Research progress of amanitin-containing mushroom poisoning_West China Medical Journal

Authors：

MA Chunmao ^1,2 , PENG Aihua ^1,3 ,  CAO Yu ^1,3

1. Department of Emergency Medicine and Laboratory of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Emergency Department of Pengzhou People’s Hospital, Pengzhou, Sichuan 611930, P. R. China;
3. Disaster Medical Center, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

CAO Yu, Email: yuyuer@126.com

Keywords：

Mushroom poisoning; amanitin; poisoning mechanism; toxic detection; clinical diagnosis and treatment

DOI：

10.7507/1002-0179.202309217

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Amanitin-containing mushroom poisoning is one of the most harmful and lethal types of mushroom poisoning events. Its basic medical and clinical medical knowledge has not been fully understood and mastered, so the basic and clinical diagnosis and treatment of amanitin-containing mushroom poisoning has always been a hot research field of acute mushroom poisoning. This article focuses on the new progress in the epidemiology, toxicological properties, poisoning mechanism, clinical diagnosis and treatment of amanitin-containing mushroom poisoning, in order to provide the basis for further study, diagnosis and treatment of amanitin-containing mushroom poisoning for basic researchers and clinical medical staff.

Citation： MA Chunmao, PENG Aihua, CAO Yu. Research progress of amanitin-containing mushroom poisoning. West China Medical Journal, 2023, 38(11): 1748-1754. doi: 10.7507/1002-0179.202309217 Copy

