Research Progress of Esophageal Cancer Stem Cells_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHENGXin-lin , XIAXue-yang ,  ZHANGJian-hua , LiBin

Department of General Thoracic Surgery, Second Affiliated Hospital, Lanzhou University, Lanzhou 730030, P. R. China;

Corresponding?author：

ZHANGJian-hua, Email: 972659434@qq.com

Keywords：

Esophageal cancer; Esophageal cancer stem cells; Separation; Indentification

DOI：

10.7507/1007-4848.20160217

Video：

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Abstract Full text Figures/Tables Video References Cited by

Esophageal carcinoma is a kind of common malignant tumor in the digestive tract. Although a lot of basic researches and clinical trials have been carried out all over the world, neither the diagnostic level nor the therapeutic effects have been obviously improved. The 5-year survival rate of esophageal cancer patient is still lower than that of other malignant tumors. Up to now, some frontier researches consider that the reason of the esophageal carcinoma being difficult to cure is related to the stem cells in it. Elimination or suppression of these stem cells may bring new hope for the treatment of esophageal cancer. This article generally introduces the specific markers, separation and indentification methods about the esophageal cancer stem cell. The targeted therapy is also mentioned.

Citation： ZHENGXin-lin, XIAXue-yang, ZHANGJian-hua, LiBin. Research Progress of Esophageal Cancer Stem Cells. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2016, 23(9): 907-911. doi: 10.7507/1007-4848.20160217 Copy

