The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage <b>Ⅰ</b>-<b>Ⅲ</b>A by two different follow-up patterns: A multi-center, real-world study_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

SUN Daqiang ¹ , CHEN Pingyan ² , LIU Lunxu ³ , LI Xiaofei ⁴ , HU Jian ⁵ , XU Lin ⁶ , FU Xiangning ⁷ , LIU Yang ⁸ , LIU Deruo ⁹ , ZHANG Xun ¹ ,  HE Jianxing ¹⁰

1. Department of Thoracic Surgery of Tianjin Chest Hospital, Tianjin, 300051, P.R.China;
2. Hainan Institute of Real World Data, Department of Biostatistics, Southern Medical University, Guangzhou, 510515, P.R.China;
3. Department of Thoracic Surgery of West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
4. Department of Thoracic Surgery of Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, P.R.China;
5. Department of Thoracic Surgery of The First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou, 310009, P.R.China;
6. Department of Thoracic Surgery of Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, 210009, P.R.China;
7. Department of Thoracic Surgery of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430010, P.R.China;
8. Department of Thoracic Surgery of Chinese People’s Liberation Army General Hospital, Beijing, 100038, P.R.China;
9. Department of Thoracic Surgery of China-Japan Friendship Hospital, Beijing, 100029, P.R.China;
10. Department of Thoracic Surgery of The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P.R.China;

Corresponding?author：

HE Jianxing, Email: drjianxing.he@gmail.com

Keywords：

Non-small cell lung cancer; surgical resection; follow-up pattern; 5-year survival rate; real-world study

DOI：

10.7507/1007-4848.202104103

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Abstract Full text Figures/Tables Video References Cited by

Objective To compare the 5-year survival rates between two different follow-up patterns of postoperative stage Ⅰ-ⅢA non-small cell lung cancer (NSCLC) patients.Methods Pathological stage Ⅰ-ⅢA NSCLC 11 958 patients who underwent surgical resection and received follow-up within 6 months after initial diagnosis through telephone follow-up system were included in nine hospitals from July 2014 to July 2020. The patients were divided into two groups including a proactive follow-up group (n=3 825) and a passive follow-up group (n=8133) according to the way of following-up. There were 6 939 males and 5 019 females aged 59.8±9.5 years. The Kaplan-Meier and Cox proportional hazards regression model were used.Results The median follow-up frequency was 8.0 times in the proactive follow-up group and 7.0 times in the passive follow-up group. The median call duration was 3.77 minutes in the proactive follow-up group and 3.58 minutes in the passive follow-up group. The 5-year survival rate was 81.8% and 74.2% (HR=0.60, 95CI 0.53-0.67, P<0.001) in the proactive follow-up group and the passive follow-up group, respectively. Multivariate analysis showed that follow-up pattern, age, gender and operation mode were independent prognostic factors, and the results were consistent in all subgroups stratified by clinical stages.Conclusion The proactive follow-up leads to better overall survival for resected stage Ⅰ-ⅢA NSCLC patients, especially in the stage ⅢA.

Citation： SUN Daqiang, CHEN Pingyan, LIU Lunxu, LI Xiaofei, HU Jian, XU Lin, FU Xiangning, LIU Yang, LIU Deruo, ZHANG Xun, HE Jianxing. The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage Ⅰ-ⅢA by two different follow-up patterns: A multi-center, real-world study. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2021, 28(6): 615-622. doi: 10.7507/1007-4848.202104103 Copy

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19.	常艷鵬, 魏戌, 謝雁鳴. 臨床隨訪研究中存在的問題及對策. 中醫雜志, 2012, 53(22): 1913-1916.

