Analysis of the occurrence and influencing factors of fatigue in asthma patients_West China Medical Journal

Authors：

QIN Fujia ¹ ,  CUI Miaoling ² , NONG ying ³

1. Graduate School of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;
2. Department of Nursing, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;
3. Department of Respiratory Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;

Corresponding?author：

CUI Miaoling, Email: cuimiaoling@126.com

Keywords：

Bronchial asthma; Fatigue; Influencing factors; Depression

DOI：

10.7507/1002-0179.201909024

Video：

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Objective To investigate the fatigue of asthma patients, and to analyze its influencing factors, and provide a reference for clinical intervention.Methods The convenience sampling method was adopted to select asthma patients who were in clinic of the First Affiliated Hospital of Guangxi Medical University from November 2018 to March 2019. The patients’ lung function were measured. And questionnaires were conducted, including general data questionnaire, Chinese version of Checklist Individual Strength-Fatigue, Asthma Control Test, Chinese version of Self-rating Depression Scale. Relevant data were collected for multiple stepwise linear regression analysis.Results Finally, 120 patients were enrolled. The results of multiple stepwise linear regression analysis showed that age, education level, place of residence, time period of frequent asthma symptoms, degree of small airway obstruction, Asthma Control Test score and degree of depression were the influencing factors of fatigue in asthma patients (P≤0.05). Multivariate linear stepwise regression analysis showed that degree of small airway obstruction, degree of depression and time period of frequent asthma symptoms were the main influencing factors of fatigue in asthma patients, which could explain 51.8% of the variance of fatigue (ΔR²=0.518).Conclusions The incidence of fatigue in asthma patients is at a relatively high level. Medical staff should pay attention to the symptoms of fatigue in asthma patients. For asthma patients, it is recommended to strengthen standardized diagnosis and treatment, reduce the onset of symptoms at night and eliminate small airway obstruction. Psychological intervention methods are needed to improve patients’ depression, reduce fatigue symptoms, and improve quality of life.

Citation： QIN Fujia, CUI Miaoling, NONG ying. Analysis of the occurrence and influencing factors of fatigue in asthma patients. West China Medical Journal, 2021, 36(1): 45-49. doi: 10.7507/1002-0179.201909024 Copy

1.	張曉巖, 林江濤. 2017 年全球哮喘防治倡議指南解讀. 中國實用內科雜志, 2017, 37(8): 709-711.
2.	Van Herck M, Spruit MA, Burtin C, et al. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J Clin Med, 2018, 7(12): 471.
3.	Small S, Lamb M. Fatigue in chronic illness: the experience of individuals with chronic obstructive pulmonary disease and with asthma. J Adv Nurs, 1999, 30(2): 469-478.
4.	倪平, 陳京立, 劉娜. 護理研究中量性研究的樣本量估計. 中華護理雜志, 2010, 45(4): 378-380.
5.	中華醫學會兒科學分會呼吸學組肺功能協作組, 《中華實用兒科臨床雜志》編輯委員會. 兒童肺功能系列指南(二): 肺容積和通氣功能. 中華實用兒科臨床雜志, 2016, 31(10): 744-750.
6.	羅國標, 張靈娟, 劉國清, 等. 肺功能中不同氣道功能指標聯合篩查用于慢性阻塞性肺疾病早期診斷價值及預后判斷研究. 心肺血管病雜志, 2019, 38(4): 377-381.
7.	Vercoulen JH, Swanink CM, Fennis JF, et al. Dimensional assessment of chronic fatigue syndrome. J Psychosom Res, 1994, 38(5): 383-392.
8.	吳春薇, 劉占東, 張擁波, 等. 個人疲勞強度問卷中譯本在腦梗死患者中的臨床應用與評價. 中國康復理論與實踐, 2008, 14(2): 116-118.
9.	Schatz M, Sorkness CA, Li JT, et al. Asthma control test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists. J Allergy Clin Immunol, 2006, 117(3): 549-556.
10.	段泉泉, 勝利. 焦慮及抑郁自評量表的臨床效度. 中國心理衛生雜志, 2012, 26(9): 676-679.
11.	王天芳, 張翠珍, 劉雁峰. 慢性疲勞綜合征病人的疲勞、抑郁、焦慮與生活事件的特點及其相關性分析. 中國行為醫學科學, 2000, 9(2): 84.
12.	Peters JB, Rijssenbeek-Nouwens LH, Bron AO, et al. Health status measurement in patients with severe asthma. Respir Med, 2014, 108(2): 278-286.
13.	王文雅. 2010-2011 年北京地區 14 歲以上人群哮喘患病情況及相關危險因素的流行病學調查. 北京: 北京協和醫學院, 2013:1-100.
14.	徐藝園, 王凱, 王佳音, 等. 疲勞產生相關機制研究進展. 科學技術創新, 2019(23): 50-51.
15.	Demyttenaere K, De Fruyt J, Stahl SM. The many faces of fatigue in major depressive disorder. Int J Neuropsychopharmacol, 2005, 8(1): 93-105.
16.	Michel P, Bogousslavsky J. Shared mechanisms of ischaemic and haemorrhagic stroke: still a lot to learn. J Neurol Neurosurg Psychiatry, 2006, 77(1): 1.
17.	Bossola M, Di Stasio E, Giungi S, et al. Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. J Pain Symptom Manage, 2015, 49(3): 578-585.
18.	房莉穎, 李圣青, 吳林. 支氣管哮喘與抑郁相關性研究. 陜西醫學雜志, 2016, 45(9): 1120-1122.
19.	Yohannes AM, Baldwin RC, Connolly MJ. Depression and anxiety in elderly patients with chronic obstructive pulmonary disease. Age Ageing, 2006, 35(5): 457-459.