1.	Govorushko S, Rezaee R, Dumanov J, et al. Poisoning associated with the use of mushrooms: a review of the global pattern and main characteristics. Food Chem Toxicol, 2019, 128: 267-279.
2.	鐘加菊, 姚群梅, 唐燕, 等. 活性炭對鵝膏毒肽及鬼筆毒肽的體外吸附研究. 中國急救醫學, 2021, 41(8): 709-713.
3.	Lecot J, Cellier M, Courtois A, et al. Cyclopeptide mushroom poisoning: a retrospective series of 204 patients. Basic Clin Pharmacol Toxicol, 2023, 132(6): 533-542.
4.	余成敏, 李海蛟. 中國含鵝膏毒肽蘑菇中毒臨床診斷治療專家共識. 中華危重癥醫學雜志(電子版), 2020, 13(1): 20-28.
5.	Cervellin G, Comelli I, Rastelli G, et al. Epidemiology and clinics of mushroom poisoning in Northern Italy: a 21-year retrospective analysis. Hum Exp Toxicol, 2018, 37(7): 697-703.
6.	Li W, Pires SM, Liu Z, et al. Mushroom poisoning outbreaks - China, 2010-2020. China CDC Wkly, 2021, 3(24): 518-522.
7.	Chen L, Sun L, Zhang R, et al. Epidemiological analysis of wild mushroom poisoning in Zhejiang province, China, 2016-2018. Food Sci Nutr, 2021, 10(1): 60-66.
8.	圖力古爾, 包海鷹, 李玉. 中國毒蘑菇名錄. 菌物學報, 2014, 33(3): 517-548.
9.	Lewinsohn D, Lurie Y, Gaon A, et al. The epidemiology of wild mushroom poisoning in Israel. Mycologia, 2023, 115(3): 317-325.
10.	Cai Q, Cui YY, Yang ZL. Lethal Amanita species in China. Mycologia, 2016, 108(5): 993-1009.
11.	Vo KT, Montgomery ME, Mitchell ST, et al. Amanita phalloides mushroom poisonings - Northern California, December 2016. MMWR Morb Mortal Wkly Rep, 2017, 66(21): 549-553.
12.	Cassidy N, Duggan E, Tracey JA. Mushroom poisoning in Ireland: the collaboration between the National Poisons Information Centre and expert mycologists. Clin Toxicol (Phila), 2011, 49(3): 171-176.
13.	Somrithipol S, Pinruan U, Sommai S, et al. Mushroom poisoning in Thailand between 2003 and 2017. Mycoscience, 2022, 63(6): 267-273.
14.	Meng H, Chen Z, Chen L, et al. An outbreak of Amanita exitialis poisoning. Clin Toxicol (Phila), 2023, 61(4): 270-275.
15.	Li H, Zhang H, Zhang Y, et al. Mushroom poisoning outbreaks - China, 2021. China CDC Wkly, 2022, 4(3): 35-40.
16.	Li H, Zhang Y, Zhang H, et al. Mushroom poisoning outbreaks - China, 2022. China CDC Wkly, 2023, 5(3): 45-50.
17.	Li H, Zhang H, Zhang Y, et al. Mushroom poisoning outbreaks - China, 2020. China CDC Wkly, 2021, 3(3): 41-45.
18.	鄧旺秋, 李泰輝, 張明, 等. 華南常見毒鵝膏菌及其中毒事件分析. 菌物學報, 2020, 39(9): 1750-1758.
19.	Brandenburg WE, Ward KJ. Mushroom poisoning epidemiology in the United States. Mycologia, 2018, 110(4): 637-641.
20.	Sun J, Li HJ, Zhang HS, et al. Investigating and analyzing three cohorts of mushroom poisoning caused by Amanita exitialis in Yunnan, China. Hum Exp Toxicol, 2018, 37(7): 665-678.
21.	Liu J, Bai L, Li W, et al. Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011. Front Med, 2018, 12(1): 48-57.
22.	Karami Matin B, Amrollahi-Sharifabadi M, Rezaei S, et al. Epidemiology and economic burden of an outbreak of cyclopeptide-containing mushroom poisoning in the west of Iran. Front Public Health, 2022, 10: 910024.
23.	White J, Weinstein SA, De Haro L, et al. Mushroom poisoning: a proposed new clinical classification. Toxicon, 2019(157): 53-65.
24.	Diaz JH. Nephrotoxic mushroom poisoning: global epidemiology, clinical manifestations, and management. Wilderness Environ Med, 2021, 32(4): 537-544.
25.	Diaz JH. Evolving global epidemiology, syndromic classification, general management, and prevention of unknown mushroom poisonings. Crit Care Med, 2005, 33(2): 419-426.