1. 鄭榮壽, 孫可欣, 張思維, 等. 2015年中國惡性腫瘤流行情況分析. 中華腫瘤雜志, 2019, 41(1): 19-28.
2. 周來燕, 盧鈾. 早期非小細胞肺癌術后復發的預測因子. 臨床腫瘤學雜志, 2020, 25(7): 650-655.
3. 劉倫旭, 高樹庚, 何建行, 等. 非小細胞肺癌術后隨訪中國胸外科專家共識. 中國胸心血管外科臨床雜志, 2021, 28(1): 4-10.
4. Yun YH, Kim YA, Sim JA, et al. Prognostic value of quality of life score in disease-free survivors of surgically-treated lung cancer. BMC Cancer, 2016, 20(16): 505.
5. Denis F, Basch E, Septans AL, Bennouna J, et al. Two-year survival comparing web-based symptom monitoring vs routine surveillance following treatment for lung cancer. JAMA, 2019, 321(3): 306-307.
6. Ruland CM, Holte HH, R?islien J, et al. Effects of a computer-supported interactive tailored patient assessment tool on patient care, symptom distress, and patients' need for symptom management support: A randomized clinical trial. JAMIA, 2010, 17(4): 403-410.
7. Gustavell T, Sundberg K, Segersv?rd R, et al. Decreased symptom burden following surgery due to support from an interactive app for symptom management for patients with pancreatic and periampullary cancer. Acta Oncol, 2019, 58(9): 1307-1314.
8. 廖虎, 梅建東, 劉成武, 等. 中國三級醫院胸外科學科臨床發展現狀的調查研究. 中華外科雜志, 2018, 56(12): 888-891.
9. 李萍, 蘇澤琦, 李園, 等. 影響中醫臨床隨訪研究數據質量的常見問題及對策. 現代中醫臨床, 2019, 26(6): 44-49.
10. 王天園, 孫星, 胡晶, 等. 中醫藥臨床試驗中電話隨訪的方法學應對與思考. 中國全科醫學, 2021, 24(2): 248-252.
11. U. S. Department of Health and Human Services FDA Center for Drug Evaluation and Research, U. S. Department of Health and Human Services FDA Center for Biologics Evaluation and Research; U. S. Department of Health and Human Services FDA Center for Devices and Radiological Health. Guidance for industry: Patient-reported outcome measures: Use in medical product development to support labeling claims: Draft guidance. Health Qual Life Outcomes, 2006, 4: 79.
12. Gustavell T, Sundberg K, Langius-Ekl?f A. Using an interactive app for symptom reporting and management following pancreatic cancer surgery to facilitate person-centered care: Descriptive study. JMIR Mhealth Uhealth, 2020, 8(6): e17855.
13. Onuma AE, Palmer Kelly E, Chakedis J, et al. Patient preferences on the use of technology in cancer surveillance after curative surgery: A cross-sectional analysis. Surg, 2019, 165(4): 782-788.
14. Degenhardt T, Harbeck N, Fasching PA, et al. Documentation patterns and impact on observed side effects of the CANKADO ehealth application: An exploratory analysis of the PreCycle trial. J Clin Oncol, 2020, 38(15): 2083-2083.
15. Basch E, Deal AM, Dueck AC, et al. Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment. JAMA, 2017, 318(2): 197-198.
16. Sawicki C, Friend KE, Patel R, et al. Two-way clinical messaging in a CML specialty pharmacy service model. J Manag Care Spec Pharm, 2019, 25(11): 1290-1296.
17. 戴維, 石丘玲, 李強, 等. 基于患者報告結局的癥狀管理在肺癌外科的應用現狀. 中國胸心血管外科臨床雜志, 2020, 27(10): 1228-1234.
18. 劉加林, 梁傳余, 王力紅, 等. 《華西醫學》臨床資料隨訪的現狀與對策. 華西醫學, 2005, 20(1): 7-8.
19. 常艷鵬, 魏戌, 謝雁鳴. 臨床隨訪研究中存在的問題及對策. 中醫雜志, 2012, 53(22): 1913-1916.

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The 5-year survival rate of 11 958 postoperative non-small cell lung cancer patients in stage Ⅰ-ⅢA by two different follow-up patterns: A multi-center, real-world study

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