Research Progress of Black Cohosh Root Extract in The Treatment of Menopausal Symptoms for Patients with Breast Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHAIYu-lin ¹ , SONGYi-ning ¹ , SUJun-qiang ² ,  JIHong-liang ¹

1. Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, Heilongjiang Province, China;
2. Department of Surgical Oncology, The First Affiliated Hospital of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China;

Corresponding?author：

JIHong-liang, Email: jihongliang2012@163.com

Keywords：

Black cohosh root extract; Menopausal symptoms; Breast cancer

DOI：

10.7507/1007-9424.20140380

Video：

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Objective To summarize the research progress of black cohosh root extract in the treatment of menopausal symptoms for patients with breast cancer. Methods Domestic and foreign literatures about the effect of black cohosh root extract in the treatment of menopausal symptoms for patients with breast cancer were collected to make a review. Results Black cohosh root extract was a kind of herbal preparations. In the treatment of menopausal symptoms in breast cancer patients, it not only had significantly curative effect but also had less adverse reactions. Conclusions In the treatment of menopausal symptoms in breast cancer patients, black cohosh root extract gives people a new treatment idea. It has significant side effect and can be widely promoted and applied in clinical.

Citation： CHAIYu-lin, SONGYi-ning, SUJun-qiang, JIHong-liang. Research Progress of Black Cohosh Root Extract in The Treatment of Menopausal Symptoms for Patients with Breast Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2014, 21(12): 1598-1601. doi: 10.7507/1007-9424.20140380 Copy

