Clinical application status of target temperature management for cardiac arrest patients in domestic and international medical institutions_West China Medical Journal

Authors：

ZHU Wei ¹ , LIU Ruihong ¹ , YANG Xinsheng ² , XIE Lei ³ ,  HE Bosheng ⁴

1. Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Nantong University / Nantong First People’s Hospital, Nantong, Jiangsu 226000, P. R. China;
2. Department of Ophthalmology, Nantong Wen Ci Eye Hospital, Nantong, Jiangsu 226000, P. R. China;
3. Department of Reproductive Medicine, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200120, P. R. China;
4. Center for Translational Medicine Research, the Second Affiliated Hospital of Nantong University / Nantong First People’s Hospital, Nantong, Jiangsu 226000, P. R. China;

Corresponding?author：

HE Bosheng, Email: 15906290998@163.com

Keywords：

Medical institutions; cardiac arrest; target temperature management

DOI：

10.7507/1002-0179.202408024

Video：

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Abstract Full text Figures/Tables Video References Cited by

In recent years, target temperature management (TTM) has been increasingly applied to cardiac arrest patients, and programs and strategies for TTM are in a constant state of update and refinement. This paper analyzes and proposes relevant strategies from the concept of TTM, its clinical application status for cardiac arrest patients in domestic and international medical institutions, its deficiencies in the clinical practice, and factors affecting the development of TTM, with a view to providing a realistic basis for the development of high-quality TTM in medical institutions.

Citation： ZHU Wei, LIU Ruihong, YANG Xinsheng, XIE Lei, HE Bosheng. Clinical application status of target temperature management for cardiac arrest patients in domestic and international medical institutions. West China Medical Journal, 2024, 39(11): 1809-1814. doi: 10.7507/1002-0179.202408024 Copy

