Diagnosis value of microRNA-1 for acute myocardial infarction: A meta-analysis_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

YI Kang ^1,2 , MA Long ^2,3 ,  YOU Tao ^1,2 , XU Jianguo ^2,3 , HOU Xiaodong ^1,2 , WANG Dan ^2,3 , YANG Kexin ^2,3

1. Department of Cardiovascular Surgery, Gansu Provincial Hospital, Lanzhou, 730000, P.R.China;
2. The First Clinical Medical College of Lanzhou University, Lanzhou, 73000, P.R.China;
3. Congenital Heart Disease Diagnosis and Treatment Gansu Province International Science and Technology Cooperation Base, Lanzhou, 730000, P.R.China;

Corresponding?author：

YOU Tao, Email: syxzwk@126.com

Keywords：

MicroRNA-1; myocardial infarction; diagnosis; meta-analysis

DOI：

10.7507/1007-4848.201810043

Video：

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Objective To systematically evaluate the clinical value of miRNA-1 in the diagnosis of acute myocardial infarction (AMI) patients.Methods We searched PubMed, EMbase, Cochrane Library, CNKI, Wangfang, VIP, etc databases to identify literature about miRNA-1 in the diagnosis of AMI. Quality of the included literature was assessed by (quality assessment for diagnostic accuracy studies-2, QUADAS-2). The indices of pooled sensitivity (Sen), specificity (Spe), positivity likelihood ratio (PLR), negative likelihood ratio (NLR), diagnosis odds ratio (DOR), and the area under the summary receiver operating characteristic (SROC) curve were pooled using MetaDisc 1.4 software.Results A total of 12 articles were included. According to the different populations of miRNA-1 to be tested, subgroup analysis of healthy people (7 articles) and non-AMI disease groups (5 articles) was conducted. The results showed that AMI compared with healthy people, the pooled Sen was 0.78 with 95%CI 0.73 to 0.82, Spe was 0.88 with 95%CI 0.83 to 0.91 of miRNA-1 in the diagnosis of AMI. AUC of SROC curve was 0.911 2. Comparison of AMI and non-AMI patients, the pooled Sen was 0.59 with 95%CI 0.54 to 0.64, Spe was 0.74 with 95%CI 0.68 to 0.79 of miRNA-1 in the diagnosis of AMI. AUC of SROC curve was 0.743 2.Conclusion MiRNA-1 has a certain value in the diagnosis of AMI. It has an advantage in identifying AMI and patients with other systemic diseases, and can be combined with other biomarkers to diagnose AMI.

Citation： YI Kang, MA Long, YOU Tao, XU Jianguo, HOU Xiaodong, WANG Dan, YANG Kexin. Diagnosis value of microRNA-1 for acute myocardial infarction: A meta-analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(7): 633-641. doi: 10.7507/1007-4848.201810043 Copy

