Advances in intervention strategies for enhancing intrinsic capacity in geriatric orthopedic patients_West China Medical Journal

Authors：

CHEN Xia ¹ , LI Peifang ¹ , YANG Xun ² , WU Aijia ² , CHEN Jiali ¹ ,  NING Ning ¹

1. Department of Orthopedic Surgery, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Sichuan Provincial Public Health Comprehensive Clinical Center, Chengdu, Sichuan 610000, P. R. China;

Corresponding?author：

NING Ning, Email: gkningning@126.com

Keywords：

Orthopedics; geriatric; intrinsic capacity; comprehensive assessment; intervention strategies

DOI：

10.7507/1002-0179.202605168

Video：

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Abstract Full text Figures/Tables Video References Cited by

The growing population aging has contributed to a high incidence of orthopedic conditions including geriatric fractures, osteoarthritis and spinal degenerative disorders, which seriously impair older adults’ quality of life and clinical prognosis. The concept of intrinsic capacity proposed by the World Health Organization offers a new research direction for the rehabilitation of geriatric orthopedic patients and healthy aging. To clarify the application value of intrinsic capacity in the rehabilitation of geriatric orthopedic patients and optimize clinical intervention schemes, this paper systematically reviews relevant studies published in recent years, summarizes the current status and limitations of research on intrinsic capacity among geriatric orthopedic patients, and prospects the development of precise and intelligent interventions, to provide theoretical references for clinicians to formulate individualized and standardized strategies to improve intrinsic capacity in geriatric orthopedic patients, so as to advance the achievement of healthy aging goals.

Citation： CHEN Xia, LI Peifang, YANG Xun, WU Aijia, CHEN Jiali, NING Ning. Advances in intervention strategies for enhancing intrinsic capacity in geriatric orthopedic patients. West China Medical Journal, 2026, 41(9): 1408-1413. doi: 10.7507/1002-0179.202605168 Copy

