Clinical characteristics of dengue fever cases in a large general hospital located in a dengue fever category <b>Ⅱ</b> area_West China Medical Journal

Authors：

ZENG Qinghui ^1,2 , HUANG Wenzhi ² , PAN Xianmou ³ , WANG Yantong ² , LEI Na ² , ZONG Zhiyong ¹ , CHEN Yi ² ,  QIAO Fu ²

1. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Infection Control, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Department of Infection Control, West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan 610213, P. R. China;

Corresponding?author：

QIAO Fu, Email: qiaofu2005@scu.edu.cn

Keywords：

Dengue fever; imported case; clinical characteristics; prevention and control

DOI：

10.7507/1002-0179.202601206

Video：

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Objective To understand the clinical characteristics of dengue fever cases in a large general hospital located in a dengue fever category Ⅱ area, and to provide scientific evidence for formulating dengue fever prevention and control strategies for similar medical institutions. Methods The dengue fever case data reported by West China Hospital of Sichuan University between January 1, 2015, and December 31, 2024 were retrospectively collected, and their clinical characteristics were analyzed. Results A total of 56 dengue fever cases were reported, with the majority being confirmed cases (76.79%) and no deaths. Among the confirmed cases, there was one severe case. The primary department for initial diagnosis was emergency department, followed by fever clinic. Most cases were mild, and patients were treated with oral symptomatic medications and observed at home. The seasonal distribution of dengue fever cases was evident. The male-to-female ratio was 0.93∶1, with an average age of 34.07 years. The majority of cases were in the commercial service sector. There were no local cases, 55 were imported cases, and 1 case, which was the only severe dengue fever case, may have been transmitted through non-mosquito vectors. Conclusion In dengue fever category Ⅱ areas, large general hospitals should prioritize the early identification of imported dengue fever cases and implement standardized treatment for these cases, to prevent the risk of local transmission caused by the importation of dengue fever outbreaks.

Citation： ZENG Qinghui, HUANG Wenzhi, PAN Xianmou, WANG Yantong, LEI Na, ZONG Zhiyong, CHEN Yi, QIAO Fu. Clinical characteristics of dengue fever cases in a large general hospital located in a dengue fever category Ⅱ area. West China Medical Journal, 2026, 41(3): 402-406. doi: 10.7507/1002-0179.202601206 Copy

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2.	Sarker A, Dhama N, Gupta RD. Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement. Front Immunol, 2023, 14: 1200195.
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14.	林健燕, 郭澤強, 邱昌文. 非蚊媒途徑傳播登革病毒的研究進展. 中國熱帶醫學, 2018, 18(4): 406-409.
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17.	穆雪純, 王凌航. 登革熱的威脅和防治進展. 中國病毒病雜志, 2024, 14(3): 211-217.
18.	Li N, Feng Y, Vrancken B, et al. Assessing the impact of COVID-19 border restrictions on dengue transmission in Yunnan province, China: an observational epidemiological and phylogenetic analysis. Lancet Reg Health West Pac, 2021, 14: 100259.
19.	Sheng ZY, Li M, Yang R, et al. COVID-19 prevention measures reduce dengue spread in Yunnan province, China, but do not reduce established outbreak. Emerg Microbes Infect, 2022, 11(1): 240-249.
20.	岳玉娟, 劉小波, 郭玉紅, 等. 2020-2022 年中國登革熱時空分布及相關環境因素分析. 環境衛生學雜志, 2023, 13(5): 341-345.
21.	陳曉光. 他山之石, 可以攻玉——登革熱防控研究新進展. 中國熱帶醫學, 2024, 24(10): 1161-1162.
22.	中華醫學會熱帶病與寄生蟲學分會, 中華預防醫學會媒介生物學及控制分會, 中國疫苗行業協會基礎研究專業委員會, 等. 登革熱疾病負擔及預防控制策略中國專家共識. 中國人獸共患病學報, 2024, 40(6): 489-497.
23.	李煜姍, 汪如良, 劉曉青, 等. 氣溫對亞熱帶季風氣候內陸城市登革熱傳播的影響. 中國熱帶醫學, 2021, 21(10): 932-938.
24.	劉燿, 周萍, 肖權泉, 等. 2017-2023 年四川省宜賓市登革熱媒介伊蚊監測結果分析. 中國媒介生物學及控制雜志, 2025, 36(2): 165-170.
25.	Liu WH, Shi C, Lu Y, et al. Epidemiological characteristics of imported acute infectious diseases in Guangzhou, China, 2005-2019. PLoS Negl Trop Dis, 2022, 16(12): e0010940.
26.	Tan FL, Loh DL, Prabhakaran K, et al. Dengue haemorrhagic fever after living donor renal transplantation. Nephrol Dial Transplant, 2005, 20(2): 447-448.
27.	Paz-Bailey G, Adams LE, Deen J, et al. Dengue. Lancet, 2024, 403(10427): 667-682.
28.	韓輝, 伍波, 周奇, 等. 2025 年 11 月全球傳染病疫情研判分析. 疾病監測, 2025, 40(12): 1502-1504.
29.	楊昕娉, 龐明樊, 房元圣, 等. 2025 年 11 月全球傳染病事件風險評估. 疾病監測, 2025, 40(12): 1509-1513.

