Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
Supervisor：Ministry of Education of People’s Republic of ChinaSponsor：Sichuan University Editor-in-chief：Liu Lunxu Publishing period：
Monthly
ISSN：1007-4848CN：51-1492/R
Objective To investigate the protective effect and mechanism of curcumin on lipopolysaccharide (LPS)-induced acute lung injury.Methods Totally 24 SD rats were randomly divided into a control group, a LPS group and a LPS+curcumin group (n=8 in each group). The degree of lung injury (oxygen partial pressure, wet/dry ratio, pathological scores) and inflammatory levels [tumor necrosis factor (TNF)-α, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, Toll-like receptor 4 (TLR4), mobility group box 1 protein (HMGB1) expression] of the lung were detected in different groups.Results Oxygen partial pressure was significantly lower in the LPS group than that in the control group (P<0.05), while wet/dry ratio, pathological scores and expression levels of TNF-α, IL-6, MCP-1, TLR4 and HMGB1 were significantly higher in the LPS group than those in the control group (P<0.05). Compared with the LPS group, curcumin significantly reduced wet/dry ratio, pathological scores and expression levels of TNF-α, IL-6, MCP-1, TLR4 and HMGB1 in the LPS+curcumin group (P<0.05), while it significantly improved oxygen partial pressure (P<0.05).Conclusion Curcumin might protect LPS-induced acute lung injury through inhibition of TLR4-HMGB1-inflammation pathway.
Citation：QIN Zhen, WANG Bo, TAN Zhaoxia, LUO Shuhua. Curcumin inhibits Toll-like receptor 4/high mobility group box 1 pathway to protect lipopolysaccharide-induced acute lung injury. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(6): 685-688. doi: 10.7507/1007-4848.202002050Copy
Copyright ? the editorial department of Chinese Journal of Clinical Thoracic and Cardiovascular Surgery of West China Medical Publisher. All rights reserved
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1. Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: advances in diagnosis and treatment. JAMA, 2018, 319(7): 698-710.
2. Patel VJ, Biswas Roy S, Mehta HJ, et al. Alternative and natural therapies for acute lung injury and acute respiratory distress syndrome. Biomed Res Int, 2018, 2018: 2476824.
3. He Y, Yue Y, Zheng X, et al. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules, 2015, 20(5): 9183-9213.
4. Jantan I, Bukhari SN, Lajis NH, et al. Effects of diarylpentanoid analogues of curcumin on chemiluminescence and chemotactic activities of phagocytes. J Pharm Pharmacol, 2012, 64(3): 404-412.
6. Cheng K, Yang A, Hu X, et al. Curcumin attenuates pulmonary inflammation in lipopolysaccharide induced acute lung injury in neonatal rat model by activating peroxisome proliferator-activated receptor γ (PPARγ) pathway. Med Sci Monit, 2018, 24: 1178-1184.
7. Kim J, Jeong SW, Quan H, et al. Effect of curcumin (curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK. J Anesth, 2016, 30(1): 100-108.
8. P?óciennikowska A, Hromada-Judycka A, Borz?cka K, et al. Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling. Cell Mol Life Sci, 2015, 72(3): 557-581.
9. Andersson U, Yang H, Harris H. Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert Opin Ther Targets, 2018, 22(3): 263-277.
10. Tanger?s LH, Silva GB, St?dle GS, et al. Placental inflammation by HMGB1 activation of TLR4 at the syncytium. Placenta, 2018, 72-73: 53-61.
11. Shang L, Wang L, Shi X, et al. HMGB1 was negatively regulated by HSF1 and mediated the TLR4/MyD88/NF-κB signal pathway in asthma. Life Sci, 2020, 241: 117120.
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Citation：QIN Zhen, WANG Bo, TAN Zhaoxia, LUO Shuhua. Curcumin inhibits Toll-like receptor 4/high mobility group box 1 pathway to protect lipopolysaccharide-induced acute lung injury. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2020, 27(6): 685-688. doi: 10.7507/1007-4848.202002050
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