Clinical Application Research of Fluorescent Tracer Technique in cN0 Papillary Thyroid Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 WUWei ,  FEIZhe-wei

Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China;

Corresponding?author：

FEIZhe-wei, Email: zheweifei2013@sina.cn

Keywords：

Fluorescent tracer technique; Papillary thyroid carcinoma; Sentinel lymph node biopsy; Dissection of the central area of neck lymph node

DOI：

10.7507/1007-9424.20160302

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the value of fluorescence tracer technique in sentinel lymph node (SLN) orientation of cN0 papillary thyroid cancer. Methods The total clinical data of 40 cT1-3N0M0 thyroid cancer patients admitted from January 2015 to January 2016 in our hospital were collected, and the SLN with indocyanine green (ICG) as fluorescent trace agent were observed and detected, and the effect of ICG detecting SLN and the guide role of SLNB on the dissection of the central area of neck lymph nodes by intraoperative frozen biopsy pathology and postoperative paraffin pathology were analyzed. Results A total of 40 thyroid cancer patients were treated by SLNB and then conducted by the dissection of the central area of neck lymph nodes, and 37 cases detected SLN, so the detection rate was 92.5% (37/40). And a total of 98 SLNs were detected, 1-5 for each case, average of 2.65/case. Intraoperative frozen pathological detected 28 cases of patients with metastases in SLN, and 9 patients without metastasis, including 1 case with postoperative pathology detecting micrometastasis in SLN and other 8 cases without metastasis in the central area of neck lymph nodes. Three cases who were not detected the SLN showed no metastases in final postoperative paraffin pathology. The SLNB of ICG fluorescent tracer was with a sensitivity of 96.6% (28/29), false-negative rate of 3.45% (1/29). Conclusion The fluorescent tracer technique can guide the dissection of the central of neck lymph node of cN0 thyroid cancer patients accurately with a high detection rate and advantages of high sensitivity in detecting the SLN of thyroid cancer.

Citation： WU Wei, FEI Zhe-wei. Clinical Application Research of Fluorescent Tracer Technique in cN0 Papillary Thyroid Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1178-1181. doi: 10.7507/1007-9424.20160302 Copy

