CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

WANGChen , LITing , LUOPengfei , LIUYingying , WUGuosheng , CHENGDasheng ,  BENDaofeng , XIAZhaofan

Department of Burn and Trauma Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China;

Corresponding?author：

BENDaofeng, Email: bendf2001@aliyun.com

Keywords：

Liquid wound dressing; Chronic ulcer wound; Bacterial biofilm; Wound healing

DOI：

10.7507/1002-1892.20160312

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Objective To evaluate the effectiveness of liquid wound dressing in the treatment of chronic ulcer wounds. Methods Between January 2014 and October 2015, 84 patients with chronic ulcer wounds were included and divided into 2 groups randomly. The chronic ulcer wounds were covered with liquid wound dressing in the treatment group (n=44) and were managed with iodophor in the control group (n=40). There was no significant difference in age, gender, causes, location, wound area, and disease duration between 2 groups (P > 0.05). The frequency of dress changing, effective rate of treatment, wound healing time, wound healing rate at 5, 10, and 20 days, positive rate of bacteria culture at 1, 5, and 10 days, and the rate of side effect were recorded and compared between 2 groups. Vancouver scar scale was used to evaluate scar formation. Results The effective rate of the treatment group (100%) was significantly higher than that of the control group (85%) (P=0.009). The frequency of dress changing in the treatment group[(11.36±3.40) times] was significantly lower than that in the control group[(16.94±4.51) times] (t=-6.231, P=0.000). The wound healing rates at 5, 10, and 20 days were significantly increased (P < 0.05) and the wound healing time was significantly decreased (t=-6.627, P=0.000) in the treatment group when compared with the control group. The positive rates of bacteria culture at 5 and 10 days in the treatment group were significantly lower than those in the control group (χ²=12.313, P=0.000; P=0.005), but no significant difference was found at 1 day (χ²=0.066, P=0.797). Side effect was observed in 4 cases of the control group. Vancouver scar scale score was 8.59±1.32 in the treatment group and was 9.85±1.65 in the control group, showing significant difference (t=-3.752, P=0.000). Conclusion The application of the liquid wound dressing in the treatment of chronic ulcer wound can improve the wound healing rate, shorten the healing time and decrease the frequency of dress change, which could promote the wound healing process.

Citation： WANGChen, LITing, LUOPengfei, LIUYingying, WUGuosheng, CHENGDasheng, BENDaofeng, XIAZhaofan. CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(12): 1507-1511. doi: 10.7507/1002-1892.20160312 Copy

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9.	姚興偉, 孫偉晶, 韓德志, 等.小兒大面積深Ⅱ度燒傷休克期磨痂效果觀察.中華損傷與修復雜志(電子版), 2013, 8(4):26-29.
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11.	劉海兵, 唐丹, 曹海燕, 等.溫哥華瘢痕量表的信度研究.中國康復醫學雜志, 2006, 21(3):240-242.
12.	朱學駿.皮膚病學與性病學.北京:北京大學醫學出版社, 2003:10-11.
13.	Hunt TK, Hopf HW. Wound healing and wound infection. What Surgeons and anesthesiologists can do. Surg Clin North Am, 1997, 77(3):587-606.
14.	Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms:a common cause of persistent infections. Science, 1999, 284(5418):1318-1322.
15.	James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen, 2008, 16(1):37-44.
16.	Wolcott RD, Rhoads DD. A study of biofilm-based wound management in subjects with critical limb ischaemia. J Wound Care, 2008, 17(4):145-155.
17.	Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds, 2008, 20(6):171-175.
18.	Yasuda K, Ohmizo C, Katsu T. Potassium and tetraphenyl phosphonium ion-selective electrodes for monitoring changes in the permeability of bacterial outer and cytoplasmic membranes. J Microbiol Methods, 2003, 54(1):111-115.

1. Choi HK, Curhan G. Gout:epidemiology and lifestyle choices. Curr Opin Rheumatol, 2005, 17(3):341-345.
2. 黃曉元.加強創面感染的防治.中華損傷與修復雜志(電子版), 2015, 10(5):1-4.
3. Jiang Y, Huang S, Fu X, et al. Epidemiology of chronic cutaneous wounds in China. Wound Repair Regen, 2011, 19(2):181-188.
4. 王永滿, 陳崢.改性甲殼素創面修復凝露聯合紅光照射治療慢性皮膚潰瘍的效果觀察.中國醫學前沿雜志(電子版), 2015, 7(11):141-143.
5. 張陳威, 柳大烈, 梁智, 等.封閉式負壓引流與人工真皮聯合應用治療下肢慢性潰瘍.中國修復重建外科雜志, 2013, 27(8):1023-1024.
6. 閆欣, 劉中國, 尹治暉, 等.液體傷口敷料用于治療皮膚淺表損傷的療效與安全性臨床研究.中國藥物與臨床, 2014, 14(1):69-70.
7. 姚玲鳳, 周金才, 趙曉玲.慶大胰島素高糖混合液外敷治療下肢慢性潰瘍的護理體會.中國社區醫師(醫學專業), 2010, 12(19):230.
8. 常菲, 房賀, 賁道鋒, 等.無菌生物膜在小兒淺Ⅱ度燒傷創面中的臨床應用.中華損傷與修復雜志(電子版), 2013, 8(4):30-33.
9. 姚興偉, 孫偉晶, 韓德志, 等.小兒大面積深Ⅱ度燒傷休克期磨痂效果觀察.中華損傷與修復雜志(電子版), 2013, 8(4):26-29.
10. Bill JD, Berriman SJ, Noble DL, et al. Pilot study to evaluate a novel three-dimensional wound measurement device. Int Wound J, 2015.[Epub ahead of print].
11. 劉海兵, 唐丹, 曹海燕, 等.溫哥華瘢痕量表的信度研究.中國康復醫學雜志, 2006, 21(3):240-242.
12. 朱學駿.皮膚病學與性病學.北京:北京大學醫學出版社, 2003:10-11.
13. Hunt TK, Hopf HW. Wound healing and wound infection. What Surgeons and anesthesiologists can do. Surg Clin North Am, 1997, 77(3):587-606.
14. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms:a common cause of persistent infections. Science, 1999, 284(5418):1318-1322.
15. James GA, Swogger E, Wolcott R, et al. Biofilms in chronic wounds. Wound Repair Regen, 2008, 16(1):37-44.
16. Wolcott RD, Rhoads DD. A study of biofilm-based wound management in subjects with critical limb ischaemia. J Wound Care, 2008, 17(4):145-155.
17. Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds, 2008, 20(6):171-175.
18. Yasuda K, Ohmizo C, Katsu T. Potassium and tetraphenyl phosphonium ion-selective electrodes for monitoring changes in the permeability of bacterial outer and cytoplasmic membranes. J Microbiol Methods, 2003, 54(1):111-115.

Chinese Journal of Reparative and Reconstructive Surgery

CLINICAL APPLICATION OF LIQUID WOUND DRESSING IN TREATMENT OF CHRONIC ULCER WOUNDS

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