Analysis of <i>Helicobacter pylori</i> infection and its risk factors among health examination participants in a general hospital_West China Medical Journal

Authors：

SONG Yu ¹ ,  ZHOU Yunzhu ¹ , XUE Peili ¹ , CAI Zhouquan ¹ , LAN Yajia ²

1. Department of Health Management, Sichuan Science City Hospital, Mianyang, Sichuan 621000, P. R. China;
2. Department of Occupational and Environmental Medicine, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

ZHOU Yunzhu, Email: yunzhu_zhou@163.com

Keywords：

Helicobacter pylori; Infection rate; Risk factors

DOI：

10.7507/1002-0179.202002261

Video：

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Objective To investigate and analyze the prevalence and influencing factors of Helicobacter pylori (Hp), to provide scientific basis for the development of Hp infection prevention and control program.Methods The Hp infection of healthy population who received ¹³C-urea breath test in Sichuan Science City Hospital from January to December 2018 were retrospectively analyzed. Medical examination reports were collected and sorted out. We compared the gender and age differences of Hp infection, and binary logistic regression analysis was performed to analyze the risk factors of Hp infection.Results A total of 8 093 healthy participants were included, including 5 530 males (68.33%) and 2 563 females (31.67%). The infection rate of Hp was 37.80% (3 059/8 093) in all subjects. The infection rate of males [39.48% (2 183/5 530)] was significantly higher than that of females [34.18% (876/2 563)] (χ²=20.899, P<0.001). The infection rate of 50-59 years old group was the highest (43.87%), and that of <30 years old group was the lowest (30.93%). The difference of Hp infection rate among different age groups was statistically significant (χ²=64.577, P<0.001). Logistic regression analysis showed that male [odds ratio (OR) =1.257, P<0.001], 40-49 years old (OR=1.446, P<0.001), 50-59 years old (OR=1.756, P<0.001), 60-69 years old (OR=1.512, P<0.001), high total cholesterol level (OR=1.221, P=0.003) and obesity (OR=1.403, P<0.001) were risk factors for Hp infection.Conclusions The prevalence of Hp infection in the general hospital is lower than the national average level, and male, 40-69 years old, high total cholesterol level and obesity are predictors of Hp infection. Effective measures should be taken to prevent and control the infection of Hp.

Citation： SONG Yu, ZHOU Yunzhu, XUE Peili, CAI Zhouquan, LAN Yajia. Analysis of Helicobacter pylori infection and its risk factors among health examination participants in a general hospital. West China Medical Journal, 2021, 36(4): 493-498. doi: 10.7507/1002-0179.202002261 Copy

1.	何濤君, 吳正林, 鐘小強, 等. 乙肝患者 HBV 載量與 IgA, IgG, IgM 及 C3, C4 相關性研究. 現代檢驗醫學雜志, 2015, 30(4): 67-70.
2.	Nam SY, Ryu KH, Park BJ, et al. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter, 2015, 20(2): 125-132.
3.	Xie C, Lu NH. Review: clinical management of Helicobacter pylori infection in China. Helicobacter, 2014, 20(1): 1-10.
4.	劉捷, 王永紅, 羅蓉, 等. 重慶地區 ¹³C 尿素呼氣試驗陽性的健康體檢人群幽門螺桿菌感染率及相關危險因素分析. 重慶醫科大學學報, 2017, 42(10): 1358-1362.
5.	中國肥胖問題工作組. 中國成人超重與肥胖癥預防與控制指南(節錄). 營養學報, 2004, 26(1): 1-4.
6.	Vilaichone RK, Mahachai V, Shiota S, et al. Extremely high prevalence of Helicobacter pylori infection in Bhutan. World J Gastroenterol, 2013, 19(18): 2806-2810.
7.	Hunt RH, Xiao SD, Megraud F, et al. Helicobacter pylori in developing countries. World gastroenterology organisation global guideline. J Gastrointestin Liver Dis, 2011, 20(3): 299-304.
8.	唐懷蓉, 范云潔, 劉莎. 成都地區幽門螺桿菌感染現狀及相關影響因素分析. 四川大學學報(醫學版), 2014, 45(5): 823-826.
9.	孟凡娜, 孫麗. 重慶地區健康體檢人群中幽門螺旋桿菌感染現狀研究分析. 現代檢驗醫學雜志, 2018, 33(5): 121-122, 125.
10.	Park JY, Forman D, Waskito LA, et al. Epidemiology of Helicobacter pylori and CagA-positive infections and global variations in gastric cancer. Toxins (Basel), 2018, 10(4): 163.
11.	Hu Y, Zhu Y, Lu N. Novel and effective therapeutic regimens for Helicobacter pylori in an era of increasing antibiotic resistance. Front Cell Infect Microbiol, 2017, 7: 168.
12.	Syam AF, Miftahussurur M, Makmun D, et al. Risk factors and prevalence of Helicobacter pylori in five largest islands of Indonesia: a preliminary study. PLoS One, 2015, 10(11): e140186.
13.	Maru?i? M, Majstorovi? Bara? K, Bili? A, et al. Do gender and age influence the frequency of Helicobacter pylori infection?. Wien Klin Wochenschr, 2013, 125(21-22): 714-716.
14.	于海婧. 吸煙飲酒對胃部疾病幽門螺旋桿菌感染的影響. 局解手術學雜志, 2011, 20(1): 84.
15.	Kopacova M, Koupil I, Seifert B, et al. Blood pressure and stature in Helicobacter pylori positive and negative persons. World J Gastroenterol, 2014, 20(19): 5625-5631.
16.	Roman S, Pandolfino JE. Environmental-lifestyle related factors. Best Pract Res Clin Gastroenterol, 2010, 24(6): 847-859.
17.	林燕, 楊國勝, 潘克勤. 52 例老年幽門螺桿菌感染者胃黏膜病變觀察. 浙江預防醫學, 2003, 15(9): 62-63.
18.	Salles N. Helicobacter pylori infection in elderly patients. Rev Med Interne, 2007, 28(6): 400-411.
19.	張玫, 湯哲, 湯欣, 等. 社會因素對老年人群幽門螺桿菌感染的影響. 世界華人消化雜志, 2005, 13(14): 1779-1780.
20.	李琳, 張婉紅, 陳偉才, 等. 幽門螺旋桿菌感染和年齡與血脂異常的臨床相關性研究. 江西醫藥, 2018, 53(7): 685-687.
21.	Jeon CY, Haan MN, Cheng C, et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care, 2012, 35(3): 520-525.