1.	張海燕, 任鈞, 張高東, 等.產后婦女骨密度變化及影響因素研究[J].重慶醫學, 2011, 40(25):2539-2540.
2.	Freeman EW, Guthrie KA, Caan B, et al.Efficacy of escitalopram for hot flashes in healthy menopausal women:a randomized controlled trial[J].JAMA, 2011, 305(3):267-274.
3.	Parkin DM, Pisani P, Ferlay J.Global cancer statistics[J].CA Cancer J Clin, 1999, 49(1):33-64.
4.	Cancer Genome Atlas Network.Comprehensive molecular portr-aits of human breast tumours[J].Nature, 2012, 490(7418):61-70.
5.	Henneicke-Von Zepelin HH, Meden H, Kostev K, et al.Isopro-panolic black cohosh extract and recurrence-free survival after breast cancer[J].Int J Clin Pharmacol Ther, 2007, 45(3):143-154.
6.	Park IH, Han HS, Lee H, et al.Resumption or persistence of menstruation after cytotoxic chemotherapy is a prognostic factor for poor disease-free survival in premenopausal patients with early breast cancer[J].Ann Oncol, 2012, 23(9):2283-2289.
7.	黃秀霞, 陳麗珍.性激素替代治療婦女更年期綜合征100例臨床分析[J].中外醫學研究, 2011, 9(15):51-52.
8.	Fillmore CM, Gupta PB, Rudnick JA, et al.Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling[J].Proc Natl Acad Sci U S A, 2010, 107(50):21737-21742.
9.	林莉芬.小劑量雌激素治療圍絕經期綜合征療效分析[J].中國當代醫藥, 2012, 19(6):65-67.
10.	Kloosterboer HJ.Historical milestones in the development of tibolone (Livial^?)[J].Climacteric, 2011, 14(6):609-621.
11.	Saxe EL.Chemopreventive potential and action of the herb black cohosh on Sprague-Dawley rats[J].Anticancer Res, 2012, 3(1):455-457.
12.	張莉.圍絕經期抑郁癥狀與血清性激素水平的關聯性研究[J].安徽衛生職業技術學院學報, 2010, 9((2):29-30.
13.	方芳, 張紹芬.絕經后激素治療應用時機及期限[J].中國實用婦科與產科雜志, 2011, 27(5):330-333.
14.	Lobo RA.Potential options for preservation of fertility in women[J].N Engl J Med, 2005, 353(1):64-73.
15.	Posada MN, Kolp L, Garcia JE.Fertility options for female cancer patients:facts and fiction[J].Fertil Steril, 2001, 75(4):647-653.
16.	Fiaher B, Dignam J, Bryant J, et al.Five versus more than five years of tamoxifen for lymph node-negative breast cancer:updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial[J].J Natl Cancer Inst, 2001, 93(9):684-690.
17.	孫寧霞, 金志軍, 賈曉峰, 等.黑升麻制劑改善絕經后婦女陰道萎縮癥狀的探討[J].第二軍醫大學學報, 2012, 33(3):339-342.
18.	李文, 孫寧霞, 陳旭, 等.早期子宮內膜癌患者術后應用黑升麻制劑治療絕經相關癥狀[J].第二軍醫大學學報, 2012, 33(5):562-564.
19.	Hostanska K, Nisslein T, Freudenstein J, et al.Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells[J].Biol Pharm Bull, 2004, 27(12):1970-1975.
20.	Liske E, H?nggi W, Henneicke-Von Zepelin HH, et al.Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma):a 6-month clinical study demonstrates no systemic estrogenic effect[J].J Womens Health Gend Based Med, 2002, 11(2):163-174.
21.	Bodinet C, Freudenstein J.Influence of marketed herbal menopause preparations on MCF-7 cell proliferation[J].Menopause, 2004, 11(3):281-289.
22.	Gurley BJ, Swain A, Hubbard MA, et al.Clinical assessment of CYP2D6-mediated herb-drug interactions in humans:effects of milk thistle, black cohosh, goldenseal, kava kava, St.John's wort, and Echinacea[J].Mol Nutr Food Res, 2008, 52(7):755-763.
23.	Powell SL, G?decke T, Nikolic D, et al.In vitro serotonergic activity of black cohosh and identification of N (omega)-methylserotonin as a potential active constituent[J].J Agric Food Chem, 2008, 56(24):11718-11726.
24.	馬曉艷, 張慧, 王珂, 等.莉芙敏對去卵巢大鼠下丘腦視前區5-HT1AR和5-HT2AR表達的影響[J].國際婦產科學雜志, 2011, 38(2):148-154.
25.	Cicek SS, Khom S, Taferner B, et al.Bioactivity-guided isolation of GABA (A) receptor modulating constituents from the rhizo-mes of Actaea racemosa[J].J Nat Prod, 2010, 73(12):2024-2028.
26.	Reame NE, Lukacs JL, Padmanabhan V, et al.Black cohosh has central opioid activity in postmenopausal women:evidence from naloxone blockade and positron emission tomography neuroimaging[J].Menopause, 2008, 15(5):832-840.
27.	Teschke R, Schwarzenboeck A.Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root):critical analysis and structured causality assessment[J].Phytomedicine, 2009, 16(1):72-84.
28.	潘雪飛, 杜斌, 范群, 等.綜合分析藥物性肝損傷4076例[J].東南國防醫藥, 2009, 11(6):505-507.
29.	Kass-Annese B.Altemative therapies for menopause[J].Clin Obstet Gynecol, 2000, 43(1):162-183.
30.	曹澤毅.中華婦產科學[M].北京:人民衛生出版社, 1999:518-519.
31.	Burdette JE, Liu J, Chen SN, et al.Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor[J].J Agric Food Chem, 2003, 51(19):5661-5670.
32.	Hickey M, Davis SR, Sturdee DW.Treatment of menopausal zymptoms:what shall we do now?[J].Lancet, 2005, 366(9483):409-421.
33.	Rebbeck TR, Troxel AB, Norman S, et al.A retrospective case-control study of the use of hormone-related supplements and association with breast cancer[J].Int J Cancer, 2007, 120(7):1523-1528.
34.	龐雪, 孟莉英, 張欣, 等.治療圍絕經期綜合征的傳統植物藥——莉芙敏[J].中國藥學雜志, 2010, 45(16):1279-1280.
35.	Rossouw JE, Anderson GL, Prentice RL, et al.Risks and benefits of estrogen plus progestin in healthy postmenopausal women:principal results from the Women's Health Initiative randomized controlled trial[J].JAMA, 2002, 288(3):321-333.
36.	Bai W, Henneicke-Von Zepelin HH, Wang S, et al.Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms:a randomized, double blind, parallel-controlled study versus tibolone[J].Maturitas, 2007, 58(1):31-41.
37.	Borrelli F, Ernst E.Cimicifuga racemosa:a systematic review of its clinical efficacy[J].Eur J Clin Pharmacol, 2002, 58(4):235-241.
38.	Qsmers R, Friede M, Liske E, et al.Efficacy and safety of isopro-panolic black cohosh extract for climacteric symptoms[J].Obstet Gynecol, 2005, 105(5 Pt 1):1074-1083.
39.	徐融.莉芙敏片與利維愛改善圍絕經期癥狀的效果和安全性比較[J].中國全科醫學, 2011, 14(35):4060-4063.
40.	李軼琳, 崔滿華, 高雙.黑升麻類藥物莉芙敏治療更年期癥狀臨床療效觀察[J].現代婦產科進展, 2011, 20(6):462-465.
41.	Jacobsen DE, Melis RJ, Verhaar HJ, et al.Raloxifene and tibo-lone in elderly women:a randomized, double-blind, double-dummy, placebo-controlled trial[J].J Am Med Dir Assoc, 2012, 13(2):189.e1-189.e7.
42.	Ahn BS, Yang M, Jang H, et al.Evaluation of the antiosteopo-rotic potential of Cimicifuga heracleifolia in female mice[J].Phytother Res, 2012, 26(5):663-668.
43.	Li-Yu J, Perez EC, Ca?ete A, et al.Consensus statements on osteoporosis diagnosis, prevention, and management in the Philippines[J].Int J Rheum Dis, 2011, 14(3):223-238.

