Mediastinal ectopic papillary thyroid carcinoma: A case report_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

MAO Mingyi ¹ , LIU Lei ² , LI Shanqing ² ,  CHEN Yeye ²

1. 4+4 Medical Doctor Program, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, P. R. China;
2. Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, P. R. China;

Corresponding?author：

CHEN Yeye, Email: chenyeye@pumch.cn

Keywords：

Mediastinal tumor; ectopic thyroid carcinoma; case report

DOI：

10.7507/1007-4848.202208026

Video：

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We report a 50-year-old man with mediastinal tumor. The patient received the thoracoscopic resection for mediastinal tumor with the operative time of 1 h and intraoperative blood loss of 10 mL. The final diagnosis after surgical excision was an ectopic papillary thyroid carcinoma. The patient recovered well without surgery-related complications, and was discharged on the 2nd day after the operation. No recurrence was found during the follow-up. We also reviewed relevant literature to explore the clinical features, diagnosis, and treatment of ectopic thyroid carcinoma.

Citation： MAO Mingyi, LIU Lei, LI Shanqing, CHEN Yeye. Mediastinal ectopic papillary thyroid carcinoma: A case report. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2023, 30(11): 1666-1668. doi: 10.7507/1007-4848.202208026 Copy

1.	Guerra G, Cinelli M, Mesolella M, et al. Morphological, diagnostic and surgical features of ectopic thyroid gland: A review of literature. Int J Surg, 2014, 12 Suppl 1: S3-S11.
2.	金鋒, 王明訓, 楊寶嶺. 完全型縱隔內甲狀腺癌一例. 實用癌癥雜志, 1992, (4): 276.
3.	Dominguez-Malagon H, Guerrero-Medrano J, Suster S. Ectopic poorly differentiated (insular) carcinoma of the thyroid. Report of a case presenting as an anterior mediastinal mass. Am J Clin Pathol, 1995, 104(4): 408-412.
4.	Sand J, Pehkonen E, Mattila J, et al. Pulsating mass at the sternum: A primary carcinoma of ectopic mediastinal thyroid. J Thorac Cardiovasc Surg, 1996, 112(3): 833-835.
5.	杜淼, 張哉根. 縱隔異位甲狀腺乳頭狀腺癌一例. 中華腫瘤雜志, 2003, (3): 90.
6.	李高峰, 張長弓, 巫正偉. 胸內異位甲狀腺乳頭狀腺癌1例. 云南醫藥, 2003, 24(2): 164.
7.	Yoshino M, Mizobuchi T, Fujiwara T, et al. Large mediastinal cyst of an ectopic thyroid with small nodules diagnosed as papillary carcinoma. Jpn J Thorac Cardiovasc Surg, 2006, 54(12): 550-554.
8.	Shah BC, Ravichand C, Juluri S, et al. Ectopic thyroid cancer. Anna Thorac Cardiovasc Surg, 2007, 13(2): 122.
9.	Camargos EF, Pandolfi MB, Toledo MA, et al. A 95-year-old woman with leucocytosis and eosinophilia: Anaplastic carcinoma in an ectopic thyroid. BMJ Case Rep, 2010, 2010: 2823.
10.	Piciu D, Piciu A, Irimie A. Papillary thyroid microcarcinoma and ectopic papillary thyroid carcinoma in mediastinum: A case report. Clin Nucl Med, 2012, 37(2): 214-215.
11.	林鋒, 肖家榮, 冉鵬, 等. 頸部甲狀腺腺瘤并縱隔異位甲狀腺癌一例. 中華外科雜志, 2013, 51(10): 958.
12.	Shafiee S, Sadrizade A, Jafarian A, et al. Ectopic papillary thyroid carcinoma in the mediastinum without any tumoral involvement in the thyroid gland. A case report. Asia Ocean J Nucl Med Biol, 2013, 1(1): 44-46.
13.	吳彬, 楊洋, 齊宇, 等. 縱隔異位甲狀腺癌誤診一例. 中華外科雜志, 2014, 52(10): 800.
14.	Hu J, Li M, Xu L. Ectopic thyroid cancer diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. Thorac Cancer, 2017, 8(6): 703-705.
15.	Karim F, Inam H, Choudry UK, et al. Ectopic follicular variant of papillary thyroid carcinoma in anterior mediastinum with a normal thyroid gland. A case report. Int J Surg Case Rep, 2018, 51: 213-217.
16.	Lomelino Pinheiro S, Damásio I, Figueiredo A, et al. Mediastinal thyroid carcinoma and Graves' disease: A rare presentation. Case Rep Endocrinol, 2021, 2021: 6584616.
17.	高永山, 姜偉華, 董躍華, 等. 胸腔鏡輔助小切口切除縱隔異位惡性潛能未定的甲狀腺濾泡性腫瘤1例. 中國臨床研究, 2022, 35(4): 549-551.
18.	Okuda M, Yokomise H, Chang SS, et al. Mediastinal metastasis of the thyroid papillary carcinoma mimicking thymoma. Gen Thorac Cardiovasc Surg, 2008, 56(10): 518-520.
19.	Bhamidipati CM, Mukhopadhyay S, Feliu C, et al. Cystic metastases of papillary thyroid carcinoma mimicking a primary mediastinal cyst. J Thorac Oncol, 2009, 4(1): 105-106.

