Bone Marrow Mesenchymal Stem Cells for Treatment of Seawater Drowning Induced Acute Lung Injury_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

GUOShuai ,  ZENGZhi-yong , YANGSheng-sheng , XUChi , YEShi-xin

Department of Cardio-Thoracic Surgery, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University, Fuzhou 350025, P. R. China;

Corresponding?author：

ZENGZhi-yong, Email: zengzhiyong623@sina.com

Keywords：

Bone marrow mesenchymal stem cells; Seawater drowning; Acute lung injury; Acute respiratory distress syndrome

DOI：

10.7507/1007-4848.20150099

Video：

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Abstract Full text Figures/Tables Video References Cited by

With the growth of offshore activities, the incidence rates of seawater drowning (SWD) induced acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) increase significantly higher than before. Pulmonary interstitial edema, alveolar septum fracture, red blood cells, and inflammatory cells infiltration can be seen under light microscope in the pathologic changes of lungs. The major clinical manifestations are continual hyoxemia and acidosis, which lead to a severe condition, a high death rate, and a poor treatment effect. Bone marrow mesenchymal stem cells are capable of self-renewal, multilineage differentiation and injured lung-homing, which are induced to differentiate into alveolar epithelial cells and pulmonary vascular endothelial cells for tissues repairing. This may be a new way to treat SWD-ALI and SW-ARDS.

Citation： GUOShuai, ZENGZhi-yong, YANGSheng-sheng, XUChi, YEShi-xin. Bone Marrow Mesenchymal Stem Cells for Treatment of Seawater Drowning Induced Acute Lung Injury. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2015, 22(4): 375-379. doi: 10.7507/1007-4848.20150099 Copy