1. Messina JP, Brady OJ, Golding N, et al. The current and future global distribution and population at risk of dengue. Nat Microbiol, 2019, 4(9): 1508-1515.
2. Sarker A, Dhama N, Gupta RD. Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement. Front Immunol, 2023, 14: 1200195.
3. Procopio AC, Colletta S, Laratta E, et al. Integrated one health strategies in dengue. One Health, 2024, 18: 100684.
4. Parveen S, Riaz Z, Saeed S, et al. Dengue hemorrhagic fever: a growing global menace. J Water Health, 2023, 21(11): 1632-1650.
5. Bhatt S, Gething PW, Brady OJ, et al. The global distribution and burden of dengue. Nature, 2013, 496(7446): 504-507.
6. 韓輝, 伍波, 周奇. 2025 年 2 月全球傳染病疫情研判分析. 疾病監測, 2025, 40(3): 284-286.
7. 劉起勇. 我國登革熱流行新趨勢、防控挑戰及策略分析. 中國媒介生物學及控制雜志, 2020, 31(1): 1-6.
8. 趙錦, 周銀柱, 陳水連, 等. 中國登革熱發病趨勢與時空分布特征. 中國熱帶醫學, 2024, 24(8): 920-924.
9. 劉燕, 呂強, 杜飛, 等. 2023 年四川省法定傳染病疫情分析. 預防醫學情報雜志, 2024, 40(8): 988-996.
10. 曹一鷗, 呂強, 張佳珂, 等. 2019 年四川省首例登革熱本地病例調查與疫區處置情況分析. 預防醫學情報雜志, 2020, 36(11): 1499-1503.
11. 曹一鷗, 袁珩, 周興余, 等. 四川省 2019-2024 年登革熱流行病學特征. 中國熱帶醫學, 2025, 25(9): 1108-1112.
12. 衛生部. 登革熱診斷標準(WS 216-2008). 北京: 中國出版社, 2008.
13. 國家衛生和計劃生育委員會. 登革熱診斷(WS 216-2018). 北京: 中國標準出版社, 2018.
14. 林健燕, 郭澤強, 邱昌文. 非蚊媒途徑傳播登革病毒的研究進展. 中國熱帶醫學, 2018, 18(4): 406-409.
15. 郭祖超. 醫用數理統計方法. 3 版. 北京: 人民衛生出版社, 1988.
16. Wu T, Wu Z, Li YP. Dengue fever and dengue virus in the People’s Republic of China. Rev Med Virol, 2022, 32(1): e2245.
17. 穆雪純, 王凌航. 登革熱的威脅和防治進展. 中國病毒病雜志, 2024, 14(3): 211-217.
18. Li N, Feng Y, Vrancken B, et al. Assessing the impact of COVID-19 border restrictions on dengue transmission in Yunnan province, China: an observational epidemiological and phylogenetic analysis. Lancet Reg Health West Pac, 2021, 14: 100259.
19. Sheng ZY, Li M, Yang R, et al. COVID-19 prevention measures reduce dengue spread in Yunnan province, China, but do not reduce established outbreak. Emerg Microbes Infect, 2022, 11(1): 240-249.
20. 岳玉娟, 劉小波, 郭玉紅, 等. 2020-2022 年中國登革熱時空分布及相關環境因素分析. 環境衛生學雜志, 2023, 13(5): 341-345.
21. 陳曉光. 他山之石, 可以攻玉——登革熱防控研究新進展. 中國熱帶醫學, 2024, 24(10): 1161-1162.
22. 中華醫學會熱帶病與寄生蟲學分會, 中華預防醫學會媒介生物學及控制分會, 中國疫苗行業協會基礎研究專業委員會, 等. 登革熱疾病負擔及預防控制策略中國專家共識. 中國人獸共患病學報, 2024, 40(6): 489-497.
23. 李煜姍, 汪如良, 劉曉青, 等. 氣溫對亞熱帶季風氣候內陸城市登革熱傳播的影響. 中國熱帶醫學, 2021, 21(10): 932-938.
24. 劉燿, 周萍, 肖權泉, 等. 2017-2023 年四川省宜賓市登革熱媒介伊蚊監測結果分析. 中國媒介生物學及控制雜志, 2025, 36(2): 165-170.
25. Liu WH, Shi C, Lu Y, et al. Epidemiological characteristics of imported acute infectious diseases in Guangzhou, China, 2005-2019. PLoS Negl Trop Dis, 2022, 16(12): e0010940.
26. Tan FL, Loh DL, Prabhakaran K, et al. Dengue haemorrhagic fever after living donor renal transplantation. Nephrol Dial Transplant, 2005, 20(2): 447-448.
27. Paz-Bailey G, Adams LE, Deen J, et al. Dengue. Lancet, 2024, 403(10427): 667-682.
28. 韓輝, 伍波, 周奇, 等. 2025 年 11 月全球傳染病疫情研判分析. 疾病監測, 2025, 40(12): 1502-1504.
29. 楊昕娉, 龐明樊, 房元圣, 等. 2025 年 11 月全球傳染病事件風險評估. 疾病監測, 2025, 40(12): 1509-1513.

West China Medical Journal

Clinical characteristics of dengue fever cases in a large general hospital located in a dengue fever category Ⅱ area

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