights into antisynthetase syndrome. Maedica, 2016, 11(2): 130-135.
8.	黃慧, 邵池, 李珊, 等. 特發性炎性肌病相關性間質性肺疾病的診治進展. 中華結核和呼吸雜志, 2017, 40(8): 625-628.
9.	Mescam-Mancini L, Allenbach Y, Hervier BA, et al. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Brain, 2015, 138(9): 2485-2492.
10.	Marie I, Josse S, Decaux O, et al. Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 positive patients with antisynthetase syndrome. Autoimmun Rev, 2012, 11(10): 739-745.
11.	Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of Anti-PL-12 autoantibody cohort study and review of the literature. Chest, 2009, 135(6): 1550-1556.
12.	王怡, 李穎, 李升錦. 抗 MDA5 抗體對成年及幼年型皮肌炎合并間質性肺病診斷效能的 meta 分析. 臨床檢驗雜志, 2018(1): 46-52.
13.	So H, Ip RW, Wong VT, et al. Analysis of anti-melanoma differentiation-associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations. Int J Rheum Dis, 2018, 21(5): 1076-1081.
14.	Palterer B, Vitiello G, Carraresi A, et al. Bench to bedside review of myositis autoantibodies. Clin Mol Allergy, 2018, 16(1): 5.
15.	Hengstman G, ter Laak HJ, Egberts WM, et al. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis, 2006, 65(12): 1635-1638.
16.	Cottin V, Thivolet-Bejui F, Reynaud-Gaubert M, et al. Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis. Eur Respir J, 2003, 22(2): 245-250.
17.	Suzuki S, Nishikawa A, Kuwana MA, et al. Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients. Orphanet J Rare Dis, 2015, 10(1): 1-9.
18.	王濤, 石景麗, 張亞妹, 等. 抗 Mi-2 抗體不同亞型的臨床異質性研究. 中日友好醫院學報, 2017, 31(1): 7-10, 17.
19.	李珊珊, 葛永鵬, 楊闞波, 等. 皮肌炎患者 427 例肌炎特異性抗體譜及與臨床特征相關性分析. 中華風濕病學雜志, 2017, 21(9): 585-594.
20.	許叢叢, 王培光. 皮肌炎自身抗體檢測研究進展. 國際皮膚性病學雜志, 2017, 43(6): 325-328.
21.	Yang HB, Lu X, Peng QL, et al. Differential clinical associations of anti-nuclear matrix protein 2 autoantibodies in patients with idiopathic inflammatory myopathies. Arthritis Rheumatol, 2018, 70(8): 1288-1297.
22.	Tard C, Tiffreau V, Jaillette E, et al. Anti-HMGCR antibody-related necrotizing autoimmune myopathy mimicking muscular dystrophy. Neuropediatrics, 2017, 48(6): 473-476.
23.	王盼, 任立紅. 特發性炎癥性肌病的診治進展. 現代醫學, 2018(1): 97-100.
24.	陳珊珊, 李華敏, 陳建壽, 等. 大劑量 N-乙酰半胱氨酸聯合糖皮質激素治療慢性阻塞性肺疾病并肺間質纖維化的臨床療效. 實用心腦肺血管病雜志, 2017, 25(3): 97-100.
25.	劉萍, 秦興國. 間質性肺疾病治療研究進展. 國際呼吸雜志, 2015, 35(16): 1251-1254.
26.	劉玉葉, 陳秀敏, 黃閏月, 等. 利妥昔單抗治療特發性炎性肌病的系統評價. 臨床與病理雜志, 2015, 35(12): 2095-2101.
27.	Tralleroaraguás E, Berastegui C, Lópezcorbeto M, et al. SAT0339 lung transplantation in patients with interstitial lung disease associated with antisynthetase and anti-mda5 syndromes. experience from a reference spanish hospital. Eur Congr Rheumatol, 2017, 76(Suppl 2): 900.1-900.
28.	Malkan A, Cordato D, Griffith N, et al. 10. Anti-synthetase syndrome associated with necrotizing myositis – Utility of myositis specific autoantibodies in predicting prognosis and choice of treatment. Clin Neurophysiol, 2014, 125(4): e4.

