Analysis of Curative Effect of Huaier Granule Combined with Transcatheter Arterial Chemoembolization Following Radical Resection of Primary Hepatocellular Carcinoma with Microvascular Invasion_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 HUAXiang-dong , SHANGHai , HEZhong-ye , HAOZhi-qiang , MAZuo-hong , FUXi-bo

Tumor Hospital of Liaoning Province, Shenyang 110042, Liaoning Province, China;

Corresponding?author：

HUAXiang-dong, Email: huaxiangdong@cancerhosp-ln-cmu.com

Keywords：

Huaier granule; Primary hepatocellular carcinoma; Microvascular invasion; Transcatheter arterial chemoembolization

DOI：

10.7507/1007-9424.20160256

Video：

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Objective To evaluate therapeutical effects of Huaier granule combined with transcatheter arterial chemoembolization (TACE) following radical resection of primary hepatocellular carcinoma with microvascular invasion. Methods The clinical data of 45 cases of primary hepatocellular carcinoma with microvascular invasion underwent Huaier granule combined with transcatheter arterial chemoembolization (TACE) following radical resection from June 2010 to June 2013 in Liaoning Cancer Hospital were retrospectively analyzed. These patients were divided into Huaier granule plus TACE treatment group (20 cases) and simple TACE treatment group (25 cases) according to the postoperative treatment of the patients. The immune function (CD4⁺/CD8⁺ ratio and IL-2 level), 1and 3-year tumor recurrence rates and 3-year cumulative survival rate were compared between two groups after operation. Result ① The CD4⁺/CD8⁺ ratio and IL-2 level had no significant differences between the 2 groups before operation (P > 0.05), which in the Huaier granule plus TACE treatment group were significantly higher than those in the simple TACE treatment group (P < 0.05) on month 3, 6, and 12 after operation.② 1and 3-year tumor recurrence rates in the Huaier granule plus TACE treatment group were significantly lower than those in the simple TACE treatment group[15% (3/20) versus 48% (12/25), P < 0.05; 45% (9/20) versus 80% (20/25), P < 0.05]. ③ The 3-year cumulative survival rate was 75% and 68% in the Huaier granule plus TACE treatment group and the simple TACE treatment group, respectively. The survival curve analysis showed that the 3-year survival rate had a decreased trend, which in the Huaier granule plus TACE treatment group was slightly higher than that in the simple TACE treatment group, but the difference had no statistical significance between the 2 groups (P > 0.05). Conclusions Although the results of this study fails to confirm that Huaier granule plus TACE treatment for primary hepatocellular carcinoma with microvascular invasion following radical resection could significantly improve the 3-year cumulative survival rate, it could effectively decrease the recurrence rate. It is needed larger sample size to further explore in future research.

Citation： HUAXiang-dong, SHANGHai, HEZhong-ye, HAOZhi-qiang, MAZuo-hong, FUXi-bo. Analysis of Curative Effect of Huaier Granule Combined with Transcatheter Arterial Chemoembolization Following Radical Resection of Primary Hepatocellular Carcinoma with Microvascular Invasion. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(8): 982-986. doi: 10.7507/1007-9424.20160256 Copy

1.	金贇, 李江濤.肝細胞癌侵犯微血管的臨床相關因素及分子標記物的研究進展.臨床肝膽病雜志, 2013, 29(7):550-553.
2.	Kim H, Park MS, Park YN, et al. Preoperative radiologic and postoperative pathologic risk factors for early intra-hepatic recurrence in hepatocellular carcinoma patients who underwent curative resection. Yonsei Med J, 2009, 50(6):789-795.
3.	Gouw AS, Balabaud C, Kusano H, et al. Markers for microvascular invasion in hepatocellular carcinoma:where do we stand? Liver Transpl, 2011, 17 Suppl 2:S72-S80.
4.	閆濤, 畢新宇, 方儀, 等.槐耳顆粒對原發性肝癌患者術后長期生存的影響.中華肝膽外科雜志, 2012, 18(2):99-102.
5.	馬曾辰, 黃力文, 湯釗猷, 等.原發性肝癌的三級根治切除標準.中華腫瘤雜志, 2004, 26(1):33-35.
6.	周東, 劉勝, 嚴俊, 等.小肝癌微血管侵犯早期診斷指標的探討.福建醫科大學學報, 2012, 46(2):128-130.
7.	中國抗癌協會肝癌專業委員會.原發性肝癌規范化病理診斷指南(2015版).臨床與實驗病理學雜志, 2015, 31(3):241-246.
8.	Abou Al-Shaar H, Macdonald KI, Labib MA. Glomangiopericytoma simulating an intracavernous meningioma. Surg Neurol Int, 2016, 7(Suppl 5):S142-S147.
9.	陳中乾.高熱碘油超選擇肝動脈化療栓塞治療原發性肝癌中遠期療效分析.醫學信息, 2015, 28(8):27-28.
10.	陳星, 李強, 荀曉東, 等.微血管侵犯對單發小肝癌患者術后無進展生存期的影響.中華肝膽外科雜志, 2016, 22(2):171-173.
11.	周林, 鄭永根, 杜國盛.索拉非尼防治肝癌肝移植術后復發的研究進展.器官移植, 2014, 5(5):270-276.
12.	聶艷麗, 南克俊.分子靶向藥物在肝細胞肝癌治療中的研究進展.現代腫瘤醫學, 2014, 22(8):1996-1999.
13.	何麗平, 翟鳳鈺.索拉非尼聯合化療治療原發性肝癌的臨床研究.中國醫藥科學, 2013, 3(22):63-64.
14.	李立新, 葉勝龍, 王梅紅, 等.槐耳浸膏的實驗研究及臨床應用進展.中國腫瘤, 2007, 16(2):110-113.
15.	吳暉.槐耳顆粒聯合化療栓塞術治療原發性肝癌96例.中國藥業, 2014, 23(3):16-18.
16.	趙建軍, 蔡建強, 畢新宇, 等.槐耳顆粒對原發性肝癌術后轉移復發的影響.中國綜合臨床, 2007, 23(3):245-247.
17.	高慧婕, 李春霞, 劉樹玲, 等.人參皂苷Rg3聯合槐耳顆粒對免疫抑制小鼠的免疫調節作用.濟寧醫學院學報, 2014, 37(6):399-402.
18.	索龍龍, 杜國盛, 周林, 等.胸腺法新為基礎的藥物治療對肝移植術后腫瘤復發及相關細胞因子的影響.世界華人消化雜志, 2016, 24(10):1587-1592.