1. 張海燕, 任鈞, 張高東, 等.產后婦女骨密度變化及影響因素研究[J].重慶醫學, 2011, 40(25):2539-2540.
2. Freeman EW, Guthrie KA, Caan B, et al.Efficacy of escitalopram for hot flashes in healthy menopausal women:a randomized controlled trial[J].JAMA, 2011, 305(3):267-274.
3. Parkin DM, Pisani P, Ferlay J.Global cancer statistics[J].CA Cancer J Clin, 1999, 49(1):33-64.
4. Cancer Genome Atlas Network.Comprehensive molecular portr-aits of human breast tumours[J].Nature, 2012, 490(7418):61-70.
5. Henneicke-Von Zepelin HH, Meden H, Kostev K, et al.Isopro-panolic black cohosh extract and recurrence-free survival after breast cancer[J].Int J Clin Pharmacol Ther, 2007, 45(3):143-154.
6. Park IH, Han HS, Lee H, et al.Resumption or persistence of menstruation after cytotoxic chemotherapy is a prognostic factor for poor disease-free survival in premenopausal patients with early breast cancer[J].Ann Oncol, 2012, 23(9):2283-2289.
7. 黃秀霞, 陳麗珍.性激素替代治療婦女更年期綜合征100例臨床分析[J].中外醫學研究, 2011, 9(15):51-52.
8. Fillmore CM, Gupta PB, Rudnick JA, et al.Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling[J].Proc Natl Acad Sci U S A, 2010, 107(50):21737-21742.
9. 林莉芬.小劑量雌激素治療圍絕經期綜合征療效分析[J].中國當代醫藥, 2012, 19(6):65-67.
10. Kloosterboer HJ.Historical milestones in the development of tibolone (Livial^?)[J].Climacteric, 2011, 14(6):609-621.
11. Saxe EL.Chemopreventive potential and action of the herb black cohosh on Sprague-Dawley rats[J].Anticancer Res, 2012, 3(1):455-457.
12. 張莉.圍絕經期抑郁癥狀與血清性激素水平的關聯性研究[J].安徽衛生職業技術學院學報, 2010, 9((2):29-30.
13. 方芳, 張紹芬.絕經后激素治療應用時機及期限[J].中國實用婦科與產科雜志, 2011, 27(5):330-333.
14. Lobo RA.Potential options for preservation of fertility in women[J].N Engl J Med, 2005, 353(1):64-73.
15. Posada MN, Kolp L, Garcia JE.Fertility options for female cancer patients:facts and fiction[J].Fertil Steril, 2001, 75(4):647-653.
16. Fiaher B, Dignam J, Bryant J, et al.Five versus more than five years of tamoxifen for lymph node-negative breast cancer:updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial[J].J Natl Cancer Inst, 2001, 93(9):684-690.
17. 孫寧霞, 金志軍, 賈曉峰, 等.黑升麻制劑改善絕經后婦女陰道萎縮癥狀的探討[J].第二軍醫大學學報, 2012, 33(3):339-342.
18. 李文, 孫寧霞, 陳旭, 等.早期子宮內膜癌患者術后應用黑升麻制劑治療絕經相關癥狀[J].第二軍醫大學學報, 2012, 33(5):562-564.
19. Hostanska K, Nisslein T, Freudenstein J, et al.Evaluation of cell death caused by triterpene glycosides and phenolic substances from Cimicifuga racemosa extract in human MCF-7 breast cancer cells[J].Biol Pharm Bull, 2004, 27(12):1970-1975.
20. Liske E, H?nggi W, Henneicke-Von Zepelin HH, et al.Physiological investigation of a unique extract of black cohosh (Cimicifugae racemosae rhizoma):a 6-month clinical study demonstrates no systemic estrogenic effect[J].J Womens Health Gend Based Med, 2002, 11(2):163-174.
21. Bodinet C, Freudenstein J.Influence of marketed herbal menopause preparations on MCF-7 cell proliferation[J].Menopause, 2004, 11(3):281-289.
22. Gurley BJ, Swain A, Hubbard MA, et al.Clinical assessment of CYP2D6-mediated herb-drug interactions in humans:effects of milk thistle, black cohosh, goldenseal, kava kava, St.John's wort, and Echinacea[J].Mol Nutr Food Res, 2008, 52(7):755-763.