26.	Gold J, Kiernan E, Yeh M, et al. Health care utilization and outcomes associated with accidental poisonous mushroom ingestions - United States, 2016-2018. MMWR Morb Mortal Wkly Rep, 2021, 70(10): 337-341.
27.	Garcia J, Costa VM, Carvalho A, et al. Amanita phalloides poisoning: mechanisms of toxicity and treatment. Food Chem Toxicol, 2015, 86: 41-55.
28.	王晶, 史振霞, 喬潔, 等. 毒鵝膏菌和鵝膏肽類毒素研究進展. 廊坊師范學院學報(自然科學版), 2018, 18(1): 46-53, 57.
29.	秦琪, 田恩靜, 包海鷹. 蘑菇毒素分類及其結構式. 菌物研究, 2022, 20(2): 128-140.
30.	Faulstich H, Buku A, Bodenmueller H, et al. Virotoxins: actin-binding cyclic peptides of Amanita virosa mushrooms. Biochemistry (Easton), 1980, 19(14): 3334-3343.
31.	Lim CH, Song I, Lee J, et al. Toxicokinetics and tissue distribution of phalloidin in mice. Food Chem Toxicol, 2023, 179: 113994.
32.	Wieland T, Faulstich H. Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem, 1978, 5(3): 185-260.
33.	Xue J, Lou X, Ning D, et al. Mechanism and treatment of α-amanitin poisoning. Arch Toxicol, 2023, 97(1): 121-131.
34.	許悅, 王嬋, 林紓丞, 等. α-鵝膏毒肽誘導肝細胞毒性作用機制的研究進展. 昆明醫科大學學報, 2022, 43(12): 153-158.
35.	Barbosa I, Domingues C, Ramos F, et al. Analytical methods for amatoxins: a comprehensive review. J Pharm Biomed Anal, 2023, 232: 115421.
36.	Yilmaz I, Ermis F, Akata I, et al. A case study: what doses of Amanita phalloides and amatoxins are lethal to humans?. Wilderness Environ Med, 2015, 26(4): 491-496.
37.	孫健. 致命鵝膏肝毒性及鵝膏肽類毒素在比格犬體內毒代動力學初步研究. 北京: 中國疾病預防控制中心, 2018.
38.	Park R, Choi WG, Lee MS, et al. Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials. J Toxicol Environ Health A, 2021, 84(20): 821-835.
39.	Tiewsoh I, Bhattacharya PK, Barman B, et al. Delayed liver toxicity and delayed gastroenteritis: a 5 year retrospective analysis of the cause of death in mushroom poisoning. J Family Med Prim Care, 2022, 11(5): 1963-1969.
40.	Letschert K, Faulstich H, Keller D, et al. Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci, 2006, 91(1): 140-149.
41.	Escoda O, Reverter E, To-Figueras J, et al. Potential value of urinary amatoxin quantification in patients with hepatotoxic mushroom poisoning. Liver Int, 2019, 39(6): 1128-1135.
42.	盧中秋, 洪廣亮, 孫承業, 等. 中國蘑菇中毒診治臨床專家共識. 臨床急診雜志, 2019, 20(8): 583-598.
43.	Wieland T. The toxic peptides from Amanita mushrooms. Int J Pept Protein Res, 1983, 22(3): 257-276.
44.	Bushnell DA, Cramer P, Kornberg RD. Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A, 2002, 99(3): 1218-1222.
45.	Kaplan CD, Larsson KM, Kornberg RD. The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol Cell, 2008, 30(5): 547-556.
46.	Wang D, Bushnell DA, Westover KD, et al. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell, 2006, 127(5): 941-954.
47.	Nguyen VT, Giannoni F, Dubois MF, et al. In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. Nucleic Acids Res, 1996, 24(15): 2924-2929.
48.	Andera L, Wasylyk B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Molecular medicine (Cambridge, Mass. ), 1997, 3(12): 852-863.
49.	Arima Y, Nitta M, Kuninaka S, et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem, 2005, 280(19): 19166-19176.
50.	Gartel AL. Transcriptional inhibitors, p53 and apoptoss. Biochim Biophys Acta, 2008, 1786(2): 83-86.
51.	Magdalan J, Piotrowska A, Gomu?kiewicz A, et al. Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures. Exp Toxicol Pathol, 2011, 63(4): 311-315.
