Survey of the prevalence and epidemiological characteristics of primary palmar hyperhidrosis among adolescents in Yangzhou_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YANG Junfeng , WANG Yao , SHAN Yibo , LIU Xingchen , FAN Yiwei ,  SHI Hongcan

Department of Thoracic Surgery, Medical College of Yangzhou University, Yangzhou, 225001, Jiangsu, P.R.China;

Corresponding?author：

SHI Hongcan, Email: shihongcan@hotmail.com

Keywords：

Palmar hyperhidrosis; epidemiology; adolescents; questionnaire survey

DOI：

10.7507/1007-4848.201610018

Video：

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Objective To investigate the prevalence and related factors of primary palmar hyperhidrosis in adolescents in Yangzhou. Methods On-site questionnaire survey was performed on students selected by cluster random sampling from the two colleges and two high or middle schools, with each class as a unit. Data were collected through the questionnaire to make the diagnosis and severity grading. Results A total of 3 487 copies of the questionnaire were distributed in the survey and 3 299 were finished, among which 3 083 were effective with an effective rate of 88.41%. Among them, 1 358 respondents were males and 1 725 were females; 933 were middle school students, 809 high school students, and the remaining 1 341 college students. According to the diagnostic criteria, 104 respondents were diagnosed with palmar hyperhidrosis with an overall prevalence of 3.37%. There were 60 (4.41%) males and 44 (2.55%) females. Although the prevalence of palmar hyperhidrosis in males was higher than that of females (χ²=8.130, P<0.05), severe palmar hyperhidrosis was more often to be observed in females than in males, and females were also more likely to have hyperhidrosis in other parts of the body. In addition, the age of the first onset of the disease was mainly 10 to 20 years old and 36.54% of the patients had a family history. Conclusion The prevalence of palmar hyperhidrosis in adolescents in Yangzhou was 3.37%, and there is a significant difference in the gender. The palmar hyperhidros is often accompanied by hyperhidrosis symptoms of other parts of body, and the disease shows an obvious genetic predisposition.

Citation： YANG Junfeng, WANG Yao, SHAN Yibo, LIU Xingchen, FAN Yiwei, SHI Hongcan. Survey of the prevalence and epidemiological characteristics of primary palmar hyperhidrosis among adolescents in Yangzhou. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(10): 774-778. doi: 10.7507/1007-4848.201610018 Copy

