Expression of Cyclin D1 in Different Molecular Subtypes of Breast Cancer and Its Impact on Prognosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 Adina-Jiakulin , Dilimina-Yilamu ,  GUOLi-ying

Deparment of Breast Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China;

Corresponding?author：

GUOLi-ying, Email: ggs318@126.com

Keywords：

Breast cancer; Cyclin D1 protein; Molecular subtype; Prognosis

DOI：

10.7507/1007-9424.20140043

Video：

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Objective To detect the expression of cyclin D1 in different kinds of clinical molecular subtypes of breast cancer tissue, and to analyze the relationships of the expression to clinicopathologic characteristics and prognosis. Methods The expression of cyclin D1 was detected in 175 cases of different kinds of clinical molecular subtypes of breast cancer by immunohistochemical method.The expression was compared among different kinds of clinical molecular subtypes of breast cancer by chi-square test.The correlations with clinicopathologic characteristics were analyzed by Spearman rank correlation.The impact of different expression of cyclin D1 on the prognosis was analyzed by the Kaplan-Meier survival curve. Results ①In the positive expression group of cyclin D1 in the breast cancer, Luminal A type was the highest proportion (P < 0.05);but in the negative expression group of cyclin D1 in the breast cancer, Luminal B type was the highest proportion (P < 0.05).②The expression of cyclin D1 had no correlation with clinical stage, histological grade or PR (P > 0.05), was positively correlated with number of lymph node metastasis (r_s=0.197, P < 0.01) or ER (r_s=0.139, P < 0.05), was negatively correlated with Her-2(r_s=-0.131, P < 0.05).③The positive expression of cyclin D1 was stronger, the tumor free survival time was longer (P < 0.05). Conclusion This study shows that there is a correlation between the positive expression of cyclin D1 and ER, Her-2, or number of lymph node metastasis, and its positive expression prompts a relatively good prognosis, can be used as the prognosis indicator for breast cancer.

Citation： Adina-Jiakulin, Dilimina-Yilamu, GUOLi-ying. Expression of Cyclin D1 in Different Molecular Subtypes of Breast Cancer and Its Impact on Prognosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(2): 187-191. doi: 10.7507/1007-9424.20140043 Copy

