Ultrasonographic features of gastrointestinal stromal tumors_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 SHEN Shihua , LI Jianwei , WU Songsong , ZHU Lin , CHEN Sheng , YE Zhensheng

Department of Ultrasound, Fujian Provincial Hospital, Fuzhou 350001, P.R.China;

Corresponding?author：

SHEN Shihua, Email: 13635264982@163.com

Keywords：

color Doppler; gastrointestinal stromal tumor; gastrointestinal cancer

DOI：

10.7507/1007-9424.201610001

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze features of color Doppler ultrasonography in gastrointestinal stromal tumors. Method The ultrasound images of gastrointestinal stromal tumors (51 cases) and gastrointestinal cancers (59 cases) confirmed by operation and pathology were compared and analyzed. Results The gastric stromal tumor mainly occurred at the bottom of the stomach and the body of the stomach (17 cases), the intestinal stromal tumor mainly occurred at the small intestine (24 cases). The gastric cancer mainly occurred at the gastric antrum (18 cases), the intestinal cancer all occurred at the colon (20 cases) and rectum (12 cases). Compared with the gastrointestinal cancers, the gastrointestinal cavity was not surrounded by tumor, the peripheral boundary was clear, the morphology was more regular, the internal echo was uneven, and there was no peripheral lymph node metastasis in the gastrointestinal stromal tumors, the differences were statistically significant (P<0.05). There were no significant differences in the degree of blood flow and tumor diameter between the gastrointestinal stromal tumors and the gastrointestinal cancers (P>0.05), but the blood flow of the intestinal stromal tumor was significantly more abundant as compared with the intestinal cancer (P<0.05). Conclusion Color Doppler ultrasonography, as a simple and rapid method, has a certain diagnostic value for differentiation of gastrointestinal stromal tumors and gastrointestinal cancers.

Citation： SHEN Shihua, LI Jianwei, WU Songsong, ZHU Lin, CHEN Sheng, YE Zhensheng. Ultrasonographic features of gastrointestinal stromal tumors. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2017, 24(5): 606-610. doi: 10.7507/1007-9424.201610001 Copy