1.	Jiang, F, Lu, C, Zeng, Z, et al. Global burden of disease for musculoskeletal disorders in all age groups, from 2024 to 2050, and a bibliometric-based survey of the status of research in geriatrics, geriatric orthopedics, and geriatric orthopedic diseases[J]. J Orthop Surg Res, 2025, 20(1): 179.
2.	de Oliveira, FN, Dami?o, EP, Dos Santos, L, et al. Prevalence and factors associated with low functional mobility in older adults[J]. Aging Med (Milton), 2024, 7(3): 292-300.
3.	中華醫學會老年醫學分會, 國家老年疾病臨床醫學研究中心(宣武醫院), 馬麗娜. 老年人內在能力篩查與綜合評估中國專家共識[J]. 中國全科醫學, 2026, 29(10): 1225-1238, 1245.
4.	林靜雯, 劉永兵. 老年人內在能力研究進展[J]. 右江醫學, 2025, 53(4): 296-304.
5.	Bevilacqua R, Soraci L, Stara V, et al. A systematic review of multidomain and lifestyle interventions to support the intrinsic capacity of the older population[J]. Front Med (Lausanne), 2022, 9: 929261.
6.	Logvinov I, Neff DF. Assessing intrinsic capacity in older adults: a concept analysis[J]. Geriatr Nurs, 2026, 68: 103826.
7.	Locquet M, Sanchez-Rodriguez D, Bruyère O, et al. Intrinsic capacity defined using four domains and mortality risk: a 5-year follow-up of the SarcoPhAge cohort[J]. J Nutr Health Aging, 2022, 26(1): 23-29.
8.	Ma CHK, Chua DQL, Tay L, et al. The feasibility of implementing the WHO Integrated Care For Older People (ICOPE) framework in singapore[J]. J Frailty Aging, 2024, 13(4): 514-521 .
9.	Giudici KV, de Souto Barreto P, Guyonnet S, et al. Predictive capacity of the integrated care for older people screening tool for intrinsic capacity impairments: results from the INSPIRE-T cohort[J]. J Gerontol A Biol Sci Med Sci, 2024, 79(7): glae112.
10.	李夏夏, Jagadish K Chhetri, 陳雨濛, 等. 世界衛生組織老年整合照護篩查工具的漢化及信效度檢驗[J]. 中國臨床保健雜志, 2024, 27(5): 621-625.
11.	Gutiérrez-Robledo LM, García-Chanes RE, Pérez-Zepeda MU. Allostatic load as a biological substrate to intrinsic capacity: a secondary analysis of CRELES[J]. J Nutr Health Aging, 2019, 23(9): 788-795.
12.	Charles A, Buckinx F, Locquet M, et al. Prediction of adverse outcomes in nursing home residents according to intrinsic capacity proposed by the World Health Organization[J]. J Gerontol A Biol Sci Med Sci, 2020, 75(8): 1594-1599.
13.	Musalek C, Kirchengast S. Grip strength as an indicator of health-related quality of life in old age-a pilot study[J]. Int J Environ Res Public Health, 2017, 14(12): 1447.
14.	丁瑞叢, 王峰, 徐曉玉, 等. 滌痰湯加味方對血管性癡呆認知功能、相關炎性指標的改善及影響[J]. 中華中醫藥學刊, 2024, 42(7): 96-100.
15.	中華護理學辭典. 老年抑郁量表(GDS)[J]. 中國護理管理, 2017, 17(7): 885.
16.	Tavassoli N, Piau A, Berbon C, et al. Framework implementation of the INSPIRE ICOPE-CARE program in collaboration with the World Health Organization (WHO) in the Occitania Region[J]. J Frailty Aging, 2021, 10(2): 103-109.
17.	Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinician[J]. J Psychiatr Res, 1975, 12(3): 189-198.
18.	中華醫學會神經病學分會癡呆與認知障礙學組. 輕度認知損害的神經心理評估專家共識(2025 版)[J]. 中華醫學雜志, 2025, 105(3): 204-218.
19.	劉一儒, 姜朝陽, 魏坤, 等. 老年髖部骨折護理風險評估工具的研究進展[J]. 數理醫藥學雜志, 2026, 39(8): 605-613.
20.	胡怡陽, 于陽, 李偉, 等. 老年人內在能力研究進展[J]. 循證護理, 2026, 12(1): 132-136.