1.	Chen WQ, Zheng RS, Zhang SW, et al. Esophageal cancer incidence and mortality in China, 2010. Thorac Cancer, 2014, 5(4):343-348.
2.	Makino S. The role of tumor stemcells in regrowth of the tumor following drastic applications. Acta Unio Int Contra Cancrum, 1959, 15(Suppl1):196-198.
3.	Driessens G, Beck B, Caauwe A, et al. Defining the mode of tumour growth by clonal analysis. Nature, 2012, 488(7412):527-530.
4.	Ogawa K, Yoshioka Y, Isohashi F, et al. Radiotherapy targetting cancer stem cells:current views and future perspecti ves. Anticancer Res, 2013, 33(3):747-754.
5.	Sachlos E, Risueno RM, Laronde S, et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer shem cells. Cell, 2012, 149(6):1284-1297.
6.	Schepers AG, Snippert HJ, Stange DE, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adeNomas. Science, 2012, 337(6095):730-735.
7.	Chen J, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 2012, 488(7412):522-526.
8.	Yang YM, Chang JW. Current status and issue in cancer stem cell study. Cancer Invest, 2008, 26(7):741-755.
9.	Okumura T, Shimada Y, Imamura M, et al. Neurotrophin receptor p75(NTR) characterizes human esophageal keratinceyte stem cells in vitro. Oneogene, 2003, 22(26):4017-4026.
10.	Huang SD, Yuan Y, Liu XH, et al. Self-renewal and chemotherapy resistance of side of P75NTR positive cells in esophageal squamous cell carcinomas. BMC Cancer, 2009, 9(9):9-17.
11.	張麗榮, 郭長青, 李印, 等.侵襲性及非侵襲性KYSE150細胞的體外分離及P75NTR的表達.鄭州大學學報(醫學版), 2008, 43(4):631-633.
12.	孫志剛, 黃盛東, 張寶仁, 等.應用P75NTR分選食管腫瘤干細胞并鑒定其生物學特性.第二軍醫大學學報, 2009, 30(5):480-486.
13.	Shigeishi H, Biddle A, Gammon L, et al. Maintenance of stem cell self renewal in head and neck cancers requires action of GSK3β by CD44 and RHAMM. Stem Cells, 2013, 31(10):2073-2083.
14.	Smit JK, Faber H, Niemantsverdriet M, et al. Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiother Oncol, 2013, 107(3):434-441.
15.	Zhao JS, Li WJ, Ge D, et al. Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. PLoS One, 2011, 6(6):e21419.
16.	汪建林, 孫志強, 于靜萍, 等.食管癌細胞株中腫瘤干細胞樣細胞的分離培養及生物鑒定.南京大學學報(自然科學版), 2013, 33(10):1362-1367.
17.	徐兵, 李偉新, 張利.干細胞轉錄因子Oct4在食管鱗癌中表達的研究.醫學動物防治, 2014, 30(3):242-245.
18.	趙生霞, 黃燕燕, 慕曉玲.食管癌Eca109單克隆細胞株的干細胞特性研究.石河子大學學報(醫學版), 2013, 31(2):197-201.
19.	黃燕燕, 趙生霞, 李秋霞, 等.人食管鱗癌Eca109細胞株中腫瘤干細胞的分離鑒定.石河子大學學報(醫學版), 2014, 32(3):335-339.
20.	He W, Li K, Wang F, et al. Expression of OCT4 in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis. Word J Gastroenterol, 2012, 18(7):712-719.
21.	Zhou X, Huang GR, Hu P. Over-expression of Oct4 in human esophageal squamous cell carcinoma. Mol Cells, 2011, 32(1):39-45.
22.	Rossi DJ, Jamieson CH, Weissman IL. Stem cells and the path-ways to aging and cancer. Cell, 2008, 132(4):681-696.
23.	Silva J, Garcia V, Garcia JM, et al. Circulating Bim-l mRNA as a possible prognostic factor for advanced breast cancer patients. Breast Cancer Res, 2007, 9(4):R55.
24.	Liu JH, Song LB, Zhang X, et al. Bmi-l expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol, 2008, 97(3):267-272.
25.	Wang G, Liu L, Sharma S, et al. Bmi-l confers adaptive radioresistance to KYSE-50R esophaeal carcinoma cells. Biochem Biophys Res Commun, 2012, 425(2):309-314.
26.	Huang DZ, Gao Q, Guo L, et al. Isolaion and identification of cancer stem-like cells in esophageal carcinoma cell lines. Stem Cells Dev, 2009, 18(3):465-473.
