Intervention effect of music therapy on children with autism spectrum disorder: a meta-analysis_West China Medical Journal

Authors：

WANG Wei , WANG Qi ,  YU Qinming

School of Humanities and Management, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P. R. China;

Corresponding?author：

YU Qinming, Email: 4773615@qq.com

Keywords：

Music therapy; autism spectrum disorder; children; meta-analysis

DOI：

10.7507/1002-0179.202210209

Video：

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Objective To explore the intervention effect of music therapy on children with autism spectrum disorder. Methods The China National Knowledge Infrastructure, Wanfang, Chongqing VIP, PubMed, Embase, Cochrane Library were searched by computer to comprehensively collect randomized controlled trials on the intervention effect of music therapy on children with autism spectrum disorder. The search period was from the establishment of the database to December 31, 2022. RevMan 5.4 software was used for meta-analysis. Results Finally, 20 articles were included, including 913 cases in the music therapy group and 811 cases in the control group, with a total sample size of 1724 cases. The meta-analysis results showed that the overall treatment effect [standardized mean difference (SMD)=?0.95, 95% confidence interval (CI) (?1.12, ?0.78)], the treatment effect of language [SMD=?0.71, 95%CI (?0.84, ?0.57)], behavior [SMD=?0.65, 95%CI (?0.78, ?0.52)], social interaction [SMD=?0.52, 95%CI (?0.63, ?0.40)], cognition [SMD=1.37, 95%CI (1.00, 1.74)] and sensory perception [SMD=?0.89, 95%CI (?1.03, ?0.74)] of the music therapy group were better than those of the control group (P<0.05). Conclusion The existing data show that music therapy applied to children with autism spectrum disorder can effectively improve their language, behavior, social interaction, cognition, and sensory perception, thereby having a positive impact on the overall treatment effect of children. However, due to the limitations of the number and quality of included studies, more high-quality studies are needed to verify.

Citation： WANG Wei, WANG Qi, YU Qinming. Intervention effect of music therapy on children with autism spectrum disorder: a meta-analysis. West China Medical Journal, 2023, 38(7): 1065-1072. doi: 10.7507/1002-0179.202210209 Copy

