Analysis of risk factors for lymph node metastasis in T2 stage non-small cell lung cancer_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

ZHANG Xianfei , JIN Runsen , ZHENG Yuyan , ZHANG Yajie , HAN Dingpei , CHEN Kai ,  LI Hecheng

Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R.China;

Corresponding?author：

LI Hecheng, Email: lihecheng2000@hotmail.com

Keywords：

Non-small cell lung cancer; T2 stage; risk factors; surgery

DOI：

10.7507/1007-4848.202001039

Video：

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Objective To explore the risk factors for lymph node metastasis in patients with T2 stage non-small cell lung cancer.Methods The clinical data of 271 patients with non-small cell lung cancer who underwent surgical treatment in our hospital from 2014 to 2017 were collected, including 179 males and 92 females, with an average age of 62.73±0.58 years. The patients were divided into N0, N1, and N2 groups according to the lymph node metastasis status. The clinical data of the patients in different groups were compared.Results The body mass index (BMI, P=0.043), preoperative lymph node enlargement (P<0.001), and tumor diameter (P<0.001) were significantly different among groups. The BMI (OR=1.131, 95%CI 1.001-1.277, P=0.048) and preoperative lymph node enlargement (OR=3.498, 95%CI 1.666-7.342, P=0.001) were independent risk factors for N2 lymph node metastasis, and tumor diameter was an independent risk factor for both N1 (OR=1.538, 95%CI 1.067-2.218, P=0.021) and N2 (OR=1.814, 95%CI 1.196-2.752, P=0.005) lymph node metastasis.Conclusion Patients with high BMI or enlarged lymph nodes before surgery have a high risk for N2 lymph node metastasis, and those with large tumor diameter have a high risk for both N1 and N2 lymph node metastasis.

Citation： ZHANG Xianfei, JIN Runsen, ZHENG Yuyan, ZHANG Yajie, HAN Dingpei, CHEN Kai, LI Hecheng. Analysis of risk factors for lymph node metastasis in T2 stage non-small cell lung cancer. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(10): 1194-1200. doi: 10.7507/1007-4848.202001039 Copy

1.	Detterbeck FC, Boffa DJ, Kim AW, <italic>et al</italic>. The eighth edition lung cancer stage classification. Chest, 2017, 151(1): 193-203.
2.	Chansky K, Detterbeck FC, Nicholson AG, <italic>et al</italic>. The IASLC Lung Cancer Staging Project: External validation of the revision of the TNM Stage Groupings in the eighth edition of the TNM classification of lung cancer. J Thorac Oncol, 2017, 12(7): 1109-1121.
3.	Sui X, Jiang W, Chen H, <italic>et al</italic>. Validation of the stage groupings in the eighth edition of the TNM classification for lung cancer. J Thorac Oncol, 2017, 12(11): 1679-1686.
4.	李珊珊, 許凝, 高巖, 等. T2 期非小細胞肺癌 N1 特點及影響因素分析. 中國胸心血管外科臨床雜志, 2018, 25(3): 293-298.
5.	蔡磊, 梁津逍, 陳倩, 等. 非小細胞肺癌患者 N2 組淋巴結轉移相關因素分析和淋巴結清除范圍選擇. 中國醫師雜志, 2019, 21(2): 232-234, 238.
6.	Secretan B, Straif K, Baan R, <italic>et al</italic>. A review of human carcinogens--Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol, 2009, 10(11): 1033-1034.
7.	蘇鳴崗, 李芳蘭, 田蓉, 等. 非小細胞肺癌 N2 淋巴結轉移的危險因素分析. 中華核醫學與分子影像雜志, 2014, 34(2): 86-90.
8.	Chen B, Xia W, Wang Z, <italic>et al</italic>. Risk analyses of N2 lymph-node metastases in patients with T1 non-small cell lung cancer: a multi-center real-world observational study in China. J Cancer Res Clin Oncol, 2019, 145(11): 2771-2777.
9.	張曉林, 余建群, 李春晴, 等. CT 檢查非小細胞肺癌患者縱隔淋巴結轉移效果研究. 河北醫藥, 2018, 40(21): 3253-3256.
10.	張治發. 術前增強 CT 檢查與淋巴結轉移相關性在非小細胞肺癌患者診斷中的研究. 影像研究與醫學應用, 2019, 3(17): 129-130.

1. Detterbeck FC, Boffa DJ, Kim AW, <italic>et al</italic>. The eighth edition lung cancer stage classification. Chest, 2017, 151(1): 193-203.
2. Chansky K, Detterbeck FC, Nicholson AG, <italic>et al</italic>. The IASLC Lung Cancer Staging Project: External validation of the revision of the TNM Stage Groupings in the eighth edition of the TNM classification of lung cancer. J Thorac Oncol, 2017, 12(7): 1109-1121.
3. Sui X, Jiang W, Chen H, <italic>et al</italic>. Validation of the stage groupings in the eighth edition of the TNM classification for lung cancer. J Thorac Oncol, 2017, 12(11): 1679-1686.
4. 李珊珊, 許凝, 高巖, 等. T2 期非小細胞肺癌 N1 特點及影響因素分析. 中國胸心血管外科臨床雜志, 2018, 25(3): 293-298.
5. 蔡磊, 梁津逍, 陳倩, 等. 非小細胞肺癌患者 N2 組淋巴結轉移相關因素分析和淋巴結清除范圍選擇. 中國醫師雜志, 2019, 21(2): 232-234, 238.
6. Secretan B, Straif K, Baan R, <italic>et al</italic>. A review of human carcinogens--Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol, 2009, 10(11): 1033-1034.
7. 蘇鳴崗, 李芳蘭, 田蓉, 等. 非小細胞肺癌 N2 淋巴結轉移的危險因素分析. 中華核醫學與分子影像雜志, 2014, 34(2): 86-90.
8. Chen B, Xia W, Wang Z, <italic>et al</italic>. Risk analyses of N2 lymph-node metastases in patients with T1 non-small cell lung cancer: a multi-center real-world observational study in China. J Cancer Res Clin Oncol, 2019, 145(11): 2771-2777.
9. 張曉林, 余建群, 李春晴, 等. CT 檢查非小細胞肺癌患者縱隔淋巴結轉移效果研究. 河北醫藥, 2018, 40(21): 3253-3256.
10. 張治發. 術前增強 CT 檢查與淋巴結轉移相關性在非小細胞肺癌患者診斷中的研究. 影像研究與醫學應用, 2019, 3(17): 129-130.

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Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Analysis of risk factors for lymph node metastasis in T2 stage non-small cell lung cancer

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