Advances in the role of neutrophils in pulmonary vascular endothelial injury after cardiopulmonary resuscitation_West China Medical Journal

Authors：

ZHANG Jianjun ^1,2 , XU Ping ² ,  CAO Yu ¹

1. Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Emergency, Zigong Fourth People’s Hospital, Zigong, Sichuan 643000, P. R. China;

Corresponding?author：

CAO Yu, Email: yuyuer@126.com

Keywords：

Cardiopulmonary resuscitation; Pulmonary vascular endothelial injury; Neutrophils

DOI：

10.7507/1002-0179.201901166

Video：

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The body of patient undergoing cardiopulmonary resuscitation after cardiac arrest experiences a process of ischemia, hypoxia, and reperfusion injury. This state of intense stress response is accompanied with hemodynamic instability, systemic hypoperfusion, and subsequent multiple organ dysfunction, and is life-threatening. Pulmonary vascular endothelial injury after cardiopulmonary resuscitation is a pathological manifestation of lung injury in multiple organ injury. Possible mechanisms include inflammatory response, neutrophil infiltration, microcirculatory disorder, tissue oxygen uptake and utilization disorder, etc. Neutrophils can directly damage or indirectly damage lung vascular endothelial cells through activation and migration activities. They also activate the body to produce large amounts of oxygen free radicals and release a series of damaging cytokines that further impaire the lung tissue.

Citation： ZHANG Jianjun, XU Ping, CAO Yu. Advances in the role of neutrophils in pulmonary vascular endothelial injury after cardiopulmonary resuscitation. West China Medical Journal, 2019, 34(4): 429-432. doi: 10.7507/1002-0179.201901166 Copy

1.	蔣華馳, 劉峰, 鄭明峰, 等. 再次肺移植治療肺移植術后閉塞性細支氣管炎綜合征. 中華移植雜志(電子版), 2017, 11(4): 221-224.
2.	葉心怡, 陳剛領, 劉晗, 等. 中性粒細胞NADPH氧化酶與組織缺血再灌注關系的研究進展. 現代生物醫學進展, 2017, 32(17): 6380-6385.
3.	張慶光, 凌霜, 劉俊, 等. 嗜中性粒細胞胞外誘捕網對缺血再灌注損傷的影響及中醫藥干預研究進展. 上海中醫藥大學學報, 2018, 32(3): 97-102, 108.
4.	鎮艷, 易偉民, 王華軍, 等. 缺血處理對大鼠缺血再灌注性壓瘡中性粒細胞浸潤度的影響. 嶺南急診醫學雜志, 2018, 23(1): 17-19, 23.
5.	孫麗, 郭瑜, 朱利娟, 等. 心肺復蘇后腦缺血再灌注損傷治療理念及相關動物模型研究進展. 現代生物醫學進展, 2014, 14(32): 6379-6382.
6.	Zhou X, Yong L, Huang Y, et al. The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation. J Cell Physiol, 2018, 233(9): 6902-6910.
7.	Dong LY, Zheng JH, Qiu XX, et al. Ischemic preconditioning reduces deep hypothermic circulatory arrest cardiopulmonary bypass induced lung injury. Eur Rev Med Pharmacol Sci, 2013, 17(13): 1789-1799.
8.	Fink K, Moebes M, Vetter C, et al. Selenium prevents microparticle-induced endothelial inflammation in patients after cardiopulmonary resuscitation. Crit Care, 2015, 19(1): 58.
9.	武軍元, 王爍, 李春盛, 等. 烏司他丁對改善豬心肺復蘇后炎癥反應和心肺組織損傷的作用. 中華危重病急救醫學, 2013, 25(2): 106-108.
10.	梁穎紅, 張成詩, 魏明, 等. 輸血相關急性肺損傷大鼠肺組織細胞間黏附分子1和細胞因子誘導的中性粒細胞趨化因子1的表達. 中華生物醫學工程雜志, 2016, 22(4): 287-292.
11.	Li B, Lu X, Wang J, et al. The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR^-/- mice. Int J Biol Sci, 2018, 14(1): 36-46.
12.	Ge L, Zhou X, Ji WJ, et al. Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy. Am J Physiol Heart Circ Physiol, 2015, 308(5): H500-H509.
13.	Cedervall J, Zhang YY, Huang H, et al. Neutrophil extracellular traps accumulate in peripheral blood vessels and compromise organ function in tumor-bearing animals. Cancer Res, 2015, 75(13): 2653-2662.
14.	Takhtfooladi HA, Hesaraki S, Razmara F, et al. Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind limb ischemia/reperfusion injury. J Bras Pneumol, 2016, 42(1): 9-14.
15.	李璐, 傅海東. 中性粒細胞胞外誘捕網在兒童系統性紅斑狼瘡的研究進展. 中國當代兒科雜志, 2018, 20(3): 251-255.
16.	Albadawi H, Oklu R, Malley RE, et al. Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice. J Vasc Surg, 2016, 64(2): 484-493.
17.	Doris P, Mathieu-Beno?t V, Abigail W, et al. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med, 2012, 209(6): 1219-1234.
18.	趙利軍, 李開濟, 盧秋玲, 等. 缺血后處理對大鼠肢體缺血再灌注后肺損傷的保護作用及其機制. 吉林大學學報(醫學版), 2016, 42(2): 255-259.
19.	張燕, 嚴冰, 劉毅. 中性粒細胞胞外陷阱誘導血管內皮細胞損傷在皮肌炎合并肺間質病變中的作用. 中華內科雜志, 2017, 56(9): 650-654.
20.	Gomes EC, An SA, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev, 2012(3): 756132.
21.	Naha PC, Davoren M, Lyng FM, et al. Reactive Oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol Appl Pharmacol, 2010, 246(1/2): 91-99.
22.	Soccal PM, Gasche Y, Miniati DN, et al. Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. Am J Transplant, 2015, 4(1): 41-50.
23.	楊斌, 陳海龍. 中性粒細胞彈性蛋白酶在重癥急性胰腺炎并急性肺損傷發病中的表達和意義. 臨床軍醫雜志, 2012, 40(4): 765-769, 封4.
24.	Mihara K, Ramachandran R, Renaux BA, et al. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem, 2013, 288(46): 32979-32990.
25.	陶元東, 唐麗. 中性粒細胞異質性的研究進展. 細胞與分子免疫學雜志, 2016, 32(12): 1704-1706.