1.	Amonkar N, Su WC, Bhat AN, et al. Effects of creative movement therapies on social communication, behavioral-affective, sensorimotor, cognitive, and functional participation skills of individuals with autism spectrum disorder: a systematic review. Front Psychiatry, 2021, 12: 722874.
2.	Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ, 2014, 63(2): 1-21.
3.	Roman-Urrestarazu A, van Kessel R, Allison C, et al. Association of race/ethnicity and social disadvantage with autism prevalence in 7 million school children in England. JAMA Pediatr, 2021, 175(6): e210054.
4.	許潔霜, 梁霽, 諸臻穎. 上海市兒童孤獨癥康復機構現狀研究. 中國婦幼健康研究, 2016, 27(10): 1221-1224.
5.	寇聰, 柯曉殷, 張英, 等. 孤獨癥流行病學和病因學探討. 國際精神病學雜志, 2015, 42(2): 132-135.
6.	丁一蕓, 衛利, 王素梅. 自閉癥中西醫研究進展及中醫研究思路淺析. 世界中醫藥, 2014(6): 820-823.
7.	陳蕾, 陶洪梅, 李紅, 等. 音樂治療干預自閉癥兒童臨床效果的實證研究. 重慶醫學, 2010, 39(18): 2481-2482, 2485.
8.	宋黎喆雄, 李曉宇, 仇雅嵐, 等. 音樂療法在身心疾病中的應用. 中華中醫藥雜志, 2019, 34(9): 4186-4189.
9.	Kim J, Wigram T, Gold C. Emotional, motivational and interpersonal responsiveness of children with autism in improvisational music therapy. Autism, 2009, 13(4): 389-409.
10.	Finnigan E, Starr E. Increasing social responsiveness in a child with autism. A comparison of music and non-music interventions. Autism, 2010, 14(4): 321-348.
11.	Katagiri J. The effect of background music and song texts on the emotional understanding of children with autism. J Music Ther, 2009, 46(1): 15-31.
12.	陳毅克, 王月, 陳翠蓉, 等. 音樂療法及構音訓練對自閉癥兒童言語功能及自閉癥評定量表評分的影響. 安徽醫藥, 2022, 26(1): 61-65.
13.	Hampton LH, Stern Y, Roberts M. Meta-analysis suggests early intervention for infants and toddlers at risk for autism may be effective for improving developmental outcomes. Evid Based Commun Assess Interv, 2018, 12(4): 1-3.
14.	Sharma SR, Gonda X, Tarazi FI. Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther, 2018, 190: 91-104.
15.	廖娟, 葉曉婉, 曹棟, 等. 中國傳統音樂療法對腫瘤相關抑郁狀態的影響—系統評價和薈萃分析. 世界科學技術-中醫藥現代化, 2023, 25(1): 331-340.
16.	Bieleninik L, Geretsegger M, M?ssler K, et al. Effects of improvisational music therapy vs enhanced standard care on symptom severity among children with autism spectrum disorder: the TIME-A randomized clinical trial. JAMA, 2017, 318(6): 525-535.
17.	何迎霜, 劉桂華, 張鈺紅, 等. 親子合作式音樂療法對孤獨癥譜系障礙兒童及其母親影響的前瞻性隨機對照研究. 中國當代兒科雜志, 2022, 24(5): 472-481.
18.	周凡. 自閉癥兒童康復中音樂治療的臨床應用分析. 名醫, 2019(11): 71.
19.	周宇航. 音樂療法聯合語言訓練對孤獨癥患兒語言功能康復的影響. 中國療養醫學, 2018, 27(11): 1157-1159.
20.	張海燕, 史雅寧, 李凱. 音樂療法聯合系統康復訓練對自閉癥患兒病情控制及社交溝通能力的影響. 中國實用醫刊, 2022, 49(22): 66-69.
21.	曹彩紅. 音樂療法結合語言訓練對孤獨癥兒童語言康復的效果. 中國保健營養, 2019, 29(10): 335.
22.	李倩, 高超. 音樂療法在兒童孤獨癥康復治療中的應用效果觀察. 中國民康醫學, 2018, 30(14): 69-70.
23.	李潘紅. 音樂護理在自閉癥兒童護理中的應用. 河南醫學研究, 2020, 29(3): 549-551.
24.	段奕. 音樂療法與語言訓練聯合應用于孤獨癥的效果研究. 實用中西醫結合臨床, 2019, 19(11): 45-46.
25.	牛源. 音樂治療在自閉癥兒童康復中的應用價值體會. 北方音樂, 2019(16): 248-249.
26.	王獻娜, 李華鈺, 駱維維. 音樂治療在孤獨癥譜系障礙兒童康復訓練中的應用研究. 中國婦幼健康研究, 2017(增刊 2): 2.
