Outcome of thoracoscopic lobectomy for stageⅠ/Ⅱnon-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

DOU Yawei ¹ ,  LV Shanshan ² , TIAN Wei ¹ , WANG Hongtao ¹ , ZHU Jianfei ¹ , DAI Yun ¹ , LUO Xianghui ¹

1. Department of Thoracic Surgery, Shaanxi People's Hospital, Xi'an, 710068, P.R.China;
2. Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710068, P.R.China;

Corresponding?author：

LV Shanshan, Email: lvshan2007@163.com

Keywords：

Video-assisted thoracoscopic surgery; lobectomy; non-small cell lung cancer

DOI：

10.7507/1007-4848.201607031

Video：

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Objective To evaluate the efficacy and safety of total thoracoscopic lobectomy for patients with stage Ⅰ/Ⅱ non-small cell lung cancer (NSCLC). Methods The clinical data of 138 NSCLC patients from January 2013 to June 2015 in Shaanxi People's Hospital were retrospectively analyzed. There were 88 males and 50 females with an average age of 57.4±8.8 years, ranging from 44 to 76 years. According to the operation methods, they were divided into a video-assisted thoracoscopic surgery (VATS) group (thoracoscopic lobectomy in 63 cases) and a thoracotomy group (conventional open chest surgery in 75 cases). The intra- and postoperative clinical data, surgical complications and pulmonary function were compared. Results There was no significant difference in the operation time, intraoperative lymph node dissection groups, intraoperative lymph node dissection number between two groups (P>0.05). The blood loss, postoperative drainage volume, duration of postoperative analgesia, Numeric Rating Scale for pain and hospital stay in the VATS group were significantly lower than those of the thoracotomy group (P<0.05). The pre- and postoperative FVC%pred and FEV1%pred in both groups were compared and there was no significant difference (P>0.05). However the postoperative FVC%pred and FEV1%pred in both groups significantly reduced compared with preoperative ones (P<0.05). Complication rate of thoracoscopic group was significantly less than that of the thoracotomy group (20.63%vs. 32.00%,χ²=3.974,P=0.046). Conclusion Thoracoscopic lobectomy for NSCLCⅠ/Ⅱpatients is reliable, and achieves rapid postoperative recovery as well as less complications.

Citation： DOU Yawei, LV Shanshan, TIAN Wei, WANG Hongtao, ZHU Jianfei, DAI Yun, LUO Xianghui. Outcome of thoracoscopic lobectomy for stageⅠ/Ⅱnon-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(3): 192-195. doi: 10.7507/1007-4848.201607031 Copy