1. 何濤君, 吳正林, 鐘小強, 等. 乙肝患者 HBV 載量與 IgA, IgG, IgM 及 C3, C4 相關性研究. 現代檢驗醫學雜志, 2015, 30(4): 67-70.
2. Nam SY, Ryu KH, Park BJ, et al. Effects of Helicobacter pylori infection and its eradication on lipid profiles and cardiovascular diseases. Helicobacter, 2015, 20(2): 125-132.
3. Xie C, Lu NH. Review: clinical management of Helicobacter pylori infection in China. Helicobacter, 2014, 20(1): 1-10.
4. 劉捷, 王永紅, 羅蓉, 等. 重慶地區 ¹³C 尿素呼氣試驗陽性的健康體檢人群幽門螺桿菌感染率及相關危險因素分析. 重慶醫科大學學報, 2017, 42(10): 1358-1362.
5. 中國肥胖問題工作組. 中國成人超重與肥胖癥預防與控制指南(節錄). 營養學報, 2004, 26(1): 1-4.
6. Vilaichone RK, Mahachai V, Shiota S, et al. Extremely high prevalence of Helicobacter pylori infection in Bhutan. World J Gastroenterol, 2013, 19(18): 2806-2810.
7. Hunt RH, Xiao SD, Megraud F, et al. Helicobacter pylori in developing countries. World gastroenterology organisation global guideline. J Gastrointestin Liver Dis, 2011, 20(3): 299-304.
8. 唐懷蓉, 范云潔, 劉莎. 成都地區幽門螺桿菌感染現狀及相關影響因素分析. 四川大學學報(醫學版), 2014, 45(5): 823-826.
9. 孟凡娜, 孫麗. 重慶地區健康體檢人群中幽門螺旋桿菌感染現狀研究分析. 現代檢驗醫學雜志, 2018, 33(5): 121-122, 125.
10. Park JY, Forman D, Waskito LA, et al. Epidemiology of Helicobacter pylori and CagA-positive infections and global variations in gastric cancer. Toxins (Basel), 2018, 10(4): 163.
11. Hu Y, Zhu Y, Lu N. Novel and effective therapeutic regimens for Helicobacter pylori in an era of increasing antibiotic resistance. Front Cell Infect Microbiol, 2017, 7: 168.
12. Syam AF, Miftahussurur M, Makmun D, et al. Risk factors and prevalence of Helicobacter pylori in five largest islands of Indonesia: a preliminary study. PLoS One, 2015, 10(11): e140186.
13. Maru?i? M, Majstorovi? Bara? K, Bili? A, et al. Do gender and age influence the frequency of Helicobacter pylori infection?. Wien Klin Wochenschr, 2013, 125(21-22): 714-716.
14. 于海婧. 吸煙飲酒對胃部疾病幽門螺旋桿菌感染的影響. 局解手術學雜志, 2011, 20(1): 84.
15. Kopacova M, Koupil I, Seifert B, et al. Blood pressure and stature in Helicobacter pylori positive and negative persons. World J Gastroenterol, 2014, 20(19): 5625-5631.
16. Roman S, Pandolfino JE. Environmental-lifestyle related factors. Best Pract Res Clin Gastroenterol, 2010, 24(6): 847-859.
17. 林燕, 楊國勝, 潘克勤. 52 例老年幽門螺桿菌感染者胃黏膜病變觀察. 浙江預防醫學, 2003, 15(9): 62-63.
18. Salles N. Helicobacter pylori infection in elderly patients. Rev Med Interne, 2007, 28(6): 400-411.
19. 張玫, 湯哲, 湯欣, 等. 社會因素對老年人群幽門螺桿菌感染的影響. 世界華人消化雜志, 2005, 13(14): 1779-1780.
20. 李琳, 張婉紅, 陳偉才, 等. 幽門螺旋桿菌感染和年齡與血脂異常的臨床相關性研究. 江西醫藥, 2018, 53(7): 685-687.
21. Jeon CY, Haan MN, Cheng C, et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care, 2012, 35(3): 520-525.

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