1.	Ma Q, Feng L, Wang T, et al. 2020 expert consensus statement on neuro-protection after cardiac arrest in China. Ann Transl Med, 2021, 9(2): 175.
2.	Schenone AL, Cohen A, Patarroyo G, et al. Therapeutic hypothermia after cardiac arrest: a systematic review/meta-analysis exploring the impact of expanded criteria and targeted temperature. Resuscitation, 2016, 108: 102-110.
3.	Callaway CW, Donnino MW, Fink EL, et al. Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 2015, 132(18 Suppl 2): S465-S482.
4.	Roedl K, Wolfrum S, Michels G, et al. Temperature control in adults after cardiac arrest: a survey of current clinical practice in Germany. Crit Care, 2023, 27(1): 35.
5.	de Longeaux K, Bailly P. Post-resuscitation care following cardiac arrest in intensive care units: a French national survey. Resuscitation, 2023, 184: 109701.
6.	Fordyce CB, Chen AY, Wang TY, et al. Patterns of use of targeted temperature management for acute myocardial infarction patients following out-of-hospital cardiac arrest: insights from the National Cardiovascular Data Registry. Am Heart J, 2018, 206: 131-133.
7.	梁大煉, 陳嘉萍, 張秀濃. 廣東省臨床護士對心臟驟停復蘇后患者目標體溫管理現狀調查及分析. 中外醫學研究, 2020, 18(34): 88-91.
8.	馬莉, 杜蘭芳, 馬青變, 等. 北京市護理人員對心臟驟停患者目標體溫管理的現狀調查. 中華護理雜志, 2019, 54(9): 1373-1378.
9.	Karnatovskaia LV, Wartenberg KE, Freeman WD. Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications. Neurohospitalist, 2014, 4(3): 153-163.
10.	中國醫師協會急診醫師分會, 中國醫藥教育協會急診醫學專業委員會, 成人急危重癥腦損傷患者目標溫度管理臨床實踐專家共識組. 成人急危重癥腦損傷患者目標溫度管理臨床實踐專家共識. 中華急診醫學雜志, 2019, 28(3): 282-291.
11.	Skulec R, Truhlár A, Knor J, et al. The practice of therapeutic mild hypothermia in cardiac arrest survivors in the Czech republic. Minerva Anestesiol, 2010, 76(8): 617-623.
12.	Rao MP, Dupre ME, Pokorney SD, et al. Therapeutic hypothermia for patients with out-of-hospital cardiac arrest in North Carolina. Prehosp Emerg Care, 2016, 20(5): 630-636.
13.	Nunnally ME, Jaeschke R, Bellingan GJ, et al. Targeted temperature management in critical care: a report and recommendations from five professional societies. Crit Care Med, 2011, 39(5): 1113-1125.
14.	Sheila AA, 高雯. 目標體溫管理在腦保護中的應用研究進展. 中華急危重癥護理雜志, 2020, 1(5): 468-474.
15.	Morrison LJ, Thoma B. Translating targeted temperature management trials into postarrest care. N Engl J Med, 2021, 384(24): 2344-2345.
16.	Gr?sner JT, Herlitz J, Tjelmeland IBM, et al. European Resuscitation Council Guidelines 2021: epidemiology of cardiac arrest in Europe. Resuscitation, 2021, 161: 61-79.
17.	Cariou A, Payen JF, Asehnoune K, et al. Targeted temperature management in the ICU: guidelines from a French expert panel. Ann Intensive Care, 2017, 7(1): 70.
18.	Howes D, Gray SH, Brooks SC, et al. Canadian Guidelines for the use of targeted temperature management (therapeutic hypothermia) after cardiac arrest: a joint statement from The Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG). Resuscitation, 2016, 98: 48-63.
19.	Nolan JP, Sandroni C, Andersen LW, et al. ERC-ESICM guidelines on temperature control after cardiac arrest in adults. Resuscitation, 2022, 172: 229-236.
20.	中國研究型醫院學會神經再生與修復專業委員會心臟重癥腦保護學組, 中國研究型醫院學會神經再生與修復專業委員會神經重癥護理與康復學組. 亞低溫腦保護中國專家共識. 中華危重病急救醫學, 2020, 32(4): 385-391.
21.	Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med, 2013, 369(23): 2197-2206.
22.	Hermel M, Bosson N, Fang A, et al. Implementation of targeted temperature management after out-of-hospital cardiac arrest: observations from the Los Angeles County Regional System. J Am Heart Assoc, 2020, 9(24): e016652.
23.	Jorge-Perez P, Nikolaou N, Donadello K, et al. Management of comatose survivors of out-of-hospital cardiac arrest in Europe: current treatment practice and adherence to guidelines. A joint survey by the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Resuscitation Council (ERC), the European Society for Emergency Medicine (EUSEM), and the European Society of Intensive Care Medicine (ESICM). Eur Heart J Acute Cardiovasc Care, 2023, 12(2): 96-105.
24.	J?rpestam S, Martinell L, Rylander C, et al. Post-cardiac arrest intensive care in Sweden: a survey of current clinical practice. Acta Anaesthesiol Scand, 2023, 67(9): 1249-1255.