27.	田利媛. 音樂干預療法對自閉癥患兒語言障礙的康復效果分析. 臨床研究, 2018, 26(9): 108-109.
28.	聶曼蒂, 李霞. 音樂療法對兒童孤獨癥康復訓練的影響. 中國繼續醫學教育, 2017, 9(19): 192-193.
29.	胡世園, 吳佳妮, 張尹佳. 語言認知訓練聯合音樂療法對兒童孤獨癥患者語言表達、理解能力的改善效果. 現代實用醫學, 2021, 33(6): 802-804.
30.	趙永紅, 聞春波, 戚亞敏, 等. 組內音樂療法治療自閉癥患兒臨床觀察. 實用中醫內科雜志, 2020, 34(8): 23-26.
31.	陳云靜, 牛帥楊, 宋燕燕, 等. 音樂療法聯合語言認知訓練治療兒童孤獨癥的療效觀察. 中外女性健康研究, 2019(23): 86, 97.
32.	陳雅燕, 曾麗玉, 張義王. 可視音樂訓練孤獨癥譜系障礙患兒的效果. 中國民康醫學, 2022, 34(1): 58-60.
33.	隨廣紅. 音樂治療對兒童孤獨癥的療效研究. 天津: 天津醫科大學, 2017.
34.	饒艷君. 音樂療法在自閉癥兒童護理干預中的應用. 婦幼護理, 2022, 2(2): 397-399, 403.
35.	黃零一. 音樂治療在自閉癥兒童康復中的應用. 中國繼續醫學教育, 2015(18): 153-154.
36.	王悅, 雷曉梅, 楊媛媛, 等. 音樂療法對孤獨癥譜系障礙患兒干預效果的 Meta 分析. 中國兒童保健雜志, 2019, 27(1): 66-72.
37.	劉加柱, 王詩雨, 余光武. 語言與音樂關系認知神經研究述評. 解放軍外國語學院學報, 2022, 45(6): 58-65.
38.	Patel AD. Language, music, syntax and the brain. Nat Neurosci, 2003, 6(7): 674-681.
39.	Sandiford GA, Mainess KJ, Daher NS. A pilot study on the efficacy of melodic based communication therapy for eliciting speech in nonverbal children with autism. J Autism Dev Disord, 2013, 43(6): 1298-1307.
40.	Choi YK. The effect of music and progressive muscle relaxation on anxiety, fatigue, and quality of life in family caregivers of hospice patients. J Music Ther, 2010, 47(1): 53-69.
41.	American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). United States: American Psychiatric Association, 2000.
42.	LaGasse AB. Social outcomes in children with autism spectrum disorder: a review of music therapy outcomes. Patient Relat Outcome Meas, 2017, 8: 23-32.
43.	郝小路, 周娜, 劉安國, 等. 音樂療法干預輕度認知障礙機制的研究進展. 中外醫學研究, 2023, 21(13): 171-175.
44.	Maseda A, Cibeira N, Lorenzo-López L, et al. Multisensory stimulation and individualized music sessions on older adults with severe dementia: effects on mood, behavior, and biomedical parameters. J Alzheimers Dis, 2018, 63(4): 1415-1425.
45.	章艷, 黃雪花. 第三版 PEP-3 孤獨癥評估量表在 ASD 患兒早期篩查及療效評價價值. 四川醫學, 2021, 42(2): 149-152.
46.	Standley JM. A meta-analysis on the effects of music as reinforcement for education/therapy objectives. J Res Music Educ. 1996, 44(2): 28.
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48.	Geretsegger M, Elefant C, M?ssler KA, et al. Music therapy for people with autism spectrum disorder. Cochrane Database Syst Rev, 2014, 2014(6): CD004381.
49.	石志敏, 林桂紅, 謝清. 音樂療法對自閉癥患兒情緒、語言、行為、社交能力影響的 Meta 分析. 護理研究, 2016(8): 922-926.
50.	Mayer-Benarous H, Benarous X, Vonthron F, et al. Music therapy for children with autistic spectrum disorder and/or other neurodevelopmental disorders: a systematic review. Front Psychiatry, 2021, 12: 643234.
51.	Gassner L, Geretsegger M, Mayer-Ferbas J. Effectiveness of music therapy for autism spectrum disorder, dementia, depression, insomnia and schizophrenia: update of systematic reviews. Eur J Public Health, 2022, 32(1): 27-34.
