Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 Yangdancairang ^1,2 , SHAOJun ³ , ZHANGYang ³ , RENLi ^1,2 , HOULi-zhao ^1,2 , WANGHai-jiu ^1,2 , ZHOUYing ^1,2 , WANGHu ⁴ ,  FANHai-ning ^1,2

1. Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China;
2. Qinghai Province Key Labrotory of Hydatid Disease Research, Xining 810001, Qinghai Province, China;
3. Medical College of Qinghai University, Xining 810001, Qinghai Province, China;
4. Qinghai Province Health & Family Planning Commission, Xining 810000, Qinghai Province, China;

Corresponding?author：

FANHai-ning, Email: fanhaining@medmail.com.cn

Keywords：

Hepatic alveolar echinococcosis; Chemokine; Interleukin-17; Interleukin-27

DOI：

10.7507/1007-9424.20160247

Video：

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Objective To detect expressions of interleukin-17 (IL-17) and interleukin-27 (IL-27) proteins in liver tissue of hepatic alveolar echinococcosis. Methods The edge liver tissues (from the lesion edge 0.5 cm) and the normal liver tissues (from the lesion edge 5 cm) of 20 patients with hepatic alveolar echinococcosis in the Affiliated Hospital of Qinghai University were collected and stored at-80℃ freezer. The immunohistochemical method was used to detect the expressions of IL-17 and IL-27 proteins in these two tissues. Result The positive rates of IL-17 and IL-27 protein expressions in the edge liver tissues were significantly higher than those in the normal liver tissues[IL-17:80.0% (16/20) versus 10.0% (2/20), χ²=12.36, P < 0.01; IL-27:85.0% (17/20) versus 20.0% (4/20), χ²=12.36, P < 0.01]. Conclusion High expressions of IL-17 and IL-27 protein in edge liver tissue might participate in progress of hepatic alveolar echinococcosis.

Citation： Yangdancairang, SHAOJun, ZHANGYang, RENLi, HOULi-zhao, WANGHai-jiu, ZHOUYing, WANGHu, FANHai-ning. Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 944-947. doi: 10.7507/1007-9424.20160247 Copy