1. Guerra G, Cinelli M, Mesolella M, et al. Morphological, diagnostic and surgical features of ectopic thyroid gland: A review of literature. Int J Surg, 2014, 12 Suppl 1: S3-S11.
2. 金鋒, 王明訓, 楊寶嶺. 完全型縱隔內甲狀腺癌一例. 實用癌癥雜志, 1992, (4): 276.
3. Dominguez-Malagon H, Guerrero-Medrano J, Suster S. Ectopic poorly differentiated (insular) carcinoma of the thyroid. Report of a case presenting as an anterior mediastinal mass. Am J Clin Pathol, 1995, 104(4): 408-412.
4. Sand J, Pehkonen E, Mattila J, et al. Pulsating mass at the sternum: A primary carcinoma of ectopic mediastinal thyroid. J Thorac Cardiovasc Surg, 1996, 112(3): 833-835.
5. 杜淼, 張哉根. 縱隔異位甲狀腺乳頭狀腺癌一例. 中華腫瘤雜志, 2003, (3): 90.
6. 李高峰, 張長弓, 巫正偉. 胸內異位甲狀腺乳頭狀腺癌1例. 云南醫藥, 2003, 24(2): 164.
7. Yoshino M, Mizobuchi T, Fujiwara T, et al. Large mediastinal cyst of an ectopic thyroid with small nodules diagnosed as papillary carcinoma. Jpn J Thorac Cardiovasc Surg, 2006, 54(12): 550-554.
8. Shah BC, Ravichand C, Juluri S, et al. Ectopic thyroid cancer. Anna Thorac Cardiovasc Surg, 2007, 13(2): 122.
9. Camargos EF, Pandolfi MB, Toledo MA, et al. A 95-year-old woman with leucocytosis and eosinophilia: Anaplastic carcinoma in an ectopic thyroid. BMJ Case Rep, 2010, 2010: 2823.
10. Piciu D, Piciu A, Irimie A. Papillary thyroid microcarcinoma and ectopic papillary thyroid carcinoma in mediastinum: A case report. Clin Nucl Med, 2012, 37(2): 214-215.
11. 林鋒, 肖家榮, 冉鵬, 等. 頸部甲狀腺腺瘤并縱隔異位甲狀腺癌一例. 中華外科雜志, 2013, 51(10): 958.
12. Shafiee S, Sadrizade A, Jafarian A, et al. Ectopic papillary thyroid carcinoma in the mediastinum without any tumoral involvement in the thyroid gland. A case report. Asia Ocean J Nucl Med Biol, 2013, 1(1): 44-46.
13. 吳彬, 楊洋, 齊宇, 等. 縱隔異位甲狀腺癌誤診一例. 中華外科雜志, 2014, 52(10): 800.
14. Hu J, Li M, Xu L. Ectopic thyroid cancer diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration. Thorac Cancer, 2017, 8(6): 703-705.
15. Karim F, Inam H, Choudry UK, et al. Ectopic follicular variant of papillary thyroid carcinoma in anterior mediastinum with a normal thyroid gland. A case report. Int J Surg Case Rep, 2018, 51: 213-217.
16. Lomelino Pinheiro S, Damásio I, Figueiredo A, et al. Mediastinal thyroid carcinoma and Graves' disease: A rare presentation. Case Rep Endocrinol, 2021, 2021: 6584616.
17. 高永山, 姜偉華, 董躍華, 等. 胸腔鏡輔助小切口切除縱隔異位惡性潛能未定的甲狀腺濾泡性腫瘤1例. 中國臨床研究, 2022, 35(4): 549-551.
18. Okuda M, Yokomise H, Chang SS, et al. Mediastinal metastasis of the thyroid papillary carcinoma mimicking thymoma. Gen Thorac Cardiovasc Surg, 2008, 56(10): 518-520.
19. Bhamidipati CM, Mukhopadhyay S, Feliu C, et al. Cystic metastases of papillary thyroid carcinoma mimicking a primary mediastinal cyst. J Thorac Oncol, 2009, 4(1): 105-106.

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