Value on The Differential Diagnosis of Ultrasound Contrast in Hepatocellular Carcinoma and Hepatic Focal Nodular Hyperplasia_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 CHENHan-xun , LUMin-yan , SHUQi , FANGJie-ying , QIUYi-de

Ultrasonic Diagnosis and Treatment Ccenter, The First People's Hospital of Foshan City, Foshan 528000, Guangdong Province, China;

Corresponding?author：

CHENHan-xun, Email: chx198004@126.com

Keywords：

Ultrasound contrast; Hepatocellular carcinoma; Hepatic focal nodular hyperplasia; Differential diagnosis

DOI：

10.7507/1007-9424.20150020

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the value of ultrasound contrast in the differential diagnosis for hepatocellular carcinoma (HCC) and hepatic focal nodular hyperplasia (FNH). Methods Twenty-three HCC patients and 23 cases hepatic FNH patients from January 1, 2012 to January 1, 2014 in our hospital were selected, all of them were underwent ultrasound contrast examination before operation. The ultrasound contrast results of 2 groups patients were comparative analyzed. Results In HCC group, the contrast arrival time was (3.8±1.9) s, peak time was (21.8±11.9) s, and peak strength was (28.8 ±3.1) dB; in hepatic FNH group, these indicators was (2.3±1.4) s, (35.3±14.8) s, and (22.3±7.9) dB, respectively. These indicators of HCC group was longer or shorter or higher than those of hepatic FNH group, respectively (P < 0.05). The sensitivity, specificity, and accuracy of ultrasound contrast diagnosed HCC was 91.3% (21/23), 87.0% (20/23), and 95.7% (22/23), and diagnosed hepatic FHN was 87.0% (20/23), 91.3% (21/23), and 91.3% (21/23), respectively, the difference were not statistically significant between the two groups (P > 0.05). Conclusion Ultrasound contrast has very important application value in the differential diagnosis of HCC and hepatic FNH, can be used in clinical application.

Citation： CHENHan-xun, LUMin-yan, SHUQi, FANGJie-ying, QIUYi-de. Value on The Differential Diagnosis of Ultrasound Contrast in Hepatocellular Carcinoma and Hepatic Focal Nodular Hyperplasia. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(1): 85-87. doi: 10.7507/1007-9424.20150020 Copy

1.	朱峰, 張火俊.肝局灶性結節性增生與肝細胞癌MRI平掃及強化特征分析.中國醫藥導報, 2013, 10(30):138-140.
2.	徐莉莉, 盛復庚, 陸虹, 等.釓塞酸二鈉在肝臟FNH診斷中的臨床價值.醫學影像學雜志, 2013, 23(5):715-718.
3.	陳娟, 劉慧, 張秀萍, 等. CT雙期增強掃描在肝臟FNH和肝腺瘤中的診斷價值.醫學臨床研究, 2013, 30(5):902-904.
4.	Yoneda N, Matsui O, Kitao A, et al. Hepatocyte transporter expression in FNH and FNH-like nodule:correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images. Jpn J Radiol, 2012, 30(6):499-508.
5.	Xiong W, Sun LP, Chen XM, et al. Comparison of microRNA expression profiles in HCC-derived microvesicles and the parental cells and evaluation of their roles in HCC. J Huazhong Univ Sci Technolog Med Sci, 2013, 33(3):346-352.
6.	周建華, 韓峰, 李安華, 等.超聲造影定量分析動脈相血流灌注參數在肝局灶性結節增生和肝細胞肝癌鑒別診斷中的價值.中華醫學超聲雜志:電子版, 2009, 6(1):19-21.
7.	顏見, 潘楚芝, 姚志成, 等.肝癌家族史對原發性肝癌患者手術治療預后的影響.中華普通外科雜志, 2012, 27(10):798-801.
8.	Liu YF, Cao LJ, Hillengass J, et al. Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, and histology. Acta Radiol, 2013, 54(2):205-213.
9.	魏秀華.肝臟局灶性結節增生(FNH)的影像診斷與鑒別.按摩與康復醫學(中旬刊), 2012, 3(3):205.
10.	裴小青, 陳敏山, 劉隆中, 等.肝細胞癌與肝局灶性結節增生的超聲造影動態灌注曲線對比分析.中國超聲醫學雜志, 2010, 26(5):444-448.
11.	劉建民, 楊林, 江山岳, 等.肝細胞癌門靜脈癌檢弦門靜脈海綿樣變性飼支循環的影像特征探討.西部醫學, 201l, 23(11):2240-2242.
12.	Qiao Y, Cao H, Zhang S, et al. Sonochemiluminescence observation of lipidand polymer-shelled ultrasound contrast agents in 1.2 MHz focused ultrasound field. Ultrason Sonochem, 2013, 20(1):162-170.
13.	彭成忠, 范小明, 王力.正常直腸腔內灌注超聲造影和靜脈超聲造影表現.臨床超聲醫學雜志, 2014, 16(2):14-16.
14.	賀宇平, 王晉, 田民.肝局灶性結節性增生患者螺旋CT多期增強掃描結果分析(附10例報告).山東醫藥, 2011, 51(14):38-39.
15.	于麗波.肝局灶性結節性增生與肝細胞癌MRI特征對比分析.中國醫學創新, 2013, 10(14):82-83.
16.	張代橋, 明照亭.肝局灶性結節性增生的CT診斷.內蒙古中醫藥, 2013, 32(14):180.
17.	Quaia E, Calliada F, Bertolotto M, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent:diagnostic performance and confidence. Radiology, 2004, 232(2):420-430.
18.	吳薇, 陳敏華, 戴瑩, 等.超聲造影在肝硬化增生結節病變中的應用.中華超聲影像學雜志, 2010, 19(9):776-779.

