Research Progress of High Risk Factors and Diagnosis in Primary Carcinoma of Gallbladder_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 XUSong ¹ ,  CAONong ²

1. The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, Gansu Province, China;
2. Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China;

Corresponding?author：

CAONong, Email: caonong1955@163.com

Keywords：

Primary carcinoma of gallbladder; High risk factor; Early diagnosis

DOI：

10.7507/1007-9424.20140028

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To understand the advance in research of high risk factors and diagnosis in primary carci-noma of gallbladder. Methods The literatures at home and abroad during recent years were reviewed, and the research progress of high risk factors and inchoate diagnosis about primary gallbladder carcinoma were summarized. Results Cholecystolithiasis, cholecystitis, and other factors have a certain correlation with primary gallbladder carcinoma.The rate of early diagnosis of primary gallbladder carcinoma can be enhanced through the detailed history taking and physical examination, supplemented by a variety of imaging examination methods, and molecular biological technologies. Conclusion It can enhance the rate of early diagnosis of primary gallbladder carcinoma that understand the risk factors and master various methods for early diagnosis of carcinoma of gallbladder.

Citation： XUSong, CAONong. Research Progress of High Risk Factors and Diagnosis in Primary Carcinoma of Gallbladder. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(1): 121-125. doi: 10.7507/1007-9424.20140028 Copy