1. 張曉巖, 林江濤. 2017 年全球哮喘防治倡議指南解讀. 中國實用內科雜志, 2017, 37(8): 709-711.
2. Van Herck M, Spruit MA, Burtin C, et al. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J Clin Med, 2018, 7(12): 471.
3. Small S, Lamb M. Fatigue in chronic illness: the experience of individuals with chronic obstructive pulmonary disease and with asthma. J Adv Nurs, 1999, 30(2): 469-478.
4. 倪平, 陳京立, 劉娜. 護理研究中量性研究的樣本量估計. 中華護理雜志, 2010, 45(4): 378-380.
5. 中華醫學會兒科學分會呼吸學組肺功能協作組, 《中華實用兒科臨床雜志》編輯委員會. 兒童肺功能系列指南(二): 肺容積和通氣功能. 中華實用兒科臨床雜志, 2016, 31(10): 744-750.
6. 羅國標, 張靈娟, 劉國清, 等. 肺功能中不同氣道功能指標聯合篩查用于慢性阻塞性肺疾病早期診斷價值及預后判斷研究. 心肺血管病雜志, 2019, 38(4): 377-381.
7. Vercoulen JH, Swanink CM, Fennis JF, et al. Dimensional assessment of chronic fatigue syndrome. J Psychosom Res, 1994, 38(5): 383-392.
8. 吳春薇, 劉占東, 張擁波, 等. 個人疲勞強度問卷中譯本在腦梗死患者中的臨床應用與評價. 中國康復理論與實踐, 2008, 14(2): 116-118.
9. Schatz M, Sorkness CA, Li JT, et al. Asthma control test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists. J Allergy Clin Immunol, 2006, 117(3): 549-556.
10. 段泉泉, 勝利. 焦慮及抑郁自評量表的臨床效度. 中國心理衛生雜志, 2012, 26(9): 676-679.
11. 王天芳, 張翠珍, 劉雁峰. 慢性疲勞綜合征病人的疲勞、抑郁、焦慮與生活事件的特點及其相關性分析. 中國行為醫學科學, 2000, 9(2): 84.
12. Peters JB, Rijssenbeek-Nouwens LH, Bron AO, et al. Health status measurement in patients with severe asthma. Respir Med, 2014, 108(2): 278-286.
13. 王文雅. 2010-2011 年北京地區 14 歲以上人群哮喘患病情況及相關危險因素的流行病學調查. 北京: 北京協和醫學院, 2013:1-100.
14. 徐藝園, 王凱, 王佳音, 等. 疲勞產生相關機制研究進展. 科學技術創新, 2019(23): 50-51.
15. Demyttenaere K, De Fruyt J, Stahl SM. The many faces of fatigue in major depressive disorder. Int J Neuropsychopharmacol, 2005, 8(1): 93-105.
16. Michel P, Bogousslavsky J. Shared mechanisms of ischaemic and haemorrhagic stroke: still a lot to learn. J Neurol Neurosurg Psychiatry, 2006, 77(1): 1.
17. Bossola M, Di Stasio E, Giungi S, et al. Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. J Pain Symptom Manage, 2015, 49(3): 578-585.
18. 房莉穎, 李圣青, 吳林. 支氣管哮喘與抑郁相關性研究. 陜西醫學雜志, 2016, 45(9): 1120-1122.
19. Yohannes AM, Baldwin RC, Connolly MJ. Depression and anxiety in elderly patients with chronic obstructive pulmonary disease. Age Ageing, 2006, 35(5): 457-459.

West China Medical Journal

Analysis of the occurrence and influencing factors of fatigue in asthma patients

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