27.	于茜穎. miR-203調控食管癌干細胞自我更新及食管癌相關基因ECRC1轉錄調控的研究.北京:北京協和醫學院, 2010.博士學位論文.
28.	葉仕新, 曾志勇, 黃盛東, 等. p75NTR陽性人食管鱗癌細胞的干細胞特性研究.山東醫藥, 2012, 52(7):41-43.
29.	Zhao Y, Bao Q, Schwarz B, et al. Stem cell like side populations in esophagealcancer:a source of chemotherapy resistence and metastases. Stem Cells Dev, 2014, 23(2):180-192.
30.	李步強, 慕曉玲.食管腫瘤干細胞的研究進展.中國現代醫藥雜志, 2011, 13(3):124-125.
31.	Wang JL, Yu JP, Sun ZQ, et al. Radiobiological characteristics of cancer stem cells from esophageal cancer cell lines. World J Gastroenterol, 2014, 28(48):18296-18305.
32.	Li JC, Liu D, Yang Y, et al. Growth clonability and radiation resistance of esopheal carcinoma-derived stem-like cells. Asian Pac J Cancer Prev, 2013, 14(8):4891-4896.
33.	Zhang X, Komaki R, Wang L, et al. Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus. Clin Cancer Res, 2008, 14(9):2813-2823.
34.	Che SM, Zhang XZ, Liu XL, et al. The radiosensitization effect of NS398 on esophaeal cancer stem cell-like radioresistant cells. Dis Esophagus, 2011, 24(4):265-273.
35.	許健.食管癌干細胞的分選與鑒定.石河子:石河子大學, 2011.
36.	Wong R, Malthaner R. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized caicinoma of the esophague. Cochrance Database Syst Rev, 2010, (1):CD002092.
37.	Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood, 2005, 105(11):4163-4169.
38.	Ulla M, Cavadas D, Mu?oz I, et al. Esophageal cancer:pneumo-64-MDCT. Abdom Imaging, 2010, 35(4):383-389.
39.	Jensen AD, Grehn C, Nikoghosyan A, et al. Catch me if you can use the image guidance in the radiotherapy of an unusual case of esophageal cancer. Srahlenther Onkol, 2009, 185(7):469-473.
40.	李珂, 龍輝, 王潔蓮, 等.鉬對人食管癌細胞ECA-109的化療增敏作用及對食管癌干細胞P75NTR的影響.世界華人雜志, 2012, 20(11):959-963.
41.	Huang JX, Chen WC, Lin M, et al. Clinicopathological significance of cyclooxygenase-2 and cell cycle-regulatory proteins expression in patients with esophageal squamous cell carcinoma. Dis Esophagus, 2011, 15(10):1442-2050.
42.	Yoon MS, Nam TK, Lee JS, et al. VEGF as a predictor for response to definitive chemoradiotherapy and COX-2 as a prognosticator for survival in esophageal squamous cell carcinoma. J Korean Med Sci, 2011, 26(4):513-520.
43.	朱兆峰, 盧鑫, 肖寶榮, 等. COX-2和VEGF在食管癌中的表達及其與放射敏感性的關系.臨床腫瘤學雜志, 2011, 16(1):27-30.
44.	龍輝, 李歡, 王潔蓮, 等. NS-398對人食管癌細胞放射增敏機制的研究.胃腸病學和肝病學雜志, 2011, 20(12):1102-1104.
45.	鄭嬌嬌, 吳清明, 陳建華, 等. P162對食管癌細胞株Eca109的放射增敏作用及其對P75NTR表達的影響.中國病理生理雜志, 2013, 29(1):103-107.
46.	陳琦, 吳清明, 程靜, 等.冬凌草甲素對食管癌干細胞放射增敏作用的研究.中國現代醫學雜志, 2012, 22(29):57-60.
47.	Ma XY, Zheng RL, Meng XQ. The antitumor activity of clostridium difficile toxin A. Chinese Pharm acological Bulletin, 2003, 19(4):458-461.
48.	張建華, 宋鐵牛, 李斌, 等.艱難梭菌A毒素對食管癌干細胞損傷的研究.中國現代醫學雜志, 2013, 23(25):16-18.
49.	Mori Y, Ishiguro H, Kuwabara Y, et al. MicroRNA-21 induces cell proliferation and invasion in esophageal squamous cell carcinoma.Mol Med Report, 2009, 2(2):235-239.
50.	Huang S, Li XQ, Chen X, et al. Inhibition of microRNA-21 increases radiosensitivity of esophageal cancer cells through phosphatase and tensin homolog deleted on chromosome 10 activation. Dis Esophagus, 2013, 26(8):823-831.
51.	Guo GH, Chen SZ, Zhang J, et al. Antitumor activity of a fusion of esophageal carcinoma cells with dendritic cells derived from cord blood. Vaccine, 2005, 23(45):5225-5230.