1.	Siegel R, Naishadham D, Jemal A.Cancer statistics, 2013[J].CA Cancer J Clin, 2013, 63(1):11-30.
2.	Witjes CD, van den Akker SA, Visser O, et al.Gallbladder cancer in the netherlands:incidence, treatment and survival patterns since 1989[J].Dig Surg, 2012, 29(2):92-98.
3.	Stinton LM, Shaffer EA.Epidemiology of gallbladder disease:cholelithiasis and cancer[J].Gut Liver, 2012, 6(2):172-187.
4.	Glauser PM, Strub D, Kaser SA, et al.Incidence, management, and outcome of incidental gallbladder carcinoma:analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery[J].Surg Endosc, 2010, 24(9):2281-2286.
5.	Pilgrim CH, Groeschl RT, Christians KK, et al.Modern perspe-ctives on factors predisposing to the development of gallbladder cancer[J].HPB (Oxford), 2013 Jan 18.[Epub ahead of print].
6.	Hsing AW, Gao YT, Han TQ, et al.Gallstones and the risk of biliary tract cancer:a population-based study in China[J].Br J Cancer, 2007, 97(11):1577-1582.
7.	Tewari M, Mishra RR, Shukla HS.Salmonella typhi and gallbl-adder cancer:report from an endemic region[J].Hepatobiliary Pancreat Dis Int, 2010, 9(5):524-530.
8.	石景森, 孫學軍.原發性膽囊癌診治的歷史、現狀及展望[J].西安交通大學學報:醫學版, 2007, 28(5):473-478.
9.	石景森, 劉剛.膽囊癌與膽囊結石的相關研究[J].實用腫瘤雜志, 2005, 20(1):10-11.
10.	Mathur SK, Duhan A, Singh S, et al.Correlation of gallstone characteristics with mucosal changes in gall bladder[J].Trop Gastroenterol, 2012, 33(1):39-44.
11.	Roa I, Arava JC, Villaseca M, et al.Preneoplastie lesions and gallbladder cancer:an estimate of the period require for progression[J].Gastroenterology, 1996, 111(31):232-236.
12.	Vitetta L, Sali A, Little P, et al.Gallstones and gallbladder carci-noma[J].Aust NZ J Surg, 2000, 70(9):667-673.
13.	Cairns V, Neal CP, Dennison AR, et al.Risk and cost-effectiveness of surveillance followed by cholecystectomy for gallbladder polyps[J].Arch Surg, 2012, 147(12):1078-1083.
14.	于嵐, 何小東, 武嶠.膽囊癌發生相關危險因素的探討[J].中華消化外科雜志, 2012, 11(5):433-436.
15.	Roa I, Ibacaehe G, Roa J, et al.Gallstones and gallbladder cancer volume and weight of gallstones are associated with gallbladder cancer:a ease-control study[J].J Surg Oneol, 2006, 93(6):624-628.
16.	Maurer KJ, Carey MC, Fox JG.Roles of infection, inflammation, and the immune system in cholesterol gallstone formation[J].Gastroenterology, 2009, 136(2):425-440.
17.	Vilkin A, Nudelman I, Morgenstern S, et al.Gallbladder inflammation is associated with increase in mucin expression and pigme-nted stone formation[J].Dig Dis Sci, 2007, 52(7):1613-1620.
18.	楊竹林, 蘭思根, 付汐, 等.膽囊癌及其良性病變組織中CC13及其受體表達的臨床病理意義[J].中華肝膽外科雜志, 2009, 15(1):25-27.
19.	Han HS, Chol JY, Yoon YS, et al.Preoperative inflammation is a prognostic factor for gallbladder carcinoma[J].Br J Surg, 2011, 98(1):111-116.
20.	張毅, 張積華, 袁梅, 等.膽囊小隆起性病變的臨床病理學特點與超聲診斷的對比[J].世界華人消化雜志, 2010, 18(25):2707-2711.
21.	張興, 范一宏, 呂賓.膽囊膽固醇性息肉的發病機制和診治進展[J].胃腸病學, 2012, 17(1):47-49.
22.	Morera-Ocón FJ, Ballestín-Vicente J, Calatayud-Blas AM, et al.Surgical indications in gallbladder polyps[J].Cir Esp, 2013, 91(5):324-30.
23.	Lee SH, Lee DS, You IY, et al.Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder[J].Korean J Gastroenterol, 2010, 55(2):119-126.
24.	張林, 鄒聲泉.膽囊腺瘤-腺癌中的DNA含量和基因表達[J].中華肝膽外科雜志, 2004, 10(7):460-462.
25.	Oolani T, Shirai Y, Tsukada K, et al.Relationship between gallbladder carcinoma and the segmental type of adenomyomatosis of the gallbladder[J].Cancer, 1992, 69(11):2647-2652.
26.	Kamisawa T, Anjiki H, Egawa N, et al.Diagnosis and clinical implications of pancreatobiliary reflux[J].World J Gastroenterol, 2008, 14(43):6622-6626.
