Progress in CT-guided implantation of iodine-125 seeds for malignant tumors assisted by individualized 3D template_West China Medical Journal

Authors：

LI Xingchang , LI Yixing , LIU Dehui , HU Pan ,  LAI Jianping

Department of Nuclear Medicine, the People’s Hospital of Three Gorges University, the First People’s Hospital of Yichang, Yichang, Hubei 443000, P. R. China;

Corresponding?author：

LAI Jianping, Email: ljp2116cn@163.com

Keywords：

Individualized 3D template; CT-guided; Iodine-125 seeds implantation; Malignant tumor

DOI：

10.7507/1002-0179.201904138

Video：

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The iodine-125 (¹²⁵I) seeds interstitial implantation has the advantages of minimal invasiveness, high local control rate, and few complications; it has attracted worldwide attention. With the application of 3D printing technology in medicine, individualized 3D templates are gradually applied to clinical practice. Individualized 3D templates combining with CT-guided ¹²⁵I seeds implantation are easy to operate and can not only effectively ensure the consistency and accuracy of preoperative and postoperative dose, but also minimize complications to achieve optimal efficacy. This paper reviews the application of CT-guided implantation of ¹²⁵I seeds for malignant tumors assisted by individualized 3D template, and further demonstrates the safety and effectiveness of clinical application in ¹²⁵I seeds implantation to provide a reliable basis for the standardization of ¹²⁵I seeds implantation.

Citation： LI Xingchang, LI Yixing, LIU Dehui, HU Pan, LAI Jianping. Progress in CT-guided implantation of iodine-125 seeds for malignant tumors assisted by individualized 3D template. West China Medical Journal, 2019, 34(8): 948-952. doi: 10.7507/1002-0179.201904138 Copy

