Effect of Laparoscopic Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones in Patients with Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIKun , CAOTing-bao , KONGYan-long , HANXiao-peng , SULin ,  LIUHong-bin

Department of General Surgery, General Hospital of Lanzhou PLA, Lanzhou 730050, Gansu Province, China;

Corresponding?author：

LIUHong-bin, Email: liuhongbin999@163.com

Keywords：

Laparoscope; Radical gastrectomy; Gastrointestinal motility; Gastrointestinal hormones

DOI：

10.7507/1007-9424.20160245

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To investigate effect of laparoscopic radical gastrectomy on gastrointestinal motility and gastrointestinal hormones in patients with gastric cancer. Methods Two hundred and eighty-nine patients who underwent laparoscopic radical gastrectomy from December 2013 to December 2015 were selected as observation group, 325 patients underwent laparotomy radical gastrectomy during the same period were selected as control group. The postoperative bowel sounds recovery time, the first anal exhaust time, and gastrin, motilin and vasoactive intestinal peptide levels in blood at 12 h before operation and at 24 h after operation were compared between these two groups. Results The baselines had no significant differences between these two groups (P > 0.05). The postoperative bowel sounds recovery time and the first anal exhaust time in the observation group were significantly shorter than those in the control group (P < 0.05). Compared with the levels at 12 h before operation, the gastrin and motilin levels were significantly decreased and the vasoactive intestinal peptide level was significantly increased at 24 h after operation in these two groups (P < 0.05); Compared with the control group, the gastrin and motilin levels at 24 h after operation were significantly increased (P < 0.05) and the vasoactive intestinal peptide level was significantly decreased in the observation group (P < 0.05). Conclusions Postoperative gastrointestinal motility recovery time in patients undergoing laparoscopic radical gastrectomy is significantly faster than that of laparotomy radical gastrectomy. There is a certain relation between gastrin, motilin or vasoactive intestinal peptide change and operation mode, it might be one of mechanisms of faster recovery of gastrointestinal motility after laparoscopic radical gastrectomy for gastric cancer.

Citation： LIKun, CAOTing-bao, KONGYan-long, HANXiao-peng, SULin, LIUHong-bin. Effect of Laparoscopic Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones in Patients with Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 936-939. doi: 10.7507/1007-9424.20160245 Copy

1.	?Kitano S, Iso Y, Moriyama M, et al. Laparoscopy-assisted BillrothⅠgastrectomy. Surg Laparosc Endosc, 1994, 4(2): 146-148.
2.	余佩武, 羅華星.腹腔鏡胃癌手術規范化實施的策略與技術.中華消化外科雜志, 2015, 14(3): 179-182.
3.	王紅巖, 趙曉丹, 李國勝, 等.腹腔鏡輔助與開腹胃癌D2根治術治療局部進展期遠端胃癌的安全性及近期療效Meta分析.中國醫科大學學報, 2015, 44(3): 252-258.
4.	李長風, 黃娜, 于濤.腹腔鏡直腸癌根治術后胃腸功能的恢復優勢及機制探討.醫學理論與實踐, 2015, 28(18): 2469-2470.
5.	Coate KC, Kliewer SA, Mangelsdorf DJ. SnapShot: hormones of the gastrointestinal tract. Cell, 2014, 159(6): 1478-1478.e1.
6.	中華醫學會外科分會腹腔鏡與內鏡外科學組.腹腔鏡胃惡性腫瘤手術操作指南(2007版).外科理論與實踐, 2007, 12(6): 610-614.
7.	謝翠, 賴麗蓮.綜合干預措施對腎癌術后患者胃腸道功能恢復的影響.世界華人消化雜志, 2015, 14(23): 2328-2332.
8.	曹暉, 卞育海, 趙剛.進一步認識和提高進展期胃癌綜合治療的理念.中華胃腸外科雜志, 2014, 17(11): 1051-1059.
9.	Piessen G, Lefèvre JH, Cabau M, et al. Laparoscopic versus open surgery for gastric gastrointestinal stromal tumors: what is the impact on postoperative outcome and oncologic results? Ann Surg, 2015, 262(5): 831-840.
10.	白洪祥, 劉現立.腹腔鏡下結腸癌根治術安全性及對患者術后胃腸道功能的影響.中國老年學雜志, 2014, 34(14): 4039-4040.
11.	王錫山.腹部手術后不容忽視的問題—消化道功能障礙.中華胃腸外科雜志, 2015, 18(5): 509-511.
12.	T?rnblom H, Simrén M, Abrahamsson H. Gastrointestinal motility and neurogastroenterology. Scand J Gastroenterol, 2015, 50(6): 685-697.
13.	王歡, 黃永坤, 劉梅.胃腸激素與胃腸道功能及疾病的關系.醫學綜述, 2013, 19(15): 2735-2738.
14.	Andreas S, Yvette T. Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage. Curr Protein Pept Sci, 2011, 12(4): 293-304.
15.	Sanger GJ. Ghrelin and motilin receptor agonists: time to introduce bias into drug design. Neurogastroenterol Motil, 2014, 26(2): 149-155.
16.	全俊, 嚴晉, 丁懿, 等. D-IBS與FD重疊征大鼠精神狀態、胃腸激素水平改變.胃腸病學和肝病學雜志, 2015, 24(8): 930-934.
17.	Vu JP, Larauche M, Flores M, et al. Regulation of appetite, body composition, and metabolic hormones by vasoactive intestinal polypeptide (VIP). J Mol Neurosci, 2015, 56(2): 377-387.