52.	Magdalan J, Piotrowska A, Gomu?kiewicz A, et al. Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin. Hum Exp Toxicol, 2011, 30(1): 38-43.
53.	Wang M, Chen Y, Guo Z, et al. Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity. Toxicon, 2018, 15: 156: 34-40.
54.	Chen X, Shao B, Yu C, et al. The cyclopeptide α-amatoxin induced hepatic injury via the mitochondrial apoptotic pathway associated with oxidative stress. Peptides, 2020, 129: 170314.
55.	Le Daré B, Ferron PJ, Gicquel T. Toxic effects of amanitins: repurposing toxicities toward new therapeutics. Toxins (Basel), 2021, 13(6): 417.
56.	Zheleva A, Tolekova A, Zhelev M, et al. Free radical reactions might contribute to severe alpha amanitin hepatotoxicity--a hypothesis. Med Hypotheses, 2007, 69(2): 361-367.
57.	賴福平, 胡杰, 陸元蘭, 等. ROS 激活 P53 調控線粒體凋亡途徑在 α-鵝膏毒肽中毒肝損害中作用的研究進展. 東南大學學報(醫學版), 2022, 41(5): 734-739.
58.	Wang B, Wan AH, Xu Y, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun, 2023, 14(1): 2241.
59.	Enjalbert F, Rapior S, Nouguier-Soulé J, et al. Treatment of amatoxin poisoning: 20-year retrospective analysis. J Toxicol Clin Toxicol, 2002, 40(6): 715-757.
60.	De Olano J, Wang JJ, Villeneuve E, et al. Current fatality rate of suspected cyclopeptide mushroom poisoning in the United States. Clin Toxicol (Phila), 2021, 59(1): 24-27.
61.	Bever CS, Adams CA, Hnasko RM, et al. Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms. PLoS One, 2020, 15(4): e0231781.
62.	陳宵, 李斌, 邵兵, 等. 基于 Meta 分析的不同臨床治療方法對鵝膏毒肽中毒治療效果的定量評估. 中國工業醫學雜志, 2020, 33(3): 217-222, 246.
63.	Zellner T, Prasa D, F?rber E, et al. The use of activated charcoal to treat intoxications. Dtsch Arztebl Int, 2019, 116(18): 311-317.
64.	Sun J, Zhang YT, Niu YM, et al. Effect of biliary drainage on the toxicity and toxicokinetics of Amanita exitialis in Beagles. Toxins (Basel), 2018, 10(6): 215.
65.	布冰, 楊超, 馬秀英, 等. 經開腹膽囊造瘺引流成功救治致命鵝膏中毒致肝衰竭 1 例. 中華危重病急救醫學, 2023, 35(2): 206-208.
66.	楊江英, 吳邦富, 江朝強, 等. 傳統血液凈化、血漿置換及 MARS 人工肝救治肝損害型白毒傘類毒蘑菇中毒. 中國血液凈化, 2003(7): 54-57.
67.	郭俊芝. 不同時期行血液凈化治療對鵝膏菌中毒患者預后的影響. 大理: 大理大學, 2022.
68.	張靜靜, 賈貝, 盧雪連. 連續血液凈化治療異味鵝膏蘑菇中毒的臨床效果. 臨床研究, 2022, 30(5): 13-17.
69.	王亞云, 何亞萍, 王澈, 等. 毒蘑菇中毒致急性肝衰竭 1 例報告. 中國工業醫學雜志, 2022, 35(2): 133-135.
70.	時一. 急診急性毒蘑菇中毒患者臨床特征及治療分析. 中國醫學工程, 2021, 29(8): 26-29.
71.	彭曉波, 王春燕, 白麗麗, 等. 48 例急性毒蕈中毒患者臨床分析. 中華危重病急救醫學, 2018, 30(3): 266-269, 274.
72.	Magdalan J, Ostrowska A, Piotrowska A, et al. Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin. Exp Toxicol Pathol, 2010, 62(4): 367-373.
73.	Poucheret P, Fons F, Doré JC, et al. Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis. Toxicon, 2010, 55(7): 1338-1345.
74.	Liu J, Chen Y, Gao Y, et al. N-acetylcysteine as a treatment for amatoxin poisoning: a systematic review. Clin Toxicol (Phila), 2020, 58(11): 1015-1022.
75.	肖桂林. 靈芝煎劑治療急性鵝膏毒蕈中毒的臨床及實驗研究. 長沙: 中南大學, 2007.
76.	Garcia J, Costa VM, Bovolini A, et al. An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication. Arch Toxicol, 2019, 93(5): 1449-1463.
77.	楊晶. 多粘菌素 B 對 α-鵝膏毒肽中毒兔肝功能損傷的療效分析. 昆明: 昆明醫科大學, 2019.
78.	Garcia J, Carvalho A, das Neves RP, et al. Antidotal effect of cyclosporine A against α-amanitin toxicity in CD-1 mice, at clinical relevant doses. Food Chem Toxicol, 2022, 166: 113198.
79.	Rodrigues DF, Pires das Neves R, Carvalho ATP, et al. In vitro mechanistic studies on α-amanitin and its putative antidotes. Arch Toxicol, 2020, 94(6): 2061-2078.