1.	?Orosz Z, Tornóczky T, Sápi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res, 2005, 11(1): 11-21.
2.	Joensuu H, Fletcher C, Dimitrijevic S, et al. Management of malignant gastrointestinal stromal tumours. Lancet Oncol, 2002, 3(11): 655-664.
3.	Ponsaing LG, Hansen MB. Therapeutic procedures for submucosal tumors in the gastrointestinal tract. World J Gastroenterol, 2007, 13(24): 3316-3322.
4.	El-Hanafy E, El-Hemaly M, Hamdy E, et al. Surgical management of gastric gastrointestinal stromal tumor: a single center experience. Saudi J Gastroenterol, 2011, 17(3): 189-193.
5.	Korenkov MK, Hong NJ, Raut CP. Individual surgery for gastric gastrointestinal stromal tumors. Surg Technol Int, 2014, 24: 139-145.
6.	牟一, 胡兵, 易航, 等. 內鏡下切除與外科手術治療胃腸道間質瘤的療效比較. 中華消化雜志, 2013, 33(10): 705-706.
7.	CSCO胃腸間質瘤專家委員會. 中國胃腸間質瘤診斷治療共識(2013 年版). 臨床腫瘤學雜志, 2013, 18(11): 1025-1032.
8.	ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol, 2014, 25 Suppl 3: iii21-iii6.
9.	曹暉, 汪明. NCCN《軟組織肉瘤—胃腸間質瘤臨床實踐指南(2015 年第 1 版)》更新介紹與解讀. 中國實用外科雜志, 2015, 35(6): 599-603.
10.	Adler DD, Carson PL, Rubin JM, et al. Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings. Ultrasound Med Biol, 1990, 16(6): 553-559.
11.	趙巧玲, 穆俊武, 王居頒, 等. 原發性小腸腫瘤的超聲顯像分析. 現代腫瘤學, 1997, 5(4): 200-201.
12.	程伏林, 魏正專. 103 例胃腸道間質瘤的臨床病理與預后分析. 腫瘤防治研究, 2007, 34(11): 864-867.
13.	劉艷君, 王學梅. 胃腸道間質瘤的超聲檢查與病理檢查對比分析. 中國醫科大學學報, 2007, 36(4): 480-482.
14.	曹海根, 王金銳. 實用腹部超聲診斷學. 北京: 人民衛生出版社, 1994: 408-412.
15.	朱建偉, 王雷, 郭杰芳, 等. 超聲內鏡在胃腸道間質瘤診斷中的應用價值. 中華消化內鏡雜志, 2014, 31(6): 342-344.
16.	吳龍云, 彭春艷, 呂瑛, 等. 原發性胃小間質瘤的臨床處理及評價: 一項單中心的回顧性研究. 中華消化內鏡雜志, 2016, 33(7): 442-446.
17.	Logro?o R, Jones DV, Faruqi S, et al. Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther, 2004, 3(3): 251-258.
18.	李洪林, 郝玉芝, 陳宇, 等. 胃腸道間質瘤的超聲診斷. 中國超聲醫學雜志, 2005, 21(12): 921-923.
19.	Naitoh I, Okayama Y, Hirai M, et al. Exophytic pedunculated gastrointestinal stromal tumor with remarkable cystic change. J Gastroenterol, 2003, 38(12): 1181-1184.
20.	Takao H, Yamahira K, DoiI, et al. Gastrointestinal stromal tumor of the retroperitoneum: CT and MR findings. Eur Radiol, 2004, 14(10): 1926-1929.
21.	李耀平, 梁小波, 原韶玲, 等. 超聲在小腸間質瘤中的應用價值. 山西醫科大學學報, 2007, 38(6): 537-539.
22.	Fang SH, Dong DJ, Zhang SZ, et al. Angiographic findings of gastrointestinal stromal tumor. World J Gastroenterol, 2004, 10(19): 2905-2907.
23.	Chung JC, Chu CW, Cho GS, et al. Management and outcome of gastrointestinal stromal tumors of the duodenum. J Gastrointest Surg, 2010, 14(5): 880-883.
24.	黃鵬, 吳河水. 胃腸道間質瘤 30 例外科診治分析. 中國臨床新醫學, 2016, 9(4): 298-301.
25.	Johnston FM, Kneuertz PJ, Cameron JL, et al. Presentation and management of gastrointestinal stromal tumors of the duodenum: a multi-institutional analysis. Ann Surg Oncol, 2012, 19(11): 3351-3360.
26.	Miettinen M, Lasota J. Histopathology of gastrointestinal stromal tumor. J Surg Oncol, 2011, 104(8): 865-873.
27.	王黔, 嚴芝強, 王海斌, 等. 99 例胃腸道間質瘤臨床分析. 中國現代普通外科進展, 2012, 15(6): 463-465.
28.	Dietrich C, Hartung E, Ignee A. The use of contrast-enhanced ultrasound in patients with GIST metastases that are negative in CT and PET. Ultraschall Med, 2008, 29 Suppl 5: 276-277.
29.	Burkill GJ, Badran M, Al-Muderis O, et al. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology, 2003, 226(2): 527-532.
30.	李成明, 張瑜, 祝青松, 等. CT 診斷為間質瘤. 中國醫學影像學雜志, 2008, 16(2): 145-146.
31.	劉長青, 譚詩云, 李軍華, 等. 超聲內鏡聯合 CT 對胃間質瘤的臨床診斷價值. 世界華人消化雜志, 2012, 20(25): 2404-2406.
32.	王岑立. 胃腸道間質瘤 45 例臨床分析. 中華內分泌外科雜志, 2014, 8(1): 62-63.
33.	彭春艷, 呂瑛, 徐桂芳, 等. 術前超聲內鏡對胃間質瘤的診斷及侵襲危險性評估價值研究. 中華消化內鏡雜志, 2015, 32(6): 361-366.
34.	鄂連成. 胃腸道間質瘤的臨床診斷和治療分析. 中國實用醫刊, 2014, 41(20): 82-84.
35.	丁偉超, 張蓬波, 張秀忠, 等. 胃腸道間質瘤的術前診斷分析. 中國腫瘤外科雜志, 2014, 6(1): 54-56.