1. 朱峰, 張火俊.肝局灶性結節性增生與肝細胞癌MRI平掃及強化特征分析.中國醫藥導報, 2013, 10(30):138-140.
2. 徐莉莉, 盛復庚, 陸虹, 等.釓塞酸二鈉在肝臟FNH診斷中的臨床價值.醫學影像學雜志, 2013, 23(5):715-718.
3. 陳娟, 劉慧, 張秀萍, 等. CT雙期增強掃描在肝臟FNH和肝腺瘤中的診斷價值.醫學臨床研究, 2013, 30(5):902-904.
4. Yoneda N, Matsui O, Kitao A, et al. Hepatocyte transporter expression in FNH and FNH-like nodule:correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images. Jpn J Radiol, 2012, 30(6):499-508.
5. Xiong W, Sun LP, Chen XM, et al. Comparison of microRNA expression profiles in HCC-derived microvesicles and the parental cells and evaluation of their roles in HCC. J Huazhong Univ Sci Technolog Med Sci, 2013, 33(3):346-352.
6. 周建華, 韓峰, 李安華, 等.超聲造影定量分析動脈相血流灌注參數在肝局灶性結節增生和肝細胞肝癌鑒別診斷中的價值.中華醫學超聲雜志:電子版, 2009, 6(1):19-21.
7. 顏見, 潘楚芝, 姚志成, 等.肝癌家族史對原發性肝癌患者手術治療預后的影響.中華普通外科雜志, 2012, 27(10):798-801.
8. Liu YF, Cao LJ, Hillengass J, et al. Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, and histology. Acta Radiol, 2013, 54(2):205-213.
9. 魏秀華.肝臟局灶性結節增生(FNH)的影像診斷與鑒別.按摩與康復醫學(中旬刊), 2012, 3(3):205.
10. 裴小青, 陳敏山, 劉隆中, 等.肝細胞癌與肝局灶性結節增生的超聲造影動態灌注曲線對比分析.中國超聲醫學雜志, 2010, 26(5):444-448.
11. 劉建民, 楊林, 江山岳, 等.肝細胞癌門靜脈癌檢弦門靜脈海綿樣變性飼支循環的影像特征探討.西部醫學, 201l, 23(11):2240-2242.
12. Qiao Y, Cao H, Zhang S, et al. Sonochemiluminescence observation of lipidand polymer-shelled ultrasound contrast agents in 1.2 MHz focused ultrasound field. Ultrason Sonochem, 2013, 20(1):162-170.
13. 彭成忠, 范小明, 王力.正常直腸腔內灌注超聲造影和靜脈超聲造影表現.臨床超聲醫學雜志, 2014, 16(2):14-16.
14. 賀宇平, 王晉, 田民.肝局灶性結節性增生患者螺旋CT多期增強掃描結果分析(附10例報告).山東醫藥, 2011, 51(14):38-39.
15. 于麗波.肝局灶性結節性增生與肝細胞癌MRI特征對比分析.中國醫學創新, 2013, 10(14):82-83.
16. 張代橋, 明照亭.肝局灶性結節性增生的CT診斷.內蒙古中醫藥, 2013, 32(14):180.
17. Quaia E, Calliada F, Bertolotto M, et al. Characterization of focal liver lesions with contrast-specific US modes and a sulfur hexafluoride-filled microbubble contrast agent:diagnostic performance and confidence. Radiology, 2004, 232(2):420-430.
18. 吳薇, 陳敏華, 戴瑩, 等.超聲造影在肝硬化增生結節病變中的應用.中華超聲影像學雜志, 2010, 19(9):776-779.

Previous Article
全胸腔鏡下二尖瓣置換術麻醉體會
Next Article
促進《胸外科圍手術期氣道管理專家共識》的轉化與更新——胸外科氣道管理論壇亮點總結

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Value on The Differential Diagnosis of Ultrasound Contrast in Hepatocellular Carcinoma and Hepatic Focal Nodular Hyperplasia

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content