Research Progress on Related Gene of Stem Cell Therapy for Acute-on-Chronic Liver Failure_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 MALin-jie , CHENXiao , ZOULong ,  CHENGang , LIUHong

Department of Hepatobiliary and Pancreatic Surgery, Ganmei Hospital Affiliated to Kunming Medical University, Kunming 65000, Yunnan Province, China;

Corresponding?author：

CHENGang, Email: chengang201501@126.com

Keywords：

Stem cells; Acute-on-chronic liver failure; Gene; Mechanism

DOI：

10.7507/1007-9424.20160327

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the changes and mechanism of related genes induced by stem cell therapy in acute-on-chronic liver failure (ACLF) in recent years, and in order to guide the clinical value of ACLF and curative effect evaluation. Methods Through searching Wanfang med, CNKI, Pubmed database and so on in recent years, the differentially expressed genes induced by stem cell therapy for ACLF in recent years was retrieved and the changes of related genes induced during the treatment process were discussed. Results Both at home and abroad had reported that stem cell therapy in the process of ACLF caused mir-27b, TRAIL, and Tg737 genetic changes, some genetic changes had an fixed change trend. Conclusions Stem cells in the treatment of ACLF, cause mir-27b, TRAIL, Tg737 genetic changes, which can provides a new way and method for monitoring stem cell therapy ACLF.

Citation： MA Lin-jie, CHEN Xiao, ZOU Long, CHEN Gang, LIU Hong. Research Progress on Related Gene of Stem Cell Therapy for Acute-on-Chronic Liver Failure. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1276-1279. doi: 10.7507/1007-9424.20160327 Copy