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1. 芮萌, 段蘊鈾, 王海龍, 等.地塞米松對兔海水淹溺型急性肺損傷肺組織NF-κB活性改變的影響.第二軍醫大學學報, 2010, 31(4):394-398.
2. Mann A, Early GL.Acute respiratory distress syndrome.Mo Med, 2012, 109(5):371-375.
3. Szpilman D.Near-drowing and drowing classification:a proposal to stratify mortality based on the analysis of 1 831 cases.Chest, 1997, 112(3):660.
4. 金發光, 郭佑民.地塞米松調節claudin-4減輕海水淹溺性肺水腫的機制研究.中華肺部疾病雜志, 2013, 6(2):124-129.
5. 馬李杰, 李艷燕, 趙詣林, 等.乙酰化白藜蘆醇通過調節縫隙連接蛋白43表達減輕海水淹溺型急性肺損傷.中華肺部疾病雜志, 2013, 6(1):15-19.
6. 古妙寧, 肖金仿, 黃毅然, 等.海水和淡水直接肺損傷作用的比較.中華麻醉學雜志, 2003, 23(8):608-612.
7. 梁源, 楚東嶺, 金發光, 等.豬肺表面活性物質對海水淹溺性肺損傷大鼠治療的量效關系.現代生物醫學進展, 2008, 8(4):619-621.
8. 韓志海, 段蘊鈾, 胡明.機械通氣對海水淹溺肺水腫兔肺組織學的影響.中華航海醫學與高氣壓醫學雜志, 2004, 1(1):12-16.
9. 楊昱, 王關嵩, 鄧朝霞, 等.海水淹溺型肺損傷與淡水淹溺型肺損傷特征的比較.解放軍醫學雜志, 2009, 34(4):393-396.
10. 周長喜, 錢桂生, 王關嵩.海水淹溺機制研究進展.人民軍醫, 2008, 51(10):630-631.
11. 李天林, 文文, 賴國祥, 等.血管緊張素轉化酶2在海水淹溺誘導大鼠急性肺損傷中的作用.中國呼吸與危重監護雜志, 2012, 11(6):537-540.
12. Kingma PS, Unitsett JA, Waters P, et al.In defense of the lung:surfactant protein A and surfactant protein D.Curr Opin Pharmacol, 2006, 6(3):277-283.
13. 杜娟, 高偉良, 左右, 等.早期機械通氣治療海水淹溺肺水腫.實用醫學雜志, 2008, 24(10):1777-1778.
14. 黃毅然, 古妙寧, 肖金仿, 等.早期肺灌洗治療犬海水淹溺肺損傷的實驗研究.第一軍醫大學學報, 2003, 23(10):1062-1065.
15. Huang TY, Tsai PS, Wang TY, et al.Hyperbaric oxygen attenuation of lipopolysaccharide-induced acute lung injury involves heme oxygenase-1.Acta Anaesthesiol Scand, 2005, 49(9):1293-1301.
16. 張新紅, 段蘊鈾, 芮萌, 等.不同劑量地塞米松對海水淹溺型急性肺損傷的治療作用觀察.解放軍醫學雜志, 2009, 34(7):815-818.
17. Xinmin D, Yunyou D, Chaosheng P, et al.Dexamethasone treatment attenuates early seawater instillation-induced acute lung injury in rabbits.Pharmacol Res, 2006, 53(4):372-379.
18. 刁孟元, 張斌, 黃鳳樓.血管內皮生長因子與海水淹溺型急性肺損傷的關系.中國療養醫學, 2013, 22(3):237-239.
19. Beyer Nardi N, da Silva Meirelles L.Mesenchymal stem cells:isolation, in vitro expansion and characterization.Handb ExpPharmacol, 2006, (174):249-282.
20. García-Castro J, Trigueros C, Madrenas J, et al.Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.J Cell Mol Med, 2008, 12(6B):2552-2565.
21. Ortiz LA, Gambelli F, McBride C, et al.Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects.Proc Natl Acad Sci USA, 2003, 100(14):8407-8411.
22. Ortiz LA, Dutreil M, Fattman C, et al.Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury.Proc Natl Acad Sci USA, 2007, 104(26):11002-11007.
23. Rojas M, Xu J, Woods CR, et al.Bone marrow-drived mesenchymal stem cells in repair of the injured lung.Am J Respir Cell Mol Biol, 2005, 33(2):145-152.
24. Gupta N, Su X, Popov B, et al.Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice.J Immunol, 2007, 179(3):1855-1863.
25. Xu J, Woods CR, Mora AL, et al.Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.Am J Physiol Lung Cell Mol Physiol, 2007, 293(1):L131-L141.
26. Sueblinvong V, Weiss DJ.Cell therapy approaches for lung diseases:current status.Curr OpinPharmacol, 2009, 9(3):268-273.
27. Aslam M, Baveja R, Liang OD, et al.Bone marrow stromal cells attenuate lung injury in amurine model of neonatal chronic lung disease.Am J Respir Crit Care Med, 2009, 180(11):1122-1130.
28. Van Haaften T, Byrne R, Bonnet S, et al.Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats.Am J Respir Crit Care Med, 2009, 180(11):1131-1142.
29. Chang YS, Oh W, Choi SJ, et al.Human umbilical cord blood derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats.Cell Transplant, 2009, 18(8):869-886.
30. Weiss DJ, Kolls JK, Ortiz LA, et al.Stem cells and cell therapies in lung biology and lung diseases.Proc Am Thorac Soc, 2008, 5(5):637-667.
31. Zhen G, Liu H, Gu N, et al.Mesenchymal stem cells transplantation protects against rat pulmonary emphysema.Front Biosci, 2008, 13:3415-3422.
32. 華靜, 馮華松, 王慶, 等.海水淹溺致大鼠急性肺損傷模型的建立.現代生物醫學進展, 2013, 13(27):5242-5246.
33. 張紅霞, 王蒙蒙, 李惠萍, 等.白藜蘆醇對博來霉素誘導小鼠肺損傷的保護作用.第二軍醫大學學報, 2013, 34(12):1287-1290.
34. 張祺嘉鈺, 王國全, 余林中, 等.兩種內毒素經支氣管給藥致急性肺損傷模型再評價研究.中藥藥理與臨床, 2012, 28(5):226-229.
35. Loebinger MR, Sage EK, Janes SM.Mesenchymal stem cells as vectors for lung disease.Proc Am Thorac Soc, 2008, 5(6):711-716.
36. 張兵華, 費晉秀, 趙亞玲, 等.兔海水淹溺性肺水腫與鈉鉀-ATP酶的關系及不同劑量地塞米松對其影響.陜西醫學雜志, 2011, 40(1):11-14.
37. 張紅珊, 方建培.骨髓間充質干細胞修復肺損傷研究進展.中國呼吸與危重監護雜志, 2011, 10(5):505-508.
38. Ohno N, Kajiume T, Sear Y, et al.Short-term culture of umbilical cord blood-derived CD34 cells enhances engraftment into NOD/SCID mice through increased CXCR4 expression.Stem Cells Dev, 2009, 18(8):1221-1226.
39. 顧興, 金發光, 劉同剛.三七總皂苷對海水淹溺兔肺泡巨噬細胞TNF-αmRNA表達的影響.中國中醫急癥, 2011, 20(10):1608-1610.
40. 張新紅, 段蘊鈾, 芮萌.海水淹溺型急性肺損傷兔血管內皮生長因子及其受體的表達.解放軍醫學雜志, 2009, 34(7):819-822.
41. Krause DS.Bone marrow-derived cells and stem cells in lung repair.Proc Am Thorac Soc, 2008, 5(3):323-327.
42. Prockop DJ.Marrow stromal cells as stem cells for non-hematopoietic tissues.Science, 1997, 276(5309):71-74.
43. 王關嵩, 張志遠, 錢桂生.溺海肺損傷的發病機制和治療的研究進展.中國急救醫學, 2008, 28(3):262-266.
44. 趙峰, 李圣青, 張宇飛, 等.骨髓間充質干細胞在肺損傷大鼠肺組織的分化.解放軍醫學雜志, 2007, 32(2):131-133.
45. Snyder JC, Teisanu RM, Stripp BR.Endogenous lung stem cells and contribution to disease.J Pathol, 2009, 217(2):254-264.
46. 趙詣林, 馬李杰, 陳向軍, 等.核轉錄因子-5在海水淹溺性肺水腫中的作用及機制.中華肺部疾病雜志:電子版, 2013, 6(1):25-29.
47. 劉秋平, 盧曉昭, 費晉秀, 等.骨髓間充質干細胞移植對急性肺水腫大鼠肺組織的影響.中華危重癥醫學雜志:電子版, 2011, 4(3):150-154.
48. Németh K, Leelahavanichkul A, Yuen PS, et al.Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogramming of host macrophages to increase their interleukin-10 production.Nat Med, 2009, 15(1):42-49.
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