Analysis of Influence Factors of Gallstone_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 LIUQing ,  JINJun-zhe , LüHong-yang , XINGBao-jian

Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China;

Corresponding?author：

JINJun-zhe, Email: jccccj@126.com

Keywords：

Gallstone; Influence factor; Serum lipids; Fasting blood glucose; Gender; Age; Diabetes

DOI：

10.7507/1007-9424.20160376

Video：

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Objective To explore the influence factors of gallstone. Methods Clinical data of 511 patients who were admitted to our hospital from Apr. 2015 to Apr. 2016 were retrospectively analyzed. Results Of 511 patients, there were 274 patients with gallstone (gallstone group) and 237 patients without gallstone (control group). Univariate analysis results showed that, no significant difference of age, gender, and diabetes was found between gallstone group and control group (P > 0.050), but the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C), and fasting blood glucose (FBG) were significantly higher in patients of gallstone group (P < 0.050), but the level of serum high density lipoprotein (HDL-C) was significantly lower in patients of gallstone group (P=0.001). Logistic regression results showed that four factors including diabetes〔OR=4.491; 95% CI is (2.021, 9.976); P < 0.001〕, the serum TC〔OR=2.548; 95% CI is (1.944, 3.338); P < 0.001〕, HDL-C〔OR=0.115; 95% CI is (0.056, 0.237); P < 0.001〕, and FBG〔OR=1.277; 95% CI is (1.086, 1.502); P=0.003〕 entered the final regression model after controlling confounding factors. The results showed that patients who combined with diabetes, high levels of serum TC and FBG, and low level of serum HDL-C, had higher ratio of galls-tone. Conclusion Diabetes, high-level of serum TC and FBG, low-level of serum HDL-C were risk factors of gallstone.

Citation： LIUQing, JINJun-zhe, LüHong-yang, XINGBao-jian. Analysis of Influence Factors of Gallstone. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(12): 1492-1495. doi: 10.7507/1007-9424.20160376 Copy

1.	陳孝平, 汪建平.外科學.第8版.北京:人民衛生出版社, 2013:453.
2.	裘法祖.外科學.第4版.北京:人民衛生出版社, 1995:551.
3.	李前春, 鐘立明.血脂與膽囊結石的相關性分析.安徽醫藥, 2015, 19(5):937-938.
4.	孫曉敏, 徐萍, 馬志紅, 等.上海松江地區膽囊良性疾病的流行病學調查30901例.世界華人消化雜志, 2011, 19(27):2881-2885.
5.	陳敏, 張濤, 克力木, 等.維吾爾族和漢族膽囊結石患病現狀及特點分析.中華臨床醫師雜志:電子版, 2015, 9(8):1352-1358.
6.	劉江偉, 呂復君, 呂輝琴, 等.新疆地區維吾爾族、漢族和哈薩克族三個民族膽囊結石的流行病學分析.中華臨床醫師雜志:電子版, 2013, 7(21):9542-9548.
7.	Wang W, Li N. The association of gallstone disease and diabetes mellitus. A meta-analysis. Saudi Med J, 2014, 35(9):1005-1012.
8.	韓天權, 蔣兆彥, 張圣道.膽固醇結石形成機制的基因研究現狀與展望.外科理論與實踐, 2009, 14(2):125-127.
9.	Liu FL, Lu WB, Niu WX. XbaI polymorphisms of apolipoprotein B gene:another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol, 2010, 16(20):2549-2553.
10.	沈安紅.膽囊結石患者血脂水平檢測分析.國際檢驗醫學雜志, 2012, 33(20):2552-2554.
11.	吳著學. 356例機關工作人員脂肪肝和膽囊結石與血脂水平的關系分析.中國現代醫生, 2007, 45(9):57.
12.	Scragg RK, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone disease:a case-control study. Br Med J (Clin Res Ed), 1984, 289(6444):521-525.
13.	沈安東, 馬榮賡, 文洽先.膽囊結石與血脂水平的關系.實用醫學雜志, 1993, 9(5):53.
14.	Yu JG, Javorschi S, Hevener AL, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes, 2002, 51(10):2968-2974.
15.	Xue Y, Sheng Y, Dai H, et al. Risk of development of acute pancreatitis with pre-existing diabetes:a meta-analysis. Eur J Gastroenterol Hepatol, 2012, 24(9):1092-1098.
16.	王春城, 張萬星, 曹月敏.膽囊結石與糖尿病的關系.河北醫科大學學報, 2015, 36(11):1362-1364.
17.	陳子廣.血糖、血脂水平與膽囊結石發病的關系分析.醫學理論與實踐, 2015, 28(7):910-911.
18.	孫明德.分析膽囊結石相關危險因素及防治對策.當代醫學, 2013, 19(25):99.
19.	朱穎, 吳治宇, 馬向明, 等.開灤集團職工膽囊結石臨床流行病學調查.臨床肝膽病雜志, 2015, 31(10):1621-1624.
20.	Abu-Eshy SA, Mahfouz AA, Badr A, et al. Prevalence and risk factors of gallstone disease in a high altitude Saudi population. East Mediterr Health J, 2007, 13(4):794-802.
21.	張靜, 劉靜, 陳丹, 等.新疆地區體檢人群膽囊結石與代謝綜合征及其組分相關性分析.中華實用診斷與治療雜志, 2016, 30(9):894-896.
22.	Barbara L, Sama C, Morselli Labate AM, et al. A population study on the prevalence of gallstone disease:the Sirmione Study. Hepatology, 1987, 7(5):913-917.
23.	張超, 王旺河.性激素與膽囊結石成因臨床研究.肝膽胰外科雜志, 1997, 9(3):119-120.
24.	Einarsson K, Nilsell K, Leijd B, et al. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med, 1985, 313(5):277-282.
25.	Ansari-Moghaddam A, Khorram A, Miri-Bonjar M, et al. The preva-lence and risk factors of gallstone among adults in south-east of Iran:a population-based study. Glob J Health Sci, 2015, 8(4):60-67.