1.	Lee HS, Park C, Kim SW, et al. Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients. J Laryngol Otol, 2016, 130(3):302-308.
2.	Suman P, Wang CH, Abadin SS, et al. Risk factors for central lymph node metastasis in papillary thyroid carcinoma:A National Cancer Data Base (NCDB) study. Surgery, 2016, 159(1):31-40.
3.	黃韜. 分化型甲狀腺癌的規范治療. 中國普外基礎與臨床雜志, 2012, 19(8):805-808.
4.	李茵, 楊中元, 李秋梨, 等. 分化型甲狀腺癌區域淋巴結清掃策略及爭議. 中國實用外科雜志, 2015, 35(6):642-646.
5.	Goodman S, O'Connor A, Kandil D, et al. The ever-changing role of sentinel lymph node biopsy in the management of breast cancer. Arch Pathol Lab Med, 2014, 138(1):57-64.
6.	Sun W, Lan X, Zhang H, et al. Risk factors for central lymph node metastasis in cN0 papillary thyroid carcinoma:a systematic review and meta-analysis. PloS One, 2015, 10(10):e0139021.
7.	Xu XF, Gu J. The application of carbon nanoparticles in the lymph node biopsy of cN0 papillary thyroid carcinoma:A randomized controlled clinical trial. Asian J Surg, Available online 15 Jan. 2016.
8.	Pitsinis V, Provenzano E, Kaklamanis L, et al. Indocyanine green fluorescence mapping for sentinel lymph node biopsy in early breast cancer. Surg Oncol, 2015, 24(4):375-379.
9.	Cloyd JM, Wapnir IL, Read BM, et al. Indocyanine green and fluorescence lymphangiography for sentinel lymph node identification in cutaneous melanoma. J Surg Oncol, 2014, 110(7):888-892.
10.	Buda A, Dell'Anna T, Vecchione F, et al. Near infrared sentinel lymph node mapping with indocyanine green (ICG) using the VITOM exoscope for open surgery in case of gynecological malignancies. J Minim Invasive Gynecol, 2016, 23(4):628-632.
11.	Kowalski LP, Bagietto R, Lara JR, et al. Prognostic significance of the distribution of neck node metastasis from oral carcinoma. Head Neck, 2000, 22(3):207-214.
12.	郭文斌, 高偉, 劉金濤, 等. 吲哚菁綠熒光導航技術在乳腺癌前哨淋巴結活檢中的應用.中國普通外科雜志, 2015, 24(5):658-662.
13.	Adam MA, Goffredo P, Youngwirth L, et al. Same thyroid cancer, different national practice guidelines:When discordant American Thyroid Association and National Comprehensive Cancer Network surgery recommendations are associated with compromised patient outcome. Surgery, 2016, 159(1):41-51.
14.	朱精強. 分化型甲狀腺癌頸淋巴結清掃的相關問題. 中國普外基礎與臨床雜志, 2012, 19(8):809-813.
15.	Ji YB, Lee KJ, Park YS, et al. Clinical efficacy of sentinel lymph node biopsy using methylene blue dye in clinically node-negative papillary thyroid carcinoma. Ann Surg Oncol, 2012, 19(6):1868-1873.
16.	張永蘭, 王家東, 周爭. 放射性納米示蹤劑在甲狀腺頸部淋巴結中的實驗研究. 中華耳鼻咽喉頭頸外科雜志, 2010, 45(10):849-853.
17.	蘇力夫, 張生彬, 朱永蒙. 納米碳示蹤前哨淋巴結在cN0甲狀腺乳頭狀癌中的應用. 中國現代醫學雜志, 2013, 23(7):110-112.
18.	寇德強, 邱鏡丹, 王全勝, 等. 吲哚菁綠在乳腺癌前哨淋巴結活檢中的應用觀察. 解放軍醫學雜志, 2015, 40(5):392-395.
19.	Boschin IM, Pelizzo MR, Giammarile F, et al. Lymphoscintigraphy in differentiated thyroid cancer. Clin Nucl Med, 2015, 40(7):e343-e350.
20.	Siesto G, Romano F, Fiamengo B, et al. Sentinel node mapping using indocyanine green and near-infrared fluorescence imaging technology for uterine malignancies:preliminary experience with the Da Vinci Xi System. J Minim Invasive Gynecol, 2016, 23(4):470-471.
21.	Laios A, Volpi D, Tullis ID, et al. A prospective pilot study of detection of sentinel lymph nodes in gynaecological cancers using a novel near infrared fluorescence imaging system. BMC Res Notes, 2015, 8:608.
22.	龔曉軍, 毛紅巖, 劉慧民, 等. 吲哚菁綠熒光法在乳腺癌前哨淋巴結活檢中的應用. 中國普外基礎與臨床雜志, 2016, 23(2):221-224.
23.	張賈震男, 歐江華, 張晨光, 等. 聯合吲哚菁綠熒光法與藍染法行乳腺癌前哨淋巴結活檢的臨床研究. 中國普通外科雜志, 2016, 25(5):705-710.
24.	Choi HJ, Kim TJ, Lee YY, et al. Time-lapse imaging of sentinel lymph node using indocyanine green with near-infrared fluorescence imaging in early endometrial cancer. J Gynecol Oncol, 2016, 27(3):e27.
25.	Papadia A, Imboden S, Siegenthaler F, et al. Laparoscopic indocyanine green sentinel lymph node mapping in endometrial cancer. Ann Surg Oncol, 2016, 23(7):2206-2211.