27.	Chijiiwa K, Tanaka M, Nakayama F.Adenocarcinoma of the gallbladder associated with anomalous pancreaticobiliary ductal junction[J].Am Surg, 1993, 59(7):430-434.
28.	Hasumi A, Sugaya H, Aoki H, et al.pancreaticobiliary maljunction and biliary duct cancer[J].Bil tract Pancr, 1995, 16(8):753-757.
29.	Takuma K, Kamisawa T, Tabata T, et al.Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation[J].World J Gastroenterol, 2012, 18(26):3409-3414.
30.	Funabiki T, Sugiue K, Matsubara T, et al.Bile acids and biliary carcinoma in pancreaticobiliary maljunction[J].Keio J Med, 1991, 40(3):118-122.
31.	樂問津, 丁佑銘, 易佐慧子.膽囊息肉樣病變惡變危險因素的Meta分析[J].臨床肝膽病雜志, 2011, 27(9):934-938, 943.
32.	Jain K, Sreenivas V, Velpandian T, et al.Risk factors for gallbladder cancer:A case-control study[J].Int J Cancer, 2013, 132(7):1660-1666.
33.	Nasu Y, Tanaka E, Hirano S, et al.The prognosis after curative resection of gallbladder cancer with hilar invasion is similar to that of hilar cholangiocarcinoma[J].J Hepatobiliary Pancreat Sci, 2012, 19(3):274-280.
34.	Mou Y, Xing R, Liu C.Diagnosis of gallbladder cancer using matrix assisted laser desorption ionization time-of-flight profiling[J].Am J Med Sci, 2012, 343(2):119-123.
35.	Tan Y, Ma SY, Wang FQ, et al.Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer[J].Oncol Rep, 2011, 26(4):853-859.
36.	Meng H, Wang X, Fong Y, et al.Outcomes of radical surgery for gallbladder cancer patients with lymphatic metastases[J].Jpn J Clin Oncol, 2011, 41(8):992-998.
37.	Brown KM, Geller DA.Porcelain gallbladder and risk of gallbla-dder cancer[J].Arch Surg, 2011, 146(10):1148.
38.	Liu B, Balkwill A, Roddam A, et al.Separate and joint effects of alcohol and smoking on the risks of cirrhosis and gallbladder disease in middle-aged women[J].Am J Epidemiol, 2009, 169(2):153-160.
39.	陳炯, 杜敏.膽囊癌病因學研究進展[J].臨床誤診誤治, 2007, 23(3):6-8.
40.	張學宏, 高玉堂, 鄧杰, 等.飲食與膽囊癌關系的流行病學研究[J].腫瘤, 2005, 25(4):351-356.
41.	Chang CK, Astrakianakis G, Thomas DB, et al.Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers:a case-cohort study[J].Am J Ind Med, 2006, 49(8):690-698.
42.	耿金宏, 袁金鳳, 吳鳴.膽囊癌流行分布及高危因素探討[J].研究臨床和實驗醫學雜志, 2012, 11(16):1336-1337.
43.	Wang F, Wang B, Qiao L.Association between obesity and gallb-ladder cancer[J].Frontiers in bioscience:a journal and virtual library, 2012, 17:2550-2558.
44.	Schnelldorfer T.Porcelain gallbladder:a benign process or concern for malignancy?[J].J Gastrointest Surg, 2013, 17(6):1161-1168.
45.	劉忠, 高政南, 劉暢.2型糖尿病患者高發膽囊息肉樣病變原因分析[J].臨床消化病雜志, 2007, 19(5):325-326.
46.	曹澤偉, 李方儒, 白景文, 等.糖尿病膽囊超微結構的改變[J].天津醫學, 2004, 32(7):421.
47.	Yarmenitis SD.Ultrasound of the gallbladder and the biliary tree[J].Eur Radiol, 2002, 12(2):270-282.
48.	Xie XH, Xu HX, Xie XY, et al.Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound[J].Eur Radiol, 2010, 20(1):239-248.
49.	Zeno Sparchez, Pompilia Radu.Role of CEUS in the diagnosis of gallbladder disease[J].Med Ultrason, 2012, 14(4):326-330.
50.	Ijin Joo, Jae Young Lee, Jung Hoon Kim, et al.Differentiation of adenomyomatosis of the gallbladder from early-stage, wall-thic-kening-type gallbladder cancer using high-resolution ultrasound[J].Eur Radiol, 2013, 23(3):730-738.
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1. Siegel R, Naishadham D, Jemal A.Cancer statistics, 2013[J].CA Cancer J Clin, 2013, 63(1):11-30.
2. Witjes CD, van den Akker SA, Visser O, et al.Gallbladder cancer in the netherlands:incidence, treatment and survival patterns since 1989[J].Dig Surg, 2012, 29(2):92-98.
3. Stinton LM, Shaffer EA.Epidemiology of gallbladder disease:cholelithiasis and cancer[J].Gut Liver, 2012, 6(2):172-187.