23. Powell SL, G?decke T, Nikolic D, et al.In vitro serotonergic activity of black cohosh and identification of N (omega)-methylserotonin as a potential active constituent[J].J Agric Food Chem, 2008, 56(24):11718-11726.
24. 馬曉艷, 張慧, 王珂, 等.莉芙敏對去卵巢大鼠下丘腦視前區5-HT1AR和5-HT2AR表達的影響[J].國際婦產科學雜志, 2011, 38(2):148-154.
25. Cicek SS, Khom S, Taferner B, et al.Bioactivity-guided isolation of GABA (A) receptor modulating constituents from the rhizo-mes of Actaea racemosa[J].J Nat Prod, 2010, 73(12):2024-2028.
26. Reame NE, Lukacs JL, Padmanabhan V, et al.Black cohosh has central opioid activity in postmenopausal women:evidence from naloxone blockade and positron emission tomography neuroimaging[J].Menopause, 2008, 15(5):832-840.
27. Teschke R, Schwarzenboeck A.Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root):critical analysis and structured causality assessment[J].Phytomedicine, 2009, 16(1):72-84.
28. 潘雪飛, 杜斌, 范群, 等.綜合分析藥物性肝損傷4076例[J].東南國防醫藥, 2009, 11(6):505-507.
29. Kass-Annese B.Altemative therapies for menopause[J].Clin Obstet Gynecol, 2000, 43(1):162-183.
30. 曹澤毅.中華婦產科學[M].北京:人民衛生出版社, 1999:518-519.
31. Burdette JE, Liu J, Chen SN, et al.Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor[J].J Agric Food Chem, 2003, 51(19):5661-5670.
32. Hickey M, Davis SR, Sturdee DW.Treatment of menopausal zymptoms:what shall we do now?[J].Lancet, 2005, 366(9483):409-421.
33. Rebbeck TR, Troxel AB, Norman S, et al.A retrospective case-control study of the use of hormone-related supplements and association with breast cancer[J].Int J Cancer, 2007, 120(7):1523-1528.
34. 龐雪, 孟莉英, 張欣, 等.治療圍絕經期綜合征的傳統植物藥——莉芙敏[J].中國藥學雜志, 2010, 45(16):1279-1280.
35. Rossouw JE, Anderson GL, Prentice RL, et al.Risks and benefits of estrogen plus progestin in healthy postmenopausal women:principal results from the Women's Health Initiative randomized controlled trial[J].JAMA, 2002, 288(3):321-333.
36. Bai W, Henneicke-Von Zepelin HH, Wang S, et al.Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms:a randomized, double blind, parallel-controlled study versus tibolone[J].Maturitas, 2007, 58(1):31-41.
37. Borrelli F, Ernst E.Cimicifuga racemosa:a systematic review of its clinical efficacy[J].Eur J Clin Pharmacol, 2002, 58(4):235-241.
38. Qsmers R, Friede M, Liske E, et al.Efficacy and safety of isopro-panolic black cohosh extract for climacteric symptoms[J].Obstet Gynecol, 2005, 105(5 Pt 1):1074-1083.
39. 徐融.莉芙敏片與利維愛改善圍絕經期癥狀的效果和安全性比較[J].中國全科醫學, 2011, 14(35):4060-4063.
40. 李軼琳, 崔滿華, 高雙.黑升麻類藥物莉芙敏治療更年期癥狀臨床療效觀察[J].現代婦產科進展, 2011, 20(6):462-465.
41. Jacobsen DE, Melis RJ, Verhaar HJ, et al.Raloxifene and tibo-lone in elderly women:a randomized, double-blind, double-dummy, placebo-controlled trial[J].J Am Med Dir Assoc, 2012, 13(2):189.e1-189.e7.
42. Ahn BS, Yang M, Jang H, et al.Evaluation of the antiosteopo-rotic potential of Cimicifuga heracleifolia in female mice[J].Phytother Res, 2012, 26(5):663-668.
43. Li-Yu J, Perez EC, Ca?ete A, et al.Consensus statements on osteoporosis diagnosis, prevention, and management in the Philippines[J].Int J Rheum Dis, 2011, 14(3):223-238.

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Research Progress of Black Cohosh Root Extract in The Treatment of Menopausal Symptoms for Patients with Breast Cancer

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