1.	?龍志華. 全胸腔鏡肺葉切除系統淋巴結清掃對Ⅰ至ⅡA期非小細胞肺癌 (NSCLC) 的臨床療效研究. 中國實用醫藥, 2014, 9(12): 72-73.
2.	牟志民, 張海, 毛廣顯, 等. 胸腔鏡肺葉切除術與開胸肺葉切除術治療臨床Ⅰa 期非小細胞肺癌對比研究. 新鄉醫學院學報, 2015, 32(2): 149-151.
3.	Kato M, Onishi H, Furugaki K, et al. New approach to complete video-assisted thoracoscopic lobectomy in T2 and T3 non-small cell lung cancer. Anticancer Res, 2015, 35(6): 3585-3589.
4.	田文鑫, 佟宏峰, 孫耀光, 等. 非小細胞肺癌胸腔鏡與常規開胸術后血清 VEGF、MMP-9 變化的研究. 中國肺癌雜志, 2014, 17(1): 24-29.
5.	何圓, 尤長宣. 非小細胞肺癌免疫治療進展. 中國肺癌雜志, 2014, 46(3): 277-281.
6.	張衛強, 左建新, 譚健, 等. 電視胸腔鏡手術對老年非小細胞肺癌患者術后心肺并發癥的影響分析. 中國全科醫學, 2014, 17(2): 220-222.
7.	廉政君, 黃建國. 晚期非小細胞肺癌預后相關因素分析. 現代腫瘤醫學, 2014, 22(1): 95-97.
8.	梁宇強, 黃健, 王茂生, 等. 電視胸腔鏡在Ⅰ-Ⅱ期 NSCLC 切除中的中遠期療效及安全性分析. 臨床肺科雜志, 2014, 19(10): 1874-1877.
9.	周亞夫, 顏建華, 馮鍵, 等. 全胸腔鏡肺葉切除術與傳統開放式肺葉切除術在Ⅰ、Ⅱ期肺癌治療中的對比研究. 中國臨床醫生, 2016, 44(4): 62-64.
10.	魏崴, 李勇生, 鐘標, 等. 全胸腔鏡肺葉切除術治療直徑大于 5 cm 的非小細胞肺癌. 貴陽醫學院學報, 2015, 40(4): 397-400.
11.	Kim SJ, Lee YJ, Park JS, et al. Changes in pulmonary function in lung cancer patients after video-assisted thoracic surgery. Ann Thorac Surg, 2015, 99(1): 210-217.
12.	朱勇, 梁明強, 吳維棟, 等. 單孔全胸腔鏡肺葉切除術治療非小細胞肺癌的初步探索. 福建醫科大學學報, 2014, 48(6): 382-384.
13.	王祥安, 馮國斌, 朱軍, 等. 電視胸腔鏡肺葉切除術臨床療效分析. 養生保健指南: 醫藥研究, 2016, 12(3): 18-19.
14.	毛小亮, 童繼春, 朱征, 等. 全胸腔鏡解剖性肺段切除治療Ⅰa 期非小細胞肺癌 (附 6 例報告). 實用臨床醫藥雜志, 2015, 19(24): 76-77.
15.	石正軍, 林學軍, 李鐵彬, 等. 胸腔鏡在治療早期非小細胞肺癌的臨床效果分析. 臨床肺科雜志, 2014, 19(3): 456-458.
16.	孫琦, 孫振宇, 顧敏威, 等. 全胸腔鏡肺葉切除聯合淋巴結清掃術治療老年非小細胞肺癌的療效. 中國老年學雜志, 2015, 35(10): 2736-2737.
17.	Yang ZM, Sun YH, Rui WM, et al. Meta-analysis of lobectomy, segmentectomy, and wedge resection for stage I non-small cell lung cancer. J Surg Oncol, 2015, 111(3): 334-340.
18.	Ran?i? M, Risti? L, Ran?i? S, et al. Pulmonary function parameters as prognostic factors in advanced non-small cell lung cancer. Med Glas (Zenica), 2014, 11(1): 58-65.
19.	Murakawa T, Ichinose J, Hino H, et al. Long-term outcomes of open and video-assisted thoracoscopic lung lobectomy for the treatment of early stage non-small cell lung cancer are similar: A propensity-matched study. World J Surg, 2015, 39(5): 1084-1091.
20.	Vannucci F, Gonzalez-Rivas D. Is VATS lobectomy standard of care for operable non-small cell lung cancer? Lung Cancer, 2016, 100: 114-119.

