Research progress on the regulation of tumor proliferation and metastasis by tumor-derived exosomes in hypoxic microenvironments_West China Medical Journal

Authors：

PANG Dacheng ¹ , ZHANG Shuo ² ,  TIAN Tian ¹

1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, P. R. China;
2. Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, P. R. China;

Corresponding?author：

TIAN Tian, Email: tt8324@163.com

Keywords：

Tumor microenvironment; exosomes; metastasis; metabolic reprogramming; epithelial-mesenchymal transition

DOI：

10.7507/1002-0179.202505010

Video：

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Abstract Full text Figures/Tables Video References Cited by

Inhibiting metastasis is the key to the treatment of malignant tumors. During the development of tumors, the microenvironment plays a significant role, and hypoxia is one of its important characteristics. Exosomes, as an important component of the microenvironment, connect tumor cells with the hypoxic microenvironment and mediate information exchange between cells. Tumor cells secrete more exosomes than normal cells, and hypoxia further stimulates their release. Hypoxia-induced tumor-derived exosomes carry stable genetic material and play key regulatory roles in promoting tumor proliferation, establishing a pre-metastasis microenvironment, and accelerating angiogenesis. This article comprehensively reviews the mechanisms by which tumor-derived exosomes regulate tumor proliferation and metastasis in a hypoxic microenvironment, which has potential clinical significance.

Citation： PANG Dacheng, ZHANG Shuo, TIAN Tian. Research progress on the regulation of tumor proliferation and metastasis by tumor-derived exosomes in hypoxic microenvironments. West China Medical Journal, 2025, 40(12): 2032-2038. doi: 10.7507/1002-0179.202505010 Copy

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