1. Chen WQ, Zheng RS, Zhang SW, et al. Esophageal cancer incidence and mortality in China, 2010. Thorac Cancer, 2014, 5(4):343-348.
2. Makino S. The role of tumor stemcells in regrowth of the tumor following drastic applications. Acta Unio Int Contra Cancrum, 1959, 15(Suppl1):196-198.
3. Driessens G, Beck B, Caauwe A, et al. Defining the mode of tumour growth by clonal analysis. Nature, 2012, 488(7412):527-530.
4. Ogawa K, Yoshioka Y, Isohashi F, et al. Radiotherapy targetting cancer stem cells:current views and future perspecti ves. Anticancer Res, 2013, 33(3):747-754.
5. Sachlos E, Risueno RM, Laronde S, et al. Identification of drugs including a dopamine receptor antagonist that selectively target cancer shem cells. Cell, 2012, 149(6):1284-1297.
6. Schepers AG, Snippert HJ, Stange DE, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adeNomas. Science, 2012, 337(6095):730-735.
7. Chen J, Li Y, Yu TS, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 2012, 488(7412):522-526.
8. Yang YM, Chang JW. Current status and issue in cancer stem cell study. Cancer Invest, 2008, 26(7):741-755.
9. Okumura T, Shimada Y, Imamura M, et al. Neurotrophin receptor p75(NTR) characterizes human esophageal keratinceyte stem cells in vitro. Oneogene, 2003, 22(26):4017-4026.
10. Huang SD, Yuan Y, Liu XH, et al. Self-renewal and chemotherapy resistance of side of P75NTR positive cells in esophageal squamous cell carcinomas. BMC Cancer, 2009, 9(9):9-17.
11. 張麗榮, 郭長青, 李印, 等.侵襲性及非侵襲性KYSE150細胞的體外分離及P75NTR的表達.鄭州大學學報(醫學版), 2008, 43(4):631-633.
12. 孫志剛, 黃盛東, 張寶仁, 等.應用P75NTR分選食管腫瘤干細胞并鑒定其生物學特性.第二軍醫大學學報, 2009, 30(5):480-486.
13. Shigeishi H, Biddle A, Gammon L, et al. Maintenance of stem cell self renewal in head and neck cancers requires action of GSK3β by CD44 and RHAMM. Stem Cells, 2013, 31(10):2073-2083.
14. Smit JK, Faber H, Niemantsverdriet M, et al. Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers. Radiother Oncol, 2013, 107(3):434-441.
15. Zhao JS, Li WJ, Ge D, et al. Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. PLoS One, 2011, 6(6):e21419.
16. 汪建林, 孫志強, 于靜萍, 等.食管癌細胞株中腫瘤干細胞樣細胞的分離培養及生物鑒定.南京大學學報(自然科學版), 2013, 33(10):1362-1367.
17. 徐兵, 李偉新, 張利.干細胞轉錄因子Oct4在食管鱗癌中表達的研究.醫學動物防治, 2014, 30(3):242-245.
18. 趙生霞, 黃燕燕, 慕曉玲.食管癌Eca109單克隆細胞株的干細胞特性研究.石河子大學學報(醫學版), 2013, 31(2):197-201.
19. 黃燕燕, 趙生霞, 李秋霞, 等.人食管鱗癌Eca109細胞株中腫瘤干細胞的分離鑒定.石河子大學學報(醫學版), 2014, 32(3):335-339.
20. He W, Li K, Wang F, et al. Expression of OCT4 in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis. Word J Gastroenterol, 2012, 18(7):712-719.
21. Zhou X, Huang GR, Hu P. Over-expression of Oct4 in human esophageal squamous cell carcinoma. Mol Cells, 2011, 32(1):39-45.
22. Rossi DJ, Jamieson CH, Weissman IL. Stem cells and the path-ways to aging and cancer. Cell, 2008, 132(4):681-696.
23. Silva J, Garcia V, Garcia JM, et al. Circulating Bim-l mRNA as a possible prognostic factor for advanced breast cancer patients. Breast Cancer Res, 2007, 9(4):R55.
24. Liu JH, Song LB, Zhang X, et al. Bmi-l expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol, 2008, 97(3):267-272.
25. Wang G, Liu L, Sharma S, et al. Bmi-l confers adaptive radioresistance to KYSE-50R esophaeal carcinoma cells. Biochem Biophys Res Commun, 2012, 425(2):309-314.
26. Huang DZ, Gao Q, Guo L, et al. Isolaion and identification of cancer stem-like cells in esophageal carcinoma cell lines. Stem Cells Dev, 2009, 18(3):465-473.