1.	Stashak AB, Brewer JD. Management of hyperhidrosis. Clin Cosmet Investig Dermatol, 2014, 7: 285-299.
2.	Lima SO, Arag?o JF, Machado Neto J, et al. Research of primary hyperhidrosis in students of medicine of the State of Sergipe, Brazil. An Bras Dermatol, 2015, 90(5): 661-665.
3.	Hornberger J, Grimes K, Naumann M, et al. Recognition, diagnosis, and treatment of primary focal hyperhidrosis. J Am Acad Dermatol, 2004, 51(2): 274-286.
4.	Kuhajda I, Djuric D, Milos K, et al. Semi-Fowler vs. lateral decubitus position for thoracoscopic sympathectomy in treatment of primary focal hyperhidrosis. J Thorac Dis, 2015, 7(Suppl 1): S5-S11.
5.	Kouris A, Armyra K, Christodoulou C, et al. Quality of life in patients with focal hyperhidrosis before and after treatment with botulinum toxin A. ISRN Dermatol, 2014: 308650.
6.	Lai FC, Tu YR, Li YP, et al. Nation wide epidemiological survey of primary palmar hyperhidrosis in the People’s Republic of China. Clin Auton Res, 2015, 25(2): 105-108.
7.	Lai YT, Yang LH, Chio CC, et al. Complications in patients with palmar hyperhidrosis treated with transthoracic endoscopic sympathectomy. Neurosurgery, 1997, 41(1): 110-113.
8.	Vazquez LD, Staples NL, Sears SF, et al. Psychosocial functioning of patients after endoscopic thoracic sympathectomy. Eur J Cardiothorac Surg, 2011, 39(6): 1018-1021.
9.	Augustin M, Radtke MA, Herberger K, et al. Prevalence and disease burden of hyperhidrosis in the adult population. Dermatology, 2013, 227(1): 10-13.
10.	Fujimoto T, Kawahara K, Yokozeki H. Epidemiological study and considerations of primary focal hyperhidrosis in Japan: from questionnaire analysis. J Dermatol, 2013, 40(11): 886-890.
11.	涂遠榮, 李旭, 林敏, 等. 福州市大中學生手汗癥患病情況及其相關因素. 福建醫科大學學報, 2005, 39(4): 465-466.
12.	Kuo CH, Yen M, Lin PC. Developing an instrument to measure quality of life of patients with hyperhidrosis. J Nurs Res, 2004, 12(1): 21-30.
13.	Park EJ, Han KR, Choi H, et al. An epidemiological study of hyperhidrosis patients visiting the Ajou University Hospital hyperhidrosis center in Korea. J Korean Med Sci, 2010, 25(5): 772-775.
14.	Wohl Y, Freidman T, Brenner S, et al. Screening for common dermatologic disorders amongst Israeli adolescents. Int J Dermatol, 2007, 46(10): 1046-1049.
15.	Karimian-Teherani D, Panhofer P, Ringhofer C, et al. New epidemiological aspects of patients with severe hyperhidrosis presenting for sympathetic surgery. J Eur Acad Dermatol Venereol, 2009, 23(6): 651-655.
16.	Ong W, Lee A, Tan WB, et al. Long-term results of a randomized controlled trial of T2 versus T2-T3 ablation in endoscopic thoracic sympathectomy for palmar hyperhidrosis. Surg Endosc, 2016, 30(3): 1219-1225.
17.	Ro KM, Cantor RM, Lange KL, et al. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg, 2002, 35(2): 382-386.
18.	Fronek KS, Schmelz M, Krüger S, et al. Effects of gender and level of surgical sympathetic block on vasoconstrictor function. Clin Auton Res, 2003, 13(Suppl 1): I74-I78.
19.	Kaufmann H, Saadia D, Polin C, et al. Primary hyperhidrosis--evidence for autosomal dominant inheritance. Clin Auton Res, 2003, 13(2): 96-98.
20.	李旭, 涂遠榮, 劉合焜, 等. 手汗癥家系的遺傳方式研究. 福建醫科大學學報, 2009, 43(2): 156-158.
21.	Higashimoto I, Yoshiura K, Hirakawa N, et al. Primary palmar hyperhidrosis locus maps to 14q11.2-q13. Am J Med Genet A, 2006, 140(6): 567-572.
22.	Wolosker N, Schvartsman C, Krutman M, et al. Efficacy and quality of life outcomes of oxybutynin for treating palmar hyperhidrosis in children younger than 14 years old. Pediatr Dermatol, 2014, 31(1): 48-53.
23.	Rajagopal R, Mallya NB. Comparative evaluation of botulinum toxin versus iontophoresis with topical aluminium chloride hexahydrate in treatment of palmar hyperhidrosis. Med J Armed Forces India, 2014, 70(3): 247-252.
24.	Yanagishita T, Tamada Y, Ohshima Y, et al. Histological localization of aluminum in topical aluminum chloride treatment for palmar hyperhidrosis. J Dermatol Sci, 2012, 67(1): 69-71.
25.	Kang A, Burns E, Glaser DA. Botulinum toxin A for palmar hyperhidrosis: associated pain, duration, and reasons for discontinuation of therapy. Dermatol Surg, 2015, 41(2): 297-298.
26.	黃冰, 姚明, 周煦燕, 等. CT 引導下經皮穿刺胸交感鏈阻滯治療手汗癥的臨床效果. 中華醫學雜志, 2011, 91(38): 2710-2713.
27.	Liu Y, Li H, Zheng X, et al. Sympathicotomy for palmar hyperhidrosis: the association between intraoperative palm temperature change and the curative effect. Ann Thorac Cardiovasc Surg, 2015, 21(4): 359-363.

