Effects of intravenous drug abuse on peripheral vascular disease_West China Medical Journal

Authors：

ZENG Xiangyu ¹ ,  JI Bo ²

1. School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P. R. China;
2. Department of Peripheral Vascular Diseases, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P. R. China;

Corresponding?author：

JI Bo, Email: jiand911@sina.com

Keywords：

Intravenous drug abuse; Peripheral vascular; Deep vein thrombosis; Atherosclerosis

DOI：

10.7507/1002-0179.201910018

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The way of intravenous drug abuse is to puncture the peripheral blood vessels and inject the drug directly into the blood. Therefore, this method has an impact on the peripheral artery and venous system of the users, and can cause a variety of peripheral vascular diseases, such as phlebitis, deep vein thrombosis, chronic venous insufficiency, phlebangioma, atherosclerosis, acute arterial ischemia, pseudoaneurysm, etc. However, due to the particularity of drug abusers, the vascular complications caused by intravenous drug abuse have not attracted enough attention. This paper reviewed the types and pathogenesis of peripheral vascular diseases caused by intravenous drug abuse, so as to improve the clinical understanding of peripheral vascular diseases caused by intravenous drug abuse, improve the prognosis of patients, reduce occupational exposure of medical staff, and play a certain role in social warning.

Citation： ZENG Xiangyu, JI Bo. Effects of intravenous drug abuse on peripheral vascular disease. West China Medical Journal, 2021, 36(8): 1148-1152. doi: 10.7507/1002-0179.201910018 Copy