1. Govorushko S, Rezaee R, Dumanov J, et al. Poisoning associated with the use of mushrooms: a review of the global pattern and main characteristics. Food Chem Toxicol, 2019, 128: 267-279.
2. 鐘加菊, 姚群梅, 唐燕, 等. 活性炭對鵝膏毒肽及鬼筆毒肽的體外吸附研究. 中國急救醫學, 2021, 41(8): 709-713.
3. Lecot J, Cellier M, Courtois A, et al. Cyclopeptide mushroom poisoning: a retrospective series of 204 patients. Basic Clin Pharmacol Toxicol, 2023, 132(6): 533-542.
4. 余成敏, 李海蛟. 中國含鵝膏毒肽蘑菇中毒臨床診斷治療專家共識. 中華危重癥醫學雜志(電子版), 2020, 13(1): 20-28.
5. Cervellin G, Comelli I, Rastelli G, et al. Epidemiology and clinics of mushroom poisoning in Northern Italy: a 21-year retrospective analysis. Hum Exp Toxicol, 2018, 37(7): 697-703.
6. Li W, Pires SM, Liu Z, et al. Mushroom poisoning outbreaks - China, 2010-2020. China CDC Wkly, 2021, 3(24): 518-522.
7. Chen L, Sun L, Zhang R, et al. Epidemiological analysis of wild mushroom poisoning in Zhejiang province, China, 2016-2018. Food Sci Nutr, 2021, 10(1): 60-66.
8. 圖力古爾, 包海鷹, 李玉. 中國毒蘑菇名錄. 菌物學報, 2014, 33(3): 517-548.
9. Lewinsohn D, Lurie Y, Gaon A, et al. The epidemiology of wild mushroom poisoning in Israel. Mycologia, 2023, 115(3): 317-325.
10. Cai Q, Cui YY, Yang ZL. Lethal Amanita species in China. Mycologia, 2016, 108(5): 993-1009.
11. Vo KT, Montgomery ME, Mitchell ST, et al. Amanita phalloides mushroom poisonings - Northern California, December 2016. MMWR Morb Mortal Wkly Rep, 2017, 66(21): 549-553.
12. Cassidy N, Duggan E, Tracey JA. Mushroom poisoning in Ireland: the collaboration between the National Poisons Information Centre and expert mycologists. Clin Toxicol (Phila), 2011, 49(3): 171-176.
13. Somrithipol S, Pinruan U, Sommai S, et al. Mushroom poisoning in Thailand between 2003 and 2017. Mycoscience, 2022, 63(6): 267-273.
14. Meng H, Chen Z, Chen L, et al. An outbreak of Amanita exitialis poisoning. Clin Toxicol (Phila), 2023, 61(4): 270-275.
15. Li H, Zhang H, Zhang Y, et al. Mushroom poisoning outbreaks - China, 2021. China CDC Wkly, 2022, 4(3): 35-40.
16. Li H, Zhang Y, Zhang H, et al. Mushroom poisoning outbreaks - China, 2022. China CDC Wkly, 2023, 5(3): 45-50.
17. Li H, Zhang H, Zhang Y, et al. Mushroom poisoning outbreaks - China, 2020. China CDC Wkly, 2021, 3(3): 41-45.
18. 鄧旺秋, 李泰輝, 張明, 等. 華南常見毒鵝膏菌及其中毒事件分析. 菌物學報, 2020, 39(9): 1750-1758.
19. Brandenburg WE, Ward KJ. Mushroom poisoning epidemiology in the United States. Mycologia, 2018, 110(4): 637-641.
20. Sun J, Li HJ, Zhang HS, et al. Investigating and analyzing three cohorts of mushroom poisoning caused by Amanita exitialis in Yunnan, China. Hum Exp Toxicol, 2018, 37(7): 665-678.
21. Liu J, Bai L, Li W, et al. Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011. Front Med, 2018, 12(1): 48-57.
22. Karami Matin B, Amrollahi-Sharifabadi M, Rezaei S, et al. Epidemiology and economic burden of an outbreak of cyclopeptide-containing mushroom poisoning in the west of Iran. Front Public Health, 2022, 10: 910024.
23. White J, Weinstein SA, De Haro L, et al. Mushroom poisoning: a proposed new clinical classification. Toxicon, 2019(157): 53-65.
24. Diaz JH. Nephrotoxic mushroom poisoning: global epidemiology, clinical manifestations, and management. Wilderness Environ Med, 2021, 32(4): 537-544.
25. Diaz JH. Evolving global epidemiology, syndromic classification, general management, and prevention of unknown mushroom poisonings. Crit Care Med, 2005, 33(2): 419-426.