1. ?龍志華. 全胸腔鏡肺葉切除系統淋巴結清掃對Ⅰ至ⅡA期非小細胞肺癌 (NSCLC) 的臨床療效研究. 中國實用醫藥, 2014, 9(12): 72-73.
2. 牟志民, 張海, 毛廣顯, 等. 胸腔鏡肺葉切除術與開胸肺葉切除術治療臨床Ⅰa 期非小細胞肺癌對比研究. 新鄉醫學院學報, 2015, 32(2): 149-151.
3. Kato M, Onishi H, Furugaki K, et al. New approach to complete video-assisted thoracoscopic lobectomy in T2 and T3 non-small cell lung cancer. Anticancer Res, 2015, 35(6): 3585-3589.
4. 田文鑫, 佟宏峰, 孫耀光, 等. 非小細胞肺癌胸腔鏡與常規開胸術后血清 VEGF、MMP-9 變化的研究. 中國肺癌雜志, 2014, 17(1): 24-29.
5. 何圓, 尤長宣. 非小細胞肺癌免疫治療進展. 中國肺癌雜志, 2014, 46(3): 277-281.
6. 張衛強, 左建新, 譚健, 等. 電視胸腔鏡手術對老年非小細胞肺癌患者術后心肺并發癥的影響分析. 中國全科醫學, 2014, 17(2): 220-222.
7. 廉政君, 黃建國. 晚期非小細胞肺癌預后相關因素分析. 現代腫瘤醫學, 2014, 22(1): 95-97.
8. 梁宇強, 黃健, 王茂生, 等. 電視胸腔鏡在Ⅰ-Ⅱ期 NSCLC 切除中的中遠期療效及安全性分析. 臨床肺科雜志, 2014, 19(10): 1874-1877.
9. 周亞夫, 顏建華, 馮鍵, 等. 全胸腔鏡肺葉切除術與傳統開放式肺葉切除術在Ⅰ、Ⅱ期肺癌治療中的對比研究. 中國臨床醫生, 2016, 44(4): 62-64.
10. 魏崴, 李勇生, 鐘標, 等. 全胸腔鏡肺葉切除術治療直徑大于 5 cm 的非小細胞肺癌. 貴陽醫學院學報, 2015, 40(4): 397-400.
11. Kim SJ, Lee YJ, Park JS, et al. Changes in pulmonary function in lung cancer patients after video-assisted thoracic surgery. Ann Thorac Surg, 2015, 99(1): 210-217.
12. 朱勇, 梁明強, 吳維棟, 等. 單孔全胸腔鏡肺葉切除術治療非小細胞肺癌的初步探索. 福建醫科大學學報, 2014, 48(6): 382-384.
13. 王祥安, 馮國斌, 朱軍, 等. 電視胸腔鏡肺葉切除術臨床療效分析. 養生保健指南: 醫藥研究, 2016, 12(3): 18-19.
14. 毛小亮, 童繼春, 朱征, 等. 全胸腔鏡解剖性肺段切除治療Ⅰa 期非小細胞肺癌 (附 6 例報告). 實用臨床醫藥雜志, 2015, 19(24): 76-77.
15. 石正軍, 林學軍, 李鐵彬, 等. 胸腔鏡在治療早期非小細胞肺癌的臨床效果分析. 臨床肺科雜志, 2014, 19(3): 456-458.
16. 孫琦, 孫振宇, 顧敏威, 等. 全胸腔鏡肺葉切除聯合淋巴結清掃術治療老年非小細胞肺癌的療效. 中國老年學雜志, 2015, 35(10): 2736-2737.
17. Yang ZM, Sun YH, Rui WM, et al. Meta-analysis of lobectomy, segmentectomy, and wedge resection for stage I non-small cell lung cancer. J Surg Oncol, 2015, 111(3): 334-340.
18. Ran?i? M, Risti? L, Ran?i? S, et al. Pulmonary function parameters as prognostic factors in advanced non-small cell lung cancer. Med Glas (Zenica), 2014, 11(1): 58-65.
19. Murakawa T, Ichinose J, Hino H, et al. Long-term outcomes of open and video-assisted thoracoscopic lung lobectomy for the treatment of early stage non-small cell lung cancer are similar: A propensity-matched study. World J Surg, 2015, 39(5): 1084-1091.
20. Vannucci F, Gonzalez-Rivas D. Is VATS lobectomy standard of care for operable non-small cell lung cancer? Lung Cancer, 2016, 100: 114-119.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Outcome of thoracoscopic lobectomy for stageⅠ/Ⅱnon-small cell lung cancer

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