1. Lee HS, Park C, Kim SW, et al. Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients. J Laryngol Otol, 2016, 130(3):302-308.
2. Suman P, Wang CH, Abadin SS, et al. Risk factors for central lymph node metastasis in papillary thyroid carcinoma:A National Cancer Data Base (NCDB) study. Surgery, 2016, 159(1):31-40.
3. 黃韜. 分化型甲狀腺癌的規范治療. 中國普外基礎與臨床雜志, 2012, 19(8):805-808.
4. 李茵, 楊中元, 李秋梨, 等. 分化型甲狀腺癌區域淋巴結清掃策略及爭議. 中國實用外科雜志, 2015, 35(6):642-646.
5. Goodman S, O'Connor A, Kandil D, et al. The ever-changing role of sentinel lymph node biopsy in the management of breast cancer. Arch Pathol Lab Med, 2014, 138(1):57-64.
6. Sun W, Lan X, Zhang H, et al. Risk factors for central lymph node metastasis in cN0 papillary thyroid carcinoma:a systematic review and meta-analysis. PloS One, 2015, 10(10):e0139021.
7. Xu XF, Gu J. The application of carbon nanoparticles in the lymph node biopsy of cN0 papillary thyroid carcinoma:A randomized controlled clinical trial. Asian J Surg, Available online 15 Jan. 2016.
8. Pitsinis V, Provenzano E, Kaklamanis L, et al. Indocyanine green fluorescence mapping for sentinel lymph node biopsy in early breast cancer. Surg Oncol, 2015, 24(4):375-379.
9. Cloyd JM, Wapnir IL, Read BM, et al. Indocyanine green and fluorescence lymphangiography for sentinel lymph node identification in cutaneous melanoma. J Surg Oncol, 2014, 110(7):888-892.
10. Buda A, Dell'Anna T, Vecchione F, et al. Near infrared sentinel lymph node mapping with indocyanine green (ICG) using the VITOM exoscope for open surgery in case of gynecological malignancies. J Minim Invasive Gynecol, 2016, 23(4):628-632.
11. Kowalski LP, Bagietto R, Lara JR, et al. Prognostic significance of the distribution of neck node metastasis from oral carcinoma. Head Neck, 2000, 22(3):207-214.
12. 郭文斌, 高偉, 劉金濤, 等. 吲哚菁綠熒光導航技術在乳腺癌前哨淋巴結活檢中的應用.中國普通外科雜志, 2015, 24(5):658-662.
13. Adam MA, Goffredo P, Youngwirth L, et al. Same thyroid cancer, different national practice guidelines:When discordant American Thyroid Association and National Comprehensive Cancer Network surgery recommendations are associated with compromised patient outcome. Surgery, 2016, 159(1):41-51.
14. 朱精強. 分化型甲狀腺癌頸淋巴結清掃的相關問題. 中國普外基礎與臨床雜志, 2012, 19(8):809-813.
15. Ji YB, Lee KJ, Park YS, et al. Clinical efficacy of sentinel lymph node biopsy using methylene blue dye in clinically node-negative papillary thyroid carcinoma. Ann Surg Oncol, 2012, 19(6):1868-1873.
16. 張永蘭, 王家東, 周爭. 放射性納米示蹤劑在甲狀腺頸部淋巴結中的實驗研究. 中華耳鼻咽喉頭頸外科雜志, 2010, 45(10):849-853.
17. 蘇力夫, 張生彬, 朱永蒙. 納米碳示蹤前哨淋巴結在cN0甲狀腺乳頭狀癌中的應用. 中國現代醫學雜志, 2013, 23(7):110-112.
18. 寇德強, 邱鏡丹, 王全勝, 等. 吲哚菁綠在乳腺癌前哨淋巴結活檢中的應用觀察. 解放軍醫學雜志, 2015, 40(5):392-395.
19. Boschin IM, Pelizzo MR, Giammarile F, et al. Lymphoscintigraphy in differentiated thyroid cancer. Clin Nucl Med, 2015, 40(7):e343-e350.
20. Siesto G, Romano F, Fiamengo B, et al. Sentinel node mapping using indocyanine green and near-infrared fluorescence imaging technology for uterine malignancies:preliminary experience with the Da Vinci Xi System. J Minim Invasive Gynecol, 2016, 23(4):470-471.
21. Laios A, Volpi D, Tullis ID, et al. A prospective pilot study of detection of sentinel lymph nodes in gynaecological cancers using a novel near infrared fluorescence imaging system. BMC Res Notes, 2015, 8:608.
22. 龔曉軍, 毛紅巖, 劉慧民, 等. 吲哚菁綠熒光法在乳腺癌前哨淋巴結活檢中的應用. 中國普外基礎與臨床雜志, 2016, 23(2):221-224.
23. 張賈震男, 歐江華, 張晨光, 等. 聯合吲哚菁綠熒光法與藍染法行乳腺癌前哨淋巴結活檢的臨床研究. 中國普通外科雜志, 2016, 25(5):705-710.
24. Choi HJ, Kim TJ, Lee YY, et al. Time-lapse imaging of sentinel lymph node using indocyanine green with near-infrared fluorescence imaging in early endometrial cancer. J Gynecol Oncol, 2016, 27(3):e27.
25. Papadia A, Imboden S, Siegenthaler F, et al. Laparoscopic indocyanine green sentinel lymph node mapping in endometrial cancer. Ann Surg Oncol, 2016, 23(7):2206-2211.

Previous Article
The Application of Strategic Parathyroid Autotransplantation in The Central Lymph Node Re-dissection for Papillary Thyroid Carcinoma
Next Article
甲狀腺微小乳頭狀癌的手術診療分析

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Application Research of Fluorescent Tracer Technique in cN0 Papillary Thyroid Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content