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2.	Yeh R, Sidney S, Chandra M, et al. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med, 2010, 362(23): 2155-2165.
3.	Renard D. Serum CK as a guide to the diagnosis of muscle disease. Pract Neurol, 2015, 15(2): 121.
4.	Li X, Luo R, Jiang R, et al. The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy. Heart Lung, 2014, 43(3): 219-224.
5.	Lippi G, Mattiuzzi C, Cervellin G. Circulating microRNAs (miRs) for diagnosing acute myocardial infarction: meta-analysis of available studies. Inter J Cardiol, 2013, 167(1): 277-278.
6.	Wang R, Li N, Zhang Y, et al. Circulating microRNAs are promising novel biomarkers of acute myocardial infarction. Inter Med, 2011, 50(17): 1789.
7.	Pol E, Boing AN, Harrison P, et al. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev, 2012, 64: 676-705.
8.	Huang ZP, Jr R LN, Wang DZ. Application of MicroRNA in cardiac and skeletal muscle disease gene therapy. Methods Mol Biol, 2011, 709: 197.
9.	D'Alessandra Y, Devanna P, Limana F, et al. Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J, 2010, 31(22): 2765-2773.
10.	Cheng C, Wang Q, You W, et al. MiRNAs as biomarkers of myocardial infarction: a meta-analysis. Plos One, 2014, 9(2): e88566.
11.	Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Inter Mede, 2011, 155(8): 529-536.
12.	楊壽娟, 主編. miRNA 與冠心病的關系及其臨床意義. 天津醫科大學, 2015.
13.	Li C, Fang Z, Jiang T, et al. Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. BMC Med Genomics, 2013, 6(1): 16-16.
14.	許浩軍. 循環 MicroRNA 檢測在急性冠脈綜合征的診斷及預后判斷中的意義. 江蘇大學, 2015.
15.	Ai J, Zhang R, Li Y, et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochemical & Biophysical Research Communications, 2010, 391(1): 73-77.
16.	Gidl?f O, Andersson P, Pals JVD, et al. Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples. Cardiol, 2011, 118(4): 217-226.
17.	Li YQ, Zhang MF, Wen HY, et al. Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction. Clinics, 2013, 68(1): 75-80.
18.	Long G, Feng W, Duan Q, et al. Human circulating microRNA-1 and microRNA-126 as potential Novel Indicators for Acute Myocardial Infarction. Inter J Biol Sci, 2012, 8(6): 811-818.
19.	Xian L, Zhanwei F, Tianshu Z, et al. Plasma miR-1, miR-208, miR-499 as potential predictive biomarkers for acute myocardial infarction: An independent study of Han population. Exp Gerontol, 2015, 72: 230.
20.	Li LM, Cai WB, Ye Q, et al. Comparison of plasma microRNA-1 and cardiac troponin T in early diagnosis of patients with acute myocardial infarction. World J Emergency Medicine, 2014, 5(3): 182.
21.	Kuwabara Y, Ono K, Horie T, et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet, 2011, 4(4): 446-454.
22.	Gidl?f O, Smith JG, Miyazu K, et al. Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction. BMC Cardiovasc Disorders, 2013, 13(1): 12.
23.	Wang GK, Zhu JQ, Zhang JT, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J, 2010, 31(6): 659.
24.	Jaguszewski M, Osipova J, Ghadri JR, et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. Eur Heart J, 2014, 35(15): 999.
25.	翟川楠. 血漿 microRNA-1 表達水平與冠心病診斷及預后的相關性研究. 天津醫科大學, 2016.
26.	田志鵬, 孟亮, 楊帆, 等. microRNA-1 對急性心肌梗死的早期診斷價值研究. 中國現代醫學雜志, 2015, 25(17): 30-34.
27.	徐磊, 劉宏宇. 心肌超聲造影評價存活心肌的應用進展. 中國胸心血管外科臨床雜志, 2012, 19(5): 551-554.
28.	Saunders JT, Nambi V, de Lemos JA, et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation, 2011, 123(13): 1367-1376.
29.	李春雨, 姜婷, 王魏魏, 等. 微小 RNA 對中國急性心肌梗死患者早期診斷價值的 Meta 分析. 臨床心血管病雜志, 2016, 32(7): 668-673.
30.	Mayr M, Lee R, Kaudewitz D, et al. Effects of heparin on temporal microRNA profiles. J Am Coll Cardiol, 2014, 63(9): 940-994.
31.	Sayed A S, Xia K, Yang T L, et al. Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial infarction. Disease Markers, 2014, 35(5): 561-566.