1.	Kwiatkowska W, Knysz B, G?siorowski J, et al. Deep vein thrombosis of the lower limbs in intravenous drug users. Postepy Hig Med Dosw (Online), 2015, 69: 510-520.
2.	D’Ovidio C, Vellante P, Costantini S, et al. Death due to an unrecognized groin abscess in a drug addict: a retrospective study. J Forensic Leg Med, 2013, 20(5): 382-386.
3.	陶艷玲, 周春蘭. 靜脈留置針相關靜脈炎的危險因素研究進展. 護理學雜志, 2014, 29(20): 89-92.
4.	李利華, 馮忠堂, 刑豫明, 等. 20 例海洛因成癮死亡者組織病理變化觀察. 昆明醫學院學報, 2001, 22(1): 1-4.
5.	Kunis CL, Ward HJ, Appel GB. Illicit drug abuse//de Broe ME, Porter GA, Bennett WM, et al. Clinical Nephrotoxins. Dordrecht: Springer, 2003: 383-402.
6.	陳永華, 王愛民, 孫紅振, 等. 注射毒品致四肢血管損傷的救治. 創傷外科雜志, 2007, 9(4): 331-333.
7.	李耀燁. 靜脈吸毒的艾滋病病人下肢血管病變彩色多普勒超聲檢查的表現. 中國艾滋病性病, 2012, 18(10): 685-686, 708.
8.	McColl MD, Tait RC, Greer IA, et al. Injecting drug use is a risk factor for deep vein thrombosis in women in Glasgow. Br J Haematol, 2001, 112(3): 641-643.
9.	Miller JD, Pegelow DF, Jacques AJ, et al. Skeletal muscle pump versus respiratory muscle pump: modulation of venous return from the locomotor limb in humans. J Physiol, 2005, 563(Pt 3): 925-943.
10.	Antonova N, Zvetkova E, Ivanov I, et al. Hemorheological changes and characteristic parameters derived from whole blood viscometry in chronic heroin addicts. Clin Hemorheol Microcirc, 2008, 39(1/2/3/4): 53-61.
11.	查顯友, 周燕, 王蓮娥. 海洛因依賴者血液流變學及血脂變化的研究. 中國藥物濫用防治雜志, 2012, 18(1): 14-16.
12.	Siegel AJ, Sholar MB, Mendelson JH, et al. Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. Arch Intern Med, 1999, 159(16): 1925-1929.
13.	鄒林汝, 譚開彬, 高云華, 等. 靜脈瘀滯指數對關節置換術后下肢深靜脈血栓風險的評估. 中國超聲醫學雜志, 2015, 31(11): 1032-1034.
14.	徐菁菁. 超聲在海洛因濫用者下肢靜脈和左心室心肌收縮功能中的應用價值. 合肥: 安徽醫科大學, 2018.
15.	Galante A, De Luca A, Pietroiusti A, et al. Effects of opiates on blood rheology. J Toxicol Clin Toxicol, 1994, 32(4): 411-417.
16.	Ceriello A, Dello Russo P, Curcio F, et al. Depressed antithrombin Ⅲ biological activity in opiate addicts. J Clin Pathol, 1984, 37(9): 1040-1042.
17.	張麗梅. 海洛因依賴者凝血與抗凝指標的表達水平及意義. 中國民康醫學, 2019, 31(3): 77-78.
18.	Moliterno DJ, Lange RA, Gerard RD, et al. Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis. Am J Med, 1994, 96(6): 492-496.
19.	胡杰, 楊潔, 孫脊峰. 膜性腎病凝血紊亂機制及治療進展. 解放軍醫學雜志, 2019, 44(3): 266-270.
20.	Klein SK, Slim EJ, de Kruif MD, et al. Is chronic HIV infection associated with venous thrombotic disease? A sytematic review. Neth J Med, 2005, 63(4): 129-136.
21.	Pieper B, Templin T. Chronic venous insufficiency in persons with a history of injection drug use. Res Nurs Health, 2001, 24(5): 423-432.
22.	Pieper B, Templin TN, Kirsner RS, et al. Impact of injection drug use on distribution and severity of chronic venous disorders. Wound Repair Regen, 2009, 17(4): 485-491.
23.	中華醫學會外科學分會血管外科學組. 慢性下肢靜脈疾病診斷與治療中國專家共識. 中國血管外科雜志(電子版), 2014, 6(3): 143-151.
24.	Pieper BA, Templin T, Ebright JR. Ankle mobility in relation to chronic venous insufficiency in HIV-positive persons with and without a history of injection drug use. J Assoc Nurses AIDS Care, 2006, 17(4): 30-38.
25.	Markovi? M, Draga? M, Koncar I, et al. Secondary venous aneurysm following intravenous drug abuse: a case report. Vojnosanit Pregl, 2016, 73(5): 500-503.
26.	Johnson JE, Lucas CE, Ledgerwood AM, et al. Infected venous pseudoaneurysm. A complication of drug addiction. Arch Surg, 1984, 119(9): 1097-1098.
27.	Yeager RA, Hobson RW 2nd, Padberg FT, et al. Vascular complications related to drug abuse. J Trauma, 1987, 27(3): 305-308.
28.	陳熤, 李劍, 施海明. 血小板與動脈粥樣硬化. 國際心血管病雜志, 2011, 38(3): 141-144.
29.	林艾雯, 陳竹君. 動脈粥樣硬化與內皮細胞損傷機制的研究進展. 嶺南心血管病雜志, 2015, 21(4): 580-582.
30.	項榮, 郭紅山, 孫開琪. 血小板: 動脈粥樣硬化的誘導者和推動者. 中國細胞生物學學報, 2010, 32(5): 777-780.
31.	Pradhan L, Mondal D, Chandra S, et al. Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. Cardiovasc Toxicol, 2008, 8(4): 161-171.
32.	Batista A, Macedo T, Tavares P, et al. Nitric oxide production and nitric oxide synthase expression in platelets from heroin abusers before and after ultrarapid detoxification. Ann N Y Acad Sci, 2002, 965: 479-486.
33.	邵偉, 黃維軍, 黃松帶, 等. 海洛因對人體血管內皮舒張功能影響的臨床研究. 中國醫學創新, 2010, 7(21): 29-31.
34.	Sáez CG, Olivares P, Pallavicini J, et al. Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users. Thromb Res, 2011, 128(4): e18-e23.
35.	張靜, 朱軍紅, 周曉亮. 海洛因依賴者外周血細胞變化分析. 中國藥物依賴性雜志, 2010, 19(5): 376-378.
36.	朱成全, 李銳, 周莉玲, 等. 海洛因依賴者血小板膜粘附分子表達的變化及 L-精胺酸/cGMP 體外作用. 中國藥物濫用防治雜志, 2002(2): 10-12.
37.	朱成全, 戴京萍, 向仕平, 等. 舒通安膠囊對海洛因依賴者血小板膜黏附分子表達的影響. 廣東醫學, 2007, 28(1): 149-151.
38.	方水晶, 張慧華, 張慧. 男性吸毒者血小板聚集和 vWF 水平測定及主要影響因素探討. 實用預防醫學, 2015, 22(11): 1329-1331, 1354.
39.	Zvetkova E, Antonova N, Ivanov I, et al. Platelet morphological, functional and rheological properties attributable to addictions. Clin Hemorheol Microcirc, 2010, 45(2/3/4): 245-251.
40.	Kugelmass AD, Oda A, Monahan K, et al. Activation of human platelets by cocaine. Circulation, 1993, 88(3): 876-883.
41.	Bachi K, Mani V, Jeyachandran D, et al. Vascular disease in cocaine addiction. Atherosclerosis, 2017, 262: 154-162.
42.	Klabacha ME, Miller SH, Pav JM, et al. Inadvertent intraradial arterial injection of cocaine. Ann Plast Surg, 1984, 13(1): 60-62.
43.	Fiddes R, Khattab M, Abu Dakka MA, et al. Patterns and management of vascular injuries in intravenous drug users: a literature review. Surgeon, 2010, 8(6): 353-361.
44.	Salmon AM, Dwyer R, Jauncey M, et al. Injecting-related injury and disease among clients of a supervised injecting facility. Drug Alcohol Depend, 2009, 101(1/2): 132-136.
45.	Hilbig A, Cheng A. Infective endocarditis in the intravenous drug use population at a tertiary hospital in Melbourne, Australia. Heart, Lung and Circulation, 2020, 29(2): 246-253.
46.	2018 年中國毒品形勢報告發布禁毒態勢總體趨好面臨形勢依然復雜. 上海化工, 2019, 44(7): 45.