1. 陳孝平, 汪建平.外科學.第8版.北京:人民衛生出版社, 2013:453.
2. 裘法祖.外科學.第4版.北京:人民衛生出版社, 1995:551.
3. 李前春, 鐘立明.血脂與膽囊結石的相關性分析.安徽醫藥, 2015, 19(5):937-938.
4. 孫曉敏, 徐萍, 馬志紅, 等.上海松江地區膽囊良性疾病的流行病學調查30901例.世界華人消化雜志, 2011, 19(27):2881-2885.
5. 陳敏, 張濤, 克力木, 等.維吾爾族和漢族膽囊結石患病現狀及特點分析.中華臨床醫師雜志:電子版, 2015, 9(8):1352-1358.
6. 劉江偉, 呂復君, 呂輝琴, 等.新疆地區維吾爾族、漢族和哈薩克族三個民族膽囊結石的流行病學分析.中華臨床醫師雜志:電子版, 2013, 7(21):9542-9548.
7. Wang W, Li N. The association of gallstone disease and diabetes mellitus. A meta-analysis. Saudi Med J, 2014, 35(9):1005-1012.
8. 韓天權, 蔣兆彥, 張圣道.膽固醇結石形成機制的基因研究現狀與展望.外科理論與實踐, 2009, 14(2):125-127.
9. Liu FL, Lu WB, Niu WX. XbaI polymorphisms of apolipoprotein B gene:another risk factor of gallstone formation after radical gastrectomy. World J Gastroenterol, 2010, 16(20):2549-2553.
10. 沈安紅.膽囊結石患者血脂水平檢測分析.國際檢驗醫學雜志, 2012, 33(20):2552-2554.
11. 吳著學. 356例機關工作人員脂肪肝和膽囊結石與血脂水平的關系分析.中國現代醫生, 2007, 45(9):57.
12. Scragg RK, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone disease:a case-control study. Br Med J (Clin Res Ed), 1984, 289(6444):521-525.
13. 沈安東, 馬榮賡, 文洽先.膽囊結石與血脂水平的關系.實用醫學雜志, 1993, 9(5):53.
14. Yu JG, Javorschi S, Hevener AL, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes, 2002, 51(10):2968-2974.
15. Xue Y, Sheng Y, Dai H, et al. Risk of development of acute pancreatitis with pre-existing diabetes:a meta-analysis. Eur J Gastroenterol Hepatol, 2012, 24(9):1092-1098.
16. 王春城, 張萬星, 曹月敏.膽囊結石與糖尿病的關系.河北醫科大學學報, 2015, 36(11):1362-1364.
17. 陳子廣.血糖、血脂水平與膽囊結石發病的關系分析.醫學理論與實踐, 2015, 28(7):910-911.
18. 孫明德.分析膽囊結石相關危險因素及防治對策.當代醫學, 2013, 19(25):99.
19. 朱穎, 吳治宇, 馬向明, 等.開灤集團職工膽囊結石臨床流行病學調查.臨床肝膽病雜志, 2015, 31(10):1621-1624.
20. Abu-Eshy SA, Mahfouz AA, Badr A, et al. Prevalence and risk factors of gallstone disease in a high altitude Saudi population. East Mediterr Health J, 2007, 13(4):794-802.
21. 張靜, 劉靜, 陳丹, 等.新疆地區體檢人群膽囊結石與代謝綜合征及其組分相關性分析.中華實用診斷與治療雜志, 2016, 30(9):894-896.
22. Barbara L, Sama C, Morselli Labate AM, et al. A population study on the prevalence of gallstone disease:the Sirmione Study. Hepatology, 1987, 7(5):913-917.
23. 張超, 王旺河.性激素與膽囊結石成因臨床研究.肝膽胰外科雜志, 1997, 9(3):119-120.
24. Einarsson K, Nilsell K, Leijd B, et al. Influence of age on secretion of cholesterol and synthesis of bile acids by the liver. N Engl J Med, 1985, 313(5):277-282.
25. Ansari-Moghaddam A, Khorram A, Miri-Bonjar M, et al. The preva-lence and risk factors of gallstone among adults in south-east of Iran:a population-based study. Glob J Health Sci, 2015, 8(4):60-67.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Analysis of Influence Factors of Gallstone

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