Curative Effect Observation of Thrombin in Treatment of Subcutaneous Effusion Following Radical Resection of Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 ZHOUWen ,  TANCheng , ZOUWei , BENE-yi , LIAOFeng-lin

Department of Oncological Surgery, The First People's Hospital of Yidu, Yidu 443300, Hubei Province, China;

Corresponding?author：

TANCheng, Email: wdeng_12@163.com

Keywords：

Thrombin; Breast cancer; Subcutaneous effusion

DOI：

10.7507/1007-9424.20140239

Video：

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Objective To explore the efficacy of thrombin in treatment of subcutaneous effusion after radical resection of breast cancer. Methods One hundred and ninety patients underwent radical resection of breast cancer from July 2008 to July 2013 in this hospital were divided into postoperative observation group and postoperative control group according to the operation time. A daily injection of thrombin by drainage tube was performed on day 3 after operation in the postoperative observation group, the negative pressure drainage only was performed in the postoperative control group. The drainage volume in 72 h after operation, time of extubation, cases of subcutaneous effusion were counted after operation. Then the patients with subcutaneous effusion were divided into subcutaneous effusion observation group and subcutaneous effusion control group according to the time of extubation, the thrombin was injected into cavity after pumping subcutaneous effusion with pressing and dressing in the subcutaneous effusion observation group and only pressed after pumping subcutaneous effusion in the subcutaneous effusion control group, respectively. The healing time of subcutaneous effusion was counted in these two groups. Results Compared with the postoperative control group, the drainage volume in 72 h after operation was less(P < 0.001), the time of extubation was earlier(P < 0.001), the rate of subcutaneous effusion was lower(P < 0.05), color of drainage fluid on day 2 after mastectomy was lighter(P < 0.001)in the postoperative observation group. Compared with subcutaneous effusion control group, when subcutaneous effusion was 20-50 mL or > 50 mL, the healing time of subcutaneous effusion was significantly shorter in the subcutaneous effusion observation group(P < 0.05). Conclusions Injecting thrombin by drainage tube after operation can reduce the drainage volume, decrease the rate of subcutaneous liquid, and shorten the time of extubation. Injecting thrombin into cavity of subcutaneous liquid can shorten the healing time of patients with middle and large subcutaneous effusions after radical resection of breast cancer.

Citation： ZHOUWen, TANCheng, ZOUWei, BENE-yi, LIAOFeng-lin. Curative Effect Observation of Thrombin in Treatment of Subcutaneous Effusion Following Radical Resection of Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(8): 996-1000. doi: 10.7507/1007-9424.20140239 Copy

