<trans-title xml:lang="en"/>_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

廖輝雄 ¹ , 李志剛 ² ,  謝東偉 ²

1. ;
2. ;

Corresponding?author：

謝東偉, Email: 1044126847@qq.com

Keywords：

降鈣素原; 超敏C反應蛋白; 老年; 胃十二腸潰瘍急性穿孔; 膿毒血癥

DOI：

10.7507/1007-9424.201608040

Video：

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目的探討血清降鈣素原（PCT）與超敏C反應蛋白（hs-CRP）聯合檢測對老年胃十二腸潰瘍急性穿孔合并腹膜炎的診療價值。方法選擇老年胃十二腸潰瘍急性穿孔患者共88例，所有患者于確診胃十二腸潰瘍急性穿孔使用抗菌藥物前同時檢測外周血PCT和hs-cRP水平，并同時進行白細胞計數和血培養。結果非膿毒癥組、輕度膿毒癥組和重度膿毒癥組患者的血清PCT及hs-CRP水平依次升高，3 組間差異有統計學意義（P＜0.01）。非膿毒癥組、輕度膿毒癥組和重度膿毒癥組白細胞計數依次升高，3 組間差異有統計學意義（P＜0.01）。非膿毒癥組血培養結果陽性率為 0；輕度膿毒癥組血培養結果陽性者 5 例，占全部血培養患者的5.68%；重度膿毒癥組血培養結果陽性者38例，占全部血培養患者的43.18%，3 組間的差異有統計學意義（P＜0.01）。結論 PCTM與hs-CRP聯合檢測有助于老年胃十二腸潰瘍急性穿孔合并腹膜炎患者感染狀況的判斷以及指導抗菌藥物的使用。

Citation： XIEDongwei. . CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(1): 101-103. doi: 10.7507/1007-9424.201608040 Copy

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6.	Gendrel D, Bohuon C. Procalcitonin as a marker of bacterial infection. Pediatr Infect Dis J, 2000, 19(8): 679-687.
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11.	郭曉俊, 王青, 宋穎, 等. 新鮮血液白細胞計數參考方法的測量不確定度評定. 檢驗醫學, 2015, 30(5): 512-516.
12.	Pepys MB, Hirschfield GM. C-reactive protein a critical update. J Clin Invest, 2003, 111(12): 1805-1812.
13.	侯偉偉, 肖倩茹, 江漣, 等. 血清降鈣素原作為菌血癥預示因子臨床價值的研究. 檢驗醫學, 2014, 29(8): 802-805.
14.	李龍, 王飛. 老年胃十二指腸潰瘍穿孔的診治. 中外醫學研究, 2010, 8(17): 789-793.

1. ?李榮, 羅成華. 老年人急腹癥的診斷與剖腹探查. 中國實用外科雜志, 2003, 23(7): 401-403.
2. 覃關道, 潘枝婉, 覃振黨. 螺旋CT診斷胃十二腸潰瘍穿孔的價值分析. 2014, 35(1): 69-70.
3. 葉鋼. 探討膿毒血癥預后評估中降鈣素原和N末端前體腦鈉肽的臨床意義. 中華高血壓雜志, 2015, 23(綜合3): 337-338.
4. Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev, 2006, 19(4): 788-802.
5. Schuetz P, Mueller B, Trampuz A. Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci. Infection, 2007, 35(5): 352-355.
6. Gendrel D, Bohuon C. Procalcitonin as a marker of bacterial infection. Pediatr Infect Dis J, 2000, 19(8): 679-687.
7. Vincen JL, DOnadello K, Schmit X. Biomarkers in the critically ill patient: C-reactive protein. Crit Care CLin, 2011, 27(2): 241-251.
8. Reinhart K, Karzai W, Meisner M. Procalcitonin as a marker of the systemic inflammatory response to infection. Intensive Care Med, 2000, 26(9): 1193-1200.
9. Meisner M, Schmidt J, Huttner H, et al. The natural elimination rate of procalcitonin in patients with normal and impaired renal function. Intensive Care Med, 2000, 26(Suppl 2): S212-S216.
10. Harbarth S, Holeckova K, Froidevaux C, et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med, 2001, 164(3): 396-402.
11. 郭曉俊, 王青, 宋穎, 等. 新鮮血液白細胞計數參考方法的測量不確定度評定. 檢驗醫學, 2015, 30(5): 512-516.
12. Pepys MB, Hirschfield GM. C-reactive protein a critical update. J Clin Invest, 2003, 111(12): 1805-1812.
13. 侯偉偉, 肖倩茹, 江漣, 等. 血清降鈣素原作為菌血癥預示因子臨床價值的研究. 檢驗醫學, 2014, 29(8): 802-805.
14. 李龍, 王飛. 老年胃十二指腸潰瘍穿孔的診治. 中外醫學研究, 2010, 8(17): 789-793.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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