1.	中華醫學會感染病學分會肝衰竭與人工肝學組、中華醫學會肝病學分會重型肝痛與人工肝學組. 肝衰竭診療指南. 中華臨床感染病雜志, 2012, 5(6):321-327.
2.	Sarin SK, Choudhury A. Acute-on-chronic liver failure:terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol, 2016, 13(3):131-149.
3.	Zhang J, Gao S, Duan Z, et al. Overview on acute-on-chronic liver failure. Front Med, 2016, 10(1):1-17.
4.	Shi M, Zhang Z, Xu R, et al. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem Cells Transl Med, 2012, 1(10):725-731.
5.	Liu XY, Peng F, Pan YJ, et al. Advanced therapeutic strategies for HBV-related acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int, 2015, 14(4):354-360.
6.	Lehmann TP, Korski K, Gryczka R, et al. Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. Mol Med Rep, 2015, 12(3):4692-4702.
7.	Jiang J, Yi B, Qin C, et al. Upregulation of microRNA-27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2-mediated ERK signaling. Mol Med Rep, 2016, 13(3):2267-2272.
8.	He S, Zhang J, Lin J, et al. Expression and function of microRNA-27b in hepatocellular carcinoma. Mol Med Rep, 2016, 13(3):2801-2808.
9.	Lü MH, Li CZ, Hu CJ, et al. MicroRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1α in vitro. Biochem Biophys Res Commun, 2012, 421(2):389-395.
10.	李長珠. 骨髓來源細胞參與肝臟損傷后修復的作用及其機制的實驗研究. 第三軍醫大學碩士學位論文, 2011.
11.	李光耀, 劉孟剛, 趙曉彪, 等.大鼠肝再生過程中Mir27b與Tumb1表達相關性研究. 免疫學雜志, 2015,31(1):58-62.
12.	Wu XQ, Dai Y, Yang Y, et al. Emerging role of miRNAs in regulating macrophage activation and polarization in immune response and inflammation. Immunology, 2016, 148(3):237-248.
13.	Lü MH, Hu CJ, Chen L, et al. miR-27b represses migration of mouse MSCs to burned margins and prolongs wound repair through silencing SDF-1a. PLoS One, 2013, 8(7):e68972.
14.	Chen KD, Hsu LW, Goto S, et al. Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats. Transplant Proc, 2014, 46(4):1198-1200.
15.	張愛民, 游紹莉, 萬志紅, 等. 乙型肝炎病毒相關慢加急性肝衰竭患者肝纖維化、肝功能、病毒學指標及甲胎蛋白水平與預后的關系. 臨床肝膽病雜志, 2012, 28(6):459-461.
16.	Ji J, Zhang J, Huang G, et al. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett, 2009,583(4):759-766.
17.	史曉盟, 楊文卓, 匡大鵬, 等. miRNA-27b對人星狀細胞系脂代謝與遷移能力的影響.同濟大學學報:醫學版, 2014, 35(4):19-28.
18.	Chen KD, Goto S, Hsu LW, et al. Identification of miR-27b as a novel signature from the mRNA profiles of adipose-derived mesenchymal stem cells involved in the tolerogenic response. PLoS One,2013,8(4):e60492.
19.	Yan X, Xu L, Qi J, et al. sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. Immunogenetics, 2009, 61(8):551-556.
20.	漆志平, 趙永忠. TRAIL及其受體與慢性肝病關系的研究進展. 醫學綜述, 2010, 16(5):658-661.
21.	楊文, 覃山羽, 姜海行, 等.骨髓間充質干細胞體外調控肝星狀細胞死亡受體5的表達.中國組織工程研究, 2012, 27(16):4947-4952.
22.	劉成俠. 肝癌穿刺組織中抑癌基因T9737的表達情況及其功能分析. 海南醫學院學報, 2015, 22(3):229-232.
23.	張君紅, 姜海行, 孟云超, 等.大鼠骨髓間充質干細胞旁分泌HGF上調肝星狀細胞DR5及caspase-8的表達. 基礎醫學與臨床, 2012,32(7):804-808.
24.	Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, et al. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. Lab Invest, 2015, 95(2):223-236.
25.	Wan Z, Xie G, Wu Y, et al. Cytokines elevated in patients with HBV-related acute-on-chronic liver failure promote NK cell mediated cytotoxicity through TRAIL. Dig Liver Dis, 2016, 48(5):528-535.
26.	何選秋, 李詠茵, 張小勇, 等. 自然殺傷細胞在肝臟疾病中的作用. 肝臟, 2014, 19(2):128-131.
27.	陳公英, 何劍琴, 呂國才, 等. 乙型肝炎患者CD4⁺,CD8⁺ T淋巴細胞TRAIL增高與肝損傷相關性的研究. 中華肝臟病雜志, 2004, 12(5):284-286.
28.	鄒勇. 肝臟自然殺傷細胞在病毒誘導的肝衰竭中的作用. 華中科技大學博士學位論文, 2009.
29.	王艷海. 慢性乙型肝炎患者外周血NK細胞表達研究. 疾病監測與控制雜志, 2012, 6(10):582-584.
30.	高恒. 分泌型TRAIL基因修飾人脂肪干細胞靶向腦膠質瘤治療的研究. 蘇州大學博士論文, 2013.
31.	高遠, 阮柏, 張卓, 等. 抑癌基因Tg737下調對肝癌細胞增殖的影響及其機制. 中華肝膽外科雜志, 2014, 20(12):848-851.
32.	黨立力. Tg737基因在胎肝干細胞分化過程中的作用及機制研究. 第四軍醫大學碩士學位論文, 2014.
33.	黨立力, 黃啟科, 周亮, 等, T9737基因參與胎肝干細胞正常分化的機制研究. 肝膽外科雜志, 2014, 22(1):55-58.
34.	You N, Liu W, Zhong X, et al. Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest. Mol Carcinog, 2012, 51(8):659-673.
35.	王雪. MicroRNA介導間充質干細胞向肝細胞轉分化的研究. 第四軍醫大學碩士學位論文, 2014.