26. Gold J, Kiernan E, Yeh M, et al. Health care utilization and outcomes associated with accidental poisonous mushroom ingestions - United States, 2016-2018. MMWR Morb Mortal Wkly Rep, 2021, 70(10): 337-341.
27. Garcia J, Costa VM, Carvalho A, et al. Amanita phalloides poisoning: mechanisms of toxicity and treatment. Food Chem Toxicol, 2015, 86: 41-55.
28. 王晶, 史振霞, 喬潔, 等. 毒鵝膏菌和鵝膏肽類毒素研究進展. 廊坊師范學院學報(自然科學版), 2018, 18(1): 46-53, 57.
29. 秦琪, 田恩靜, 包海鷹. 蘑菇毒素分類及其結構式. 菌物研究, 2022, 20(2): 128-140.
30. Faulstich H, Buku A, Bodenmueller H, et al. Virotoxins: actin-binding cyclic peptides of Amanita virosa mushrooms. Biochemistry (Easton), 1980, 19(14): 3334-3343.
31. Lim CH, Song I, Lee J, et al. Toxicokinetics and tissue distribution of phalloidin in mice. Food Chem Toxicol, 2023, 179: 113994.
32. Wieland T, Faulstich H. Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem, 1978, 5(3): 185-260.
33. Xue J, Lou X, Ning D, et al. Mechanism and treatment of α-amanitin poisoning. Arch Toxicol, 2023, 97(1): 121-131.
34. 許悅, 王嬋, 林紓丞, 等. α-鵝膏毒肽誘導肝細胞毒性作用機制的研究進展. 昆明醫科大學學報, 2022, 43(12): 153-158.
35. Barbosa I, Domingues C, Ramos F, et al. Analytical methods for amatoxins: a comprehensive review. J Pharm Biomed Anal, 2023, 232: 115421.
36. Yilmaz I, Ermis F, Akata I, et al. A case study: what doses of Amanita phalloides and amatoxins are lethal to humans?. Wilderness Environ Med, 2015, 26(4): 491-496.
37. 孫健. 致命鵝膏肝毒性及鵝膏肽類毒素在比格犬體內毒代動力學初步研究. 北京: 中國疾病預防控制中心, 2018.
38. Park R, Choi WG, Lee MS, et al. Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials. J Toxicol Environ Health A, 2021, 84(20): 821-835.
39. Tiewsoh I, Bhattacharya PK, Barman B, et al. Delayed liver toxicity and delayed gastroenteritis: a 5 year retrospective analysis of the cause of death in mushroom poisoning. J Family Med Prim Care, 2022, 11(5): 1963-1969.
40. Letschert K, Faulstich H, Keller D, et al. Molecular characterization and inhibition of amanitin uptake into human hepatocytes. Toxicol Sci, 2006, 91(1): 140-149.
41. Escoda O, Reverter E, To-Figueras J, et al. Potential value of urinary amatoxin quantification in patients with hepatotoxic mushroom poisoning. Liver Int, 2019, 39(6): 1128-1135.
42. 盧中秋, 洪廣亮, 孫承業, 等. 中國蘑菇中毒診治臨床專家共識. 臨床急診雜志, 2019, 20(8): 583-598.
43. Wieland T. The toxic peptides from Amanita mushrooms. Int J Pept Protein Res, 1983, 22(3): 257-276.
44. Bushnell DA, Cramer P, Kornberg RD. Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution. Proc Natl Acad Sci U S A, 2002, 99(3): 1218-1222.
45. Kaplan CD, Larsson KM, Kornberg RD. The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. Mol Cell, 2008, 30(5): 547-556.
46. Wang D, Bushnell DA, Westover KD, et al. Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis. Cell, 2006, 127(5): 941-954.
47. Nguyen VT, Giannoni F, Dubois MF, et al. In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. Nucleic Acids Res, 1996, 24(15): 2924-2929.
48. Andera L, Wasylyk B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Molecular medicine (Cambridge, Mass. ), 1997, 3(12): 852-863.
49. Arima Y, Nitta M, Kuninaka S, et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem, 2005, 280(19): 19166-19176.
50. Gartel AL. Transcriptional inhibitors, p53 and apoptoss. Biochim Biophys Acta, 2008, 1786(2): 83-86.
51. Magdalan J, Piotrowska A, Gomu?kiewicz A, et al. Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures. Exp Toxicol Pathol, 2011, 63(4): 311-315.
52. Magdalan J, Piotrowska A, Gomu?kiewicz A, et al. Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin. Hum Exp Toxicol, 2011, 30(1): 38-43.