1. Marie I, Hatron PY, Dominique S, et al. Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis a series of 107 patients. Arthritis Rheum, 2011, 63(11): 3439-3447.
2. 中華醫學會呼吸病學分會間質性肺疾病學組. 特發性肺纖維化診斷和治療中國專家共識. 中華結核和呼吸雜志, 2016, 39(6): 427-432.
3. 謝苗苗, 蔡后榮. 特發性炎性肌病自身抗體與間質性肺疾病的研究進展. 中華結核和呼吸雜志, 2017, 40(11): 870-873.
4. Fujisawa T, Suda T, Nakamura Y, et al. Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis. J Rheumatol, 2005, 32(1): 58-64.
5. Connors GR, Christopher-Stine L, Oddis CV, et al. Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years?. J Chest, 2010, 138(6): 1464-1474.
6. Malkan A, Cappelen-Smith C, Beran R, et al. Anti-synthetase syndrome associated with anti PL-12 and anti-signal recognition particle antibodies and a necrotizing auto-immune myositis. J Clin Neurosci, 2015, 22(2): 396-398.
7. Cojocaru M, Cojocaru IM, Chicos B. New insights into antisynthetase syndrome. Maedica, 2016, 11(2): 130-135.
8. 黃慧, 邵池, 李珊, 等. 特發性炎性肌病相關性間質性肺疾病的診治進展. 中華結核和呼吸雜志, 2017, 40(8): 625-628.
9. Mescam-Mancini L, Allenbach Y, Hervier BA, et al. Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis. Brain, 2015, 138(9): 2485-2492.
10. Marie I, Josse S, Decaux O, et al. Comparison of long-term outcome between anti-Jo1- and anti-PL7/PL12 positive patients with antisynthetase syndrome. Autoimmun Rev, 2012, 11(10): 739-745.
11. Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of Anti-PL-12 autoantibody cohort study and review of the literature. Chest, 2009, 135(6): 1550-1556.
12. 王怡, 李穎, 李升錦. 抗 MDA5 抗體對成年及幼年型皮肌炎合并間質性肺病診斷效能的 meta 分析. 臨床檢驗雜志, 2018(1): 46-52.
13. So H, Ip RW, Wong VT, et al. Analysis of anti-melanoma differentiation-associated gene 5 antibody in Hong Kong Chinese patients with idiopathic inflammatory myopathies: diagnostic utility and clinical correlations. Int J Rheum Dis, 2018, 21(5): 1076-1081.
14. Palterer B, Vitiello G, Carraresi A, et al. Bench to bedside review of myositis autoantibodies. Clin Mol Allergy, 2018, 16(1): 5.
15. Hengstman G, ter Laak HJ, Egberts WM, et al. Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis, 2006, 65(12): 1635-1638.
16. Cottin V, Thivolet-Bejui F, Reynaud-Gaubert M, et al. Interstitial lung disease in amyopathic dermatomyositis, dermatomyositis and polymyositis. Eur Respir J, 2003, 22(2): 245-250.
17. Suzuki S, Nishikawa A, Kuwana MA, et al. Inflammatory myopathy with anti-signal recognition particle antibodies: case series of 100 patients. Orphanet J Rare Dis, 2015, 10(1): 1-9.
18. 王濤, 石景麗, 張亞妹, 等. 抗 Mi-2 抗體不同亞型的臨床異質性研究. 中日友好醫院學報, 2017, 31(1): 7-10, 17.
19. 李珊珊, 葛永鵬, 楊闞波, 等. 皮肌炎患者 427 例肌炎特異性抗體譜及與臨床特征相關性分析. 中華風濕病學雜志, 2017, 21(9): 585-594.
20. 許叢叢, 王培光. 皮肌炎自身抗體檢測研究進展. 國際皮膚性病學雜志, 2017, 43(6): 325-328.
21. Yang HB, Lu X, Peng QL, et al. Differential clinical associations of anti-nuclear matrix protein 2 autoantibodies in patients with idiopathic inflammatory myopathies. Arthritis Rheumatol, 2018, 70(8): 1288-1297.
22. Tard C, Tiffreau V, Jaillette E, et al. Anti-HMGCR antibody-related necrotizing autoimmune myopathy mimicking muscular dystrophy. Neuropediatrics, 2017, 48(6): 473-476.
23. 王盼, 任立紅. 特發性炎癥性肌病的診治進展. 現代醫學, 2018(1): 97-100.
24. 陳珊珊, 李華敏, 陳建壽, 等. 大劑量 N-乙酰半胱氨酸聯合糖皮質激素治療慢性阻塞性肺疾病并肺間質纖維化的臨床療效. 實用心腦肺血管病雜志, 2017, 25(3): 97-100.
25. 劉萍, 秦興國. 間質性肺疾病治療研究進展. 國際呼吸雜志, 2015, 35(16): 1251-1254.
26. 劉玉葉, 陳秀敏, 黃閏月, 等. 利妥昔單抗治療特發性炎性肌病的系統評價. 臨床與病理雜志, 2015, 35(12): 2095-2101.
27. Tralleroaraguás E, Berastegui C, Lópezcorbeto M, et al. SAT0339 lung transplantation in patients with interstitial lung disease associated with antisynthetase and anti-mda5 syndromes. experience from a reference spanish hospital. Eur Congr Rheumatol, 2017, 76(Suppl 2): 900.1-900.
28. Malkan A, Cordato D, Griffith N, et al. 10. Anti-synthetase syndrome associated with necrotizing myositis – Utility of myositis specific autoantibodies in predicting prognosis and choice of treatment. Clin Neurophysiol, 2014, 125(4): e4.

West China Medical Journal

Idiopathic inflammatory myopathies associated interstitial lung disease

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