4. Glauser PM, Strub D, Kaser SA, et al.Incidence, management, and outcome of incidental gallbladder carcinoma:analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery[J].Surg Endosc, 2010, 24(9):2281-2286.
5. Pilgrim CH, Groeschl RT, Christians KK, et al.Modern perspe-ctives on factors predisposing to the development of gallbladder cancer[J].HPB (Oxford), 2013 Jan 18.[Epub ahead of print].
6. Hsing AW, Gao YT, Han TQ, et al.Gallstones and the risk of biliary tract cancer:a population-based study in China[J].Br J Cancer, 2007, 97(11):1577-1582.
7. Tewari M, Mishra RR, Shukla HS.Salmonella typhi and gallbl-adder cancer:report from an endemic region[J].Hepatobiliary Pancreat Dis Int, 2010, 9(5):524-530.
8. 石景森, 孫學軍.原發性膽囊癌診治的歷史、現狀及展望[J].西安交通大學學報:醫學版, 2007, 28(5):473-478.
9. 石景森, 劉剛.膽囊癌與膽囊結石的相關研究[J].實用腫瘤雜志, 2005, 20(1):10-11.
10. Mathur SK, Duhan A, Singh S, et al.Correlation of gallstone characteristics with mucosal changes in gall bladder[J].Trop Gastroenterol, 2012, 33(1):39-44.
11. Roa I, Arava JC, Villaseca M, et al.Preneoplastie lesions and gallbladder cancer:an estimate of the period require for progression[J].Gastroenterology, 1996, 111(31):232-236.
12. Vitetta L, Sali A, Little P, et al.Gallstones and gallbladder carci-noma[J].Aust NZ J Surg, 2000, 70(9):667-673.
13. Cairns V, Neal CP, Dennison AR, et al.Risk and cost-effectiveness of surveillance followed by cholecystectomy for gallbladder polyps[J].Arch Surg, 2012, 147(12):1078-1083.
14. 于嵐, 何小東, 武嶠.膽囊癌發生相關危險因素的探討[J].中華消化外科雜志, 2012, 11(5):433-436.
15. Roa I, Ibacaehe G, Roa J, et al.Gallstones and gallbladder cancer volume and weight of gallstones are associated with gallbladder cancer:a ease-control study[J].J Surg Oneol, 2006, 93(6):624-628.
16. Maurer KJ, Carey MC, Fox JG.Roles of infection, inflammation, and the immune system in cholesterol gallstone formation[J].Gastroenterology, 2009, 136(2):425-440.
17. Vilkin A, Nudelman I, Morgenstern S, et al.Gallbladder inflammation is associated with increase in mucin expression and pigme-nted stone formation[J].Dig Dis Sci, 2007, 52(7):1613-1620.
18. 楊竹林, 蘭思根, 付汐, 等.膽囊癌及其良性病變組織中CC13及其受體表達的臨床病理意義[J].中華肝膽外科雜志, 2009, 15(1):25-27.
19. Han HS, Chol JY, Yoon YS, et al.Preoperative inflammation is a prognostic factor for gallbladder carcinoma[J].Br J Surg, 2011, 98(1):111-116.
20. 張毅, 張積華, 袁梅, 等.膽囊小隆起性病變的臨床病理學特點與超聲診斷的對比[J].世界華人消化雜志, 2010, 18(25):2707-2711.
21. 張興, 范一宏, 呂賓.膽囊膽固醇性息肉的發病機制和診治進展[J].胃腸病學, 2012, 17(1):47-49.
22. Morera-Ocón FJ, Ballestín-Vicente J, Calatayud-Blas AM, et al.Surgical indications in gallbladder polyps[J].Cir Esp, 2013, 91(5):324-30.
23. Lee SH, Lee DS, You IY, et al.Histopathologic analysis of adenoma and adenoma-related lesions of the gallbladder[J].Korean J Gastroenterol, 2010, 55(2):119-126.
24. 張林, 鄒聲泉.膽囊腺瘤-腺癌中的DNA含量和基因表達[J].中華肝膽外科雜志, 2004, 10(7):460-462.
25. Oolani T, Shirai Y, Tsukada K, et al.Relationship between gallbladder carcinoma and the segmental type of adenomyomatosis of the gallbladder[J].Cancer, 1992, 69(11):2647-2652.
26. Kamisawa T, Anjiki H, Egawa N, et al.Diagnosis and clinical implications of pancreatobiliary reflux[J].World J Gastroenterol, 2008, 14(43):6622-6626.
27. Chijiiwa K, Tanaka M, Nakayama F.Adenocarcinoma of the gallbladder associated with anomalous pancreaticobiliary ductal junction[J].Am Surg, 1993, 59(7):430-434.
28. Hasumi A, Sugaya H, Aoki H, et al.pancreaticobiliary maljunction and biliary duct cancer[J].Bil tract Pancr, 1995, 16(8):753-757.
29. Takuma K, Kamisawa T, Tabata T, et al.Importance of early diagnosis of pancreaticobiliary maljunction without biliary dilatation[J].World J Gastroenterol, 2012, 18(26):3409-3414.
