Scope and Techniques of Lymphadenectomy Associated with Pancreaticoduodenectomy in Surgical Treatment of Adenocarcinoma of The Head of Pancreas_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 孫備 , 蘇維宏

哈爾濱醫科大學附屬第一醫院胰膽外科（黑龍江哈爾濱 150001）;

Corresponding?author：

孫備, Email: sunbei70@tom.com

Keywords：

胰十二指腸切除術; 淋巴結清掃; 手術

DOI：

10.7507/1007-9424.20140190

Video：

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Citation： 孫備, 蘇維宏. Scope and Techniques of Lymphadenectomy Associated with Pancreaticoduodenectomy in Surgical Treatment of Adenocarcinoma of The Head of Pancreas. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(7): 789-793. doi: 10.7507/1007-9424.20140190 Copy

1.	?Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1): 11-30.
2.	Japanese Pancreas Society. Classification of Pancreatic Carcinoma[M]. 2nd ed. English edn. Tokyo: Kanehara & Co, Ltd., 2003.
3.	Nakao A, Harada A, Nonami T, et al. Lymph node metastases in carcinoma of the head of the pancreas region[J]. Br J Surg, 1995, 82(3): 399-402.
4.	Ishikawa O, Ohigashi H, Sasaki Y, et al. Practical grouping of positive lymph nodes in pancreatic head cancer treated by an extended pancreatectomy[J]. Surgery, 1997, 121(3): 244-249.
5.	倪泉興, 張延齡, 蔣永劍.胰頭癌淋巴結轉移的臨床研究[J].中國現代普通外科進展, 2004, 7(4): 232-234.
6.	崔云甫.胰腺癌淋巴轉移規律的研究進展[J].肝膽胰外科雜志, 2009, 21(3): 169-172.
7.	Samra JS, Gananadha S, Hugh TJ. Surgical management of carcinoma of the head of pancreas: extended lymphadenectomy or modified en bloc resection?[J]. ANZ J Surg, 2008, 78(4): 228-236.
8.	Beger HG, Thorab FC, Liu Z, et al. Pathogenesis and treatment of neoplastic diseasesof the papilla of Vater: Kausch-Whipple procedure with lymph node dissection in cancer ofthe papilla of Vater[J]. J Hepatobiliary Pancreat Surg, 2004, 11(4): 232-238.
9.	Zacharias T, Jaeck D, Oussoultzoglou E, et al. Impact of lymph node involvement on longterm survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas[J]. J Gastrointest Surg, 2007, 11(3): 350-356.
10.	Murakami Y, Uemura K, Sudo T, et al. Number of metastatic lymph nodes, but not lymph node ratio, is an independent prognostic factor after resection of pancreatic carcinoma[J]. J Am Coll Surg, 2010, 211(2): 196-204.
11.	Kurahara H, Takao S, Maemura K, et al. Impact of lymph node micrometastasis in patients with pancreatic head cancer[J]. World J Surg, 2007, 31(3): 483-490.
12.	Fortner JG. Regional resection of cancer of the pancreas: a newsurgical approach[J]. Surgery, 1973, 73(2): 307-320.
13.	Pedrazzoli S, Beger HG, Obertop H, et al. A surgical and pathological based classification of resective treatment of pancreatic cancer[J]. Dig Surg, 1999, 16(4): 337-345.
14.	Kawarada Y, Yokoi H, Isaji S, et al. Modified standard pancreaticoduodenectomy for the treatment of pancreatic head cancer[J]. Digestion, 1999, 60(Suppl 1): s120-s125.
15.	Nakao A, Takeda S, Inoue S, et al. Indications and techniques of extended resection for pancreatic cancer[J]. World J Surg, 2006, 30(6): 976-982.
16.	Farnell MB, Pearson RK, Sarr MG, et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma[J]. Surgery, 2005, 138(4): 618-630.
17.	Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality[J]. Ann Surg, 2002, 236(3): 355-368.
18.	Pedrazzoli S, DiCarlo V, Dionigi R, et al. Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group[J]. Ann Surg, 1998, 228(4): 508-517.
19.	Nimura Y, Nagino M, Takao S, et al. Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas[J]. J Hepatobiliary Pancreat Sci, 2012, 19(3): 230-241.
20.	Capussotti L, Massucco P, Ribero D, et al. Extended lymphadenectomy and vein resection for pancreatic head cancer: outcomes and implications for therapy[J]. Arch Surg, 2003, 138(12): 1316-1322.
21.	Xu X, Zhang H, Zhou P, et al. Meta-analysis of the efficacy of pancreatoduodenectomy with extended lymphadenectomy in the treatment of pancreatic cancer[J]. World J Surg Oncol, 2013, 11(1): 311.
22.	Michalski CW, Kleeff J, Wente MN, et al. Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer[J]. Br J Surg, 2007, 94(3): 265-273.
23.	National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology; version 2. 2012.[Accessed April 16, 2013]. Available at http://www.nccn.org//professionals/physician_gls/pdf/pancreatic.pdf.
24.	郭克建.從胰腺癌生物學特性判定腫瘤的可切除性[J].中華消化外科雜志, 2007, 6(4): 252-254.
25.	Kawarada Y, Isaji S. Modified standard (D1+α) pancreaticoduodenectomy for pancreatic cancer[J]. J Gastrointest Surg, 2000, 4(3): 227-228.
26.	Jang JY, Kang MJ, Heo JS, et al. A prospective randomized controlled study comparing outcomes of standard resection and extedned resection including dissection of the nerve plexus and various lymph nodes, in patients with pancteatic head cancer[J]. Ann Surg, 2014, 259(4): 656-664.
27.	楊尹默.胰腺癌外科治療新進展[J].中華消化外科雜志, 2013, 12(1): 16-20.
28.	Nagakawa T, Nagamori M, Futakami F, et al. Results of extensive surgery for pancreatic carcinoma[J]. Cancer, 1996, 77(4): 640-645.

