Correlation analysis between blood lipid levels and clinical characteristics in IgG4-related disease_West China Medical Journal

Authors：

Lü Hanqiu ^1,2 , JI Xing ¹ ,  TAN Chunyu ¹ ,  LUO Yubin ¹

1. Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. West China Lecheng Hospital of Sichuan University, Boao, Hainan 571437, P. R. China;

Corresponding?author：

TAN Chunyu, Email: annaquintessence@163.com; LUO Yubin, Email: luoyubin2016@163.com

Keywords：

Triglycerides; cholesterol; immunoglobulin G4-related disease; clinical characteristics

DOI：

10.7507/1002-0179.202512105

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the characteristics of dyslipidemia in patients with immunoglobulin G4-related disease (IgG4-RD) and its correlation with clinical indicators and organ involvement. Methods Patients diagnosed with IgG4-RD at West China Hospital of Sichuan University between September 2020 and October 2024 were retrospectively selected. Based on lipid levels, patients were divided into a high-TG group and a normal-TG group, as well as a high-TC group and a normal-TC group. The demographic characteristics, serological indicators (lipids, IgG4, IgE), and organ involvement of the two groups were analyzed, and the correlation between the indicators was evaluated. Results A total of 125 IgG4 RD patients were included. Among them, there were 89 males (71.2%) and 36 females (28.8%); 21 cases of high TG and 29 cases of high TC. The high-density lipoprotein cholesterol level was lower in the high TG group [(1.16±0.33) vs. (1.41±0.50) mmol/L, P=0.032], and the proportion of retroperitoneal fibrosis involvement was higher (23.8% vs. 9.6%). The low-density lipoprotein cholesterol level in the high TC group was higher than that in the normal TC group [(3.09±0.95) vs. (2.39±0.93) mmol/L, P<0.001]. Correlation analysis showed that TG was positively correlated with TC (r=0.37, P<0.05), IgG4 levels were positively correlated with the number of affected organs (r=0.24, P<0.05), while lipid parameters were not correlated with IgG4, IgE, and the number of affected organs. Conclusions Dyslipidemia is common in IgG4-RD patients. High TG is associated with low high-density lipoprotein and a tendency for retroperitoneal fibrosis involvement, while high TC is associated with elevated low-density lipoprotein. Serum IgG4 levels can reflect the extent of organ involvement, but lipid indicators show no significant correlation with disease-specific immune markers. It is recommended to emphasize lipid monitoring in clinical management, particularly for patients with retroperitoneal fibrosis or those on long-term glucocorti coid therapy.

Citation： Lü Hanqiu, JI Xing, TAN Chunyu, LUO Yubin. Correlation analysis between blood lipid levels and clinical characteristics in IgG4-related disease. West China Medical Journal, 2026, 41(1): 38-41. doi: 10.7507/1002-0179.202512105 Copy

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2.	Liao KP, Liu J, Lu B, et al. Association between lipid levels and major adverse cardiovascular events in rheumatoid arthritis compared to non-rheumatoid arthritis patients. Arthritis Rheumatol, 2015, 67(8): 2004-2010.
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5.	Wallace ZS, Miles G, Smolkina E, et al. Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured adults. Ann Rheum Dis, 2023, 82(7): 957-962.
6.	Masamune A, Kikuta K, Hamada S, et al. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016. J Gastroenterol, 2020, 55(4): 462-470.
7.	Gong Y, Zhang P, Liu Z, et al. UPLC-MS based plasma metabolomics and lipidomics reveal alterations associated with IgG4-related disease. Rheumatology (Oxford), 2021, 60(7): 3252-3261.
8.	Yan S, Peng Y, Wu Z, et al. Distinct metabolic biomarkers to distinguish IgG4-related disease from Sjogren’s syndrome and pancreatic cancer and predict disease prognosis. BMC Med, 2022, 20(1): 497.
9.	Radford-Smith DE, Selvaraj EA, Peters R, et al. A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis. Liver Int, 2022, 42(6): 1344-1354.
10.	Shimizu H, Usui Y, Wakita R, et al. Differential tissue metabolic signatures in IgG4-related ophthalmic disease and orbital mucosa-associated lymphoid tissue lymphoma. Invest Ophthalmol Vis Sci, 2021, 62(1): 15.
11.	Liu Q, Li B, Li Y, et al. Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis. Gut, 2021, 71(5): 899-909.
12.	Katz G, Hernandez-Barco Y, Palumbo D, et al. Proliferative features of IgG4-related disease. Lancet Rheumatol, 2024, 6(7): e481-e492.
13.	Lanzillotta M, Culver E, Sharma A, et al. Fibrotic phenotype of IgG4-related disease. Lancet Rheumatol, 2024, 6(7): e469-e480.
14.	Della-Torre E, Rigamonti E, Perugino C, et al. B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease. J Allergy Clin Immunol, 2019. 145(3): 968-981. e14.
15.	Zongfei J, Rongyi C, Xiaomeng C et al. In vitro IL-6/IL-6R trans-signaling in fibroblasts releases cytokines that may be linked to the pathogenesis of IgG4-related disease. Front Immunol, 2020, 11: 1272.