1.	?周永昌, 郭萬學.超聲醫學.第5版.北京:科學技術文獻出版社, 2006:688.
2.	鄭強, 王曉全, 曹巖, 等.國內泡型包蟲病文獻分布.預防醫學情報雜志, 2006, 22(2):170-172.
3.	Wang J, Gottstein B. Immunoregulation in larval echinococcus multilocularis infection. Parasite Immunol, 2015 Nov 5. doi:10.1111/pim.12292.[Epub ahead of print].
4.	Chauchet A, Grenouillet F, Knapp J, et al. Increased incidence and characteristics of alveolar echinococcosis in patients with immunosuppression-associated conditions. Clin Infect Dis, 2014, 59(8):1095-1104.
5.	Pang N, Zhang F, Ma X, et al. TGF-beta/Smad signaling pathway regulates Th17/Treg balance during echinococcus multilocularis infection. Int Immunopharmacol, 2014, 20(1):248-257.
6.	La X, Zhang F, Li Y, et al. Upregulation of PD-1 on CD4(+) CD25 (+) T cells is associated with immunosuppression in liver of mice infected with echinococcus multilocularis. Int Immunopharmacol, 2015, 26(2):357-366.
7.	Li SH, Chen WJ, Yan M, et al. Expression of coinhibitory PD-L1 on CD4(+) CD25(+) FOXP3(+) regulatory T cells is elevated in patients with acute coronary syndrome. Coron Artery Dis, 2015, 26(7):598-603.
8.	Vuitton DA, Zhou H, Bresson-Hadni S, et al. Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology, 2003, 127 Suppl:S87-S107.
9.	Grosso G, Gruttadauria S, Biondi A, et al. Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J Gastroenterol, 2012, 18(13):1425-1437.
10.	張亞飛, 陸宏偉, 吉鴻, 等.肝包蟲病治療的研究進展.中國普外基礎與臨床雜志, 2015, 22(2):162-165.
11.	廖泉, 何小東, 趙玉沛, 等.非牧區肝包蟲病的診斷與治療.中國普外基礎與臨床雜志, 2000, 7(4):249-251.
12.	張萍, 鄧勇, 樊海寧, 等.相關細胞因子的表達與肝泡型棘球蚴侵襲轉移關系的研究.重慶醫學, 2013, 42(33):3989-3991.
13.	張龍, 張示杰, 曹玉文, 等.骨橋蛋白與肝泡型棘球蚴轉移的相關性研究.中國寄生蟲學與寄生蟲病雜志, 2011, 29(1):33-36.
14.	高亮亮, 張示杰.肝包蟲病相關因子的研究進展.中國人獸共患病學報, 2013, 29(1):79-81.
15.	趙娜, 邱宇杰, 朱理瑋.白細胞介素-17參與固有免疫應答的研究進展.國際免疫學雜志, 2013, 3(3):212-215.
16.	Gaffen SL. An overview of IL-17 function and signaling. Cytokine, 2008, 43(3):402-407.
17.	Paradowska-Gorycka A, wojtecka-lukasik E, Trefler J, et al. Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scard J Immunol, 2010, 72(2):134-141.
18.	Chen B, Zeng Z, Hou J, et al. Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population. Scand J Gastroenterol, 2009, 44(6):720-726.
19.	Bazzi MD, Sultan MA, AI Tassan N, et al. Interleukin-17A and F and asthma in saudi Arabia:gene polymorphism and protein levels. J Investig allergol Clin Immunol, 2011, 21(7):551-555.
20.	余盼攀, 張勝初, 張啟瑜. IL-17及其受體與肝臟疾病的關系.肝膽胰外科雜志, 2011, 23(3):262-264.
21.	陳曦, 朱波, 陳正堂. IL-17與IL-17R與惡性腫瘤.免疫學雜志, 2010, 26(4):366-369.
22.	施沛青, 朱書, 錢友存. IL-17的信號傳導及功能研究.中國細胞生物學學報, 2011, 33(4):345-357.
23.	劉麗華, 單保恩. IL-27及其免疫調節作用研究進展.免疫學雜志, 2010, 26(1):81-86.
24.	郭月英, 李國忠.白細胞介素-27研究進展.中華臨床醫師雜志, 2013, 7(21):9662-9664.
25.	牛悅, 徐芳, 杜芳, 等.白細胞介素27與疾病易感性關聯研究進展.檢驗醫學與臨床, 2014, 11(23):3361-3363.
26.	Rigano R, Profumo E, Bruschi F, et al. Modulation of human immune response by echinococcus granulosus antigen B and its possible role in evading host defense. Infect Immune, 2001, 69(1):288-296.
27.	Rigano R, Buttari B, Defalco E, et al. Echinococcus granulosuspecific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. Parasite Immunol, 2004, 26(1):45-52.
28.	馬爾丹·馬合木, 提吐爾洪江·吐遜, 馬海長, 等. IL-17mRNA在肝臟泡型包蟲病中的表達及其臨床意義.中國現代普通外科進展, 2014, 17(10):771-774.
29.	汪宏良, 翟中良, 張海燕, 等.白細胞介素-27的研究進展.檢驗醫學與臨床, 2010, 7(6):553-554.