21.	Beard JR, Jotheeswaran AT, Cesari M, et al. The structure and predictive value of intrinsic capacity in a longitudinal study of ageing[J]. BMJ Open, 2019, 9(11): e026119.
22.	蒲虹杉, 董碧蓉. 老年肌少癥與衰弱和營養[J]. 中國臨床保健雜志, 2021, 24(5): 577-581.
23.	中華護理學會老年護理專業委員會, 北京醫院國家老年醫學中心中國醫學科學院老年醫學研究院, 北京大學護理學院, 等. 老年人內在能力評估與維護指南[J]. 中華護理雜志, 2025, 60(3): 261-265.
24.	曹瑛, 魏建芬, 張瑋, 等. 在老年骨科患者圍術期中應用快速康復理念下的營養支持護理的效果[J]. 中國社區醫師, 2024, 40(32): 119-121.
25.	Gajdosova L, Jakus V, Muchova J. Understanding cognitive frailty in aging adults: prevalence, risk factors, pathogenesis and non-pharmacological interventions[J]. Bratisl Lek Listy, 2023, 124(9): 647-652.
26.	石婧, 沈干, 于普林. 老年人認知和社會心理衰弱[J]. 中國臨床保健雜志, 2022, 25(6): 762-766.
27.	He P, Zhang Y, Liu A, et al. Integrated care improved cognitive ability in older Chinese patients with impaired intrinsic capacity[J]. Innov Aging, 2025, 9(Suppl 2): 2868.
28.	Cadore EL, Sáez de Asteasu ML, Izquierdo M. Multicomponent exercise and the hallmarks of frailty: considerations on cognitive impairment and acute hospitalization[J]. Exp Gerontol, 2019, 122: 10-14.
29.	Felipe SG, Printes CB, Sato DK, et al. Impact of a multicomponent physical exercise program on intrinsic capacity in community-dwelling older adults[J]. PeerJ, 2025, 13: e19017.
30.	Yi M, Zhang W, Zhang X, et al. The effectiveness of Otago exercise program in older adults with frailty or pre-frailty: a systematic review and meta-analysis[J]. Arch Gerontol Geriatr, 2023, 114: 105083.
31.	朱愿超, 金鵬飛, 國家老年醫學中心, 等. 老年人多重用藥門診標準操作規范專家共識(2024 版)[J]. 中華老年醫學雜志, 2024, 43(11): 1382-1391.
32.	黃如飛, 李鳳, 梁丁華. 三聯預康復護理在骨科大手術患者中的應用實踐[J]. 衛生職業教育, 2024, 42(15): 154-157.
33.	中華醫學會腸外腸內營養學分會. 中國成人患者腸外腸內營養臨床應用指南(2023 版)[J]. 中華醫學雜志, 2023, 103(13): 946-974.
34.	吳蓓雯, 葉向紅, 李素云, 等. 提高口服營養補充依從性臨床管理實踐的專家共識[J]. 腫瘤代謝與營養電子雜志, 2021, 8(5): 487-494.
35.	國家衛生健康委加速康復外科專家委員會骨科專家組, 中國研究型醫院學會骨科加速康復專業委員會, 中國康復技術轉化及促進會骨科加速康復專業委員會. 骨科大手術加速康復圍手術期營養管理專家共識[J]. 中華骨與關節外科雜志, 2022, 15(10): 763-767.
36.	莊平. 認知訓練聯合生活方式干預對老年輕度認知功能障礙患者認知功能及生活質量的影響分析[J]. 中國實用醫藥, 2026, 21(10): 160-162.
37.	李琰, 許翠萍, 王曉婷, 等. 虛擬現實技術在提高老年人內在能力中的應用進展[J]. 全科護理, 2026, 24(7): 1279-1283.
38.	黃尚崗. 認知行為療法干預治療老年抑郁癥的研究進展[J]. 中國衛生標準管理, 2023, 14(1): 195-198.
39.	陶曉梅, 宋燁, 鐘小會, 等. 基于多學科協作診療的老年骨科大手術患者衰弱干預方案的構建與應用[J]. 哈爾濱醫科大學學報, 2025, 59(6): 662-669.
40.	張鵬. 基于微信的延續性護理干預對老年全髖關節置換患者術后生活質量和功能恢復的影響[J]. 河南醫學研究, 2020, 29(19): 3631-3632.
41.	徐方宸凱, 陸愛未, 周如, 等. 基于智能可穿戴設備的家庭-社區健康協同響應機制研究[J]. 公關世界, 2026(8): 28-30.
42.	Kim JH, Lee SB. Evaluation of activities of daily living: current insights and future horizons[J]. Ann Geriatr Med Res, 2025, 29(2): 143-158.
43.	劉智嵐, 賈杰. 基于計算機認知訓練技術在改善老年認知功能中的應用與展望[J]. 中國卒中雜志, 2021, 16(3): 246-250.
44.	崔菲菲, 王木桃. 基于“智慧養老”下的社區老年人出院后延續性護理效果[J]. 醫學食療與健康, 2022, 20(9): 94-96, 113.
45.	Fairhall N. Physical, nutritional, cognitive and combination interventions reduce frailty in community-dwelling prefrail and frail older people[J]. Evid Based Med, 2016, 21(4): 142.
46.	Pua YH, Tay L, Clark RA, et al. Development, validity, and utility of a model-based intrinsic capacity composite score in community-dwelling older persons[J]. J Gerontol A Biol Sci Med Sci, 2025, 80(12): glaf210.