1.	吉愛軍, 唐金海.乳腺癌術后患者Cyclin A1、A2、D1、E1表達及其臨床意義[J].南京醫科大學學報:自然科學版, 2010, 30(9):1290-1294.
2.	Kohlberger PD, Breitenecker F, Kaider A, et al.Modified true-color computer-assisted image analysis versus subjective scoringof estrogen receptor expression in breast cancer:a comparison[J].Anticancer Res, 1999, 19(3B):2189-2193.
3.	張怡, 王娟娟, 郭宇, 等.microRNA沉默SMYD3基因對乳腺癌細胞Wnt/β-Catenin通路及c-Myc基因影響的研究[J].醫學研究雜志, 2013, 42(6):171-173.
4.	張榮君, 章佳新, 扶德元, 等.SOX7、β-catenin和cyclin D1蛋白在浸潤性乳腺癌組織中的表達及臨床意義[J].國際外科學雜志, 2013, 40(9):599-604.
5.	吳玨堃.β-catenin與cyclin D1在乳腺癌中的表達及與其他臨床病理指標的相關性分析[J].實用醫學雜志, 2011, 27(9):1613-1616.
6.	師杰, 梁智勇, 劉彤華.Cyclin D1在乳腺浸潤性小葉癌的表達及其意義[J].協和醫學雜志, 2012, 3(1):8-12.
7.	疏楠, 李連宏, 孫志剛, 等.P16、CDK4、cyclin D1在乳腺癌中的表達及臨床意義[J].大連醫科大學學報, 2009, 31(4):255-259.
8.	羅潔, 陳俞霖, 許輝.β-catenin, cyclin D1和ERα在乳腺癌組織中的表達[J].實用預防醫學, 2010, 17(8):1502-1504.
9.	Zwijsen RM, Wientjens E, Klompmaker R, et al.CDK-indepen-dent activation of estrogen receptor by cyclin D1[J].Cell, 1997, 88(3):405-415.
10.	Umekita Y, Ohi Y, Sagara Y, et al.Overexpression of cyclin D1 predicts for poor prognosis in estrogen receptor-negative breast cancer patients[J].Int J Cancer, 2002, 98(3):415-418.
11.	趙俊玲, 楊金巧, 賴毅.Cyclin D1基因擴增及其蛋白表達在乳腺癌中的意義[J].中國普外基礎與臨床雜志, 2000, 7(3):147-149.
12.	Sutherland RL, Prall OW, Alle KM, et al.Cyclin dependent kinases as downstream targets of oestrogen action:potential prognostic indicators and therapeutic targets[J].Endorine Related Cancer, 1997, 4:357-370.
13.	Khalil S, Tan GA, Giri DD, et al.Activation status of Wnt/?-catenin signaling in normal and neoplastic breast tissues:relationship to HER2/neu expression in human and mouse[J].PLoS One, 2012, 7(3):e33421.
14.	Geyer FC, Lacroix-Triki M, Savage K, et al.β-Catenin pathway activation in breast cancer is associated with triple-negative pheno-type but not with CTNNB1 mutation[J].Mod Pathol, 2011, 24(2):209-231.
15.	夏紅強, 何建蓉.Ki-67、EGFR、HER-2和p53在乳腺癌中的表達及其相關性[J].臨床腫瘤學雜志, 2011, 16(2):139-143.
16.	何艷蛟, 喬超, 劉朝霞, 等.乳腺癌中β-catenin, cyclin D1, c-myc表達及意義[J].首都醫科大學學報, 2011, 32(4):549-552.
17.	Carey LA, Perou CM, Livasy CA, et al.Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study[J].JAMA, 2006, 295(21):2492-2502.
18.	張英軍, 吳君心, 侯如蓉.乳腺癌的分子分型[J].實用癌癥雜志, 2012, 27(1):98-100.
19.	Su YH, Zheng Y, Zheng W, et al.Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women:a population-based cohort study[J].BMC Cancer, 2011, 11:292.
20.	董曉, 房新志, 柴敏秀, 等.β-Catenin和Cyclin D1在乳腺癌中的表達及意義[J].新疆醫科大學學報, 2008, 31(5):541-547.
21.	高鵬, 周庚寅, 劉文君, 等.乳腺癌中細胞周期素D1基因改變和轉錄異常對其蛋白表達的影響[J].中國現代普通外科進展, 2004, 7(1):31-34.
22.	Hwang TS, Han HS, Hong YC, et al.Prognostic value of combined analysis of cyclin D1 and estrogen receptor status in breast cancer patients[J].Pathol Int, 2003, 53(2):74-80.
23.	陳曉曦, 陳吉彩, 程駿, 等.cyclin D1在乳腺癌中的表達及意義[J].山東醫藥, 2006, 46(34):64-65.
24.	Gillett C, Smith P, Gregory W, et al.Cyclin D1 and prognosis in human breast cancer[J].Int J Cancer, 1996, 69(2):92-99.
25.	Pelosio P, Barbareschi M, Bonoldi E, et al.Clinical significance of cyclin D1 expression in patients with node-positive breast carci-noma treated with adjuvant therapy[J].Ann Oncol, 1996, 7(7):695-703.
26.	張云偉, 賈宗良.乳腺癌改良根治術后復發和轉移因素分析[J].中國普外基礎與臨床雜志, 2012, 19(9):988-990.