1. 金贇, 李江濤.肝細胞癌侵犯微血管的臨床相關因素及分子標記物的研究進展.臨床肝膽病雜志, 2013, 29(7):550-553.
2. Kim H, Park MS, Park YN, et al. Preoperative radiologic and postoperative pathologic risk factors for early intra-hepatic recurrence in hepatocellular carcinoma patients who underwent curative resection. Yonsei Med J, 2009, 50(6):789-795.
3. Gouw AS, Balabaud C, Kusano H, et al. Markers for microvascular invasion in hepatocellular carcinoma:where do we stand? Liver Transpl, 2011, 17 Suppl 2:S72-S80.
4. 閆濤, 畢新宇, 方儀, 等.槐耳顆粒對原發性肝癌患者術后長期生存的影響.中華肝膽外科雜志, 2012, 18(2):99-102.
5. 馬曾辰, 黃力文, 湯釗猷, 等.原發性肝癌的三級根治切除標準.中華腫瘤雜志, 2004, 26(1):33-35.
6. 周東, 劉勝, 嚴俊, 等.小肝癌微血管侵犯早期診斷指標的探討.福建醫科大學學報, 2012, 46(2):128-130.
7. 中國抗癌協會肝癌專業委員會.原發性肝癌規范化病理診斷指南(2015版).臨床與實驗病理學雜志, 2015, 31(3):241-246.
8. Abou Al-Shaar H, Macdonald KI, Labib MA. Glomangiopericytoma simulating an intracavernous meningioma. Surg Neurol Int, 2016, 7(Suppl 5):S142-S147.
9. 陳中乾.高熱碘油超選擇肝動脈化療栓塞治療原發性肝癌中遠期療效分析.醫學信息, 2015, 28(8):27-28.
10. 陳星, 李強, 荀曉東, 等.微血管侵犯對單發小肝癌患者術后無進展生存期的影響.中華肝膽外科雜志, 2016, 22(2):171-173.
11. 周林, 鄭永根, 杜國盛.索拉非尼防治肝癌肝移植術后復發的研究進展.器官移植, 2014, 5(5):270-276.
12. 聶艷麗, 南克俊.分子靶向藥物在肝細胞肝癌治療中的研究進展.現代腫瘤醫學, 2014, 22(8):1996-1999.
13. 何麗平, 翟鳳鈺.索拉非尼聯合化療治療原發性肝癌的臨床研究.中國醫藥科學, 2013, 3(22):63-64.
14. 李立新, 葉勝龍, 王梅紅, 等.槐耳浸膏的實驗研究及臨床應用進展.中國腫瘤, 2007, 16(2):110-113.
15. 吳暉.槐耳顆粒聯合化療栓塞術治療原發性肝癌96例.中國藥業, 2014, 23(3):16-18.
16. 趙建軍, 蔡建強, 畢新宇, 等.槐耳顆粒對原發性肝癌術后轉移復發的影響.中國綜合臨床, 2007, 23(3):245-247.
17. 高慧婕, 李春霞, 劉樹玲, 等.人參皂苷Rg3聯合槐耳顆粒對免疫抑制小鼠的免疫調節作用.濟寧醫學院學報, 2014, 37(6):399-402.
18. 索龍龍, 杜國盛, 周林, 等.胸腺法新為基礎的藥物治療對肝移植術后腫瘤復發及相關細胞因子的影響.世界華人消化雜志, 2016, 24(10):1587-1592.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Curative Effect of Huaier Granule Combined with Transcatheter Arterial Chemoembolization Following Radical Resection of Primary Hepatocellular Carcinoma with Microvascular Invasion

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