Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 WUPei-ren ¹ , ZHUANGYan-zhen ² , LUXiao-hui ³ , CHENBo ¹ , ZHANGHai-fang ² , LUChuan-hui ¹ , HUANGHong-lang ² , LIUKai-hua ¹

1. Department of Oncology Surgery, First Affiliated Hospital of Xiamen University, Xiamen 361003, P. R. China;
2. Department of Pathology, First Affiliated Hospital of Xiamen University, Xiamen 361003, P. R. China;
3. Department of Clinical Laboratory, First Affiliated Hospital of Xiamen University, Xiamen 361003, P. R. China;

Corresponding?author：

WUPei-ren, Email: wpr20001@126.com

Keywords：

Human papilloma virus; Esophageal carcinoma; Minnan

DOI：

10.7507/1007-4848.20140229

Video：

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Objective To detect human papilloma virus (HPV)infection with fluorescent quantitative real-time polymerase chain reaction (FQ-PCR)in Minnan population, and explore the correlation between HPV infection and carcinogenesis of esophageal carcinoma (EC)of Minnan patients. Methods FQ-PCR was performed to examine HPV-6, HPV-11, HPV-16 and HPV-18 in 100 healthy Minnan people (healthy group, 66 males and 34 females with their age of 52.35±6.72 years)and 100 Minnan patients with squamous EC (EC group and tumor-adjacent normal tissue group, 64 males and 36 females with their age of 51.62±6.37 years)between October 2009 and December 2012. Results The incidences of HPV infection in 100 EC tissues, 100 tumor-adjacent normal tissues and 100 esophageal mucosa tissues of healthy people were 22/100, 8/100 and 6/100 respectively, which were statistically different (χ²=10.63, P < 0.01). Positive infection of HPV-6, HPV-11, HPV-16 and HPV-18 was observed in 11 cases, 11 cases, 14 cases and 15 cases in EC group respectively, 5 cases, 6 cases, 7 cases and 8 cases in tumor-adjacent normal tissue group respectively, and 5 cases, 5 cases, 6 cases and 6 cases in the healthy group respectively (P > 0.05). Positive HPV infection was observed in 1 patients with well differentiated squamous EC, 21 patients with moderately differentiated squamous EC and 5 patients with poorly differentiated squamous EC (P > 0.05). Conclusion HPV infection may exist in tumor tissue of Minnan patients with squamous EC, and may be correlated with carcinogenesis and development of squamous EC.

Citation： WUPei-ren, ZHUANGYan-zhen, LUXiao-hui, CHENBo, ZHANGHai-fang, LUChuan-hui, HUANGHong-lang, LIUKai-hua. Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2014, 21(6): 799-802. doi: 10.7507/1007-4848.20140229 Copy

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2.	Mammas IN, Sourvinos G, Zaravinos A, et al. Vaccination against human papilloma virus(HPV):epidemiological evidence of HPV in nongenital cancer. Pathol Oncol Res, 2011, 17(2):103-109.
3.	Afonso LA, Moyses N, Cavalcanti SM. Human papilloma virus detection and p16 methylation pattern in a case of esophageal papilloma. Braz J Med Biol Res, 2010, 43(6):694-696.
4.	Kusumoto-Matsuo R, Kanda T, Kukimoto I. Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts. Genes Cells, 2011, 16(1):23-33.
5.	Raybould R, Fiander A, Hibbitts S. Human papillomavirus integration and its role in cervical malignant progression. Open Clinic Can J, 2011, 5(1):1-7.
6.	Steben M, Duarte-Franco E. Human papillomavirus infection:epide-miology and pathophysiology. Gynecol Oncol, 2007, 107(1):S2-S5.
7.	Alba A, Cararach M, Rodriguez-Cerdeira C. The human papillomavirus in human pathology:Description, pathogenesis, oncogenic role, epidemiology and detection techniques. Open Dermatol J, 2009, 12(3):90-102.
8.	Duensing S, Duensing A, Crum CP, et al. Human papillomavirus type 16E7 oncoprotein induced abnormal centrosomesythesis is an earlyevent in the evolving malignamt phenotype. Cancer Res, 2001, 61(10):2356-2360.
9.	曹邦偉, 于晶琳, 荷歡.中國人群中HPV感染與食管癌發生關聯的Meta分析.首都醫科大學學報, 2010, 31(2):258-263.
10.	劉琳, 李鋒, 徐康寧, 等.人乳頭狀瘤病毒檢測與食管癌的研究進展.現代腫瘤醫學, 2011, 19(5):1005-1008.
11.	崔金環, 楊光, 蘇錫康, 等.實時熒光PCR技術檢測高危型HPV的臨床應用評價.現代預防醫學. 2011, 38(23):4948-4952.
12.	Bohn OL, Navarro L, Saldivar J, et al. Identif cation of human papillomavirus in esophageal squamous papillomas. World J Gastroenterol, 2008, 14(3):7107-7111.
13.	陳衛剛, 楊春梅, 徐麗紅, 等.通用引物巢式PCR法對哈薩克族食管鱗癌HPV感染的檢測.世界華人消化雜志, 2012, 20(12):1049-1053.
14.	吳發福, 章鏡平, 孫蘇安, 等.江蘇省淮安地區食管癌組織中HPV的檢測及其臨床意義.江蘇臨床醫學雜志, 2002, 6(4):334-336.
15.	王悅冬, 張開鄂, 周臻濤, 等.梅州市客家人食管癌與人乳頭狀瘤病毒感染的關系.腫瘤基礎與臨床, 2010, 23(5):377-378.
16.	崔明辰, 岳鶴聲, 張冬云, 等.漯河地區食管癌患者組織中人乳頭狀瘤病毒感染的檢測.醫學研究雜志, 2011, 40(11):73-74.
17.	楊蘭, 陳玲, 孫振柱, 等.新疆哈薩克族食管癌中HPV感染狀況分析.世界華人消化雜志, 2007, 15(19):2114-2119.
18.	姚品芳, 黃環元, 付由高, 等.湖北鐘祥河南移民與湖北本地居民食管鱗狀細胞癌組織中HPV感染的比較.腫瘤防治研究, 2005, 32(1):46-48.
19.	陳云昭, 姚恩生, 楊蘭, 等.人乳頭狀病毒感染與新疆哈薩克族食管癌發生關系的探討.現代預防醫學, 2008, 35(13):2407-2409.
20.	周素明, 伊力亞爾, 夏合丁, 等. HPV16與新疆維吾爾族食管鱗癌的相關性.世界華人消化雜志, 2009, 17(31):3214-3217.