1. ?周永昌, 郭萬學.超聲醫學.第5版.北京:科學技術文獻出版社, 2006:688.
2. 鄭強, 王曉全, 曹巖, 等.國內泡型包蟲病文獻分布.預防醫學情報雜志, 2006, 22(2):170-172.
3. Wang J, Gottstein B. Immunoregulation in larval echinococcus multilocularis infection. Parasite Immunol, 2015 Nov 5. doi:10.1111/pim.12292.[Epub ahead of print].
4. Chauchet A, Grenouillet F, Knapp J, et al. Increased incidence and characteristics of alveolar echinococcosis in patients with immunosuppression-associated conditions. Clin Infect Dis, 2014, 59(8):1095-1104.
5. Pang N, Zhang F, Ma X, et al. TGF-beta/Smad signaling pathway regulates Th17/Treg balance during echinococcus multilocularis infection. Int Immunopharmacol, 2014, 20(1):248-257.
6. La X, Zhang F, Li Y, et al. Upregulation of PD-1 on CD4(+) CD25 (+) T cells is associated with immunosuppression in liver of mice infected with echinococcus multilocularis. Int Immunopharmacol, 2015, 26(2):357-366.
7. Li SH, Chen WJ, Yan M, et al. Expression of coinhibitory PD-L1 on CD4(+) CD25(+) FOXP3(+) regulatory T cells is elevated in patients with acute coronary syndrome. Coron Artery Dis, 2015, 26(7):598-603.
8. Vuitton DA, Zhou H, Bresson-Hadni S, et al. Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology, 2003, 127 Suppl:S87-S107.
9. Grosso G, Gruttadauria S, Biondi A, et al. Worldwide epidemiology of liver hydatidosis including the Mediterranean area. World J Gastroenterol, 2012, 18(13):1425-1437.
10. 張亞飛, 陸宏偉, 吉鴻, 等.肝包蟲病治療的研究進展.中國普外基礎與臨床雜志, 2015, 22(2):162-165.
11. 廖泉, 何小東, 趙玉沛, 等.非牧區肝包蟲病的診斷與治療.中國普外基礎與臨床雜志, 2000, 7(4):249-251.
12. 張萍, 鄧勇, 樊海寧, 等.相關細胞因子的表達與肝泡型棘球蚴侵襲轉移關系的研究.重慶醫學, 2013, 42(33):3989-3991.
13. 張龍, 張示杰, 曹玉文, 等.骨橋蛋白與肝泡型棘球蚴轉移的相關性研究.中國寄生蟲學與寄生蟲病雜志, 2011, 29(1):33-36.
14. 高亮亮, 張示杰.肝包蟲病相關因子的研究進展.中國人獸共患病學報, 2013, 29(1):79-81.
15. 趙娜, 邱宇杰, 朱理瑋.白細胞介素-17參與固有免疫應答的研究進展.國際免疫學雜志, 2013, 3(3):212-215.
16. Gaffen SL. An overview of IL-17 function and signaling. Cytokine, 2008, 43(3):402-407.
17. Paradowska-Gorycka A, wojtecka-lukasik E, Trefler J, et al. Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scard J Immunol, 2010, 72(2):134-141.
18. Chen B, Zeng Z, Hou J, et al. Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population. Scand J Gastroenterol, 2009, 44(6):720-726.
19. Bazzi MD, Sultan MA, AI Tassan N, et al. Interleukin-17A and F and asthma in saudi Arabia:gene polymorphism and protein levels. J Investig allergol Clin Immunol, 2011, 21(7):551-555.
20. 余盼攀, 張勝初, 張啟瑜. IL-17及其受體與肝臟疾病的關系.肝膽胰外科雜志, 2011, 23(3):262-264.
21. 陳曦, 朱波, 陳正堂. IL-17與IL-17R與惡性腫瘤.免疫學雜志, 2010, 26(4):366-369.
22. 施沛青, 朱書, 錢友存. IL-17的信號傳導及功能研究.中國細胞生物學學報, 2011, 33(4):345-357.
23. 劉麗華, 單保恩. IL-27及其免疫調節作用研究進展.免疫學雜志, 2010, 26(1):81-86.
24. 郭月英, 李國忠.白細胞介素-27研究進展.中華臨床醫師雜志, 2013, 7(21):9662-9664.
25. 牛悅, 徐芳, 杜芳, 等.白細胞介素27與疾病易感性關聯研究進展.檢驗醫學與臨床, 2014, 11(23):3361-3363.
26. Rigano R, Profumo E, Bruschi F, et al. Modulation of human immune response by echinococcus granulosus antigen B and its possible role in evading host defense. Infect Immune, 2001, 69(1):288-296.
27. Rigano R, Buttari B, Defalco E, et al. Echinococcus granulosuspecific T-cell lines derived from patients at various clinical stages of cystic echinococcosis. Parasite Immunol, 2004, 26(1):45-52.
28. 馬爾丹·馬合木, 提吐爾洪江·吐遜, 馬海長, 等. IL-17mRNA在肝臟泡型包蟲病中的表達及其臨床意義.中國現代普通外科進展, 2014, 17(10):771-774.
29. 汪宏良, 翟中良, 張海燕, 等.白細胞介素-27的研究進展.檢驗醫學與臨床, 2010, 7(6):553-554.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expressions of IL-17 and IL-27 in Liver Tissue of Hepatic Alveolar Echinococcosis

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