1. Roger. Heart disease and stroke statistics-2011 update: A report from the American Heart Association. Circulation, 2011, 124(16): e426.
2. Yeh R, Sidney S, Chandra M, et al. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med, 2010, 362(23): 2155-2165.
3. Renard D. Serum CK as a guide to the diagnosis of muscle disease. Pract Neurol, 2015, 15(2): 121.
4. Li X, Luo R, Jiang R, et al. The prognostic use of serum concentrations of cardiac troponin-I, CK-MB and myoglobin in patients with idiopathic dilated cardiomyopathy. Heart Lung, 2014, 43(3): 219-224.
5. Lippi G, Mattiuzzi C, Cervellin G. Circulating microRNAs (miRs) for diagnosing acute myocardial infarction: meta-analysis of available studies. Inter J Cardiol, 2013, 167(1): 277-278.
6. Wang R, Li N, Zhang Y, et al. Circulating microRNAs are promising novel biomarkers of acute myocardial infarction. Inter Med, 2011, 50(17): 1789.
7. Pol E, Boing AN, Harrison P, et al. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev, 2012, 64: 676-705.
8. Huang ZP, Jr R LN, Wang DZ. Application of MicroRNA in cardiac and skeletal muscle disease gene therapy. Methods Mol Biol, 2011, 709: 197.
9. D'Alessandra Y, Devanna P, Limana F, et al. Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J, 2010, 31(22): 2765-2773.
10. Cheng C, Wang Q, You W, et al. MiRNAs as biomarkers of myocardial infarction: a meta-analysis. Plos One, 2014, 9(2): e88566.
11. Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Inter Mede, 2011, 155(8): 529-536.
12. 楊壽娟, 主編. miRNA 與冠心病的關系及其臨床意義. 天津醫科大學, 2015.
13. Li C, Fang Z, Jiang T, et al. Serum microRNAs profile from genome-wide serves as a fingerprint for diagnosis of acute myocardial infarction and angina pectoris. BMC Med Genomics, 2013, 6(1): 16-16.
14. 許浩軍. 循環 MicroRNA 檢測在急性冠脈綜合征的診斷及預后判斷中的意義. 江蘇大學, 2015.
15. Ai J, Zhang R, Li Y, et al. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction. Biochemical & Biophysical Research Communications, 2010, 391(1): 73-77.
16. Gidl?f O, Andersson P, Pals JVD, et al. Cardiospecific microRNA plasma levels correlate with troponin and cardiac function in patients with ST elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples. Cardiol, 2011, 118(4): 217-226.
17. Li YQ, Zhang MF, Wen HY, et al. Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction. Clinics, 2013, 68(1): 75-80.
18. Long G, Feng W, Duan Q, et al. Human circulating microRNA-1 and microRNA-126 as potential Novel Indicators for Acute Myocardial Infarction. Inter J Biol Sci, 2012, 8(6): 811-818.
19. Xian L, Zhanwei F, Tianshu Z, et al. Plasma miR-1, miR-208, miR-499 as potential predictive biomarkers for acute myocardial infarction: An independent study of Han population. Exp Gerontol, 2015, 72: 230.
20. Li LM, Cai WB, Ye Q, et al. Comparison of plasma microRNA-1 and cardiac troponin T in early diagnosis of patients with acute myocardial infarction. World J Emergency Medicine, 2014, 5(3): 182.
21. Kuwabara Y, Ono K, Horie T, et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ Cardiovasc Genet, 2011, 4(4): 446-454.
22. Gidl?f O, Smith JG, Miyazu K, et al. Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction. BMC Cardiovasc Disorders, 2013, 13(1): 12.
23. Wang GK, Zhu JQ, Zhang JT, et al. Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J, 2010, 31(6): 659.
24. Jaguszewski M, Osipova J, Ghadri JR, et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction. Eur Heart J, 2014, 35(15): 999.
25. 翟川楠. 血漿 microRNA-1 表達水平與冠心病診斷及預后的相關性研究. 天津醫科大學, 2016.
26. 田志鵬, 孟亮, 楊帆, 等. microRNA-1 對急性心肌梗死的早期診斷價值研究. 中國現代醫學雜志, 2015, 25(17): 30-34.
27. 徐磊, 劉宏宇. 心肌超聲造影評價存活心肌的應用進展. 中國胸心血管外科臨床雜志, 2012, 19(5): 551-554.
28. Saunders JT, Nambi V, de Lemos JA, et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation, 2011, 123(13): 1367-1376.
29. 李春雨, 姜婷, 王魏魏, 等. 微小 RNA 對中國急性心肌梗死患者早期診斷價值的 Meta 分析. 臨床心血管病雜志, 2016, 32(7): 668-673.
30. Mayr M, Lee R, Kaudewitz D, et al. Effects of heparin on temporal microRNA profiles. J Am Coll Cardiol, 2014, 63(9): 940-994.
31. Sayed A S, Xia K, Yang T L, et al. Circulating microRNAs: a potential role in diagnosis and prognosis of acute myocardial infarction. Disease Markers, 2014, 35(5): 561-566.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Diagnosis value of microRNA-1 for acute myocardial infarction: A meta-analysis

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