1. Syrj?nen KJ. Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. J Arch Geschwulstforsch, 1982, 52(4):283-292.
2. Mammas IN, Sourvinos G, Zaravinos A, et al. Vaccination against human papilloma virus(HPV):epidemiological evidence of HPV in nongenital cancer. Pathol Oncol Res, 2011, 17(2):103-109.
3. Afonso LA, Moyses N, Cavalcanti SM. Human papilloma virus detection and p16 methylation pattern in a case of esophageal papilloma. Braz J Med Biol Res, 2010, 43(6):694-696.
4. Kusumoto-Matsuo R, Kanda T, Kukimoto I. Rolling circle replication of human papillomavirus type 16 DNA in epithelial cell extracts. Genes Cells, 2011, 16(1):23-33.
5. Raybould R, Fiander A, Hibbitts S. Human papillomavirus integration and its role in cervical malignant progression. Open Clinic Can J, 2011, 5(1):1-7.
6. Steben M, Duarte-Franco E. Human papillomavirus infection:epide-miology and pathophysiology. Gynecol Oncol, 2007, 107(1):S2-S5.
7. Alba A, Cararach M, Rodriguez-Cerdeira C. The human papillomavirus in human pathology:Description, pathogenesis, oncogenic role, epidemiology and detection techniques. Open Dermatol J, 2009, 12(3):90-102.
8. Duensing S, Duensing A, Crum CP, et al. Human papillomavirus type 16E7 oncoprotein induced abnormal centrosomesythesis is an earlyevent in the evolving malignamt phenotype. Cancer Res, 2001, 61(10):2356-2360.
9. 曹邦偉, 于晶琳, 荷歡.中國人群中HPV感染與食管癌發生關聯的Meta分析.首都醫科大學學報, 2010, 31(2):258-263.
10. 劉琳, 李鋒, 徐康寧, 等.人乳頭狀瘤病毒檢測與食管癌的研究進展.現代腫瘤醫學, 2011, 19(5):1005-1008.
11. 崔金環, 楊光, 蘇錫康, 等.實時熒光PCR技術檢測高危型HPV的臨床應用評價.現代預防醫學. 2011, 38(23):4948-4952.
12. Bohn OL, Navarro L, Saldivar J, et al. Identif cation of human papillomavirus in esophageal squamous papillomas. World J Gastroenterol, 2008, 14(3):7107-7111.
13. 陳衛剛, 楊春梅, 徐麗紅, 等.通用引物巢式PCR法對哈薩克族食管鱗癌HPV感染的檢測.世界華人消化雜志, 2012, 20(12):1049-1053.
14. 吳發福, 章鏡平, 孫蘇安, 等.江蘇省淮安地區食管癌組織中HPV的檢測及其臨床意義.江蘇臨床醫學雜志, 2002, 6(4):334-336.
15. 王悅冬, 張開鄂, 周臻濤, 等.梅州市客家人食管癌與人乳頭狀瘤病毒感染的關系.腫瘤基礎與臨床, 2010, 23(5):377-378.
16. 崔明辰, 岳鶴聲, 張冬云, 等.漯河地區食管癌患者組織中人乳頭狀瘤病毒感染的檢測.醫學研究雜志, 2011, 40(11):73-74.
17. 楊蘭, 陳玲, 孫振柱, 等.新疆哈薩克族食管癌中HPV感染狀況分析.世界華人消化雜志, 2007, 15(19):2114-2119.
18. 姚品芳, 黃環元, 付由高, 等.湖北鐘祥河南移民與湖北本地居民食管鱗狀細胞癌組織中HPV感染的比較.腫瘤防治研究, 2005, 32(1):46-48.
19. 陳云昭, 姚恩生, 楊蘭, 等.人乳頭狀病毒感染與新疆哈薩克族食管癌發生關系的探討.現代預防醫學, 2008, 35(13):2407-2409.
20. 周素明, 伊力亞爾, 夏合丁, 等. HPV16與新疆維吾爾族食管鱗癌的相關性.世界華人消化雜志, 2009, 17(31):3214-3217.

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Correlation between Human Papilloma Virus Infection and Carcinogenesis of Esophageal Carcinoma in Minnan Population

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