25.	Bray JE, Cartledge S, Finn J, et al. The current temperature: a survey of post-resuscitation care across Australian and New Zealand intensive care units. Resusc Plus, 2020, 1-2: 100002.
26.	Madden LK, Hill M, May TL, et al. The implementation of targeted temperature management: an evidence-based guideline from the Neurocritical Care Society. Neurocrit Care, 2017, 27(3): 468-487.
27.	Kim SH, Park KN, Youn CS, et al. Outcome and status of postcardiac arrest care in Korea: results from the Korean Hypothermia Network prospective registry. Clin Exp Emerg Med, 2020, 7(4): 250-258.
28.	Hifumi T, Inoue A, Otani T, et al. Details of targeted temperature management methods for patients who had out-of-hospital cardiac arrest receiving extracorporeal cardiopulmonary resuscitation: a questionnaire survey. Ther Hypothermia Temp Manag, 2022, 12(4): 215-222.
29.	Cutuli SL, Osawa EA, Glassford NJ, et al. Body temperature measurement methods and targets in Australian and New Zealand intensive care units. Crit Care Resusc, 2018, 20(3): 241-244.
30.	Zhou SE, Barden MM, Gilmore EJ, et al. Postcardiac arrest neuroprognostication practices: a survey of Brazilian physicians. Crit Care Explor, 2021, 3(1): e0321.
31.	Bakhsh A, Alotaibi H, Alothman S, et al. Opinions and attitudes toward targeted temperature management in the emergency department and intensive care unit in a developing country: a survey study. World J Emerg Med, 2023, 14(2): 138-142.
32.	鄭康, 杜蘭芳, 李姝, 等. 北京大學第三醫院心臟驟停后目標溫度管理實施規范. 中國急救醫學, 2021, 41(7): 588-592.
33.	杜蘭芳, 鄭康, 馮璐, 等. 中國急診醫生對心臟驟停后腦保護認知及實踐現況調查. 中國急救醫學, 2022, 42(10): 845-849.
34.	Du L, Ge B, Ma Q, et al. Changes in cardiac arrest patients’ temperature management after the publication of 2015 AHA guidelines for resuscitation in China. Sci Rep, 2017, 7(1): 16087.
35.	Krawczyk P, Ko?odziej G, Szpyra B, et al. Implementation of therapeutic hypothermia after cardiac arrest in intensive care units in Poland. Kardiol Pol, 2013, 71(3): 270-274.
36.	Ko?towski L, Malesa K, Tomaniak M, et al. Implementation of mild therapeutic hypothermia for post-resuscitation care of sudden cardiac arrest survivors in cardiology units in Poland. Adv Clin Exp Med, 2017, 26(8): 1207-1212.
37.	Krawczyk P, Tarczyńska A, Dziadek G, et al. Implementation of targeted temperature management after cardiac arrest in Polish intensive care units. What has changed in the last five years?. Kardiol Pol, 2017, 75(7): 689-697.
38.	Wils EJ, van den Berg T, van Bommel J. Current practice of target temperature management post-cardiac arrest in the Netherlands, a post-TTM trial survey. Resuscitation, 2015, 96(Suppl 1): 124-125.
39.	Semeraro F, Greif R, B?ttiger BW, et al. European Resuscitation Council Guidelines 2021: systems saving lives. Resuscitation, 2021, 161: 80-97.
40.	Sinning C, Ahrens I, Cariou A, et al. The cardiac arrest centre for the treatment of sudden cardiac arrest due to presumed cardiac cause - aims, function and structure: position paper of the Association for Acute CardioVascular Care of the European Society of Cardiology (AVCV), European Association of Percutaneous Coronary Interventions (EAPCI), European Heart Rhythm Association (EHRA), European Resuscitation Council (ERC), European Society for Emergency Medicine (EUSEM) and European Society of Intensive Care Medicine (ESICM). Eur Heart J Acute Cardiovasc Care, 2020, 9(4_Suppl): S193-S202.
41.	Yeo JW, Ng ZHC, Goh AXC, et al. Impact of cardiac arrest centers on the survival of patients with nontraumatic out-of-hospital cardiac arrest: a systematic review and meta-analysis. J Am Heart Assoc, 2022, 11(1): e023806.
42.	張茂, 陳玉國. 積極推進復蘇中心建設, 加速急診醫學科發展. 中華急診醫學雜志, 2018, 27(1): 3-6.
43.	浙江省急診醫學質量控制中心, 浙江省院前醫療急救質量控制中心, 浙江省心血管疾病介入診療質控中心, 等. 復蘇中心建設浙江共識. 中華急診醫學雜志, 2023, 32(4): 455-463.
44.	心臟驟停后目標溫度管理共識專家組. 心臟驟停后目標溫度管理專家共識. 中華急診醫學雜志, 2016, 25(8): 1000-1006.
45.	Al-Adsani AM, Moussa MA, Al-Jasem LI, et al. The level and determinants of diabetes knowledge in Kuwaiti adults with type 2 diabetes. Diabetes Metab, 2009, 35(2): 121-128.