1. Jiang, F, Lu, C, Zeng, Z, et al. Global burden of disease for musculoskeletal disorders in all age groups, from 2024 to 2050, and a bibliometric-based survey of the status of research in geriatrics, geriatric orthopedics, and geriatric orthopedic diseases[J]. J Orthop Surg Res, 2025, 20(1): 179.
2. de Oliveira, FN, Dami?o, EP, Dos Santos, L, et al. Prevalence and factors associated with low functional mobility in older adults[J]. Aging Med (Milton), 2024, 7(3): 292-300.
3. 中華醫學會老年醫學分會, 國家老年疾病臨床醫學研究中心(宣武醫院), 馬麗娜. 老年人內在能力篩查與綜合評估中國專家共識[J]. 中國全科醫學, 2026, 29(10): 1225-1238, 1245.
4. 林靜雯, 劉永兵. 老年人內在能力研究進展[J]. 右江醫學, 2025, 53(4): 296-304.
5. Bevilacqua R, Soraci L, Stara V, et al. A systematic review of multidomain and lifestyle interventions to support the intrinsic capacity of the older population[J]. Front Med (Lausanne), 2022, 9: 929261.
6. Logvinov I, Neff DF. Assessing intrinsic capacity in older adults: a concept analysis[J]. Geriatr Nurs, 2026, 68: 103826.
7. Locquet M, Sanchez-Rodriguez D, Bruyère O, et al. Intrinsic capacity defined using four domains and mortality risk: a 5-year follow-up of the SarcoPhAge cohort[J]. J Nutr Health Aging, 2022, 26(1): 23-29.
8. Ma CHK, Chua DQL, Tay L, et al. The feasibility of implementing the WHO Integrated Care For Older People (ICOPE) framework in singapore[J]. J Frailty Aging, 2024, 13(4): 514-521 .
9. Giudici KV, de Souto Barreto P, Guyonnet S, et al. Predictive capacity of the integrated care for older people screening tool for intrinsic capacity impairments: results from the INSPIRE-T cohort[J]. J Gerontol A Biol Sci Med Sci, 2024, 79(7): glae112.
10. 李夏夏, Jagadish K Chhetri, 陳雨濛, 等. 世界衛生組織老年整合照護篩查工具的漢化及信效度檢驗[J]. 中國臨床保健雜志, 2024, 27(5): 621-625.
11. Gutiérrez-Robledo LM, García-Chanes RE, Pérez-Zepeda MU. Allostatic load as a biological substrate to intrinsic capacity: a secondary analysis of CRELES[J]. J Nutr Health Aging, 2019, 23(9): 788-795.
12. Charles A, Buckinx F, Locquet M, et al. Prediction of adverse outcomes in nursing home residents according to intrinsic capacity proposed by the World Health Organization[J]. J Gerontol A Biol Sci Med Sci, 2020, 75(8): 1594-1599.
13. Musalek C, Kirchengast S. Grip strength as an indicator of health-related quality of life in old age-a pilot study[J]. Int J Environ Res Public Health, 2017, 14(12): 1447.
14. 丁瑞叢, 王峰, 徐曉玉, 等. 滌痰湯加味方對血管性癡呆認知功能、相關炎性指標的改善及影響[J]. 中華中醫藥學刊, 2024, 42(7): 96-100.
15. 中華護理學辭典. 老年抑郁量表(GDS)[J]. 中國護理管理, 2017, 17(7): 885.
16. Tavassoli N, Piau A, Berbon C, et al. Framework implementation of the INSPIRE ICOPE-CARE program in collaboration with the World Health Organization (WHO) in the Occitania Region[J]. J Frailty Aging, 2021, 10(2): 103-109.
17. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinician[J]. J Psychiatr Res, 1975, 12(3): 189-198.
18. 中華醫學會神經病學分會癡呆與認知障礙學組. 輕度認知損害的神經心理評估專家共識(2025 版)[J]. 中華醫學雜志, 2025, 105(3): 204-218.
19. 劉一儒, 姜朝陽, 魏坤, 等. 老年髖部骨折護理風險評估工具的研究進展[J]. 數理醫藥學雜志, 2026, 39(8): 605-613.
20. 胡怡陽, 于陽, 李偉, 等. 老年人內在能力研究進展[J]. 循證護理, 2026, 12(1): 132-136.