1.	吳菲, 林國楨, 張晉昕. 我國惡性腫瘤發病現狀及趨勢. 中國腫瘤, 2012, 21(2): 81-85.
2.	Trombetta MG, Colonias A, Makishi D, et al. Tolerance of the aorta using intraoperative iodine-125 interstitial brachytherapy in cancer of the lung. Brachytherapy, 2008, 7(1): 50-54.
3.	王文俊, 陳志軍, 許波, 等. 3D打印非共面模板CT引導下¹²⁵I粒子植入治療惡性腫瘤臨床應用. 實用癌癥雜志, 2018, 33(9): 1557-1559.
4.	郭福新, 姜玉良, 吉喆, 等. 3D打印非共面模板輔助CT引導¹²⁵I粒子植入治療鎖骨上復發轉移癌的劑量學研究. 北京大學學報(醫學版), 2017, 49(3): 506-511.
5.	姜玉良. 北京大學第三醫院完成首例CT引導聯合3D打印模板指導放射性粒子植入治療腹膜后復發腫瘤. 北京大學學報(醫學版), 2016, 48(1): 182.
6.	Liu Q, Dai X, Zhou X, et al. Comparison of TACE combined with and without iodine-125 seeds implantation therapy for advanced stage hepatocellular carcinoma: a systematic review and meta-analysis. J BUON, 2019, 24(2): 642-649.
7.	Lu J, Huang W, Wang Z, et al. The safety and efficacy of interstitial ¹²⁵I seed implantation brachytherapy for metastatic epidural spinal cord compression. J Cancer Res Ther, 2018, 14(7): 1549-1555.
8.	Hertzanu Y, Ye X. A valuable guideline of radioactive ¹²⁵I seeds interstitial implantation brachytherapy for pancreatic cancer. J Cancer Res Ther, 2018, 14(7): 1453-1454.
9.	王俊杰, 莊永志. 放射性粒子近距離治療腫瘤. 中國微創外科雜志, 2001, 1(3): 187-191.
10.	張開賢, 秦征東, 李苓, 等. CT引導¹²⁵I放射性粒子植入治療復發性腦膠質瘤的研究. 中華腫瘤防治雜志, 2007, 14(22): 1714-1716.
11.	胡效坤, 喬志正, 梁克山, 等. CT引導下¹²⁵I放射粒子植入治療腦內腫瘤的應用研究. 中華神經醫學雜志, 2005, 4(7): 691-694.
12.	Ronco C, La Manna G. Current perspectives in kidney diseases. Blood Purif, 2017, 44(4): 311-313.
13.	Zhu HD, Guo JH, Zhu GY, et al. A novel biliary stent loaded with ¹²⁵I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent. J Hepatol, 2012, 56(5): 1104-1111.
14.	卓水清, 陳林, 張福君, 等. ¹²⁵I放射性粒子植入術后患者周圍輻射劑量的監測. 癌癥, 2007, 26(6): 666-668.
15.	Schwarz SB, Thon N, Nikolajek K, et al. Iodine-125 brachytherapy for brain tumours--a review. Radiat Oncol, 2012, 7: 30.
16.	Huang MW, Liu SM, Zheng L, et al. A digital model individual template and CT-guided ¹²⁵I seed implants for malignant tumors of the head and neck. J Radiat Res, 2012, 53(6): 973-977.
17.	Liang Y, Wang Z, Zhang H, et al. Three-dimensional-printed individual template-guided ¹²⁵I seed implantation for the cervical lymph node metastasis: a dosimetric and security study. J Cancer Res Ther, 2018, 14(1): 30-35.
18.	姜玉良, 吉喆, 田素青, 等. CT引導下¹²⁵I粒子挽救性治療頭頸部復發/轉移癌的臨床療效. 中華醫學雜志, 2018, 98(45): 3686-3691.
19.	胡效坤, 彭麗靜, 劉士鋒, 等. 靶區和劑量控制下¹²⁵I粒子治療顱內惡性腫瘤的再評價. 中華醫學雜志, 2017, 97(19): 1457-1462.
20.	Whitmore WF Jr, Hilaris B, Grabstald H. Retropubic implantation to iodine 125 in the treatment of prostatic cancer. J Urol, 1972, 108(6): 918-920.
21.	黃海鋒, 汪維, 郭宏騫, 等. 125碘粒子植入術聯合內分泌療法治療前列腺癌效果研究. 實用老年醫學, 2014(10): 839-841.
22.	Qu A, Jiang P, Sun H, et al. Efficacy and dosimetry analysis of image-guided radioactive ¹²⁵I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol, 2019, 30(1): e9.
23.	貢桔, 王忠敏, 陳克敏, 等. CT引導下經皮穿刺¹²⁵I粒子植入治療肺癌的臨床應用. 介入放射學雜志, 2009, 18(9): 677-680.
24.	吉喆, 姜玉良, 郭福新, 等. 三維打印共面坐標模板聯合CT引導¹²⁵I粒子植入治療胸部惡性腫瘤的劑量學評價. 中華核醫學與分子影像雜志, 2018, 38(1): 4-8.
25.	van Riet YE, Maaskant AJ, Creemers GJ, et al. Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 iodine seed. Eur J Surg Oncol, 2010, 36(2): 164-169.
26.	Yu YH, Wei CY, Qin QH, et al. Efficacy of iodine-125 seed implantation in locoregionally recurrent and unresectable breast cancer: a retrospective study. Pathol Oncol Res, 2019, 25(1): 327-332.
27.	張穎, 林琦, 袁苑, 等. 3D打印個體化模板聯合CT引導¹²⁵I粒子植入治療胸壁轉移瘤1例. 山東大學學報(醫學版), 2016, 54(4): 94-96.
28.	張穎, 林琦, 袁苑, 等. 3D打印個體化模板聯合CT引導¹²⁵I粒子植入治療腫瘤術前術后劑量學比較. 山東大學學報(醫學版), 2017, 55(2): 45-49.
29.	張穎, 林琦, 袁苑, 等. 3D打印個體化模板聯合CT引導¹²⁵I粒子植入治療惡性腫瘤質量評價. 山東大學學報(醫學版), 2016, 54(11): 44-50.
30.	Wang ZM, Liu Y, Liu FJ, et al. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. Eur Radiol, 2010, 20(7): 1786-1791.
31.	趙鵬, 崔紅凱, 楊瑞民, 等. 放射性¹²⁵I粒子支架治療中、晚期食管癌的療效觀察. 介入放射學雜志, 2011, 20(6): 448-451.
32.	鄭家平, 邵國良, 羅君, 等. CT引導下I¹²⁵粒子組織間植入治療難治性肝癌. 介入放射學雜志, 2015, 24(3): 260-264.
33.	王俊杰, 唐勁天, 黎功. 放射性粒子近距離治療腫瘤. 北京: 北京醫科大學出版社, 2001: 172.
34.	王俊杰. 放射性粒子治療腫瘤臨床應用規范. 北京: 北京大學醫學出版社, 2011: 33.
35.	Martinez-Monge R, Nag S, Nieroda CA, et al. Iodine-125 brachytherapy in the treatment of colorectal adenocarcinoma metastatic to the liver. Cancer, 1999, 85(6): 1218-1225.
36.	Wang P, Shen LQ, Zhang H, et al. Quality of life after I-125 seed implantation using computed tomography and three-dimensional-printed template guidance in patients with advanced malignant tumor. J Cancer Res Ther, 2018, 14(7): 1492-1496.