1. Kwiatkowska W, Knysz B, G?siorowski J, et al. Deep vein thrombosis of the lower limbs in intravenous drug users. Postepy Hig Med Dosw (Online), 2015, 69: 510-520.
2. D’Ovidio C, Vellante P, Costantini S, et al. Death due to an unrecognized groin abscess in a drug addict: a retrospective study. J Forensic Leg Med, 2013, 20(5): 382-386.
3. 陶艷玲, 周春蘭. 靜脈留置針相關靜脈炎的危險因素研究進展. 護理學雜志, 2014, 29(20): 89-92.
4. 李利華, 馮忠堂, 刑豫明, 等. 20 例海洛因成癮死亡者組織病理變化觀察. 昆明醫學院學報, 2001, 22(1): 1-4.
5. Kunis CL, Ward HJ, Appel GB. Illicit drug abuse//de Broe ME, Porter GA, Bennett WM, et al. Clinical Nephrotoxins. Dordrecht: Springer, 2003: 383-402.
6. 陳永華, 王愛民, 孫紅振, 等. 注射毒品致四肢血管損傷的救治. 創傷外科雜志, 2007, 9(4): 331-333.
7. 李耀燁. 靜脈吸毒的艾滋病病人下肢血管病變彩色多普勒超聲檢查的表現. 中國艾滋病性病, 2012, 18(10): 685-686, 708.
8. McColl MD, Tait RC, Greer IA, et al. Injecting drug use is a risk factor for deep vein thrombosis in women in Glasgow. Br J Haematol, 2001, 112(3): 641-643.
9. Miller JD, Pegelow DF, Jacques AJ, et al. Skeletal muscle pump versus respiratory muscle pump: modulation of venous return from the locomotor limb in humans. J Physiol, 2005, 563(Pt 3): 925-943.
10. Antonova N, Zvetkova E, Ivanov I, et al. Hemorheological changes and characteristic parameters derived from whole blood viscometry in chronic heroin addicts. Clin Hemorheol Microcirc, 2008, 39(1/2/3/4): 53-61.
11. 查顯友, 周燕, 王蓮娥. 海洛因依賴者血液流變學及血脂變化的研究. 中國藥物濫用防治雜志, 2012, 18(1): 14-16.
12. Siegel AJ, Sholar MB, Mendelson JH, et al. Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. Arch Intern Med, 1999, 159(16): 1925-1929.
13. 鄒林汝, 譚開彬, 高云華, 等. 靜脈瘀滯指數對關節置換術后下肢深靜脈血栓風險的評估. 中國超聲醫學雜志, 2015, 31(11): 1032-1034.
14. 徐菁菁. 超聲在海洛因濫用者下肢靜脈和左心室心肌收縮功能中的應用價值. 合肥: 安徽醫科大學, 2018.
15. Galante A, De Luca A, Pietroiusti A, et al. Effects of opiates on blood rheology. J Toxicol Clin Toxicol, 1994, 32(4): 411-417.
16. Ceriello A, Dello Russo P, Curcio F, et al. Depressed antithrombin Ⅲ biological activity in opiate addicts. J Clin Pathol, 1984, 37(9): 1040-1042.
17. 張麗梅. 海洛因依賴者凝血與抗凝指標的表達水平及意義. 中國民康醫學, 2019, 31(3): 77-78.
18. Moliterno DJ, Lange RA, Gerard RD, et al. Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis. Am J Med, 1994, 96(6): 492-496.
19. 胡杰, 楊潔, 孫脊峰. 膜性腎病凝血紊亂機制及治療進展. 解放軍醫學雜志, 2019, 44(3): 266-270.
20. Klein SK, Slim EJ, de Kruif MD, et al. Is chronic HIV infection associated with venous thrombotic disease? A sytematic review. Neth J Med, 2005, 63(4): 129-136.
21. Pieper B, Templin T. Chronic venous insufficiency in persons with a history of injection drug use. Res Nurs Health, 2001, 24(5): 423-432.
22. Pieper B, Templin TN, Kirsner RS, et al. Impact of injection drug use on distribution and severity of chronic venous disorders. Wound Repair Regen, 2009, 17(4): 485-491.
23. 中華醫學會外科學分會血管外科學組. 慢性下肢靜脈疾病診斷與治療中國專家共識. 中國血管外科雜志(電子版), 2014, 6(3): 143-151.
24. Pieper BA, Templin T, Ebright JR. Ankle mobility in relation to chronic venous insufficiency in HIV-positive persons with and without a history of injection drug use. J Assoc Nurses AIDS Care, 2006, 17(4): 30-38.
