Research progress and applications of biologically derived materials in scleral reconstruction_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

GUO Mengyao ¹ , CHEN Hongsha ² ^{共同第一作者} ,  HE Shuai ² ,  XIE Huiqi ^3,4 ,  LI Xiaoming ¹

1. School of Biological Science and Medical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, P. R. China;
2. Department of Ophthalmology, the Fourth Central Hospital of Baoding City, Baoding Hebei, 072350, P. R. China;
3. Stem Cell and Tissue Engineering Research Center, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;
4. Department of Orthopedics/Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China;

Corresponding?author：

HE Shuai, Email: 183690509@qq.com; XIE Huiqi, Email: xiehuiqi@scu.edu.cn; LI Xiaoming, Email: lixm@buaa.edu.cn

Keywords：

Scleral reconstruction; biologically derived materials; posterior scleral reinforcement; scleral defect repair; glaucoma drainage device; chemical crosslinking

DOI：

10.7507/1002-1892.202603035

Video：

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Objective To review the research progress and clinical applications of biologically derived materials in scleral reconstruction. Methods A comprehensive review of recent domestic and international literature was conducted to systematically summarize various biologically derived materials, analyzing their therapeutic outcomes and modification strategies in posterior scleral reinforcement (PSR), scleral defect repair, and glaucoma drainage device (GDD) tube coverage. Results Biologically derived materials show distinct advantages in different scenarios of scleral reconstruction. In PSR, allogeneic sclera, dura mater, and bovine pericardium can enhance mechanical support of the posterior pole and slow axial elongation; emerging materials such as silk fibroin and gelatin methacrylcyl demonstrate potential in promoting collagen deposition and scleral remodeling. In scleral defect repair, sclera, cornea, amniotic membrane, and collagen matrix can facilitate defect closure, vascularization, and stromal integration. In GDD tube coverage, sclera, cornea, pericardium, and amniotic membrane-umbilical cord tissue can reduce the risk of tube exposure. Overall, individual materials remain limited by mechanical properties, donor availability, or biological activity. Crosslinking modification and composite reinforcement can significantly improve mechanical support and tissue-inductive capacity, promoting the transition from passive repair to active physiological remodeling. Conclusion Biologically derived materials hold significant value in scleral reconstruction. The development of intelligent and multifunctional composite materials represents the core direction for future research.

Citation： GUO Mengyao, CHEN Hongsha, HE Shuai, XIE Huiqi, LI Xiaoming. Research progress and applications of biologically derived materials in scleral reconstruction. Chinese Journal of Reparative and Reconstructive Surgery, 2026, 40(8): 1304-1313. doi: 10.7507/1002-1892.202603035 Copy

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Chinese Journal of Reparative and Reconstructive Surgery

Research progress and applications of biologically derived materials in scleral reconstruction

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