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1. Amonkar N, Su WC, Bhat AN, et al. Effects of creative movement therapies on social communication, behavioral-affective, sensorimotor, cognitive, and functional participation skills of individuals with autism spectrum disorder: a systematic review. Front Psychiatry, 2021, 12: 722874.
2. Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ, 2014, 63(2): 1-21.
3. Roman-Urrestarazu A, van Kessel R, Allison C, et al. Association of race/ethnicity and social disadvantage with autism prevalence in 7 million school children in England. JAMA Pediatr, 2021, 175(6): e210054.
4. 許潔霜, 梁霽, 諸臻穎. 上海市兒童孤獨癥康復機構現狀研究. 中國婦幼健康研究, 2016, 27(10): 1221-1224.
5. 寇聰, 柯曉殷, 張英, 等. 孤獨癥流行病學和病因學探討. 國際精神病學雜志, 2015, 42(2): 132-135.
6. 丁一蕓, 衛利, 王素梅. 自閉癥中西醫研究進展及中醫研究思路淺析. 世界中醫藥, 2014(6): 820-823.
7. 陳蕾, 陶洪梅, 李紅, 等. 音樂治療干預自閉癥兒童臨床效果的實證研究. 重慶醫學, 2010, 39(18): 2481-2482, 2485.
8. 宋黎喆雄, 李曉宇, 仇雅嵐, 等. 音樂療法在身心疾病中的應用. 中華中醫藥雜志, 2019, 34(9): 4186-4189.
9. Kim J, Wigram T, Gold C. Emotional, motivational and interpersonal responsiveness of children with autism in improvisational music therapy. Autism, 2009, 13(4): 389-409.
10. Finnigan E, Starr E. Increasing social responsiveness in a child with autism. A comparison of music and non-music interventions. Autism, 2010, 14(4): 321-348.
11. Katagiri J. The effect of background music and song texts on the emotional understanding of children with autism. J Music Ther, 2009, 46(1): 15-31.
12. 陳毅克, 王月, 陳翠蓉, 等. 音樂療法及構音訓練對自閉癥兒童言語功能及自閉癥評定量表評分的影響. 安徽醫藥, 2022, 26(1): 61-65.
13. Hampton LH, Stern Y, Roberts M. Meta-analysis suggests early intervention for infants and toddlers at risk for autism may be effective for improving developmental outcomes. Evid Based Commun Assess Interv, 2018, 12(4): 1-3.
14. Sharma SR, Gonda X, Tarazi FI. Autism spectrum disorder: classification, diagnosis and therapy. Pharmacol Ther, 2018, 190: 91-104.
15. 廖娟, 葉曉婉, 曹棟, 等. 中國傳統音樂療法對腫瘤相關抑郁狀態的影響—系統評價和薈萃分析. 世界科學技術-中醫藥現代化, 2023, 25(1): 331-340.
16. Bieleninik L, Geretsegger M, M?ssler K, et al. Effects of improvisational music therapy vs enhanced standard care on symptom severity among children with autism spectrum disorder: the TIME-A randomized clinical trial. JAMA, 2017, 318(6): 525-535.
17. 何迎霜, 劉桂華, 張鈺紅, 等. 親子合作式音樂療法對孤獨癥譜系障礙兒童及其母親影響的前瞻性隨機對照研究. 中國當代兒科雜志, 2022, 24(5): 472-481.
18. 周凡. 自閉癥兒童康復中音樂治療的臨床應用分析. 名醫, 2019(11): 71.
19. 周宇航. 音樂療法聯合語言訓練對孤獨癥患兒語言功能康復的影響. 中國療養醫學, 2018, 27(11): 1157-1159.
20. 張海燕, 史雅寧, 李凱. 音樂療法聯合系統康復訓練對自閉癥患兒病情控制及社交溝通能力的影響. 中國實用醫刊, 2022, 49(22): 66-69.
21. 曹彩紅. 音樂療法結合語言訓練對孤獨癥兒童語言康復的效果. 中國保健營養, 2019, 29(10): 335.
22. 李倩, 高超. 音樂療法在兒童孤獨癥康復治療中的應用效果觀察. 中國民康醫學, 2018, 30(14): 69-70.
23. 李潘紅. 音樂護理在自閉癥兒童護理中的應用. 河南醫學研究, 2020, 29(3): 549-551.
24. 段奕. 音樂療法與語言訓練聯合應用于孤獨癥的效果研究. 實用中西醫結合臨床, 2019, 19(11): 45-46.
25. 牛源. 音樂治療在自閉癥兒童康復中的應用價值體會. 北方音樂, 2019(16): 248-249.