25. Markovi? M, Draga? M, Koncar I, et al. Secondary venous aneurysm following intravenous drug abuse: a case report. Vojnosanit Pregl, 2016, 73(5): 500-503.
26. Johnson JE, Lucas CE, Ledgerwood AM, et al. Infected venous pseudoaneurysm. A complication of drug addiction. Arch Surg, 1984, 119(9): 1097-1098.
27. Yeager RA, Hobson RW 2nd, Padberg FT, et al. Vascular complications related to drug abuse. J Trauma, 1987, 27(3): 305-308.
28. 陳熤, 李劍, 施海明. 血小板與動脈粥樣硬化. 國際心血管病雜志, 2011, 38(3): 141-144.
29. 林艾雯, 陳竹君. 動脈粥樣硬化與內皮細胞損傷機制的研究進展. 嶺南心血管病雜志, 2015, 21(4): 580-582.
30. 項榮, 郭紅山, 孫開琪. 血小板: 動脈粥樣硬化的誘導者和推動者. 中國細胞生物學學報, 2010, 32(5): 777-780.
31. Pradhan L, Mondal D, Chandra S, et al. Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. Cardiovasc Toxicol, 2008, 8(4): 161-171.
32. Batista A, Macedo T, Tavares P, et al. Nitric oxide production and nitric oxide synthase expression in platelets from heroin abusers before and after ultrarapid detoxification. Ann N Y Acad Sci, 2002, 965: 479-486.
33. 邵偉, 黃維軍, 黃松帶, 等. 海洛因對人體血管內皮舒張功能影響的臨床研究. 中國醫學創新, 2010, 7(21): 29-31.
34. Sáez CG, Olivares P, Pallavicini J, et al. Increased number of circulating endothelial cells and plasma markers of endothelial damage in chronic cocaine users. Thromb Res, 2011, 128(4): e18-e23.
35. 張靜, 朱軍紅, 周曉亮. 海洛因依賴者外周血細胞變化分析. 中國藥物依賴性雜志, 2010, 19(5): 376-378.
36. 朱成全, 李銳, 周莉玲, 等. 海洛因依賴者血小板膜粘附分子表達的變化及 L-精胺酸/cGMP 體外作用. 中國藥物濫用防治雜志, 2002(2): 10-12.
37. 朱成全, 戴京萍, 向仕平, 等. 舒通安膠囊對海洛因依賴者血小板膜黏附分子表達的影響. 廣東醫學, 2007, 28(1): 149-151.
38. 方水晶, 張慧華, 張慧. 男性吸毒者血小板聚集和 vWF 水平測定及主要影響因素探討. 實用預防醫學, 2015, 22(11): 1329-1331, 1354.
39. Zvetkova E, Antonova N, Ivanov I, et al. Platelet morphological, functional and rheological properties attributable to addictions. Clin Hemorheol Microcirc, 2010, 45(2/3/4): 245-251.
40. Kugelmass AD, Oda A, Monahan K, et al. Activation of human platelets by cocaine. Circulation, 1993, 88(3): 876-883.
41. Bachi K, Mani V, Jeyachandran D, et al. Vascular disease in cocaine addiction. Atherosclerosis, 2017, 262: 154-162.
42. Klabacha ME, Miller SH, Pav JM, et al. Inadvertent intraradial arterial injection of cocaine. Ann Plast Surg, 1984, 13(1): 60-62.
43. Fiddes R, Khattab M, Abu Dakka MA, et al. Patterns and management of vascular injuries in intravenous drug users: a literature review. Surgeon, 2010, 8(6): 353-361.
44. Salmon AM, Dwyer R, Jauncey M, et al. Injecting-related injury and disease among clients of a supervised injecting facility. Drug Alcohol Depend, 2009, 101(1/2): 132-136.
45. Hilbig A, Cheng A. Infective endocarditis in the intravenous drug use population at a tertiary hospital in Melbourne, Australia. Heart, Lung and Circulation, 2020, 29(2): 246-253.
46. 2018 年中國毒品形勢報告發布禁毒態勢總體趨好面臨形勢依然復雜. 上海化工, 2019, 44(7): 45.

Previous Article
Application of continuity of care in patients with end-stage renal disease complicated with sarcopenia
Next Article
馬紅球菌感染性心包炎一例

West China Medical Journal

Effects of intravenous drug abuse on peripheral vascular disease

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content