1. Peyronel F, Della-Torre E, Maritati F, et al. IgG4-related disease and other fibro-inflammatory conditions. Nat Rev Rheumatol, 2025, 21(5): 275-290.
2. Liao KP, Liu J, Lu B, et al. Association between lipid levels and major adverse cardiovascular events in rheumatoid arthritis compared to non-rheumatoid arthritis patients. Arthritis Rheumatol, 2015, 67(8): 2004-2010.
3. Xuan J, Deng C, Lu H, et al. Serum lipid profile in systemic lupus erythematosus. Front Immunol, 2025, 15: 1503434.
4. 中國血脂管理指南修訂聯合專家委員會. 中國血脂管理指南(基層版 2024 年). 臨床心血管病雜志, 2024, 40(4): 249-256.
5. Wallace ZS, Miles G, Smolkina E, et al. Incidence, prevalence and mortality of IgG4-related disease in the USA: a claims-based analysis of commercially insured adults. Ann Rheum Dis, 2023, 82(7): 957-962.
6. Masamune A, Kikuta K, Hamada S, et al. Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016. J Gastroenterol, 2020, 55(4): 462-470.
7. Gong Y, Zhang P, Liu Z, et al. UPLC-MS based plasma metabolomics and lipidomics reveal alterations associated with IgG4-related disease. Rheumatology (Oxford), 2021, 60(7): 3252-3261.
8. Yan S, Peng Y, Wu Z, et al. Distinct metabolic biomarkers to distinguish IgG4-related disease from Sjogren’s syndrome and pancreatic cancer and predict disease prognosis. BMC Med, 2022, 20(1): 497.
9. Radford-Smith DE, Selvaraj EA, Peters R, et al. A novel serum metabolomic panel distinguishes IgG4-related sclerosing cholangitis from primary sclerosing cholangitis. Liver Int, 2022, 42(6): 1344-1354.
10. Shimizu H, Usui Y, Wakita R, et al. Differential tissue metabolic signatures in IgG4-related ophthalmic disease and orbital mucosa-associated lymphoid tissue lymphoma. Invest Ophthalmol Vis Sci, 2021, 62(1): 15.
11. Liu Q, Li B, Li Y, et al. Altered faecal microbiome and metabolome in IgG4-related sclerosing cholangitis and primary sclerosing cholangitis. Gut, 2021, 71(5): 899-909.
12. Katz G, Hernandez-Barco Y, Palumbo D, et al. Proliferative features of IgG4-related disease. Lancet Rheumatol, 2024, 6(7): e481-e492.
13. Lanzillotta M, Culver E, Sharma A, et al. Fibrotic phenotype of IgG4-related disease. Lancet Rheumatol, 2024, 6(7): e469-e480.
14. Della-Torre E, Rigamonti E, Perugino C, et al. B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease. J Allergy Clin Immunol, 2019. 145(3): 968-981. e14.
15. Zongfei J, Rongyi C, Xiaomeng C et al. In vitro IL-6/IL-6R trans-signaling in fibroblasts releases cytokines that may be linked to the pathogenesis of IgG4-related disease. Front Immunol, 2020, 11: 1272.

West China Medical Journal

Correlation analysis between blood lipid levels and clinical characteristics in IgG4-related disease

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