53. Wang M, Chen Y, Guo Z, et al. Changes in the mitochondrial proteome in human hepatocytes in response to alpha-amanitin hepatotoxicity. Toxicon, 2018, 15: 156: 34-40.
54. Chen X, Shao B, Yu C, et al. The cyclopeptide α-amatoxin induced hepatic injury via the mitochondrial apoptotic pathway associated with oxidative stress. Peptides, 2020, 129: 170314.
55. Le Daré B, Ferron PJ, Gicquel T. Toxic effects of amanitins: repurposing toxicities toward new therapeutics. Toxins (Basel), 2021, 13(6): 417.
56. Zheleva A, Tolekova A, Zhelev M, et al. Free radical reactions might contribute to severe alpha amanitin hepatotoxicity--a hypothesis. Med Hypotheses, 2007, 69(2): 361-367.
57. 賴福平, 胡杰, 陸元蘭, 等. ROS 激活 P53 調控線粒體凋亡途徑在 α-鵝膏毒肽中毒肝損害中作用的研究進展. 東南大學學報(醫學版), 2022, 41(5): 734-739.
58. Wang B, Wan AH, Xu Y, et al. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat Commun, 2023, 14(1): 2241.
59. Enjalbert F, Rapior S, Nouguier-Soulé J, et al. Treatment of amatoxin poisoning: 20-year retrospective analysis. J Toxicol Clin Toxicol, 2002, 40(6): 715-757.
60. De Olano J, Wang JJ, Villeneuve E, et al. Current fatality rate of suspected cyclopeptide mushroom poisoning in the United States. Clin Toxicol (Phila), 2021, 59(1): 24-27.
61. Bever CS, Adams CA, Hnasko RM, et al. Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms. PLoS One, 2020, 15(4): e0231781.
62. 陳宵, 李斌, 邵兵, 等. 基于 Meta 分析的不同臨床治療方法對鵝膏毒肽中毒治療效果的定量評估. 中國工業醫學雜志, 2020, 33(3): 217-222, 246.
63. Zellner T, Prasa D, F?rber E, et al. The use of activated charcoal to treat intoxications. Dtsch Arztebl Int, 2019, 116(18): 311-317.
64. Sun J, Zhang YT, Niu YM, et al. Effect of biliary drainage on the toxicity and toxicokinetics of Amanita exitialis in Beagles. Toxins (Basel), 2018, 10(6): 215.
65. 布冰, 楊超, 馬秀英, 等. 經開腹膽囊造瘺引流成功救治致命鵝膏中毒致肝衰竭 1 例. 中華危重病急救醫學, 2023, 35(2): 206-208.
66. 楊江英, 吳邦富, 江朝強, 等. 傳統血液凈化、血漿置換及 MARS 人工肝救治肝損害型白毒傘類毒蘑菇中毒. 中國血液凈化, 2003(7): 54-57.
67. 郭俊芝. 不同時期行血液凈化治療對鵝膏菌中毒患者預后的影響. 大理: 大理大學, 2022.
68. 張靜靜, 賈貝, 盧雪連. 連續血液凈化治療異味鵝膏蘑菇中毒的臨床效果. 臨床研究, 2022, 30(5): 13-17.
69. 王亞云, 何亞萍, 王澈, 等. 毒蘑菇中毒致急性肝衰竭 1 例報告. 中國工業醫學雜志, 2022, 35(2): 133-135.
70. 時一. 急診急性毒蘑菇中毒患者臨床特征及治療分析. 中國醫學工程, 2021, 29(8): 26-29.
71. 彭曉波, 王春燕, 白麗麗, 等. 48 例急性毒蕈中毒患者臨床分析. 中華危重病急救醫學, 2018, 30(3): 266-269, 274.
72. Magdalan J, Ostrowska A, Piotrowska A, et al. Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin. Exp Toxicol Pathol, 2010, 62(4): 367-373.
73. Poucheret P, Fons F, Doré JC, et al. Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis. Toxicon, 2010, 55(7): 1338-1345.
74. Liu J, Chen Y, Gao Y, et al. N-acetylcysteine as a treatment for amatoxin poisoning: a systematic review. Clin Toxicol (Phila), 2020, 58(11): 1015-1022.
75. 肖桂林. 靈芝煎劑治療急性鵝膏毒蕈中毒的臨床及實驗研究. 長沙: 中南大學, 2007.
76. Garcia J, Costa VM, Bovolini A, et al. An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication. Arch Toxicol, 2019, 93(5): 1449-1463.
77. 楊晶. 多粘菌素 B 對 α-鵝膏毒肽中毒兔肝功能損傷的療效分析. 昆明: 昆明醫科大學, 2019.
78. Garcia J, Carvalho A, das Neves RP, et al. Antidotal effect of cyclosporine A against α-amanitin toxicity in CD-1 mice, at clinical relevant doses. Food Chem Toxicol, 2022, 166: 113198.
79. Rodrigues DF, Pires das Neves R, Carvalho ATP, et al. In vitro mechanistic studies on α-amanitin and its putative antidotes. Arch Toxicol, 2020, 94(6): 2061-2078.

West China Medical Journal

Research progress of amanitin-containing mushroom poisoning

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content