1. 蔣華馳, 劉峰, 鄭明峰, 等. 再次肺移植治療肺移植術后閉塞性細支氣管炎綜合征. 中華移植雜志(電子版), 2017, 11(4): 221-224.
2. 葉心怡, 陳剛領, 劉晗, 等. 中性粒細胞NADPH氧化酶與組織缺血再灌注關系的研究進展. 現代生物醫學進展, 2017, 32(17): 6380-6385.
3. 張慶光, 凌霜, 劉俊, 等. 嗜中性粒細胞胞外誘捕網對缺血再灌注損傷的影響及中醫藥干預研究進展. 上海中醫藥大學學報, 2018, 32(3): 97-102, 108.
4. 鎮艷, 易偉民, 王華軍, 等. 缺血處理對大鼠缺血再灌注性壓瘡中性粒細胞浸潤度的影響. 嶺南急診醫學雜志, 2018, 23(1): 17-19, 23.
5. 孫麗, 郭瑜, 朱利娟, 等. 心肺復蘇后腦缺血再灌注損傷治療理念及相關動物模型研究進展. 現代生物醫學進展, 2014, 14(32): 6379-6382.
6. Zhou X, Yong L, Huang Y, et al. The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation. J Cell Physiol, 2018, 233(9): 6902-6910.
7. Dong LY, Zheng JH, Qiu XX, et al. Ischemic preconditioning reduces deep hypothermic circulatory arrest cardiopulmonary bypass induced lung injury. Eur Rev Med Pharmacol Sci, 2013, 17(13): 1789-1799.
8. Fink K, Moebes M, Vetter C, et al. Selenium prevents microparticle-induced endothelial inflammation in patients after cardiopulmonary resuscitation. Crit Care, 2015, 19(1): 58.
9. 武軍元, 王爍, 李春盛, 等. 烏司他丁對改善豬心肺復蘇后炎癥反應和心肺組織損傷的作用. 中華危重病急救醫學, 2013, 25(2): 106-108.
10. 梁穎紅, 張成詩, 魏明, 等. 輸血相關急性肺損傷大鼠肺組織細胞間黏附分子1和細胞因子誘導的中性粒細胞趨化因子1的表達. 中華生物醫學工程雜志, 2016, 22(4): 287-292.
11. Li B, Lu X, Wang J, et al. The metabonomics study of P-selectin glycoprotein ligand-1 (PSGL-1) deficiency inhibiting the progression of atherosclerosis in LDLR^-/- mice. Int J Biol Sci, 2018, 14(1): 36-46.
12. Ge L, Zhou X, Ji WJ, et al. Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy. Am J Physiol Heart Circ Physiol, 2015, 308(5): H500-H509.
13. Cedervall J, Zhang YY, Huang H, et al. Neutrophil extracellular traps accumulate in peripheral blood vessels and compromise organ function in tumor-bearing animals. Cancer Res, 2015, 75(13): 2653-2662.
14. Takhtfooladi HA, Hesaraki S, Razmara F, et al. Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind limb ischemia/reperfusion injury. J Bras Pneumol, 2016, 42(1): 9-14.
15. 李璐, 傅海東. 中性粒細胞胞外誘捕網在兒童系統性紅斑狼瘡的研究進展. 中國當代兒科雜志, 2018, 20(3): 251-255.
16. Albadawi H, Oklu R, Malley RE, et al. Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice. J Vasc Surg, 2016, 64(2): 484-493.
17. Doris P, Mathieu-Beno?t V, Abigail W, et al. Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med, 2012, 209(6): 1219-1234.
18. 趙利軍, 李開濟, 盧秋玲, 等. 缺血后處理對大鼠肢體缺血再灌注后肺損傷的保護作用及其機制. 吉林大學學報(醫學版), 2016, 42(2): 255-259.
19. 張燕, 嚴冰, 劉毅. 中性粒細胞胞外陷阱誘導血管內皮細胞損傷在皮肌炎合并肺間質病變中的作用. 中華內科雜志, 2017, 56(9): 650-654.
20. Gomes EC, An SA, de Oliveira MR. Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxid Med Cell Longev, 2012(3): 756132.
21. Naha PC, Davoren M, Lyng FM, et al. Reactive Oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol Appl Pharmacol, 2010, 246(1/2): 91-99.
22. Soccal PM, Gasche Y, Miniati DN, et al. Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation. Am J Transplant, 2015, 4(1): 41-50.
23. 楊斌, 陳海龍. 中性粒細胞彈性蛋白酶在重癥急性胰腺炎并急性肺損傷發病中的表達和意義. 臨床軍醫雜志, 2012, 40(4): 765-769, 封4.
24. Mihara K, Ramachandran R, Renaux BA, et al. Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1). J Biol Chem, 2013, 288(46): 32979-32990.
25. 陶元東, 唐麗. 中性粒細胞異質性的研究進展. 細胞與分子免疫學雜志, 2016, 32(12): 1704-1706.

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