21. Beard JR, Jotheeswaran AT, Cesari M, et al. The structure and predictive value of intrinsic capacity in a longitudinal study of ageing[J]. BMJ Open, 2019, 9(11): e026119.
22. 蒲虹杉, 董碧蓉. 老年肌少癥與衰弱和營養[J]. 中國臨床保健雜志, 2021, 24(5): 577-581.
23. 中華護理學會老年護理專業委員會, 北京醫院國家老年醫學中心中國醫學科學院老年醫學研究院, 北京大學護理學院, 等. 老年人內在能力評估與維護指南[J]. 中華護理雜志, 2025, 60(3): 261-265.
24. 曹瑛, 魏建芬, 張瑋, 等. 在老年骨科患者圍術期中應用快速康復理念下的營養支持護理的效果[J]. 中國社區醫師, 2024, 40(32): 119-121.
25. Gajdosova L, Jakus V, Muchova J. Understanding cognitive frailty in aging adults: prevalence, risk factors, pathogenesis and non-pharmacological interventions[J]. Bratisl Lek Listy, 2023, 124(9): 647-652.
26. 石婧, 沈干, 于普林. 老年人認知和社會心理衰弱[J]. 中國臨床保健雜志, 2022, 25(6): 762-766.
27. He P, Zhang Y, Liu A, et al. Integrated care improved cognitive ability in older Chinese patients with impaired intrinsic capacity[J]. Innov Aging, 2025, 9(Suppl 2): 2868.
28. Cadore EL, Sáez de Asteasu ML, Izquierdo M. Multicomponent exercise and the hallmarks of frailty: considerations on cognitive impairment and acute hospitalization[J]. Exp Gerontol, 2019, 122: 10-14.
29. Felipe SG, Printes CB, Sato DK, et al. Impact of a multicomponent physical exercise program on intrinsic capacity in community-dwelling older adults[J]. PeerJ, 2025, 13: e19017.
30. Yi M, Zhang W, Zhang X, et al. The effectiveness of Otago exercise program in older adults with frailty or pre-frailty: a systematic review and meta-analysis[J]. Arch Gerontol Geriatr, 2023, 114: 105083.
31. 朱愿超, 金鵬飛, 國家老年醫學中心, 等. 老年人多重用藥門診標準操作規范專家共識(2024 版)[J]. 中華老年醫學雜志, 2024, 43(11): 1382-1391.
32. 黃如飛, 李鳳, 梁丁華. 三聯預康復護理在骨科大手術患者中的應用實踐[J]. 衛生職業教育, 2024, 42(15): 154-157.
33. 中華醫學會腸外腸內營養學分會. 中國成人患者腸外腸內營養臨床應用指南(2023 版)[J]. 中華醫學雜志, 2023, 103(13): 946-974.
34. 吳蓓雯, 葉向紅, 李素云, 等. 提高口服營養補充依從性臨床管理實踐的專家共識[J]. 腫瘤代謝與營養電子雜志, 2021, 8(5): 487-494.
35. 國家衛生健康委加速康復外科專家委員會骨科專家組, 中國研究型醫院學會骨科加速康復專業委員會, 中國康復技術轉化及促進會骨科加速康復專業委員會. 骨科大手術加速康復圍手術期營養管理專家共識[J]. 中華骨與關節外科雜志, 2022, 15(10): 763-767.
36. 莊平. 認知訓練聯合生活方式干預對老年輕度認知功能障礙患者認知功能及生活質量的影響分析[J]. 中國實用醫藥, 2026, 21(10): 160-162.
37. 李琰, 許翠萍, 王曉婷, 等. 虛擬現實技術在提高老年人內在能力中的應用進展[J]. 全科護理, 2026, 24(7): 1279-1283.
38. 黃尚崗. 認知行為療法干預治療老年抑郁癥的研究進展[J]. 中國衛生標準管理, 2023, 14(1): 195-198.
39. 陶曉梅, 宋燁, 鐘小會, 等. 基于多學科協作診療的老年骨科大手術患者衰弱干預方案的構建與應用[J]. 哈爾濱醫科大學學報, 2025, 59(6): 662-669.
40. 張鵬. 基于微信的延續性護理干預對老年全髖關節置換患者術后生活質量和功能恢復的影響[J]. 河南醫學研究, 2020, 29(19): 3631-3632.
41. 徐方宸凱, 陸愛未, 周如, 等. 基于智能可穿戴設備的家庭-社區健康協同響應機制研究[J]. 公關世界, 2026(8): 28-30.
42. Kim JH, Lee SB. Evaluation of activities of daily living: current insights and future horizons[J]. Ann Geriatr Med Res, 2025, 29(2): 143-158.
43. 劉智嵐, 賈杰. 基于計算機認知訓練技術在改善老年認知功能中的應用與展望[J]. 中國卒中雜志, 2021, 16(3): 246-250.
44. 崔菲菲, 王木桃. 基于“智慧養老”下的社區老年人出院后延續性護理效果[J]. 醫學食療與健康, 2022, 20(9): 94-96, 113.
45. Fairhall N. Physical, nutritional, cognitive and combination interventions reduce frailty in community-dwelling prefrail and frail older people[J]. Evid Based Med, 2016, 21(4): 142.
46. Pua YH, Tay L, Clark RA, et al. Development, validity, and utility of a model-based intrinsic capacity composite score in community-dwelling older persons[J]. J Gerontol A Biol Sci Med Sci, 2025, 80(12): glaf210.

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