1.	鄭向欣, 管小青, 吳驥, 等.乳腺癌術后皮下積液發生原因及防治(附204例報告)[J].醫學理論與實踐, 2014, 26(4): 434-435.
2.	Han J, Grothuesmann D, Neises M, et al. Quality of life and satisfaction after breast cancer operation[J]. Arch Gynecol Obstet, 2010, 282(1): 75-82.
3.	Dalberg K, Johansson H, Signomklao T, et al. A randomised study of axillary drainage and pectoral fascia preservation after mastectomy for breast cancer[J]. Eur J Surg Oncol, 2004, 30(6): 602-609.
4.	莫春連, 何沙, 盧永剛.乳腺癌改良根治術后皮下積液的發生原因與防治[J].實用癌癥雜志, 2012, 27(4): 382-383, 388.
5.	路忠志, 李東生, 李麗.乳腺癌術后皮瓣壞死及皮下積液原因及處理[J/CD].中華普通外科學文獻:電子版, 2010, 4(4): 385-388.
6.	沈俊, 邱園華, 王林波.乳腺癌術后積液產生的原因和預防[J].國際外科學雜志, 2006, 33(2): 103-106.
7.	Boostrom SY, Throckmorton AD, Boughey JC, et al. Incidence of clinically significant seroma after breast and axillary surgery[J]. J Am Coll Surg, 2009, 208(1): 148-150.
8.	趙晨陽, 劉景貞, 馬保海, 等.不同游離方法在乳腺癌改良根治術后皮瓣壞死的臨床研究[J].臨床合理用藥雜志, 2013, 6(26): 22-23.
9.	董傳江, 尚健, 孫井軍, 等.手術刀與電刀游離皮瓣防治乳腺癌術后皮下積液的臨床對比分析[J].中國當代醫藥, 2013, 20(17): 59-60, 62.
10.	董龍慶, 于棟梁, 徐龍君.乳腺癌術后皮下積液與皮瓣壞死的防治[J].臨床醫學, 2012, 32(12): 18-20.
11.	張彥收, 焦俊琴, 卞曉麗, 等.可吸收止血海綿在乳腺癌改良根治術中應用的效果觀察[J].臨床外科雜志, 2012, 20(4): 250-251.
12.	張世軍, 馬紅英.乳腺癌術后2種引流方式的療效比較[J].腫瘤基礎與臨床, 2011, 24(6): 530-531.
13.	陽旭.不同引流方式對乳腺癌術后皮下積液的作用分析[J].亞太傳統醫藥, 2012, 8(4): 131-132.
14.	宋杏麗, 王鋼.單管或雙管引流對乳腺癌改良根治術后皮下積液影響的研究[J].中國現代醫藥雜志, 2013, 15(1): 49-50.
15.	魯武偉, 彭杏芳.不同處理方法防治乳腺癌術后皮下積液的臨床效果觀察[J].中國傷殘醫學, 2013, 21(2): 80-81.
16.	林小燕, 茍菊香, 蔣義雪.乳腺癌病人術后拔管指征的探討[J].護理研究, 2013, 27(27): 2999-3000.
17.	趙凱華, 胡亦欽, 俞喬, 等.乳腺癌術后皮下積液的影響因素探討[J].中國腫瘤外科雜志, 2011, 3(1): 17-19.
18.	金科, 章遠江, 許健, 等. B超引導靜脈留置針持續引流在處理乳腺癌術后局部皮下積液中的應用[J].中國普外基礎與臨床雜志, 2013, 20(4): 444-446.
19.	張巨合, 徐皓.生物蛋白膠防治乳腺癌術后皮下積液的研究[J].中華全科醫學, 2012, 10(7): 1066-1067, 1146.
20.	馬榕, 張凱.乳腺癌術后皮下積液的性質及處理原則[J].國際外科學雜志, 2007, 34(7): 501-502.
21.	杜尖, 田茂新, 吳建平, 等.乳腺癌術后皮下積液的防治[J].中國現代醫學雜志, 2007, 17(6): 739-740, 743.
22.	吳濤, 張華兵, 曹阿丹.凝血酶在胸膜粘連術中的臨床療效評價[J].中國現代藥物應用, 2012, 6(6): 79-80.
23.	馬少林, 李潤浦, 王艷麗, 等.博萊霉素聯合白介素-2及凝血酶治療惡性胸腔積液的臨床觀察[J].現代腫瘤醫學, 2013, 21(3): 557-559.
24.	呂章春, 胡谷冰, 朱佩貞.博來霉素聯合凝血酶對惡性血性胸水的療效觀察[J].腫瘤防治研究, 2002, 29(3): 236-237.
25.	周學敏, 朱鐵年, 金普樂, 等.凝血酶治療癌性胸腔積液的臨床觀察[J].中華結核和呼吸雜志, 1996, 19(4): 50.

