腹水膽固醇濃度鑒別門靜脈高壓性與非門靜脈高壓性腹水的臨床研究_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 張迪 ,  黎一鳴 , 陸宏偉 , 吉鴻

西安交通大學醫學院第二附屬醫院普通外科（陜西西安 710004）;

Corresponding?author：

黎一鳴, Email: liyiming2003@sina.com

Keywords：

腹水; 膽固醇; 門靜脈高壓

DOI：

10.7507/1007-9424.20150126

Video：

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目的探討腹水膽固醇濃度在鑒別門靜脈高壓性與非門靜脈高壓性腹水中的臨床意義。方法應用膽固醇氧化酶比色法對159例確診病例的腹水及血液樣本進行膽固醇濃度的測定，并對檢測結果進行分析，其中包括門靜脈高壓性腹水81例，非門靜脈高壓性腹水78例。結果門靜脈高壓性腹水組腹水中膽固醇濃度為（0.61±0.55）mmol/L，非門靜脈高壓性腹水組腹水中的膽固醇濃度為（2.32±1.05）mmol/L，前者明顯低于后者（P＜0.01）。根據受試者工作特征曲線（ROC曲線），腹水膽固醇濃度診斷門靜脈高壓性腹水的敏感度為96%，特異度為98%。結論對于一些臨床表現不典型、原因不明確的腹水患者，腹水中膽固醇濃度對于門靜脈高壓性腹水與非門靜脈高壓性腹水的鑒別具有一定的價值。

Citation： 張迪, 黎一鳴, 陸宏偉, 吉鴻. 腹水膽固醇濃度鑒別門靜脈高壓性與非門靜脈高壓性腹水的臨床研究. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2015, 22(4): 482-483. doi: 10.7507/1007-9424.20150126 Copy

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2.	Rana SV, Babu SG, Kocchar R.Usefulness of ascetic fluid cholesterol as a marker for malignant ascites.Med Sci Monit, 2005, 11(3):136-142.
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8.	Kahn FY.Ascites in the state of Qatar:aetiology and diagnostic value of ascitic fluid analysis.Singapore Med J, 2007, 48(5):434-439.
9.	王繼見.門脈高壓癥發病機理的研究近況.中國普外基礎與臨床雜志, 2000, 7(4):275-276.
10.	何遠春, 李俊, 陳振東.胸腹水膽固醇測定對良惡性病變鑒別診斷的價值.安徽醫科大學學報, 2009, 44(5):655-656.
11.	Gerbes AL, Jungst D.Role of cholesterol determination in ascitic fluid analysis.Hepatology, 2009, 50(4):1320.
12.	陳國平, 桂滿元.胸腹水生化指標聯合應用的臨床診斷價值探討.中外醫學研究, 2011, 9(9):35-36.
13.	劉輝, 左芳, 胡芳.膽固醇比值對胸腹水鑒別診斷的意義.檢驗醫學與臨床, 2007, 4(6):499.
14.	張淑艷, 王海英, 熊慧順.胸腹水與血清膽固醇聯合測定對胸腹水性質的鑒別診斷意義.臨床軍醫雜志, 2011, 39(5):907-908.
15.	蔡根度, 呂雁群, 洪迎華, 等.膽固醇分析對良惡性腹水的診斷價值.上海醫藥檢驗雜志, 1996, 11(2):127.
16.	盛裕芬.胸腹水/血清膽固醇比值鑒別胸腹水性質.臨床檢驗雜志, 1994, 12(3):138.

1. Gulyás M, Kaposi AD, Elek G, et al.Value of carcinoenmbryonic antigen (CEA) and cholesterol assays of ascetic fluid in cases of inconclusive cytology.J Clin Pathol, 2001, 54(11):831-835.
2. Rana SV, Babu SG, Kocchar R.Usefulness of ascetic fluid cholesterol as a marker for malignant ascites.Med Sci Monit, 2005, 11(3):136-142.
3. 羅春麗.臨床檢驗基礎.第3版.北京:人民衛生出版社, 2004:203-204.
4. Almakdisi T, Massoud S, Makdisi G.Lymphomas and chylous ascites:review of the literature.Oncologist, 2005, 10(8):632-635.
5. Balint PV, Kane D, Sturrock RD.Case number 26:massive cholesterol crystal deposition:unusual location in rheumatoid arthritis.Arm Rheum Dis, 2003, 62(6):512.
6. Bothenherg ME.Eosinophilic gastrointeatinal disorders (EGID).J Allergy Clin Immunol, 2004, 113(1):11-28.
7. Castaldo G, Oriani G, Cimino L, et al.Total discrimination of peritoneal malignant ascites from cirrhosis and hepato-carcinoma-associated ascites by assays of ascitic cholesterol and lactate dehydrogenase.Clin Chem, 1994, 40(3):478-483.
8. Kahn FY.Ascites in the state of Qatar:aetiology and diagnostic value of ascitic fluid analysis.Singapore Med J, 2007, 48(5):434-439.
9. 王繼見.門脈高壓癥發病機理的研究近況.中國普外基礎與臨床雜志, 2000, 7(4):275-276.
10. 何遠春, 李俊, 陳振東.胸腹水膽固醇測定對良惡性病變鑒別診斷的價值.安徽醫科大學學報, 2009, 44(5):655-656.
11. Gerbes AL, Jungst D.Role of cholesterol determination in ascitic fluid analysis.Hepatology, 2009, 50(4):1320.
12. 陳國平, 桂滿元.胸腹水生化指標聯合應用的臨床診斷價值探討.中外醫學研究, 2011, 9(9):35-36.
13. 劉輝, 左芳, 胡芳.膽固醇比值對胸腹水鑒別診斷的意義.檢驗醫學與臨床, 2007, 4(6):499.
14. 張淑艷, 王海英, 熊慧順.胸腹水與血清膽固醇聯合測定對胸腹水性質的鑒別診斷意義.臨床軍醫雜志, 2011, 39(5):907-908.
15. 蔡根度, 呂雁群, 洪迎華, 等.膽固醇分析對良惡性腹水的診斷價值.上海醫藥檢驗雜志, 1996, 11(2):127.
16. 盛裕芬.胸腹水/血清膽固醇比值鑒別胸腹水性質.臨床檢驗雜志, 1994, 12(3):138.

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腹水膽固醇濃度鑒別門靜脈高壓性與非門靜脈高壓性腹水的臨床研究

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