1. ?Orosz Z, Tornóczky T, Sápi Z. Gastrointestinal stromal tumors: a clinicopathologic and immunohistochemical study of 136 cases. Pathol Oncol Res, 2005, 11(1): 11-21.
2. Joensuu H, Fletcher C, Dimitrijevic S, et al. Management of malignant gastrointestinal stromal tumours. Lancet Oncol, 2002, 3(11): 655-664.
3. Ponsaing LG, Hansen MB. Therapeutic procedures for submucosal tumors in the gastrointestinal tract. World J Gastroenterol, 2007, 13(24): 3316-3322.
4. El-Hanafy E, El-Hemaly M, Hamdy E, et al. Surgical management of gastric gastrointestinal stromal tumor: a single center experience. Saudi J Gastroenterol, 2011, 17(3): 189-193.
5. Korenkov MK, Hong NJ, Raut CP. Individual surgery for gastric gastrointestinal stromal tumors. Surg Technol Int, 2014, 24: 139-145.
6. 牟一, 胡兵, 易航, 等. 內鏡下切除與外科手術治療胃腸道間質瘤的療效比較. 中華消化雜志, 2013, 33(10): 705-706.
7. CSCO胃腸間質瘤專家委員會. 中國胃腸間質瘤診斷治療共識(2013 年版). 臨床腫瘤學雜志, 2013, 18(11): 1025-1032.
8. ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol, 2014, 25 Suppl 3: iii21-iii6.
9. 曹暉, 汪明. NCCN《軟組織肉瘤—胃腸間質瘤臨床實踐指南(2015 年第 1 版)》更新介紹與解讀. 中國實用外科雜志, 2015, 35(6): 599-603.
10. Adler DD, Carson PL, Rubin JM, et al. Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings. Ultrasound Med Biol, 1990, 16(6): 553-559.
11. 趙巧玲, 穆俊武, 王居頒, 等. 原發性小腸腫瘤的超聲顯像分析. 現代腫瘤學, 1997, 5(4): 200-201.
12. 程伏林, 魏正專. 103 例胃腸道間質瘤的臨床病理與預后分析. 腫瘤防治研究, 2007, 34(11): 864-867.
13. 劉艷君, 王學梅. 胃腸道間質瘤的超聲檢查與病理檢查對比分析. 中國醫科大學學報, 2007, 36(4): 480-482.
14. 曹海根, 王金銳. 實用腹部超聲診斷學. 北京: 人民衛生出版社, 1994: 408-412.
15. 朱建偉, 王雷, 郭杰芳, 等. 超聲內鏡在胃腸道間質瘤診斷中的應用價值. 中華消化內鏡雜志, 2014, 31(6): 342-344.
16. 吳龍云, 彭春艷, 呂瑛, 等. 原發性胃小間質瘤的臨床處理及評價: 一項單中心的回顧性研究. 中華消化內鏡雜志, 2016, 33(7): 442-446.
17. Logro?o R, Jones DV, Faruqi S, et al. Recent advances in cell biology, diagnosis, and therapy of gastrointestinal stromal tumor (GIST). Cancer Biol Ther, 2004, 3(3): 251-258.
18. 李洪林, 郝玉芝, 陳宇, 等. 胃腸道間質瘤的超聲診斷. 中國超聲醫學雜志, 2005, 21(12): 921-923.
19. Naitoh I, Okayama Y, Hirai M, et al. Exophytic pedunculated gastrointestinal stromal tumor with remarkable cystic change. J Gastroenterol, 2003, 38(12): 1181-1184.
20. Takao H, Yamahira K, DoiI, et al. Gastrointestinal stromal tumor of the retroperitoneum: CT and MR findings. Eur Radiol, 2004, 14(10): 1926-1929.
21. 李耀平, 梁小波, 原韶玲, 等. 超聲在小腸間質瘤中的應用價值. 山西醫科大學學報, 2007, 38(6): 537-539.
22. Fang SH, Dong DJ, Zhang SZ, et al. Angiographic findings of gastrointestinal stromal tumor. World J Gastroenterol, 2004, 10(19): 2905-2907.
23. Chung JC, Chu CW, Cho GS, et al. Management and outcome of gastrointestinal stromal tumors of the duodenum. J Gastrointest Surg, 2010, 14(5): 880-883.
24. 黃鵬, 吳河水. 胃腸道間質瘤 30 例外科診治分析. 中國臨床新醫學, 2016, 9(4): 298-301.
25. Johnston FM, Kneuertz PJ, Cameron JL, et al. Presentation and management of gastrointestinal stromal tumors of the duodenum: a multi-institutional analysis. Ann Surg Oncol, 2012, 19(11): 3351-3360.
26. Miettinen M, Lasota J. Histopathology of gastrointestinal stromal tumor. J Surg Oncol, 2011, 104(8): 865-873.
27. 王黔, 嚴芝強, 王海斌, 等. 99 例胃腸道間質瘤臨床分析. 中國現代普通外科進展, 2012, 15(6): 463-465.
28. Dietrich C, Hartung E, Ignee A. The use of contrast-enhanced ultrasound in patients with GIST metastases that are negative in CT and PET. Ultraschall Med, 2008, 29 Suppl 5: 276-277.
29. Burkill GJ, Badran M, Al-Muderis O, et al. Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread. Radiology, 2003, 226(2): 527-532.
30. 李成明, 張瑜, 祝青松, 等. CT 診斷為間質瘤. 中國醫學影像學雜志, 2008, 16(2): 145-146.
31. 劉長青, 譚詩云, 李軍華, 等. 超聲內鏡聯合 CT 對胃間質瘤的臨床診斷價值. 世界華人消化雜志, 2012, 20(25): 2404-2406.
32. 王岑立. 胃腸道間質瘤 45 例臨床分析. 中華內分泌外科雜志, 2014, 8(1): 62-63.
33. 彭春艷, 呂瑛, 徐桂芳, 等. 術前超聲內鏡對胃間質瘤的診斷及侵襲危險性評估價值研究. 中華消化內鏡雜志, 2015, 32(6): 361-366.
34. 鄂連成. 胃腸道間質瘤的臨床診斷和治療分析. 中國實用醫刊, 2014, 41(20): 82-84.
35. 丁偉超, 張蓬波, 張秀忠, 等. 胃腸道間質瘤的術前診斷分析. 中國腫瘤外科雜志, 2014, 6(1): 54-56.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Ultrasonographic features of gastrointestinal stromal tumors

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