Clinical Observation of Intraperitoneal Implant with Fluorouracil Sustained-Release in Operation of Rectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 陸雪明 , 王樹欽

揭陽市人民醫院腫瘤外科（廣東揭陽 522000）;

Corresponding?author：

陸雪明, Email: 505739308@qq.com; 505739308@qq.com

Keywords：

直腸癌; 手術; 氟尿嘧啶緩釋劑; 局部植入

DOI：

10.7507/1007-9424.20140121

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的觀察直腸癌術中局部植入氟尿嘧啶緩釋劑（5-FU SRI）的可行性及療效。方法 92例直腸癌患者分成治療組和對照組，治療組術中在瘤床和沿淋巴引流途徑分多點植入5-FU SRI 600 mg，對照組行常規直腸癌根治術，觀察2組患者的手術情況、毒副反應、近期并發癥及遠期療效。結果 2組的手術時間、出血量以及腹膜炎、吻合口漏、腸梗阻和切口感染發生率的差異均無統計學意義（P＞0.05）；2組患者的白細胞計數、肌酐及ALT水平治療后高于治療前（P＜0.05），但2組間差異無統計學意義（P＞0.05）。治療組腹腔局部復發率及遠處轉移率均較對照組低（P＜0.05）。結論直腸癌術中植入5-FU SRI是安全可行的，是預防術后復發轉移的有效途徑。

Citation： 陸雪明, 王樹欽. Clinical Observation of Intraperitoneal Implant with Fluorouracil Sustained-Release in Operation of Rectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(4): 495-497. doi: 10.7507/1007-9424.20140121 Copy

1.	梁君林, 萬德森, 潘志忠, 等.結直腸癌根治術后復發轉移的多因素分析[J].癌癥, 2004, 23(5):564-567.
2.	萬德森主編.臨床腫瘤學[M].第3版.北京:科學出版社, 2010:394-396.
3.	顧晉.美國NCCN直腸癌治療規范(2006)解讀[J].醫學繼續教育, 2007, 21(9):30-34.
4.	余波.結直腸癌局部復發的外科治療[J].中華胃腸外科雜志, 2006, 9(3):199-200.
5.	Li TS, Kaneda Y, Ueda K, et al. The influence of tumor resection on angiostatin levels and tumor growth:a experimental study in tumor-bearing nice[J]. Eur J Cancer, 2001, 37(3):2283-2288.
6.	Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combinedwith perioperative intraperitoneal chemotherapy for themanagement of peritoneal carcinomatosis from colorectal cancer:amult-institutional study[J]. J Clin Oncol, 2004, 22(16):3284-3292.
7.	Glehen O, Mithieux F, Osinsky D, et al. Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancerswith peritoneal carcinomatosis:a phaseⅡstudy[J]. J Clin Oncol, 2003, 21(5):799-806.
8.	Glehen O, Gilly FN, Sugarbaker PH. New perspectives in the managementof colorectal cancer:what about peritoneal carcinomatosis[J]. Scand J Surg, 2003, 92(2):178-179.
9.	朱正綱.術中腹腔內溫熱化療在胃癌外科綜合治療中的臨床意義[J].外科理論與實踐, 2000, 5(3):138-142.
10.	任統偉, 王潤蓮, 張敏, 等.植入用緩釋氟尿嘧啶治療胃腸道腫瘤安全性研究[J].腫瘤學雜志, 2007, 13(4):309-310.
11.	劉華頂, 王世亮, 武四化, 等.緩釋氟尿嘧啶植入劑在大腸癌患者的藥動學研究[J].中國新藥雜志, 2005, 14(10):1199-1200.
12.	Maeda M, Moriuchi S, Sano A, et al. New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment:application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor[J]. J Control Release, 2002, 84(1-2):15-25.
13.	Ning S, Yu N, Brown DM, et al. Radiosensitization by intratu-moral administration ofcisplatin in a sustained-release drug delivery system[J]. Radiother Oncol, 1999, 50(2):215-223.
14.	吳在德, 吳肇漢主編.外科學[M].第7版.北京:人民衛生出版社, 2012:492-496.
15.	莫雋全, 莊思敏, 譚衛民, 等.術中植入緩釋氟尿嘧啶預防大腸癌術后肝轉移的效果[J].廣東醫學, 2006, 27(9):1346-1347.

1. 梁君林, 萬德森, 潘志忠, 等.結直腸癌根治術后復發轉移的多因素分析[J].癌癥, 2004, 23(5):564-567.
2. 萬德森主編.臨床腫瘤學[M].第3版.北京:科學出版社, 2010:394-396.
3. 顧晉.美國NCCN直腸癌治療規范(2006)解讀[J].醫學繼續教育, 2007, 21(9):30-34.
4. 余波.結直腸癌局部復發的外科治療[J].中華胃腸外科雜志, 2006, 9(3):199-200.
5. Li TS, Kaneda Y, Ueda K, et al. The influence of tumor resection on angiostatin levels and tumor growth:a experimental study in tumor-bearing nice[J]. Eur J Cancer, 2001, 37(3):2283-2288.
6. Glehen O, Kwiatkowski F, Sugarbaker PH, et al. Cytoreductive surgery combinedwith perioperative intraperitoneal chemotherapy for themanagement of peritoneal carcinomatosis from colorectal cancer:amult-institutional study[J]. J Clin Oncol, 2004, 22(16):3284-3292.
7. Glehen O, Mithieux F, Osinsky D, et al. Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancerswith peritoneal carcinomatosis:a phaseⅡstudy[J]. J Clin Oncol, 2003, 21(5):799-806.
8. Glehen O, Gilly FN, Sugarbaker PH. New perspectives in the managementof colorectal cancer:what about peritoneal carcinomatosis[J]. Scand J Surg, 2003, 92(2):178-179.
9. 朱正綱.術中腹腔內溫熱化療在胃癌外科綜合治療中的臨床意義[J].外科理論與實踐, 2000, 5(3):138-142.
10. 任統偉, 王潤蓮, 張敏, 等.植入用緩釋氟尿嘧啶治療胃腸道腫瘤安全性研究[J].腫瘤學雜志, 2007, 13(4):309-310.
11. 劉華頂, 王世亮, 武四化, 等.緩釋氟尿嘧啶植入劑在大腸癌患者的藥動學研究[J].中國新藥雜志, 2005, 14(10):1199-1200.
12. Maeda M, Moriuchi S, Sano A, et al. New drug delivery system for water-soluble drugs using silicone and its usefulness for local treatment:application of GCV-silicone to GCV/HSV-tk gene therapy for brain tumor[J]. J Control Release, 2002, 84(1-2):15-25.
13. Ning S, Yu N, Brown DM, et al. Radiosensitization by intratu-moral administration ofcisplatin in a sustained-release drug delivery system[J]. Radiother Oncol, 1999, 50(2):215-223.
14. 吳在德, 吳肇漢主編.外科學[M].第7版.北京:人民衛生出版社, 2012:492-496.
15. 莫雋全, 莊思敏, 譚衛民, 等.術中植入緩釋氟尿嘧啶預防大腸癌術后肝轉移的效果[J].廣東醫學, 2006, 27(9):1346-1347.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Observation of Intraperitoneal Implant with Fluorouracil Sustained-Release in Operation of Rectal Cancer

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content