1. Ma Q, Feng L, Wang T, et al. 2020 expert consensus statement on neuro-protection after cardiac arrest in China. Ann Transl Med, 2021, 9(2): 175.
2. Schenone AL, Cohen A, Patarroyo G, et al. Therapeutic hypothermia after cardiac arrest: a systematic review/meta-analysis exploring the impact of expanded criteria and targeted temperature. Resuscitation, 2016, 108: 102-110.
3. Callaway CW, Donnino MW, Fink EL, et al. Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 2015, 132(18 Suppl 2): S465-S482.
4. Roedl K, Wolfrum S, Michels G, et al. Temperature control in adults after cardiac arrest: a survey of current clinical practice in Germany. Crit Care, 2023, 27(1): 35.
5. de Longeaux K, Bailly P. Post-resuscitation care following cardiac arrest in intensive care units: a French national survey. Resuscitation, 2023, 184: 109701.
6. Fordyce CB, Chen AY, Wang TY, et al. Patterns of use of targeted temperature management for acute myocardial infarction patients following out-of-hospital cardiac arrest: insights from the National Cardiovascular Data Registry. Am Heart J, 2018, 206: 131-133.
7. 梁大煉, 陳嘉萍, 張秀濃. 廣東省臨床護士對心臟驟停復蘇后患者目標體溫管理現狀調查及分析. 中外醫學研究, 2020, 18(34): 88-91.
8. 馬莉, 杜蘭芳, 馬青變, 等. 北京市護理人員對心臟驟停患者目標體溫管理的現狀調查. 中華護理雜志, 2019, 54(9): 1373-1378.
9. Karnatovskaia LV, Wartenberg KE, Freeman WD. Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications. Neurohospitalist, 2014, 4(3): 153-163.
10. 中國醫師協會急診醫師分會, 中國醫藥教育協會急診醫學專業委員會, 成人急危重癥腦損傷患者目標溫度管理臨床實踐專家共識組. 成人急危重癥腦損傷患者目標溫度管理臨床實踐專家共識. 中華急診醫學雜志, 2019, 28(3): 282-291.
11. Skulec R, Truhlár A, Knor J, et al. The practice of therapeutic mild hypothermia in cardiac arrest survivors in the Czech republic. Minerva Anestesiol, 2010, 76(8): 617-623.
12. Rao MP, Dupre ME, Pokorney SD, et al. Therapeutic hypothermia for patients with out-of-hospital cardiac arrest in North Carolina. Prehosp Emerg Care, 2016, 20(5): 630-636.
13. Nunnally ME, Jaeschke R, Bellingan GJ, et al. Targeted temperature management in critical care: a report and recommendations from five professional societies. Crit Care Med, 2011, 39(5): 1113-1125.
14. Sheila AA, 高雯. 目標體溫管理在腦保護中的應用研究進展. 中華急危重癥護理雜志, 2020, 1(5): 468-474.
15. Morrison LJ, Thoma B. Translating targeted temperature management trials into postarrest care. N Engl J Med, 2021, 384(24): 2344-2345.
16. Gr?sner JT, Herlitz J, Tjelmeland IBM, et al. European Resuscitation Council Guidelines 2021: epidemiology of cardiac arrest in Europe. Resuscitation, 2021, 161: 61-79.
17. Cariou A, Payen JF, Asehnoune K, et al. Targeted temperature management in the ICU: guidelines from a French expert panel. Ann Intensive Care, 2017, 7(1): 70.
18. Howes D, Gray SH, Brooks SC, et al. Canadian Guidelines for the use of targeted temperature management (therapeutic hypothermia) after cardiac arrest: a joint statement from The Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG). Resuscitation, 2016, 98: 48-63.
19. Nolan JP, Sandroni C, Andersen LW, et al. ERC-ESICM guidelines on temperature control after cardiac arrest in adults. Resuscitation, 2022, 172: 229-236.
20. 中國研究型醫院學會神經再生與修復專業委員會心臟重癥腦保護學組, 中國研究型醫院學會神經再生與修復專業委員會神經重癥護理與康復學組. 亞低溫腦保護中國專家共識. 中華危重病急救醫學, 2020, 32(4): 385-391.
21. Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med, 2013, 369(23): 2197-2206.
22. Hermel M, Bosson N, Fang A, et al. Implementation of targeted temperature management after out-of-hospital cardiac arrest: observations from the Los Angeles County Regional System. J Am Heart Assoc, 2020, 9(24): e016652.
23. Jorge-Perez P, Nikolaou N, Donadello K, et al. Management of comatose survivors of out-of-hospital cardiac arrest in Europe: current treatment practice and adherence to guidelines. A joint survey by the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Resuscitation Council (ERC), the European Society for Emergency Medicine (EUSEM), and the European Society of Intensive Care Medicine (ESICM). Eur Heart J Acute Cardiovasc Care, 2023, 12(2): 96-105.
24. J?rpestam S, Martinell L, Rylander C, et al. Post-cardiac arrest intensive care in Sweden: a survey of current clinical practice. Acta Anaesthesiol Scand, 2023, 67(9): 1249-1255.