30. Funabiki T, Sugiue K, Matsubara T, et al.Bile acids and biliary carcinoma in pancreaticobiliary maljunction[J].Keio J Med, 1991, 40(3):118-122.
31. 樂問津, 丁佑銘, 易佐慧子.膽囊息肉樣病變惡變危險因素的Meta分析[J].臨床肝膽病雜志, 2011, 27(9):934-938, 943.
32. Jain K, Sreenivas V, Velpandian T, et al.Risk factors for gallbladder cancer:A case-control study[J].Int J Cancer, 2013, 132(7):1660-1666.
33. Nasu Y, Tanaka E, Hirano S, et al.The prognosis after curative resection of gallbladder cancer with hilar invasion is similar to that of hilar cholangiocarcinoma[J].J Hepatobiliary Pancreat Sci, 2012, 19(3):274-280.
34. Mou Y, Xing R, Liu C.Diagnosis of gallbladder cancer using matrix assisted laser desorption ionization time-of-flight profiling[J].Am J Med Sci, 2012, 343(2):119-123.
35. Tan Y, Ma SY, Wang FQ, et al.Proteomic-based analysis for identification of potential serum biomarkers in gallbladder cancer[J].Oncol Rep, 2011, 26(4):853-859.
36. Meng H, Wang X, Fong Y, et al.Outcomes of radical surgery for gallbladder cancer patients with lymphatic metastases[J].Jpn J Clin Oncol, 2011, 41(8):992-998.
37. Brown KM, Geller DA.Porcelain gallbladder and risk of gallbla-dder cancer[J].Arch Surg, 2011, 146(10):1148.
38. Liu B, Balkwill A, Roddam A, et al.Separate and joint effects of alcohol and smoking on the risks of cirrhosis and gallbladder disease in middle-aged women[J].Am J Epidemiol, 2009, 169(2):153-160.
39. 陳炯, 杜敏.膽囊癌病因學研究進展[J].臨床誤診誤治, 2007, 23(3):6-8.
40. 張學宏, 高玉堂, 鄧杰, 等.飲食與膽囊癌關系的流行病學研究[J].腫瘤, 2005, 25(4):351-356.
41. Chang CK, Astrakianakis G, Thomas DB, et al.Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers:a case-cohort study[J].Am J Ind Med, 2006, 49(8):690-698.
42. 耿金宏, 袁金鳳, 吳鳴.膽囊癌流行分布及高危因素探討[J].研究臨床和實驗醫學雜志, 2012, 11(16):1336-1337.
43. Wang F, Wang B, Qiao L.Association between obesity and gallb-ladder cancer[J].Frontiers in bioscience:a journal and virtual library, 2012, 17:2550-2558.
44. Schnelldorfer T.Porcelain gallbladder:a benign process or concern for malignancy?[J].J Gastrointest Surg, 2013, 17(6):1161-1168.
45. 劉忠, 高政南, 劉暢.2型糖尿病患者高發膽囊息肉樣病變原因分析[J].臨床消化病雜志, 2007, 19(5):325-326.
46. 曹澤偉, 李方儒, 白景文, 等.糖尿病膽囊超微結構的改變[J].天津醫學, 2004, 32(7):421.
47. Yarmenitis SD.Ultrasound of the gallbladder and the biliary tree[J].Eur Radiol, 2002, 12(2):270-282.
48. Xie XH, Xu HX, Xie XY, et al.Differential diagnosis between benign and malignant gallbladder diseases with real-time contrast-enhanced ultrasound[J].Eur Radiol, 2010, 20(1):239-248.
49. Zeno Sparchez, Pompilia Radu.Role of CEUS in the diagnosis of gallbladder disease[J].Med Ultrason, 2012, 14(4):326-330.
50. Ijin Joo, Jae Young Lee, Jung Hoon Kim, et al.Differentiation of adenomyomatosis of the gallbladder from early-stage, wall-thic-kening-type gallbladder cancer using high-resolution ultrasound[J].Eur Radiol, 2013, 23(3):730-738.
51. Mishra G, Conway JD.Endoscopic ultrasound in the evaluation of radiologic abnormalities of the liver and biliary tree[J].Curr Gastroenterol Rep, 2009, 11(2):150-154.
52. Li B, Xu XX, Du Y, et al.Computed tomography for assessing resectability of gallbladder carcinoma:a systematic review and meta-analysis[J].Clinical Imaging, 2013, 37(2):327-333.
53. Tan CH, Lim KS.MRI of gallbladder cancer[J].Diagn Interv Radiol, 2013, 19(4):312-319.
54. Hsu M, Sasaki M, Igarashi S, et al.KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas[J].Cancer, 2013, 119(9):1669-1674.
55. Kumari N, Kapoor VK, Krishnani N, et al.Role of C-erbB2 expression in gallbladder cancer[J].Indian J Pathol Microbiol, 2012, 55(1):75-79.
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