26. 王獻娜, 李華鈺, 駱維維. 音樂治療在孤獨癥譜系障礙兒童康復訓練中的應用研究. 中國婦幼健康研究, 2017(增刊 2): 2.
27. 田利媛. 音樂干預療法對自閉癥患兒語言障礙的康復效果分析. 臨床研究, 2018, 26(9): 108-109.
28. 聶曼蒂, 李霞. 音樂療法對兒童孤獨癥康復訓練的影響. 中國繼續醫學教育, 2017, 9(19): 192-193.
29. 胡世園, 吳佳妮, 張尹佳. 語言認知訓練聯合音樂療法對兒童孤獨癥患者語言表達、理解能力的改善效果. 現代實用醫學, 2021, 33(6): 802-804.
30. 趙永紅, 聞春波, 戚亞敏, 等. 組內音樂療法治療自閉癥患兒臨床觀察. 實用中醫內科雜志, 2020, 34(8): 23-26.
31. 陳云靜, 牛帥楊, 宋燕燕, 等. 音樂療法聯合語言認知訓練治療兒童孤獨癥的療效觀察. 中外女性健康研究, 2019(23): 86, 97.
32. 陳雅燕, 曾麗玉, 張義王. 可視音樂訓練孤獨癥譜系障礙患兒的效果. 中國民康醫學, 2022, 34(1): 58-60.
33. 隨廣紅. 音樂治療對兒童孤獨癥的療效研究. 天津: 天津醫科大學, 2017.
34. 饒艷君. 音樂療法在自閉癥兒童護理干預中的應用. 婦幼護理, 2022, 2(2): 397-399, 403.
35. 黃零一. 音樂治療在自閉癥兒童康復中的應用. 中國繼續醫學教育, 2015(18): 153-154.
36. 王悅, 雷曉梅, 楊媛媛, 等. 音樂療法對孤獨癥譜系障礙患兒干預效果的 Meta 分析. 中國兒童保健雜志, 2019, 27(1): 66-72.
37. 劉加柱, 王詩雨, 余光武. 語言與音樂關系認知神經研究述評. 解放軍外國語學院學報, 2022, 45(6): 58-65.
38. Patel AD. Language, music, syntax and the brain. Nat Neurosci, 2003, 6(7): 674-681.
39. Sandiford GA, Mainess KJ, Daher NS. A pilot study on the efficacy of melodic based communication therapy for eliciting speech in nonverbal children with autism. J Autism Dev Disord, 2013, 43(6): 1298-1307.
40. Choi YK. The effect of music and progressive muscle relaxation on anxiety, fatigue, and quality of life in family caregivers of hospice patients. J Music Ther, 2010, 47(1): 53-69.
41. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV-TR). United States: American Psychiatric Association, 2000.
42. LaGasse AB. Social outcomes in children with autism spectrum disorder: a review of music therapy outcomes. Patient Relat Outcome Meas, 2017, 8: 23-32.
43. 郝小路, 周娜, 劉安國, 等. 音樂療法干預輕度認知障礙機制的研究進展. 中外醫學研究, 2023, 21(13): 171-175.
44. Maseda A, Cibeira N, Lorenzo-López L, et al. Multisensory stimulation and individualized music sessions on older adults with severe dementia: effects on mood, behavior, and biomedical parameters. J Alzheimers Dis, 2018, 63(4): 1415-1425.
45. 章艷, 黃雪花. 第三版 PEP-3 孤獨癥評估量表在 ASD 患兒早期篩查及療效評價價值. 四川醫學, 2021, 42(2): 149-152.
46. Standley JM. A meta-analysis on the effects of music as reinforcement for education/therapy objectives. J Res Music Educ. 1996, 44(2): 28.
47. 齊巍. 國內外音樂療法對自閉癥患者干預效果的元分析研究. 長春: 吉林大學, 2011.
48. Geretsegger M, Elefant C, M?ssler KA, et al. Music therapy for people with autism spectrum disorder. Cochrane Database Syst Rev, 2014, 2014(6): CD004381.
49. 石志敏, 林桂紅, 謝清. 音樂療法對自閉癥患兒情緒、語言、行為、社交能力影響的 Meta 分析. 護理研究, 2016(8): 922-926.
50. Mayer-Benarous H, Benarous X, Vonthron F, et al. Music therapy for children with autistic spectrum disorder and/or other neurodevelopmental disorders: a systematic review. Front Psychiatry, 2021, 12: 643234.
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West China Medical Journal

Intervention effect of music therapy on children with autism spectrum disorder: a meta-analysis

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