1. 中華醫學會感染病學分會肝衰竭與人工肝學組、中華醫學會肝病學分會重型肝痛與人工肝學組. 肝衰竭診療指南. 中華臨床感染病雜志, 2012, 5(6):321-327.
2. Sarin SK, Choudhury A. Acute-on-chronic liver failure:terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol, 2016, 13(3):131-149.
3. Zhang J, Gao S, Duan Z, et al. Overview on acute-on-chronic liver failure. Front Med, 2016, 10(1):1-17.
4. Shi M, Zhang Z, Xu R, et al. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem Cells Transl Med, 2012, 1(10):725-731.
5. Liu XY, Peng F, Pan YJ, et al. Advanced therapeutic strategies for HBV-related acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int, 2015, 14(4):354-360.
6. Lehmann TP, Korski K, Gryczka R, et al. Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. Mol Med Rep, 2015, 12(3):4692-4702.
7. Jiang J, Yi B, Qin C, et al. Upregulation of microRNA-27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2-mediated ERK signaling. Mol Med Rep, 2016, 13(3):2267-2272.
8. He S, Zhang J, Lin J, et al. Expression and function of microRNA-27b in hepatocellular carcinoma. Mol Med Rep, 2016, 13(3):2801-2808.
9. Lü MH, Li CZ, Hu CJ, et al. MicroRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1α in vitro. Biochem Biophys Res Commun, 2012, 421(2):389-395.
10. 李長珠. 骨髓來源細胞參與肝臟損傷后修復的作用及其機制的實驗研究. 第三軍醫大學碩士學位論文, 2011.
11. 李光耀, 劉孟剛, 趙曉彪, 等.大鼠肝再生過程中Mir27b與Tumb1表達相關性研究. 免疫學雜志, 2015,31(1):58-62.
12. Wu XQ, Dai Y, Yang Y, et al. Emerging role of miRNAs in regulating macrophage activation and polarization in immune response and inflammation. Immunology, 2016, 148(3):237-248.
13. Lü MH, Hu CJ, Chen L, et al. miR-27b represses migration of mouse MSCs to burned margins and prolongs wound repair through silencing SDF-1a. PLoS One, 2013, 8(7):e68972.
14. Chen KD, Hsu LW, Goto S, et al. Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats. Transplant Proc, 2014, 46(4):1198-1200.
15. 張愛民, 游紹莉, 萬志紅, 等. 乙型肝炎病毒相關慢加急性肝衰竭患者肝纖維化、肝功能、病毒學指標及甲胎蛋白水平與預后的關系. 臨床肝膽病雜志, 2012, 28(6):459-461.
16. Ji J, Zhang J, Huang G, et al. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett, 2009,583(4):759-766.
17. 史曉盟, 楊文卓, 匡大鵬, 等. miRNA-27b對人星狀細胞系脂代謝與遷移能力的影響.同濟大學學報:醫學版, 2014, 35(4):19-28.
18. Chen KD, Goto S, Hsu LW, et al. Identification of miR-27b as a novel signature from the mRNA profiles of adipose-derived mesenchymal stem cells involved in the tolerogenic response. PLoS One,2013,8(4):e60492.
19. Yan X, Xu L, Qi J, et al. sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. Immunogenetics, 2009, 61(8):551-556.
20. 漆志平, 趙永忠. TRAIL及其受體與慢性肝病關系的研究進展. 醫學綜述, 2010, 16(5):658-661.
21. 楊文, 覃山羽, 姜海行, 等.骨髓間充質干細胞體外調控肝星狀細胞死亡受體5的表達.中國組織工程研究, 2012, 27(16):4947-4952.
22. 劉成俠. 肝癌穿刺組織中抑癌基因T9737的表達情況及其功能分析. 海南醫學院學報, 2015, 22(3):229-232.
23. 張君紅, 姜海行, 孟云超, 等.大鼠骨髓間充質干細胞旁分泌HGF上調肝星狀細胞DR5及caspase-8的表達. 基礎醫學與臨床, 2012,32(7):804-808.
24. Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, et al. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. Lab Invest, 2015, 95(2):223-236.
25. Wan Z, Xie G, Wu Y, et al. Cytokines elevated in patients with HBV-related acute-on-chronic liver failure promote NK cell mediated cytotoxicity through TRAIL. Dig Liver Dis, 2016, 48(5):528-535.
26. 何選秋, 李詠茵, 張小勇, 等. 自然殺傷細胞在肝臟疾病中的作用. 肝臟, 2014, 19(2):128-131.
27. 陳公英, 何劍琴, 呂國才, 等. 乙型肝炎患者CD4⁺,CD8⁺ T淋巴細胞TRAIL增高與肝損傷相關性的研究. 中華肝臟病雜志, 2004, 12(5):284-286.
28. 鄒勇. 肝臟自然殺傷細胞在病毒誘導的肝衰竭中的作用. 華中科技大學博士學位論文, 2009.
29. 王艷海. 慢性乙型肝炎患者外周血NK細胞表達研究. 疾病監測與控制雜志, 2012, 6(10):582-584.
30. 高恒. 分泌型TRAIL基因修飾人脂肪干細胞靶向腦膠質瘤治療的研究. 蘇州大學博士論文, 2013.
31. 高遠, 阮柏, 張卓, 等. 抑癌基因Tg737下調對肝癌細胞增殖的影響及其機制. 中華肝膽外科雜志, 2014, 20(12):848-851.
32. 黨立力. Tg737基因在胎肝干細胞分化過程中的作用及機制研究. 第四軍醫大學碩士學位論文, 2014.
33. 黨立力, 黃啟科, 周亮, 等, T9737基因參與胎肝干細胞正常分化的機制研究. 肝膽外科雜志, 2014, 22(1):55-58.
34. You N, Liu W, Zhong X, et al. Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest. Mol Carcinog, 2012, 51(8):659-673.
35. 王雪. MicroRNA介導間充質干細胞向肝細胞轉分化的研究. 第四軍醫大學碩士學位論文, 2014.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress on Related Gene of Stem Cell Therapy for Acute-on-Chronic Liver Failure

Abstract Full text Figures/Tables Video References Cited by

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