原發性肝癌的綜合治療_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 戴朝六 , 趙陽

中國醫科大學附屬盛京醫院肝膽脾外科（遼寧沈陽 110004）;

Corresponding?author：

戴朝六, Email: daicl@sj-hospital.org

Keywords：

原發性肝癌; 綜合治療; 分期

DOI：

10.7507/1007-9424.20140031

Video：

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Citation： 戴朝六, 趙陽. 原發性肝癌的綜合治療. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(2): 133-137. doi: 10.7507/1007-9424.20140031 Copy

1.	Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61(2):69-90.
2.	郝捷, 陳萬青.中國腫瘤登記年報(2012)[M].北京:軍事醫學科學出版社, 2012.
3.	Okuda K, Ohtsuki T, Obata H, et al.Natural history of hepatocellular carcinoma and prognosis in relation to treatment.Study of 850 patients[J].Cancer, 1985, 56(4):918-928.
4.	Llovet JM, Bruix J.Prospective validation of the Cancer of the Liver Italian Program (CLIP) score:a new prognostic system for patients with cirrhosis and hepatocellular carcinoma[J].Hepatology, 2000, 32(3):679-680.
5.	Llovet JM, Brú C, Bruix J.Prognosis of hepatocellular carcinoma:the BCLC staging classification[J].Semin Liver Dis, 1999, 19(3):329-338.
6.	Edge SB, Compton CC, Fritz AG, et al.AJCC cancer staging manual[M].7th ed.New York, NY:Springer, 2010:237-246.
7.	Leung TW, Tang AM, Zee B, et al.Construction of the Chinese university prognostic index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the cancer of the liver Italian program staging system:a study based on 926 patients[J].Cancer, 2002, 94(6):1760-1769.
8.	Tateishi R, Yoshida H, Shiina S, et al.Proposal of a new prognostic model for hepatocellular carcinoma:an analysis of 403 patients[J].Gut, 2005, 54(3):419-425.
9.	Kudo M, Chung H, Osaki Y.Prognostic staging system for hepa-tocellular carcinoma (CLIP score):its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score)[J].J Gastroenterol, 2003, 38(3):207-215.
10.	中國抗癌協會肝癌專業委員會.原發性肝癌的臨床診斷與分期標準[J].肝臟, 2004, 9(S1):67-68.
11.	中華人民共和國衛生部.原發性肝癌診療規范(2011年版)[J].臨床肝膽病雜志, 2011, 16(11):1141-1159.
12.	Nanashima A, Tobinaga S, Masuda J, et al.Selecting treatment for hepatocellular carcinoma based on the results of hepatic resection and local ablation therapy[J].J Surg Oncol, 2010, 101(6):481-485.
13.	Hung HH, Chiou YY, Hsia CY, et al.Survival rates are comp-arable after radiofrequency ablation or surgery in patients with small hepatocellular carcinomas[J].Clin Gastroenterol Hepatol, 2011, 9(1):79-86.
14.	許秋然, 鄭鑫, 姚英民, 等.肝移植術與肝切除術治療原發性肝癌的meta分析[J].西安交通大學學報:醫學版, 2012, 33(5):576-582.
15.	Kudo M, Han KH, Kokudo N, et al.Liver cancer working group report[J].Jpn J Clin Oncol, 2010, 40(Suppl 1):i19-i27.
16.	Chen XP, Qiu FZ, Wu ZD, et al.Hepatectomy for huge hepatocellular carcinoma in 634 cases[J].World J Gastroenterol, 2006, 12(29):4652-4655.
17.	Llovet JM, Real MI, Monta?a X, et al.Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma:a randomised controlled trial[J].Lancet, 2002, 359(9319):1734-1739.
18.	Vitale A, Saracino E, Boccagni P, et al.Validation of the BCLC prognostic system in surgical hepatocellular cancer patients[J].Transplant Proc, 2009, 41(4):1260-1263.
19.	Inoue K, Nakamura T, Kinoshita T, et al.Volume reduction surgery for advanced hepatocellular carcinoma[J].J Cancer Res Clin Oncol, 2004, 130(6):362-366.
20.	韓國宏, 白葦, 梁潔, 等.TACE聯合索拉非尼治療中晚期肝細胞肝癌的初步觀察[J].臨床腫瘤學雜志, 2009, 14(5):401-404.
21.	Hsu C, Morita S, Hu FC, et al.Perspectives on the design of clinical trials combining transarterial chemoembolization and mole-cular targeted therapy[J].Liver Cancer, 2012, 1(3/4):168-176.
22.	Qin S, Bai Y, Lim HY, et al.Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxo-rubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia[J].J Clin Oncol, 2013, 31(28):3501-3508.
23.	田浩, 程朝輝, 張瑞剛, 等.FOLFOX4方案治療中晚期肝癌的臨床療效[J].腫瘤基礎與臨床, 2011, 24(6):495-496.
24.	黃蘋, 陳強, 張其忠, 等.亞砷酸注射液治療中晚期原發性肝癌的臨床研究[J].中國誤診學雜志, 2002, 2(11):1642-1643.
25.	屈鳳蓮, 郝學志, 秦叔逵, 等.亞砷酸注射液治療原發性肝癌的Ⅱ期多中心臨床研究[J].中華腫瘤雜志, 2011, 33(9):697-701.

1. Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61(2):69-90.
2. 郝捷, 陳萬青.中國腫瘤登記年報(2012)[M].北京:軍事醫學科學出版社, 2012.
3. Okuda K, Ohtsuki T, Obata H, et al.Natural history of hepatocellular carcinoma and prognosis in relation to treatment.Study of 850 patients[J].Cancer, 1985, 56(4):918-928.
4. Llovet JM, Bruix J.Prospective validation of the Cancer of the Liver Italian Program (CLIP) score:a new prognostic system for patients with cirrhosis and hepatocellular carcinoma[J].Hepatology, 2000, 32(3):679-680.
5. Llovet JM, Brú C, Bruix J.Prognosis of hepatocellular carcinoma:the BCLC staging classification[J].Semin Liver Dis, 1999, 19(3):329-338.
6. Edge SB, Compton CC, Fritz AG, et al.AJCC cancer staging manual[M].7th ed.New York, NY:Springer, 2010:237-246.
7. Leung TW, Tang AM, Zee B, et al.Construction of the Chinese university prognostic index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the cancer of the liver Italian program staging system:a study based on 926 patients[J].Cancer, 2002, 94(6):1760-1769.
8. Tateishi R, Yoshida H, Shiina S, et al.Proposal of a new prognostic model for hepatocellular carcinoma:an analysis of 403 patients[J].Gut, 2005, 54(3):419-425.
9. Kudo M, Chung H, Osaki Y.Prognostic staging system for hepa-tocellular carcinoma (CLIP score):its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score)[J].J Gastroenterol, 2003, 38(3):207-215.
10. 中國抗癌協會肝癌專業委員會.原發性肝癌的臨床診斷與分期標準[J].肝臟, 2004, 9(S1):67-68.
11. 中華人民共和國衛生部.原發性肝癌診療規范(2011年版)[J].臨床肝膽病雜志, 2011, 16(11):1141-1159.
12. Nanashima A, Tobinaga S, Masuda J, et al.Selecting treatment for hepatocellular carcinoma based on the results of hepatic resection and local ablation therapy[J].J Surg Oncol, 2010, 101(6):481-485.
13. Hung HH, Chiou YY, Hsia CY, et al.Survival rates are comp-arable after radiofrequency ablation or surgery in patients with small hepatocellular carcinomas[J].Clin Gastroenterol Hepatol, 2011, 9(1):79-86.
14. 許秋然, 鄭鑫, 姚英民, 等.肝移植術與肝切除術治療原發性肝癌的meta分析[J].西安交通大學學報:醫學版, 2012, 33(5):576-582.
15. Kudo M, Han KH, Kokudo N, et al.Liver cancer working group report[J].Jpn J Clin Oncol, 2010, 40(Suppl 1):i19-i27.
16. Chen XP, Qiu FZ, Wu ZD, et al.Hepatectomy for huge hepatocellular carcinoma in 634 cases[J].World J Gastroenterol, 2006, 12(29):4652-4655.
17. Llovet JM, Real MI, Monta?a X, et al.Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma:a randomised controlled trial[J].Lancet, 2002, 359(9319):1734-1739.
18. Vitale A, Saracino E, Boccagni P, et al.Validation of the BCLC prognostic system in surgical hepatocellular cancer patients[J].Transplant Proc, 2009, 41(4):1260-1263.
19. Inoue K, Nakamura T, Kinoshita T, et al.Volume reduction surgery for advanced hepatocellular carcinoma[J].J Cancer Res Clin Oncol, 2004, 130(6):362-366.
20. 韓國宏, 白葦, 梁潔, 等.TACE聯合索拉非尼治療中晚期肝細胞肝癌的初步觀察[J].臨床腫瘤學雜志, 2009, 14(5):401-404.
21. Hsu C, Morita S, Hu FC, et al.Perspectives on the design of clinical trials combining transarterial chemoembolization and mole-cular targeted therapy[J].Liver Cancer, 2012, 1(3/4):168-176.
22. Qin S, Bai Y, Lim HY, et al.Randomized, multicenter, open-label study of oxaliplatin plus fluorouracil/leucovorin versus doxo-rubicin as palliative chemotherapy in patients with advanced hepatocellular carcinoma from Asia[J].J Clin Oncol, 2013, 31(28):3501-3508.
23. 田浩, 程朝輝, 張瑞剛, 等.FOLFOX4方案治療中晚期肝癌的臨床療效[J].腫瘤基礎與臨床, 2011, 24(6):495-496.
24. 黃蘋, 陳強, 張其忠, 等.亞砷酸注射液治療中晚期原發性肝癌的臨床研究[J].中國誤診學雜志, 2002, 2(11):1642-1643.
25. 屈鳳蓮, 郝學志, 秦叔逵, 等.亞砷酸注射液治療原發性肝癌的Ⅱ期多中心臨床研究[J].中華腫瘤雜志, 2011, 33(9):697-701.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

原發性肝癌的綜合治療

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