1. 吳菲, 林國楨, 張晉昕. 我國惡性腫瘤發病現狀及趨勢. 中國腫瘤, 2012, 21(2): 81-85.
2. Trombetta MG, Colonias A, Makishi D, et al. Tolerance of the aorta using intraoperative iodine-125 interstitial brachytherapy in cancer of the lung. Brachytherapy, 2008, 7(1): 50-54.
3. 王文俊, 陳志軍, 許波, 等. 3D打印非共面模板CT引導下¹²⁵I粒子植入治療惡性腫瘤臨床應用. 實用癌癥雜志, 2018, 33(9): 1557-1559.
4. 郭福新, 姜玉良, 吉喆, 等. 3D打印非共面模板輔助CT引導¹²⁵I粒子植入治療鎖骨上復發轉移癌的劑量學研究. 北京大學學報(醫學版), 2017, 49(3): 506-511.
5. 姜玉良. 北京大學第三醫院完成首例CT引導聯合3D打印模板指導放射性粒子植入治療腹膜后復發腫瘤. 北京大學學報(醫學版), 2016, 48(1): 182.
6. Liu Q, Dai X, Zhou X, et al. Comparison of TACE combined with and without iodine-125 seeds implantation therapy for advanced stage hepatocellular carcinoma: a systematic review and meta-analysis. J BUON, 2019, 24(2): 642-649.
7. Lu J, Huang W, Wang Z, et al. The safety and efficacy of interstitial ¹²⁵I seed implantation brachytherapy for metastatic epidural spinal cord compression. J Cancer Res Ther, 2018, 14(7): 1549-1555.
8. Hertzanu Y, Ye X. A valuable guideline of radioactive ¹²⁵I seeds interstitial implantation brachytherapy for pancreatic cancer. J Cancer Res Ther, 2018, 14(7): 1453-1454.
9. 王俊杰, 莊永志. 放射性粒子近距離治療腫瘤. 中國微創外科雜志, 2001, 1(3): 187-191.
10. 張開賢, 秦征東, 李苓, 等. CT引導¹²⁵I放射性粒子植入治療復發性腦膠質瘤的研究. 中華腫瘤防治雜志, 2007, 14(22): 1714-1716.
11. 胡效坤, 喬志正, 梁克山, 等. CT引導下¹²⁵I放射粒子植入治療腦內腫瘤的應用研究. 中華神經醫學雜志, 2005, 4(7): 691-694.
12. Ronco C, La Manna G. Current perspectives in kidney diseases. Blood Purif, 2017, 44(4): 311-313.
13. Zhu HD, Guo JH, Zhu GY, et al. A novel biliary stent loaded with ¹²⁵I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent. J Hepatol, 2012, 56(5): 1104-1111.
14. 卓水清, 陳林, 張福君, 等. ¹²⁵I放射性粒子植入術后患者周圍輻射劑量的監測. 癌癥, 2007, 26(6): 666-668.
15. Schwarz SB, Thon N, Nikolajek K, et al. Iodine-125 brachytherapy for brain tumours--a review. Radiat Oncol, 2012, 7: 30.
16. Huang MW, Liu SM, Zheng L, et al. A digital model individual template and CT-guided ¹²⁵I seed implants for malignant tumors of the head and neck. J Radiat Res, 2012, 53(6): 973-977.
17. Liang Y, Wang Z, Zhang H, et al. Three-dimensional-printed individual template-guided ¹²⁵I seed implantation for the cervical lymph node metastasis: a dosimetric and security study. J Cancer Res Ther, 2018, 14(1): 30-35.
18. 姜玉良, 吉喆, 田素青, 等. CT引導下¹²⁵I粒子挽救性治療頭頸部復發/轉移癌的臨床療效. 中華醫學雜志, 2018, 98(45): 3686-3691.
19. 胡效坤, 彭麗靜, 劉士鋒, 等. 靶區和劑量控制下¹²⁵I粒子治療顱內惡性腫瘤的再評價. 中華醫學雜志, 2017, 97(19): 1457-1462.