1. ?Kitano S, Iso Y, Moriyama M, et al. Laparoscopy-assisted BillrothⅠgastrectomy. Surg Laparosc Endosc, 1994, 4(2): 146-148.
2. 余佩武, 羅華星.腹腔鏡胃癌手術規范化實施的策略與技術.中華消化外科雜志, 2015, 14(3): 179-182.
3. 王紅巖, 趙曉丹, 李國勝, 等.腹腔鏡輔助與開腹胃癌D2根治術治療局部進展期遠端胃癌的安全性及近期療效Meta分析.中國醫科大學學報, 2015, 44(3): 252-258.
4. 李長風, 黃娜, 于濤.腹腔鏡直腸癌根治術后胃腸功能的恢復優勢及機制探討.醫學理論與實踐, 2015, 28(18): 2469-2470.
5. Coate KC, Kliewer SA, Mangelsdorf DJ. SnapShot: hormones of the gastrointestinal tract. Cell, 2014, 159(6): 1478-1478.e1.
6. 中華醫學會外科分會腹腔鏡與內鏡外科學組.腹腔鏡胃惡性腫瘤手術操作指南(2007版).外科理論與實踐, 2007, 12(6): 610-614.
7. 謝翠, 賴麗蓮.綜合干預措施對腎癌術后患者胃腸道功能恢復的影響.世界華人消化雜志, 2015, 14(23): 2328-2332.
8. 曹暉, 卞育海, 趙剛.進一步認識和提高進展期胃癌綜合治療的理念.中華胃腸外科雜志, 2014, 17(11): 1051-1059.
9. Piessen G, Lefèvre JH, Cabau M, et al. Laparoscopic versus open surgery for gastric gastrointestinal stromal tumors: what is the impact on postoperative outcome and oncologic results? Ann Surg, 2015, 262(5): 831-840.
10. 白洪祥, 劉現立.腹腔鏡下結腸癌根治術安全性及對患者術后胃腸道功能的影響.中國老年學雜志, 2014, 34(14): 4039-4040.
11. 王錫山.腹部手術后不容忽視的問題—消化道功能障礙.中華胃腸外科雜志, 2015, 18(5): 509-511.
12. T?rnblom H, Simrén M, Abrahamsson H. Gastrointestinal motility and neurogastroenterology. Scand J Gastroenterol, 2015, 50(6): 685-697.
13. 王歡, 黃永坤, 劉梅.胃腸激素與胃腸道功能及疾病的關系.醫學綜述, 2013, 19(15): 2735-2738.
14. Andreas S, Yvette T. Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage. Curr Protein Pept Sci, 2011, 12(4): 293-304.
15. Sanger GJ. Ghrelin and motilin receptor agonists: time to introduce bias into drug design. Neurogastroenterol Motil, 2014, 26(2): 149-155.
16. 全俊, 嚴晉, 丁懿, 等. D-IBS與FD重疊征大鼠精神狀態、胃腸激素水平改變.胃腸病學和肝病學雜志, 2015, 24(8): 930-934.
17. Vu JP, Larauche M, Flores M, et al. Regulation of appetite, body composition, and metabolic hormones by vasoactive intestinal polypeptide (VIP). J Mol Neurosci, 2015, 56(2): 377-387.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Laparoscopic Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones in Patients with Gastric Cancer

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