1. Stashak AB, Brewer JD. Management of hyperhidrosis. Clin Cosmet Investig Dermatol, 2014, 7: 285-299.
2. Lima SO, Arag?o JF, Machado Neto J, et al. Research of primary hyperhidrosis in students of medicine of the State of Sergipe, Brazil. An Bras Dermatol, 2015, 90(5): 661-665.
3. Hornberger J, Grimes K, Naumann M, et al. Recognition, diagnosis, and treatment of primary focal hyperhidrosis. J Am Acad Dermatol, 2004, 51(2): 274-286.
4. Kuhajda I, Djuric D, Milos K, et al. Semi-Fowler vs. lateral decubitus position for thoracoscopic sympathectomy in treatment of primary focal hyperhidrosis. J Thorac Dis, 2015, 7(Suppl 1): S5-S11.
5. Kouris A, Armyra K, Christodoulou C, et al. Quality of life in patients with focal hyperhidrosis before and after treatment with botulinum toxin A. ISRN Dermatol, 2014: 308650.
6. Lai FC, Tu YR, Li YP, et al. Nation wide epidemiological survey of primary palmar hyperhidrosis in the People’s Republic of China. Clin Auton Res, 2015, 25(2): 105-108.
7. Lai YT, Yang LH, Chio CC, et al. Complications in patients with palmar hyperhidrosis treated with transthoracic endoscopic sympathectomy. Neurosurgery, 1997, 41(1): 110-113.
8. Vazquez LD, Staples NL, Sears SF, et al. Psychosocial functioning of patients after endoscopic thoracic sympathectomy. Eur J Cardiothorac Surg, 2011, 39(6): 1018-1021.
9. Augustin M, Radtke MA, Herberger K, et al. Prevalence and disease burden of hyperhidrosis in the adult population. Dermatology, 2013, 227(1): 10-13.
10. Fujimoto T, Kawahara K, Yokozeki H. Epidemiological study and considerations of primary focal hyperhidrosis in Japan: from questionnaire analysis. J Dermatol, 2013, 40(11): 886-890.
11. 涂遠榮, 李旭, 林敏, 等. 福州市大中學生手汗癥患病情況及其相關因素. 福建醫科大學學報, 2005, 39(4): 465-466.
12. Kuo CH, Yen M, Lin PC. Developing an instrument to measure quality of life of patients with hyperhidrosis. J Nurs Res, 2004, 12(1): 21-30.
13. Park EJ, Han KR, Choi H, et al. An epidemiological study of hyperhidrosis patients visiting the Ajou University Hospital hyperhidrosis center in Korea. J Korean Med Sci, 2010, 25(5): 772-775.
14. Wohl Y, Freidman T, Brenner S, et al. Screening for common dermatologic disorders amongst Israeli adolescents. Int J Dermatol, 2007, 46(10): 1046-1049.
15. Karimian-Teherani D, Panhofer P, Ringhofer C, et al. New epidemiological aspects of patients with severe hyperhidrosis presenting for sympathetic surgery. J Eur Acad Dermatol Venereol, 2009, 23(6): 651-655.
16. Ong W, Lee A, Tan WB, et al. Long-term results of a randomized controlled trial of T2 versus T2-T3 ablation in endoscopic thoracic sympathectomy for palmar hyperhidrosis. Surg Endosc, 2016, 30(3): 1219-1225.
17. Ro KM, Cantor RM, Lange KL, et al. Palmar hyperhidrosis: evidence of genetic transmission. J Vasc Surg, 2002, 35(2): 382-386.
18. Fronek KS, Schmelz M, Krüger S, et al. Effects of gender and level of surgical sympathetic block on vasoconstrictor function. Clin Auton Res, 2003, 13(Suppl 1): I74-I78.
19. Kaufmann H, Saadia D, Polin C, et al. Primary hyperhidrosis--evidence for autosomal dominant inheritance. Clin Auton Res, 2003, 13(2): 96-98.
20. 李旭, 涂遠榮, 劉合焜, 等. 手汗癥家系的遺傳方式研究. 福建醫科大學學報, 2009, 43(2): 156-158.
21. Higashimoto I, Yoshiura K, Hirakawa N, et al. Primary palmar hyperhidrosis locus maps to 14q11.2-q13. Am J Med Genet A, 2006, 140(6): 567-572.
22. Wolosker N, Schvartsman C, Krutman M, et al. Efficacy and quality of life outcomes of oxybutynin for treating palmar hyperhidrosis in children younger than 14 years old. Pediatr Dermatol, 2014, 31(1): 48-53.
23. Rajagopal R, Mallya NB. Comparative evaluation of botulinum toxin versus iontophoresis with topical aluminium chloride hexahydrate in treatment of palmar hyperhidrosis. Med J Armed Forces India, 2014, 70(3): 247-252.
24. Yanagishita T, Tamada Y, Ohshima Y, et al. Histological localization of aluminum in topical aluminum chloride treatment for palmar hyperhidrosis. J Dermatol Sci, 2012, 67(1): 69-71.
25. Kang A, Burns E, Glaser DA. Botulinum toxin A for palmar hyperhidrosis: associated pain, duration, and reasons for discontinuation of therapy. Dermatol Surg, 2015, 41(2): 297-298.
26. 黃冰, 姚明, 周煦燕, 等. CT 引導下經皮穿刺胸交感鏈阻滯治療手汗癥的臨床效果. 中華醫學雜志, 2011, 91(38): 2710-2713.
27. Liu Y, Li H, Zheng X, et al. Sympathicotomy for palmar hyperhidrosis: the association between intraoperative palm temperature change and the curative effect. Ann Thorac Cardiovasc Surg, 2015, 21(4): 359-363.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Survey of the prevalence and epidemiological characteristics of primary palmar hyperhidrosis among adolescents in Yangzhou

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