20. Whitmore WF Jr, Hilaris B, Grabstald H. Retropubic implantation to iodine 125 in the treatment of prostatic cancer. J Urol, 1972, 108(6): 918-920.
21. 黃海鋒, 汪維, 郭宏騫, 等. 125碘粒子植入術聯合內分泌療法治療前列腺癌效果研究. 實用老年醫學, 2014(10): 839-841.
22. Qu A, Jiang P, Sun H, et al. Efficacy and dosimetry analysis of image-guided radioactive ¹²⁵I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol, 2019, 30(1): e9.
23. 貢桔, 王忠敏, 陳克敏, 等. CT引導下經皮穿刺¹²⁵I粒子植入治療肺癌的臨床應用. 介入放射學雜志, 2009, 18(9): 677-680.
24. 吉喆, 姜玉良, 郭福新, 等. 三維打印共面坐標模板聯合CT引導¹²⁵I粒子植入治療胸部惡性腫瘤的劑量學評價. 中華核醫學與分子影像雜志, 2018, 38(1): 4-8.
25. van Riet YE, Maaskant AJ, Creemers GJ, et al. Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 iodine seed. Eur J Surg Oncol, 2010, 36(2): 164-169.
26. Yu YH, Wei CY, Qin QH, et al. Efficacy of iodine-125 seed implantation in locoregionally recurrent and unresectable breast cancer: a retrospective study. Pathol Oncol Res, 2019, 25(1): 327-332.
27. 張穎, 林琦, 袁苑, 等. 3D打印個體化模板聯合CT引導¹²⁵I粒子植入治療胸壁轉移瘤1例. 山東大學學報(醫學版), 2016, 54(4): 94-96.
28. 張穎, 林琦, 袁苑, 等. 3D打印個體化模板聯合CT引導¹²⁵I粒子植入治療腫瘤術前術后劑量學比較. 山東大學學報(醫學版), 2017, 55(2): 45-49.
29. 張穎, 林琦, 袁苑, 等. 3D打印個體化模板聯合CT引導¹²⁵I粒子植入治療惡性腫瘤質量評價. 山東大學學報(醫學版), 2016, 54(11): 44-50.
30. Wang ZM, Liu Y, Liu FJ, et al. Clinical efficacy of CT-guided iodine-125 seed implantation therapy in patients with advanced pancreatic cancer. Eur Radiol, 2010, 20(7): 1786-1791.
31. 趙鵬, 崔紅凱, 楊瑞民, 等. 放射性¹²⁵I粒子支架治療中、晚期食管癌的療效觀察. 介入放射學雜志, 2011, 20(6): 448-451.
32. 鄭家平, 邵國良, 羅君, 等. CT引導下I¹²⁵粒子組織間植入治療難治性肝癌. 介入放射學雜志, 2015, 24(3): 260-264.
33. 王俊杰, 唐勁天, 黎功. 放射性粒子近距離治療腫瘤. 北京: 北京醫科大學出版社, 2001: 172.
34. 王俊杰. 放射性粒子治療腫瘤臨床應用規范. 北京: 北京大學醫學出版社, 2011: 33.
35. Martinez-Monge R, Nag S, Nieroda CA, et al. Iodine-125 brachytherapy in the treatment of colorectal adenocarcinoma metastatic to the liver. Cancer, 1999, 85(6): 1218-1225.
36. Wang P, Shen LQ, Zhang H, et al. Quality of life after I-125 seed implantation using computed tomography and three-dimensional-printed template guidance in patients with advanced malignant tumor. J Cancer Res Ther, 2018, 14(7): 1492-1496.

West China Medical Journal

Progress in CT-guided implantation of iodine-125 seeds for malignant tumors assisted by individualized 3D template

Abstract Full text Figures/Tables Video References Cited by

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