1. 吉愛軍, 唐金海.乳腺癌術后患者Cyclin A1、A2、D1、E1表達及其臨床意義[J].南京醫科大學學報:自然科學版, 2010, 30(9):1290-1294.
2. Kohlberger PD, Breitenecker F, Kaider A, et al.Modified true-color computer-assisted image analysis versus subjective scoringof estrogen receptor expression in breast cancer:a comparison[J].Anticancer Res, 1999, 19(3B):2189-2193.
3. 張怡, 王娟娟, 郭宇, 等.microRNA沉默SMYD3基因對乳腺癌細胞Wnt/β-Catenin通路及c-Myc基因影響的研究[J].醫學研究雜志, 2013, 42(6):171-173.
4. 張榮君, 章佳新, 扶德元, 等.SOX7、β-catenin和cyclin D1蛋白在浸潤性乳腺癌組織中的表達及臨床意義[J].國際外科學雜志, 2013, 40(9):599-604.
5. 吳玨堃.β-catenin與cyclin D1在乳腺癌中的表達及與其他臨床病理指標的相關性分析[J].實用醫學雜志, 2011, 27(9):1613-1616.
6. 師杰, 梁智勇, 劉彤華.Cyclin D1在乳腺浸潤性小葉癌的表達及其意義[J].協和醫學雜志, 2012, 3(1):8-12.
7. 疏楠, 李連宏, 孫志剛, 等.P16、CDK4、cyclin D1在乳腺癌中的表達及臨床意義[J].大連醫科大學學報, 2009, 31(4):255-259.
8. 羅潔, 陳俞霖, 許輝.β-catenin, cyclin D1和ERα在乳腺癌組織中的表達[J].實用預防醫學, 2010, 17(8):1502-1504.
9. Zwijsen RM, Wientjens E, Klompmaker R, et al.CDK-indepen-dent activation of estrogen receptor by cyclin D1[J].Cell, 1997, 88(3):405-415.
10. Umekita Y, Ohi Y, Sagara Y, et al.Overexpression of cyclin D1 predicts for poor prognosis in estrogen receptor-negative breast cancer patients[J].Int J Cancer, 2002, 98(3):415-418.
11. 趙俊玲, 楊金巧, 賴毅.Cyclin D1基因擴增及其蛋白表達在乳腺癌中的意義[J].中國普外基礎與臨床雜志, 2000, 7(3):147-149.
12. Sutherland RL, Prall OW, Alle KM, et al.Cyclin dependent kinases as downstream targets of oestrogen action:potential prognostic indicators and therapeutic targets[J].Endorine Related Cancer, 1997, 4:357-370.
13. Khalil S, Tan GA, Giri DD, et al.Activation status of Wnt/?-catenin signaling in normal and neoplastic breast tissues:relationship to HER2/neu expression in human and mouse[J].PLoS One, 2012, 7(3):e33421.
14. Geyer FC, Lacroix-Triki M, Savage K, et al.β-Catenin pathway activation in breast cancer is associated with triple-negative pheno-type but not with CTNNB1 mutation[J].Mod Pathol, 2011, 24(2):209-231.
15. 夏紅強, 何建蓉.Ki-67、EGFR、HER-2和p53在乳腺癌中的表達及其相關性[J].臨床腫瘤學雜志, 2011, 16(2):139-143.
16. 何艷蛟, 喬超, 劉朝霞, 等.乳腺癌中β-catenin, cyclin D1, c-myc表達及意義[J].首都醫科大學學報, 2011, 32(4):549-552.
17. Carey LA, Perou CM, Livasy CA, et al.Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study[J].JAMA, 2006, 295(21):2492-2502.
18. 張英軍, 吳君心, 侯如蓉.乳腺癌的分子分型[J].實用癌癥雜志, 2012, 27(1):98-100.
19. Su YH, Zheng Y, Zheng W, et al.Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women:a population-based cohort study[J].BMC Cancer, 2011, 11:292.
20. 董曉, 房新志, 柴敏秀, 等.β-Catenin和Cyclin D1在乳腺癌中的表達及意義[J].新疆醫科大學學報, 2008, 31(5):541-547.
21. 高鵬, 周庚寅, 劉文君, 等.乳腺癌中細胞周期素D1基因改變和轉錄異常對其蛋白表達的影響[J].中國現代普通外科進展, 2004, 7(1):31-34.
22. Hwang TS, Han HS, Hong YC, et al.Prognostic value of combined analysis of cyclin D1 and estrogen receptor status in breast cancer patients[J].Pathol Int, 2003, 53(2):74-80.
23. 陳曉曦, 陳吉彩, 程駿, 等.cyclin D1在乳腺癌中的表達及意義[J].山東醫藥, 2006, 46(34):64-65.
24. Gillett C, Smith P, Gregory W, et al.Cyclin D1 and prognosis in human breast cancer[J].Int J Cancer, 1996, 69(2):92-99.
25. Pelosio P, Barbareschi M, Bonoldi E, et al.Clinical significance of cyclin D1 expression in patients with node-positive breast carci-noma treated with adjuvant therapy[J].Ann Oncol, 1996, 7(7):695-703.
26. 張云偉, 賈宗良.乳腺癌改良根治術后復發和轉移因素分析[J].中國普外基礎與臨床雜志, 2012, 19(9):988-990.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Cyclin D1 in Different Molecular Subtypes of Breast Cancer and Its Impact on Prognosis

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