Prognosis of Different Treatments for Colorectal Liver Metastases_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIZhao ¹ , SUNCheng-bo ¹ , CHENZhi-da ¹ , YAOMeng-jie ¹ ,  DUXiao-hui ^1,2

1. Department of General Surgery, PLA General Hospital, Beijing 100853, China;
2. Department of General Surgery, Hainan Branch of PLA General Hospital, Sanya 572013, Hainan Province, China;

Corresponding?author：

DUXiao-hui, Email: duxiaohui301@sina.com

Keywords：

Colorectal liver metastases; Surgery; Relapse-free survival time; Survival time

DOI：

10.7507/1007-9424.20150079

Video：

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Objective To analyze the influence of different surgical methods on survival and relapse-free survival in colorectal liver metastases. Methods Clinical data of 71 cases of colorectal liver metastases who treated in PLA General Hospital from January 2002 to may 2013 were collected retrospectively, to analyzed the effect of different surgical methods on survival and relapse-free survival of this kind of cases. Results All of primary lesions underwent radical resection. And for the liver metastases, 20 cases didn't received any intervention (non-intervention group), 20 cases underwent resection of liver metastases, 20 cases underwent radiofrequency ablation, and 11 cases underwent radiofrequency ablation and resection of liver metastases (all 61 cases who received intervention were classified to intervention group). Results of Cox proportional hazards model showed that, in the condition of controlling other confounding factors, intervention can improve the survival (HR=1.724, P=0.043) and relapse-free survival (HR=0.701, P=0.048) of cases of colorectal liver metastases, cases who received intervention had better survival situation and the relapse-free survival situation. Conclusion For cases of colorectal liver metastases, in condition of radical operation for colorectal cancer, the intervention for liver metastases can prolong the survival time and relapse-free survival time.

Citation： LIZhao, SUNCheng-bo, CHENZhi-da, YAOMeng-jie, DUXiao-hui. Prognosis of Different Treatments for Colorectal Liver Metastases. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(3): 293-296. doi: 10.7507/1007-9424.20150079 Copy

1.	?de Jong MC, Mayo SC, Pulitano C, et al. Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis:results from an international multi-institutional analysis. J Gastrointest Surg, 2009, 13(12):2141-2151.
2.	季加孚. 結直腸癌肝轉移的治療策略. 中國實用外科雜志, 2004, 24(7):398-400.
3.	van Gijn W, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer:12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol, 2011, 12(6):575-582.
4.	Charnley RM. Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br J Surg, 2012, 99(9):1269-1270.
5.	Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg, 2005, 241(5):715-724.
6.	Bentrem DJ, Dematteo RP, Blumgart LH. Surgical therapy for metastatic disease to the liver. Annu Rev Med, 2005, 56:139-156.
7.	王正康. 結腸癌的轉移與外科治療. 中國實用外科雜志, 2002, 22(6):327-329.
8.	Kajiwara Y, Yamasaki F, Hama S, et al. Expression of survivin in astrocytic tumors:correlation with malignant grade and prognosis. Cancer, 2003, 97(4):1077-1083.
9.	王舒寶. 結腸癌術后復發及肝轉移的外科治療. 中國實用外科雜志, 2002, 22(4):207-209.
10.	Neumann J, Reu S, Kirchner T. Prognostic marker profiles for risk of distant metastases in colorectal cancer. Pathologe, 2012, 33(1):39-44.
11.	Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT:a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology, 2010, 257(3):674-684.
12.	汪曉東, 曹霖, 羅德云, 等. 多學科協作診治模式下運行結直腸癌綜合治療的臨床對照研究. 中國普外基礎與臨床雜志, 2008, 15(1):63-66.
13.	王錫山. 結直腸癌綜合治療的規范化實施. 中國實用外科雜志, 2010, 30(4):260-264.
14.	崔彥, 王平, 董滿庫, 等. 經皮射頻治療結直腸癌肝轉移31例. 中華普通外科雜志, 2006, 21(1):67-68.
15.	葉穎江, 王杉. 結直腸癌肝轉移的現代治療策略. 中國實用外科雜志, 2009, 29(9):728-732.
16.	呂新生, 邱氟, 詹勇強. 結直腸癌肝轉移. 中國普通外科雜志, 2003, 12(11):801-803.
17.	程樹群, 周信達. 結直腸癌肝轉移外科治療近況. 國外醫學.外科學分冊, 1992, (5):282-284.
18.	王學浩, 李相成. 結直腸癌肝轉移外科治療的爭議. 中國實用外科雜志, 1999, 19(10):586-587.
19.	王存, 于永揚, 周總光. 腹腔鏡下結直腸癌手術(二). 中國普外基礎與臨床雜志, 2008, 15(5):375-377.
20.	顧晉, 詹天成, 姚云峰. 結直腸癌的新輔助化療. 中國普外基礎與臨床雜志, 2007, 14(6):628-629.
21.	葉穎江, 郭鵬. 科學把握結直腸癌肝轉移的多學科序貫綜合治療. 中國普外基礎與臨床雜志, 2011, 18(5):469-472.
22.	鐘蕓詩, 許劍民, 韋燁, 等. 結直腸癌肝轉移的外科手術治療. 中華肝膽外科雜志, 2007, 13(2):104-107.
23.	許劍民, 鐘蕓詩, 秦新裕. 同時性結直腸癌肝轉移的外科治療進展. 中華普外科手術學雜志:電子版, 2010, 4(1):10-15.
24.	王劍, 周曄敏, 邵初曉, 等. 腹腔鏡和手助腹腔鏡結直腸手術18例報告. 中國普外基礎與臨床雜志, 2004, 11(3):206-207.
25.	齊洪峰, 李世擁, 安萍, 等. 結直腸癌患者血清可溶性E選擇素的檢測及其臨床意義. 解放軍醫學雜志, 2006, 31(9):858-859.