1. ?Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1): 11-30.
2. Japanese Pancreas Society. Classification of Pancreatic Carcinoma[M]. 2nd ed. English edn. Tokyo: Kanehara & Co, Ltd., 2003.
3. Nakao A, Harada A, Nonami T, et al. Lymph node metastases in carcinoma of the head of the pancreas region[J]. Br J Surg, 1995, 82(3): 399-402.
4. Ishikawa O, Ohigashi H, Sasaki Y, et al. Practical grouping of positive lymph nodes in pancreatic head cancer treated by an extended pancreatectomy[J]. Surgery, 1997, 121(3): 244-249.
5. 倪泉興, 張延齡, 蔣永劍.胰頭癌淋巴結轉移的臨床研究[J].中國現代普通外科進展, 2004, 7(4): 232-234.
6. 崔云甫.胰腺癌淋巴轉移規律的研究進展[J].肝膽胰外科雜志, 2009, 21(3): 169-172.
7. Samra JS, Gananadha S, Hugh TJ. Surgical management of carcinoma of the head of pancreas: extended lymphadenectomy or modified en bloc resection?[J]. ANZ J Surg, 2008, 78(4): 228-236.
8. Beger HG, Thorab FC, Liu Z, et al. Pathogenesis and treatment of neoplastic diseasesof the papilla of Vater: Kausch-Whipple procedure with lymph node dissection in cancer ofthe papilla of Vater[J]. J Hepatobiliary Pancreat Surg, 2004, 11(4): 232-238.
9. Zacharias T, Jaeck D, Oussoultzoglou E, et al. Impact of lymph node involvement on longterm survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas[J]. J Gastrointest Surg, 2007, 11(3): 350-356.
10. Murakami Y, Uemura K, Sudo T, et al. Number of metastatic lymph nodes, but not lymph node ratio, is an independent prognostic factor after resection of pancreatic carcinoma[J]. J Am Coll Surg, 2010, 211(2): 196-204.
11. Kurahara H, Takao S, Maemura K, et al. Impact of lymph node micrometastasis in patients with pancreatic head cancer[J]. World J Surg, 2007, 31(3): 483-490.
12. Fortner JG. Regional resection of cancer of the pancreas: a newsurgical approach[J]. Surgery, 1973, 73(2): 307-320.
13. Pedrazzoli S, Beger HG, Obertop H, et al. A surgical and pathological based classification of resective treatment of pancreatic cancer[J]. Dig Surg, 1999, 16(4): 337-345.
14. Kawarada Y, Yokoi H, Isaji S, et al. Modified standard pancreaticoduodenectomy for the treatment of pancreatic head cancer[J]. Digestion, 1999, 60(Suppl 1): s120-s125.
15. Nakao A, Takeda S, Inoue S, et al. Indications and techniques of extended resection for pancreatic cancer[J]. World J Surg, 2006, 30(6): 976-982.
16. Farnell MB, Pearson RK, Sarr MG, et al. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma[J]. Surgery, 2005, 138(4): 618-630.
17. Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality[J]. Ann Surg, 2002, 236(3): 355-368.
18. Pedrazzoli S, DiCarlo V, Dionigi R, et al. Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group[J]. Ann Surg, 1998, 228(4): 508-517.
19. Nimura Y, Nagino M, Takao S, et al. Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas[J]. J Hepatobiliary Pancreat Sci, 2012, 19(3): 230-241.
20. Capussotti L, Massucco P, Ribero D, et al. Extended lymphadenectomy and vein resection for pancreatic head cancer: outcomes and implications for therapy[J]. Arch Surg, 2003, 138(12): 1316-1322.
21. Xu X, Zhang H, Zhou P, et al. Meta-analysis of the efficacy of pancreatoduodenectomy with extended lymphadenectomy in the treatment of pancreatic cancer[J]. World J Surg Oncol, 2013, 11(1): 311.
22. Michalski CW, Kleeff J, Wente MN, et al. Systematic review and meta-analysis of standard and extended lymphadenectomy in pancreaticoduodenectomy for pancreatic cancer[J]. Br J Surg, 2007, 94(3): 265-273.
23. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology; version 2. 2012.[Accessed April 16, 2013]. Available at http://www.nccn.org//professionals/physician_gls/pdf/pancreatic.pdf.
24. 郭克建.從胰腺癌生物學特性判定腫瘤的可切除性[J].中華消化外科雜志, 2007, 6(4): 252-254.
25. Kawarada Y, Isaji S. Modified standard (D1+α) pancreaticoduodenectomy for pancreatic cancer[J]. J Gastrointest Surg, 2000, 4(3): 227-228.
26. Jang JY, Kang MJ, Heo JS, et al. A prospective randomized controlled study comparing outcomes of standard resection and extedned resection including dissection of the nerve plexus and various lymph nodes, in patients with pancteatic head cancer[J]. Ann Surg, 2014, 259(4): 656-664.
27. 楊尹默.胰腺癌外科治療新進展[J].中華消化外科雜志, 2013, 12(1): 16-20.
28. Nagakawa T, Nagamori M, Futakami F, et al. Results of extensive surgery for pancreatic carcinoma[J]. Cancer, 1996, 77(4): 640-645.

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