1. 鄭向欣, 管小青, 吳驥, 等.乳腺癌術后皮下積液發生原因及防治(附204例報告)[J].醫學理論與實踐, 2014, 26(4): 434-435.
2. Han J, Grothuesmann D, Neises M, et al. Quality of life and satisfaction after breast cancer operation[J]. Arch Gynecol Obstet, 2010, 282(1): 75-82.
3. Dalberg K, Johansson H, Signomklao T, et al. A randomised study of axillary drainage and pectoral fascia preservation after mastectomy for breast cancer[J]. Eur J Surg Oncol, 2004, 30(6): 602-609.
4. 莫春連, 何沙, 盧永剛.乳腺癌改良根治術后皮下積液的發生原因與防治[J].實用癌癥雜志, 2012, 27(4): 382-383, 388.
5. 路忠志, 李東生, 李麗.乳腺癌術后皮瓣壞死及皮下積液原因及處理[J/CD].中華普通外科學文獻:電子版, 2010, 4(4): 385-388.
6. 沈俊, 邱園華, 王林波.乳腺癌術后積液產生的原因和預防[J].國際外科學雜志, 2006, 33(2): 103-106.
7. Boostrom SY, Throckmorton AD, Boughey JC, et al. Incidence of clinically significant seroma after breast and axillary surgery[J]. J Am Coll Surg, 2009, 208(1): 148-150.
8. 趙晨陽, 劉景貞, 馬保海, 等.不同游離方法在乳腺癌改良根治術后皮瓣壞死的臨床研究[J].臨床合理用藥雜志, 2013, 6(26): 22-23.
9. 董傳江, 尚健, 孫井軍, 等.手術刀與電刀游離皮瓣防治乳腺癌術后皮下積液的臨床對比分析[J].中國當代醫藥, 2013, 20(17): 59-60, 62.
10. 董龍慶, 于棟梁, 徐龍君.乳腺癌術后皮下積液與皮瓣壞死的防治[J].臨床醫學, 2012, 32(12): 18-20.
11. 張彥收, 焦俊琴, 卞曉麗, 等.可吸收止血海綿在乳腺癌改良根治術中應用的效果觀察[J].臨床外科雜志, 2012, 20(4): 250-251.
12. 張世軍, 馬紅英.乳腺癌術后2種引流方式的療效比較[J].腫瘤基礎與臨床, 2011, 24(6): 530-531.
13. 陽旭.不同引流方式對乳腺癌術后皮下積液的作用分析[J].亞太傳統醫藥, 2012, 8(4): 131-132.
14. 宋杏麗, 王鋼.單管或雙管引流對乳腺癌改良根治術后皮下積液影響的研究[J].中國現代醫藥雜志, 2013, 15(1): 49-50.
15. 魯武偉, 彭杏芳.不同處理方法防治乳腺癌術后皮下積液的臨床效果觀察[J].中國傷殘醫學, 2013, 21(2): 80-81.
16. 林小燕, 茍菊香, 蔣義雪.乳腺癌病人術后拔管指征的探討[J].護理研究, 2013, 27(27): 2999-3000.
17. 趙凱華, 胡亦欽, 俞喬, 等.乳腺癌術后皮下積液的影響因素探討[J].中國腫瘤外科雜志, 2011, 3(1): 17-19.
18. 金科, 章遠江, 許健, 等. B超引導靜脈留置針持續引流在處理乳腺癌術后局部皮下積液中的應用[J].中國普外基礎與臨床雜志, 2013, 20(4): 444-446.
19. 張巨合, 徐皓.生物蛋白膠防治乳腺癌術后皮下積液的研究[J].中華全科醫學, 2012, 10(7): 1066-1067, 1146.
20. 馬榕, 張凱.乳腺癌術后皮下積液的性質及處理原則[J].國際外科學雜志, 2007, 34(7): 501-502.
21. 杜尖, 田茂新, 吳建平, 等.乳腺癌術后皮下積液的防治[J].中國現代醫學雜志, 2007, 17(6): 739-740, 743.
22. 吳濤, 張華兵, 曹阿丹.凝血酶在胸膜粘連術中的臨床療效評價[J].中國現代藥物應用, 2012, 6(6): 79-80.
23. 馬少林, 李潤浦, 王艷麗, 等.博萊霉素聯合白介素-2及凝血酶治療惡性胸腔積液的臨床觀察[J].現代腫瘤醫學, 2013, 21(3): 557-559.
24. 呂章春, 胡谷冰, 朱佩貞.博來霉素聯合凝血酶對惡性血性胸水的療效觀察[J].腫瘤防治研究, 2002, 29(3): 236-237.
25. 周學敏, 朱鐵年, 金普樂, 等.凝血酶治療癌性胸腔積液的臨床觀察[J].中華結核和呼吸雜志, 1996, 19(4): 50.

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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Curative Effect Observation of Thrombin in Treatment of Subcutaneous Effusion Following Radical Resection of Breast Cancer

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