25. Bray JE, Cartledge S, Finn J, et al. The current temperature: a survey of post-resuscitation care across Australian and New Zealand intensive care units. Resusc Plus, 2020, 1-2: 100002.
26. Madden LK, Hill M, May TL, et al. The implementation of targeted temperature management: an evidence-based guideline from the Neurocritical Care Society. Neurocrit Care, 2017, 27(3): 468-487.
27. Kim SH, Park KN, Youn CS, et al. Outcome and status of postcardiac arrest care in Korea: results from the Korean Hypothermia Network prospective registry. Clin Exp Emerg Med, 2020, 7(4): 250-258.
28. Hifumi T, Inoue A, Otani T, et al. Details of targeted temperature management methods for patients who had out-of-hospital cardiac arrest receiving extracorporeal cardiopulmonary resuscitation: a questionnaire survey. Ther Hypothermia Temp Manag, 2022, 12(4): 215-222.
29. Cutuli SL, Osawa EA, Glassford NJ, et al. Body temperature measurement methods and targets in Australian and New Zealand intensive care units. Crit Care Resusc, 2018, 20(3): 241-244.
30. Zhou SE, Barden MM, Gilmore EJ, et al. Postcardiac arrest neuroprognostication practices: a survey of Brazilian physicians. Crit Care Explor, 2021, 3(1): e0321.
31. Bakhsh A, Alotaibi H, Alothman S, et al. Opinions and attitudes toward targeted temperature management in the emergency department and intensive care unit in a developing country: a survey study. World J Emerg Med, 2023, 14(2): 138-142.
32. 鄭康, 杜蘭芳, 李姝, 等. 北京大學第三醫院心臟驟停后目標溫度管理實施規范. 中國急救醫學, 2021, 41(7): 588-592.
33. 杜蘭芳, 鄭康, 馮璐, 等. 中國急診醫生對心臟驟停后腦保護認知及實踐現況調查. 中國急救醫學, 2022, 42(10): 845-849.
34. Du L, Ge B, Ma Q, et al. Changes in cardiac arrest patients’ temperature management after the publication of 2015 AHA guidelines for resuscitation in China. Sci Rep, 2017, 7(1): 16087.
35. Krawczyk P, Ko?odziej G, Szpyra B, et al. Implementation of therapeutic hypothermia after cardiac arrest in intensive care units in Poland. Kardiol Pol, 2013, 71(3): 270-274.
36. Ko?towski L, Malesa K, Tomaniak M, et al. Implementation of mild therapeutic hypothermia for post-resuscitation care of sudden cardiac arrest survivors in cardiology units in Poland. Adv Clin Exp Med, 2017, 26(8): 1207-1212.
37. Krawczyk P, Tarczyńska A, Dziadek G, et al. Implementation of targeted temperature management after cardiac arrest in Polish intensive care units. What has changed in the last five years?. Kardiol Pol, 2017, 75(7): 689-697.
38. Wils EJ, van den Berg T, van Bommel J. Current practice of target temperature management post-cardiac arrest in the Netherlands, a post-TTM trial survey. Resuscitation, 2015, 96(Suppl 1): 124-125.
39. Semeraro F, Greif R, B?ttiger BW, et al. European Resuscitation Council Guidelines 2021: systems saving lives. Resuscitation, 2021, 161: 80-97.
40. Sinning C, Ahrens I, Cariou A, et al. The cardiac arrest centre for the treatment of sudden cardiac arrest due to presumed cardiac cause - aims, function and structure: position paper of the Association for Acute CardioVascular Care of the European Society of Cardiology (AVCV), European Association of Percutaneous Coronary Interventions (EAPCI), European Heart Rhythm Association (EHRA), European Resuscitation Council (ERC), European Society for Emergency Medicine (EUSEM) and European Society of Intensive Care Medicine (ESICM). Eur Heart J Acute Cardiovasc Care, 2020, 9(4_Suppl): S193-S202.
41. Yeo JW, Ng ZHC, Goh AXC, et al. Impact of cardiac arrest centers on the survival of patients with nontraumatic out-of-hospital cardiac arrest: a systematic review and meta-analysis. J Am Heart Assoc, 2022, 11(1): e023806.
42. 張茂, 陳玉國. 積極推進復蘇中心建設, 加速急診醫學科發展. 中華急診醫學雜志, 2018, 27(1): 3-6.
43. 浙江省急診醫學質量控制中心, 浙江省院前醫療急救質量控制中心, 浙江省心血管疾病介入診療質控中心, 等. 復蘇中心建設浙江共識. 中華急診醫學雜志, 2023, 32(4): 455-463.
44. 心臟驟停后目標溫度管理共識專家組. 心臟驟停后目標溫度管理專家共識. 中華急診醫學雜志, 2016, 25(8): 1000-1006.
45. Al-Adsani AM, Moussa MA, Al-Jasem LI, et al. The level and determinants of diabetes knowledge in Kuwaiti adults with type 2 diabetes. Diabetes Metab, 2009, 35(2): 121-128.

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