1. ?de Jong MC, Mayo SC, Pulitano C, et al. Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis:results from an international multi-institutional analysis. J Gastrointest Surg, 2009, 13(12):2141-2151.
2. 季加孚. 結直腸癌肝轉移的治療策略. 中國實用外科雜志, 2004, 24(7):398-400.
3. van Gijn W, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer:12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol, 2011, 12(6):575-582.
4. Charnley RM. Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br J Surg, 2012, 99(9):1269-1270.
5. Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg, 2005, 241(5):715-724.
6. Bentrem DJ, Dematteo RP, Blumgart LH. Surgical therapy for metastatic disease to the liver. Annu Rev Med, 2005, 56:139-156.
7. 王正康. 結腸癌的轉移與外科治療. 中國實用外科雜志, 2002, 22(6):327-329.
8. Kajiwara Y, Yamasaki F, Hama S, et al. Expression of survivin in astrocytic tumors:correlation with malignant grade and prognosis. Cancer, 2003, 97(4):1077-1083.
9. 王舒寶. 結腸癌術后復發及肝轉移的外科治療. 中國實用外科雜志, 2002, 22(4):207-209.
10. Neumann J, Reu S, Kirchner T. Prognostic marker profiles for risk of distant metastases in colorectal cancer. Pathologe, 2012, 33(1):39-44.
11. Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT:a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology, 2010, 257(3):674-684.
12. 汪曉東, 曹霖, 羅德云, 等. 多學科協作診治模式下運行結直腸癌綜合治療的臨床對照研究. 中國普外基礎與臨床雜志, 2008, 15(1):63-66.
13. 王錫山. 結直腸癌綜合治療的規范化實施. 中國實用外科雜志, 2010, 30(4):260-264.
14. 崔彥, 王平, 董滿庫, 等. 經皮射頻治療結直腸癌肝轉移31例. 中華普通外科雜志, 2006, 21(1):67-68.
15. 葉穎江, 王杉. 結直腸癌肝轉移的現代治療策略. 中國實用外科雜志, 2009, 29(9):728-732.
16. 呂新生, 邱氟, 詹勇強. 結直腸癌肝轉移. 中國普通外科雜志, 2003, 12(11):801-803.
17. 程樹群, 周信達. 結直腸癌肝轉移外科治療近況. 國外醫學.外科學分冊, 1992, (5):282-284.
18. 王學浩, 李相成. 結直腸癌肝轉移外科治療的爭議. 中國實用外科雜志, 1999, 19(10):586-587.
19. 王存, 于永揚, 周總光. 腹腔鏡下結直腸癌手術(二). 中國普外基礎與臨床雜志, 2008, 15(5):375-377.
20. 顧晉, 詹天成, 姚云峰. 結直腸癌的新輔助化療. 中國普外基礎與臨床雜志, 2007, 14(6):628-629.
21. 葉穎江, 郭鵬. 科學把握結直腸癌肝轉移的多學科序貫綜合治療. 中國普外基礎與臨床雜志, 2011, 18(5):469-472.
22. 鐘蕓詩, 許劍民, 韋燁, 等. 結直腸癌肝轉移的外科手術治療. 中華肝膽外科雜志, 2007, 13(2):104-107.
23. 許劍民, 鐘蕓詩, 秦新裕. 同時性結直腸癌肝轉移的外科治療進展. 中華普外科手術學雜志:電子版, 2010, 4(1):10-15.
24. 王劍, 周曄敏, 邵初曉, 等. 腹腔鏡和手助腹腔鏡結直腸手術18例報告. 中國普外基礎與臨床雜志, 2004, 11(3):206-207.
25. 齊洪峰, 李世擁, 安萍, 等. 結直腸癌患者血清可溶性E選擇素的檢測及其臨床意義. 解放軍醫學雜志, 2006, 31(9):858-859.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Prognosis of Different Treatments for Colorectal Liver Metastases

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