27. 于茜穎. miR-203調控食管癌干細胞自我更新及食管癌相關基因ECRC1轉錄調控的研究.北京:北京協和醫學院, 2010.博士學位論文.
28. 葉仕新, 曾志勇, 黃盛東, 等. p75NTR陽性人食管鱗癌細胞的干細胞特性研究.山東醫藥, 2012, 52(7):41-43.
29. Zhao Y, Bao Q, Schwarz B, et al. Stem cell like side populations in esophagealcancer:a source of chemotherapy resistence and metastases. Stem Cells Dev, 2014, 23(2):180-192.
30. 李步強, 慕曉玲.食管腫瘤干細胞的研究進展.中國現代醫藥雜志, 2011, 13(3):124-125.
31. Wang JL, Yu JP, Sun ZQ, et al. Radiobiological characteristics of cancer stem cells from esophageal cancer cell lines. World J Gastroenterol, 2014, 28(48):18296-18305.
32. Li JC, Liu D, Yang Y, et al. Growth clonability and radiation resistance of esopheal carcinoma-derived stem-like cells. Asian Pac J Cancer Prev, 2013, 14(8):4891-4896.
33. Zhang X, Komaki R, Wang L, et al. Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus. Clin Cancer Res, 2008, 14(9):2813-2823.
34. Che SM, Zhang XZ, Liu XL, et al. The radiosensitization effect of NS398 on esophaeal cancer stem cell-like radioresistant cells. Dis Esophagus, 2011, 24(4):265-273.
35. 許健.食管癌干細胞的分選與鑒定.石河子:石河子大學, 2011.
36. Wong R, Malthaner R. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized caicinoma of the esophague. Cochrance Database Syst Rev, 2010, (1):CD002092.
37. Guzman ML, Rossi RM, Karnischky L, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood, 2005, 105(11):4163-4169.
38. Ulla M, Cavadas D, Mu?oz I, et al. Esophageal cancer:pneumo-64-MDCT. Abdom Imaging, 2010, 35(4):383-389.
39. Jensen AD, Grehn C, Nikoghosyan A, et al. Catch me if you can use the image guidance in the radiotherapy of an unusual case of esophageal cancer. Srahlenther Onkol, 2009, 185(7):469-473.
40. 李珂, 龍輝, 王潔蓮, 等.鉬對人食管癌細胞ECA-109的化療增敏作用及對食管癌干細胞P75NTR的影響.世界華人雜志, 2012, 20(11):959-963.
41. Huang JX, Chen WC, Lin M, et al. Clinicopathological significance of cyclooxygenase-2 and cell cycle-regulatory proteins expression in patients with esophageal squamous cell carcinoma. Dis Esophagus, 2011, 15(10):1442-2050.
42. Yoon MS, Nam TK, Lee JS, et al. VEGF as a predictor for response to definitive chemoradiotherapy and COX-2 as a prognosticator for survival in esophageal squamous cell carcinoma. J Korean Med Sci, 2011, 26(4):513-520.
43. 朱兆峰, 盧鑫, 肖寶榮, 等. COX-2和VEGF在食管癌中的表達及其與放射敏感性的關系.臨床腫瘤學雜志, 2011, 16(1):27-30.
44. 龍輝, 李歡, 王潔蓮, 等. NS-398對人食管癌細胞放射增敏機制的研究.胃腸病學和肝病學雜志, 2011, 20(12):1102-1104.
45. 鄭嬌嬌, 吳清明, 陳建華, 等. P162對食管癌細胞株Eca109的放射增敏作用及其對P75NTR表達的影響.中國病理生理雜志, 2013, 29(1):103-107.
46. 陳琦, 吳清明, 程靜, 等.冬凌草甲素對食管癌干細胞放射增敏作用的研究.中國現代醫學雜志, 2012, 22(29):57-60.
47. Ma XY, Zheng RL, Meng XQ. The antitumor activity of clostridium difficile toxin A. Chinese Pharm acological Bulletin, 2003, 19(4):458-461.
48. 張建華, 宋鐵牛, 李斌, 等.艱難梭菌A毒素對食管癌干細胞損傷的研究.中國現代醫學雜志, 2013, 23(25):16-18.
49. Mori Y, Ishiguro H, Kuwabara Y, et al. MicroRNA-21 induces cell proliferation and invasion in esophageal squamous cell carcinoma.Mol Med Report, 2009, 2(2):235-239.
50. Huang S, Li XQ, Chen X, et al. Inhibition of microRNA-21 increases radiosensitivity of esophageal cancer cells through phosphatase and tensin homolog deleted on chromosome 10 activation. Dis Esophagus, 2013, 26(8):823-831.
51. Guo GH, Chen SZ, Zhang J, et al. Antitumor activity of a fusion of esophageal carcinoma cells with dendritic cells derived from cord blood. Vaccine, 2005, 23(45):5225-5230.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Research Progress of Esophageal Cancer Stem Cells

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