Curative effect of preoperative ultra-short-course chemotherapy and surgical treatment for chest wall tuberculosis_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANG Weidong , WEI Jinxing , LIU Yuanyuan , SHI Dongfeng , XUE Mingqiang ,  WU Xiaoming , LIANG Qingzheng

Department of Thoracic Surgery, Henan Provincial Chest Hospital, Zhengzhou, 450003, P.R.China;

Corresponding?author：

WU Xiaoming, Email: wxm1010@163.com

Keywords：

Chest wall; tuberculosis; ultra-short-course chemotherapy; surgical treatment

DOI：

10.7507/1007-4848.201803047

Video：

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Objective To investigate the safety and efficacy of preoperative ultra-short-course chemotherapy combined with surgical treatment of chest wall tuberculosis. Methods The clinical data of 216 patients with chest wall tuberculosis from January 2013 to June 2016 in our hospital were retrospectively analyzed, including 121 males and 95 females with an average age of 35±15 years (range, 4-74 years). Results All patients were treated with anti-tuberculosis drugs for 17.0±11.3 days preoperatively, including 12.5±5.0 days in simple chest wall tuberculosis and 19.4±12.3 days in combined chest wall tuberculosis. The postoperative recurrence rate of chest wall tuberculosis was 3.7%, which was close to or lower than that of routine preoperative antituberculous therapy in patients with ultra-short-course anti-tuberculosis treatment before surgery. Conclusion Preoperative ultra-short-course chemotherapy combined with surgical treatment for chest wall tuberculosis will not increase the recurrence rate of chest wall tuberculosis, and can effectively shorten the hospital stay. Timely adjustment of anti-tuberculosis chemotherapy based on thorough debridement, postoperative drugs, not the preoperative drugs, is the key to reinforce the surgical outcome.

Citation： ZHANG Weidong, WEI Jinxing, LIU Yuanyuan, SHI Dongfeng, XUE Mingqiang, WU Xiaoming, LIANG Qingzheng. Curative effect of preoperative ultra-short-course chemotherapy and surgical treatment for chest wall tuberculosis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2018, 25(10): 865-869. doi: 10.7507/1007-4848.201803047 Copy

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5.	Han YI, Zhao Q, Yu D, et al. Treatment of chest wall tuberculosis with transdermal ultrasound-mediated drug delivery. Exp Ther Med, 2015, 9(4): 1433-1437.
6.	王偉, 金明華, 侯慶寶, 等. 胸壁結核的外科治療. 中國胸心血管外科臨床雜志, 2006, 13(2): 139-139.
7.	郭岱. 脊柱結核并截癱患者術前不同化療天數與臨床療效的相關研究. 中南大學, 2010.
8.	鄭俊儒. 脊柱結核術前不同化療時間對手術安全性及預后的研究.新疆醫科大學, 2016.
9.	錢勇, 楊繼承, 袁躍西. 120 例胸壁結核外科治療體會. 中國現代手術學雜志, 2011, 15(5): 364-365.
10.	黃喜峰, 韋鳴, 廖勇, 等. 54 例胸壁結核的外科治療經驗回顧. 中國防癆雜志, 2011, 33(4): 247-248.
11.	金鋒, 王成, 劉景亮, 等. 外科治療復發性胸壁結核 61 例報告. 中國現代醫學雜志, 2006, 16(16): 2542-2543.
12.	王剛, 劉武新, 周旭東, 等. 外科治療 373 例胸壁結核的臨床分析. 臨床肺科雜志, 2007, 12(2): 134-135.
13.	劉麗君, 張維民, 王福臣, 等. 胸壁結核術后復發原因的探討. 中國防癆雜志, 2005, 27(4): 272-273.

1. García S, Combalía A, Serra A, et al. Unusual locations of osteoarticular tuberculosis. Arch Orthop Trauma Surg, 1997, 116(6-7): 321-323.
2. Teo TH, Ho GH, Chaturverdi A, et al. Tuberculosis of the chest wall: unusual presentation as a breast lump. Singapore Med J, 2009, 50(3): e97-e99.
3. 彭衛生, 王英年, 肖成志. 主編. 新編結核病學. 第 2 版. 北京: 中國醫藥科技出版社, 2003. 230-231.
4. 李亮, 李琦, 許紹發, 等. 主編. 結核病治療學. 第 1 版. 北京: 人民衛生出版社, 2013.314-316.
5. Han YI, Zhao Q, Yu D, et al. Treatment of chest wall tuberculosis with transdermal ultrasound-mediated drug delivery. Exp Ther Med, 2015, 9(4): 1433-1437.
6. 王偉, 金明華, 侯慶寶, 等. 胸壁結核的外科治療. 中國胸心血管外科臨床雜志, 2006, 13(2): 139-139.
7. 郭岱. 脊柱結核并截癱患者術前不同化療天數與臨床療效的相關研究. 中南大學, 2010.
8. 鄭俊儒. 脊柱結核術前不同化療時間對手術安全性及預后的研究.新疆醫科大學, 2016.
9. 錢勇, 楊繼承, 袁躍西. 120 例胸壁結核外科治療體會. 中國現代手術學雜志, 2011, 15(5): 364-365.
10. 黃喜峰, 韋鳴, 廖勇, 等. 54 例胸壁結核的外科治療經驗回顧. 中國防癆雜志, 2011, 33(4): 247-248.
11. 金鋒, 王成, 劉景亮, 等. 外科治療復發性胸壁結核 61 例報告. 中國現代醫學雜志, 2006, 16(16): 2542-2543.
12. 王剛, 劉武新, 周旭東, 等. 外科治療 373 例胸壁結核的臨床分析. 臨床肺科雜志, 2007, 12(2): 134-135.
13. 劉麗君, 張維民, 王福臣, 等. 胸壁結核術后復發原因的探討. 中國防癆雜志, 2005, 27(4): 272-273.

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Curative effect of preoperative ultra-short-course chemotherapy and surgical treatment for chest wall tuberculosis

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